If you have a dog, this article may be useful, particularly if your dog is receiving #Librela or #Lenivia, or if you are considering either treatment. #AntiNGF #Dogs #VetMed #DogArthritis #Bedinvetmab #Izenivetmab
doi.org/10.3389/fvet...
doi.org/10.3389/fvet...
Frontiers | A neurotrophic withdrawal hypothesis for multisystem adverse events associated with anti-NGF therapy for canine osteoarthritis pain
Post-marketing reports in dogs treated with bedinvetmab (Librela™, Zoetis), the first anti-nerve growth factor (NGF) monoclonal antibody approved for canine ...
doi.org
September 11, 2026 at 7:06 AM
If you have a dog, this article may be useful, particularly if your dog is receiving #Librela or #Lenivia, or if you are considering either treatment. #AntiNGF #Dogs #VetMed #DogArthritis #Bedinvetmab #Izenivetmab
doi.org/10.3389/fvet...
doi.org/10.3389/fvet...
The RPOA & antiNGF story:
One potential mechanism related to role of nerves in maintain tissue structure & repair: pubmed.ncbi.nlm.nih.gov/34400627/
If we inhibit NGF or TrkA, what happens to the tissues?
One potential mechanism related to role of nerves in maintain tissue structure & repair: pubmed.ncbi.nlm.nih.gov/34400627/
If we inhibit NGF or TrkA, what happens to the tissues?
NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma - PubMed
Pain is a central feature of soft tissue trauma, which under certain contexts, results in aberrant osteochondral differentiation of tissue-specific stem cells. Here, the role of sensory nerve fibers i...
pubmed.ncbi.nlm.nih.gov
November 16, 2024 at 11:35 AM
The RPOA & antiNGF story:
One potential mechanism related to role of nerves in maintain tissue structure & repair: pubmed.ncbi.nlm.nih.gov/34400627/
If we inhibit NGF or TrkA, what happens to the tissues?
One potential mechanism related to role of nerves in maintain tissue structure & repair: pubmed.ncbi.nlm.nih.gov/34400627/
If we inhibit NGF or TrkA, what happens to the tissues?
NGF pathway and OA pain: unfortunately RPOA events in RCTs means we aren't able to use these antiNGF agents for human OA (but we can in CATS)
👉🏿depends on mechanosensitive ion channels - like piezo2
👉🏿depends on mechanosensitive ion channels - like piezo2
November 15, 2024 at 10:49 AM
NGF pathway and OA pain: unfortunately RPOA events in RCTs means we aren't able to use these antiNGF agents for human OA (but we can in CATS)
👉🏿depends on mechanosensitive ion channels - like piezo2
👉🏿depends on mechanosensitive ion channels - like piezo2