CRN Team Vangheluwe found that cholesterol build-up in APOE4 astrocytes impairs α-synuclein clearance and promotes pathology in human "miBrain" models.
🔗 Read the #publication: bit.ly/4ju4pL7
🔗 Read the #publication: bit.ly/4ju4pL7
November 2, 2026 at 4:18 PM
CRN Team Vangheluwe found that cholesterol build-up in APOE4 astrocytes impairs α-synuclein clearance and promotes pathology in human "miBrain" models.
🔗 Read the #publication: bit.ly/4ju4pL7
🔗 Read the #publication: bit.ly/4ju4pL7
Does the Amount of APOE4 in the Brain Matter More Than Its Lipid Transport?
open.substack.com/pub/hyassine...
open.substack.com/pub/hyassine...
Does the Amount of APOE4 in the Brain Matter More Than Its Lipid Transport?
New findings suggest that APOE4 levels in brain fluid are more closely associated with tau pathology than small or large HDL particles.
open.substack.com
November 1, 2026 at 8:35 PM
Does the Amount of APOE4 in the Brain Matter More Than Its Lipid Transport?
open.substack.com/pub/hyassine...
open.substack.com/pub/hyassine...
Happy #fluorescencefriday Our APOE4 mice showing blood vessels (magenta), amyloid (cyan) and microglia (yellow) by @shahrzadbahrampour.bsky.social and @arashsalah.bsky.social with the @mind-western.bsky.social we want to map the relationship between microglia and plaques with blood vessels
October 30, 2026 at 3:40 PM
Happy #fluorescencefriday Our APOE4 mice showing blood vessels (magenta), amyloid (cyan) and microglia (yellow) by @shahrzadbahrampour.bsky.social and @arashsalah.bsky.social with the @mind-western.bsky.social we want to map the relationship between microglia and plaques with blood vessels
Thinking about an Alzheimer's prevention trial with APOE4?
Ask three things first: do you have the time, do you want to learn new results about yourself, and is the drug's risk OK for you.
Jessica Langbaum, PhD, on what trials really ask:
Ask three things first: do you have the time, do you want to learn new results about yourself, and is the drug's risk OK for you.
Jessica Langbaum, PhD, on what trials really ask:
APOE4: Should You Join a Prevention Trial?
Thinking about joining an Alzheimer's prevention trial as a healthy...
youtu.be
November 2, 2026 at 5:45 PM
Thinking about an Alzheimer's prevention trial with APOE4?
Ask three things first: do you have the time, do you want to learn new results about yourself, and is the drug's risk OK for you.
Jessica Langbaum, PhD, on what trials really ask:
Ask three things first: do you have the time, do you want to learn new results about yourself, and is the drug's risk OK for you.
Jessica Langbaum, PhD, on what trials really ask:
Happy #FluorescenceFriday! 🔬✨ Fascinating work investigating the relationship between microglia, amyloid plaques, and blood vessels in APOE4 mice!
Happy #fluorescencefriday Our APOE4 mice showing blood vessels (magenta), amyloid (cyan) and microglia (yellow) by @shahrzadbahrampour.bsky.social and @arashsalah.bsky.social with the @mind-western.bsky.social we want to map the relationship between microglia and plaques with blood vessels
October 30, 2026 at 5:10 PM
Happy #FluorescenceFriday! 🔬✨ Fascinating work investigating the relationship between microglia, amyloid plaques, and blood vessels in APOE4 mice!
MIT Study Ties Alzheimer's Gene APOE4 to a Myelin Defect, Partly Reversed in Mice and Organoids
#Alzheimers #Apoe4 #CRISPR #MIT #Neurology
edufabtech.com/news/mit-apo...
#Alzheimers #Apoe4 #CRISPR #MIT #Neurology
edufabtech.com/news/mit-apo...
November 1, 2026 at 12:28 PM
MIT Study Ties Alzheimer's Gene APOE4 to a Myelin Defect, Partly Reversed in Mice and Organoids
#Alzheimers #Apoe4 #CRISPR #MIT #Neurology
edufabtech.com/news/mit-apo...
#Alzheimers #Apoe4 #CRISPR #MIT #Neurology
edufabtech.com/news/mit-apo...
My free APOE4 Genetic Testing & Family Guide covers the disclosure talk and the daily habits I follow as a 4/4 carrier:
apoe4.link/disclosure
Education, not medical advice.
apoe4.link/disclosure
Education, not medical advice.
November 2, 2026 at 9:11 PM
My free APOE4 Genetic Testing & Family Guide covers the disclosure talk and the daily habits I follow as a 4/4 carrier:
apoe4.link/disclosure
Education, not medical advice.
apoe4.link/disclosure
Education, not medical advice.
🧵 3/3
Prevention figures are population-level, they lower risk, not a promise. Not medical advice.
Walk in prepared: bring your genotype, ask what's actionable now. Want my free Doctor Conversation Kit? apoe4.link/doctorgap
Prevention figures are population-level, they lower risk, not a promise. Not medical advice.
Walk in prepared: bring your genotype, ask what's actionable now. Want my free Doctor Conversation Kit? apoe4.link/doctorgap
November 3, 2026 at 9:12 PM
🧵 3/3
Prevention figures are population-level, they lower risk, not a promise. Not medical advice.
Walk in prepared: bring your genotype, ask what's actionable now. Want my free Doctor Conversation Kit? apoe4.link/doctorgap
Prevention figures are population-level, they lower risk, not a promise. Not medical advice.
Walk in prepared: bring your genotype, ask what's actionable now. Want my free Doctor Conversation Kit? apoe4.link/doctorgap
For APOE4 carriers, forgetting a name or where you parked can trigger fears about Alzheimer's. But constantly monitoring every memory lapse can create an anxiety loop that makes you even more forgetful.
Watch -
Watch -
APOE4 and the Anxiety Around Forgetting Things
For APOE4 carriers, everyday memory lapses can sometimes trigger fe...
youtube.com
November 1, 2026 at 8:04 PM
For APOE4 carriers, forgetting a name or where you parked can trigger fears about Alzheimer's. But constantly monitoring every memory lapse can create an anxiety loop that makes you even more forgetful.
Watch -
Watch -
November 3, 2026 at 9:12 PM
Her full method, free:
apoe4.link/analyst
Education, not medical advice. Talk to your clinician before changing how you eat.
apoe4.link/analyst
Education, not medical advice. Talk to your clinician before changing how you eat.
November 1, 2026 at 9:10 PM
Her full method, free:
apoe4.link/analyst
Education, not medical advice. Talk to your clinician before changing how you eat.
apoe4.link/analyst
Education, not medical advice. Talk to your clinician before changing how you eat.
🧵 3/3
Honest limits: these studies measured anxiety and behavior, not Alzheimer's outcomes. You choose the timing. Not medical advice.
A genetic counselor can help you plan it. Want my free Genetic Testing & Family Guide? apoe4.link/disclosure
Honest limits: these studies measured anxiety and behavior, not Alzheimer's outcomes. You choose the timing. Not medical advice.
A genetic counselor can help you plan it. Want my free Genetic Testing & Family Guide? apoe4.link/disclosure
November 2, 2026 at 9:11 PM
🧵 3/3
Honest limits: these studies measured anxiety and behavior, not Alzheimer's outcomes. You choose the timing. Not medical advice.
A genetic counselor can help you plan it. Want my free Genetic Testing & Family Guide? apoe4.link/disclosure
Honest limits: these studies measured anxiety and behavior, not Alzheimer's outcomes. You choose the timing. Not medical advice.
A genetic counselor can help you plan it. Want my free Genetic Testing & Family Guide? apoe4.link/disclosure
🧵 1/3
If your doctor seemed unsure about your APOE4 result, it wasn't them, it was the calendar: guidelines advised against routine testing until 2023.
ARIA risk on new amyloid drugs: 5.4% with no copies, 10.9% with one, 32.6% with two (Hanson 2023, CLARITY AD).
If your doctor seemed unsure about your APOE4 result, it wasn't them, it was the calendar: guidelines advised against routine testing until 2023.
ARIA risk on new amyloid drugs: 5.4% with no copies, 10.9% with one, 32.6% with two (Hanson 2023, CLARITY AD).
November 3, 2026 at 9:12 PM
🧵 1/3
If your doctor seemed unsure about your APOE4 result, it wasn't them, it was the calendar: guidelines advised against routine testing until 2023.
ARIA risk on new amyloid drugs: 5.4% with no copies, 10.9% with one, 32.6% with two (Hanson 2023, CLARITY AD).
If your doctor seemed unsure about your APOE4 result, it wasn't them, it was the calendar: guidelines advised against routine testing until 2023.
ARIA risk on new amyloid drugs: 5.4% with no copies, 10.9% with one, 32.6% with two (Hanson 2023, CLARITY AD).
The full breakdown, free:
apoe4.link/defiedodds
Education, not medical advice. These are genetic findings, not promises. Talk to your clinician.
apoe4.link/defiedodds
Education, not medical advice. These are genetic findings, not promises. Talk to your clinician.
October 31, 2026 at 9:45 PM
The full breakdown, free:
apoe4.link/defiedodds
Education, not medical advice. These are genetic findings, not promises. Talk to your clinician.
apoe4.link/defiedodds
Education, not medical advice. These are genetic findings, not promises. Talk to your clinician.
October 30, 2026 at 9:10 PM
🧵 3/3
The Christchurch case is one remarkable person, blending human and lab findings. Supporting these pathways is sensible care, not a guarantee. Not medical advice.
Don't envy the lucky genes, work the levers they reveal. Want the full breakdown? apoe4.link/defiedodds
The Christchurch case is one remarkable person, blending human and lab findings. Supporting these pathways is sensible care, not a guarantee. Not medical advice.
Don't envy the lucky genes, work the levers they reveal. Want the full breakdown? apoe4.link/defiedodds
October 31, 2026 at 9:45 PM
🧵 3/3
The Christchurch case is one remarkable person, blending human and lab findings. Supporting these pathways is sensible care, not a guarantee. Not medical advice.
Don't envy the lucky genes, work the levers they reveal. Want the full breakdown? apoe4.link/defiedodds
The Christchurch case is one remarkable person, blending human and lab findings. Supporting these pathways is sensible care, not a guarantee. Not medical advice.
Don't envy the lucky genes, work the levers they reveal. Want the full breakdown? apoe4.link/defiedodds
🧵 3/3
Her message to older carriers: 'You can't reach this age without some issues. Just do what you can.' This is one person's story, not medical advice.
Don't let perfect be the enemy of good. Just start. Want the full breakdown? apoe4.link/diagnosed
Her message to older carriers: 'You can't reach this age without some issues. Just do what you can.' This is one person's story, not medical advice.
Don't let perfect be the enemy of good. Just start. Want the full breakdown? apoe4.link/diagnosed
October 29, 2026 at 9:10 PM
🧵 3/3
Her message to older carriers: 'You can't reach this age without some issues. Just do what you can.' This is one person's story, not medical advice.
Don't let perfect be the enemy of good. Just start. Want the full breakdown? apoe4.link/diagnosed
Her message to older carriers: 'You can't reach this age without some issues. Just do what you can.' This is one person's story, not medical advice.
Don't let perfect be the enemy of good. Just start. Want the full breakdown? apoe4.link/diagnosed
MIT researchers used a genome-wide CRISPR screen to show how the Alzheimer's risk gene APOE4 disrupts myelin-making cells, then partly reversed the defect with a research compound in organoids and mice.
November 1, 2026 at 12:28 PM
MIT researchers used a genome-wide CRISPR screen to show how the Alzheimer's risk gene APOE4 disrupts myelin-making cells, then partly reversed the defect with a research compound in organoids and mice.
🧵 3/3
Robin's A1C and weight are one carrier's self-reported experience, not a trial. Not medical advice.
That 5.7 to 5.4 swing is one of the most underrated levers for carriers in their 40s and 50s. Want the full breakdown? apoe4.link/analyst
Robin's A1C and weight are one carrier's self-reported experience, not a trial. Not medical advice.
That 5.7 to 5.4 swing is one of the most underrated levers for carriers in their 40s and 50s. Want the full breakdown? apoe4.link/analyst
November 1, 2026 at 9:10 PM
🧵 3/3
Robin's A1C and weight are one carrier's self-reported experience, not a trial. Not medical advice.
That 5.7 to 5.4 swing is one of the most underrated levers for carriers in their 40s and 50s. Want the full breakdown? apoe4.link/analyst
Robin's A1C and weight are one carrier's self-reported experience, not a trial. Not medical advice.
That 5.7 to 5.4 swing is one of the most underrated levers for carriers in their 40s and 50s. Want the full breakdown? apoe4.link/analyst
Extract: The Department of Biochemistry and Biophysics at Stockholm University is seeking a PhD student to conduct research on the liver-brain axis communication and neurodegenerative diseases, focusing on the APOE4 genotype's impact on Alzheimer's disease.
November 2, 2026 at 7:08 AM
Extract: The Department of Biochemistry and Biophysics at Stockholm University is seeking a PhD student to conduct research on the liver-brain axis communication and neurodegenerative diseases, focusing on the APOE4 genotype's impact on Alzheimer's disease.
The authors included RRIDs in their paper! Thanks for making your methods matter! #BetterScience #OpenScience #methodsmatter
Progressive behavioral and cognitive decline in Drosophila harboring AD-associated APOE4 variants
Read the full paper: Progressive behavioral and cognitive decline in Drosophila harboring AD-associated APOE4 variants
doi.org
October 30, 2026 at 7:09 AM
The authors included RRIDs in their paper! Thanks for making your methods matter! #BetterScience #OpenScience #methodsmatter
A new #Alzheimers study from @mit.edu shows that APOE4 leads to a suppression of Wnt signaling in the oligodendrocyte cells that provide neurons with myelin.
⚗️ Abstract: https://bit.ly/4sC8srm
🗞️ Press release: https://bit.ly/4jNzAkI
⚗️ Abstract: https://bit.ly/4sC8srm
🗞️ Press release: https://bit.ly/4jNzAkI
October 29, 2026 at 9:50 PM
A new #Alzheimers study from @mit.edu shows that APOE4 leads to a suppression of Wnt signaling in the oligodendrocyte cells that provide neurons with myelin.
⚗️ Abstract: https://bit.ly/4sC8srm
🗞️ Press release: https://bit.ly/4jNzAkI
⚗️ Abstract: https://bit.ly/4sC8srm
🗞️ Press release: https://bit.ly/4jNzAkI
🧵 3/3
'It's like I found my people,' after lonely years and fear-filled Facebook groups. Not medical advice.
Her advice: if you're young, so much research is coming. If you're older, don't freak out, you have control. Want the full breakdown? apoe4.link/sharp72
'It's like I found my people,' after lonely years and fear-filled Facebook groups. Not medical advice.
Her advice: if you're young, so much research is coming. If you're older, don't freak out, you have control. Want the full breakdown? apoe4.link/sharp72
October 30, 2026 at 9:10 PM
🧵 3/3
'It's like I found my people,' after lonely years and fear-filled Facebook groups. Not medical advice.
Her advice: if you're young, so much research is coming. If you're older, don't freak out, you have control. Want the full breakdown? apoe4.link/sharp72
'It's like I found my people,' after lonely years and fear-filled Facebook groups. Not medical advice.
Her advice: if you're young, so much research is coming. If you're older, don't freak out, you have control. Want the full breakdown? apoe4.link/sharp72
Her full story, free:
apoe4.link/diagnosed
Education, not medical advice. Talk to your clinician before changing anything.
apoe4.link/diagnosed
Education, not medical advice. Talk to your clinician before changing anything.
October 29, 2026 at 9:10 PM
Her full story, free:
apoe4.link/diagnosed
Education, not medical advice. Talk to your clinician before changing anything.
apoe4.link/diagnosed
Education, not medical advice. Talk to your clinician before changing anything.
How the biggest Alzheimer’s risk gene disrupts the process of insulating neurons
MIT News
news.mit.edu/2026/how-big...
MIT News
news.mit.edu/2026/how-big...
How the biggest Alzheimer’s risk gene disrupts the process of insulating neurons
MIT researchers discovered how the biggest Alzheimer’s risk gene disrupts the process of insulating neurons: The APOE4 gene variant suppresses molecular signaling needed for oligodendrocytes to myelin...
news.mit.edu
October 30, 2026 at 3:44 AM
How the biggest Alzheimer’s risk gene disrupts the process of insulating neurons
MIT News
news.mit.edu/2026/how-big...
MIT News
news.mit.edu/2026/how-big...