Can confirm. Adding the F word to your google searches turns off AI summaries. E.g.:
"how do massively parallel reporter assays work?"
vs
"how do f*cking massively parallel reporter assays work?"
"how do massively parallel reporter assays work?"
vs
"how do f*cking massively parallel reporter assays work?"
February 1, 2025 at 10:51 AM
Can confirm. Adding the F word to your google searches turns off AI summaries. E.g.:
"how do massively parallel reporter assays work?"
vs
"how do f*cking massively parallel reporter assays work?"
"how do massively parallel reporter assays work?"
vs
"how do f*cking massively parallel reporter assays work?"
Okay this is top-tier satire.
But also recombinant factor C assays pls
But also recombinant factor C assays pls
RFK Jr.: Vaccines No More Effective Than Drinking Horseshoe Crab Blood Straight theonion.com/rfk-jr-...
June 27, 2025 at 3:55 PM
Okay this is top-tier satire.
But also recombinant factor C assays pls
But also recombinant factor C assays pls
Comparison between a neuronal massively parallel reporter assay for 50,000 sequences and 20,000 variants with mouse enhancer assays provide complimentary information. Great work by Michael Kosicki, Dianne Laboy Cintrón, Len Pennacchio, Martin Kircher lab & many others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Massively parallel reporter assays and mouse transgenic assays provide correlated and complementary information about neuronal enhancer activity - Nature Communications
MPRAs and in vivo transgenic mouse assays are two potentially complementary ways to assay the impact of noncoding variants. Here, authors find a strong and specific correlation between the assays in n...
www.nature.com
May 24, 2025 at 7:08 PM
Comparison between a neuronal massively parallel reporter assay for 50,000 sequences and 20,000 variants with mouse enhancer assays provide complimentary information. Great work by Michael Kosicki, Dianne Laboy Cintrón, Len Pennacchio, Martin Kircher lab & many others.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Brilliant article by Despoina Mavridou and team in npj AMR clearly describing how MIC assays should be done so they are meaningful and reproducible. www.nature.com/articles/s44...
Antibiotic susceptibility testing using minimum inhibitory concentration (MIC) assays - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Antibiotic susceptibility testing using minimum inhibitory concentration (MIC) assays
www.nature.com
November 11, 2024 at 9:31 AM
Brilliant article by Despoina Mavridou and team in npj AMR clearly describing how MIC assays should be done so they are meaningful and reproducible. www.nature.com/articles/s44...
Pretty sure there is nothing more mesmerizing than microtubule gliding assays 🤩 #kinesingliding @zaniclab.bsky.social
November 20, 2024 at 11:11 PM
Pretty sure there is nothing more mesmerizing than microtubule gliding assays 🤩 #kinesingliding @zaniclab.bsky.social
Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU
Multiplexed assays of variant effect for clinical variant interpretation
Nature Reviews Genetics - Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et...
www.nature.com
July 21, 2025 at 7:34 PM
Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU
Interesting paper:
A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific
www.frontiersin.org/journals/imm...
A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific
www.frontiersin.org/journals/imm...
Frontiers | A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific
Antigen-driven T-cell proliferation is often measured using fluorescent dye dilution assays, such as the CFSE-based proliferation assay. Dye dilution assays ...
www.frontiersin.org
November 19, 2024 at 8:51 AM
Interesting paper:
A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific
www.frontiersin.org/journals/imm...
A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific
www.frontiersin.org/journals/imm...
clinical problems that we face.
1) Why do some people test positive on certain persistence assays and negative on others? How can we use all of the commercially and scientifically available assays to create a unifying test for persistence that helps us to understand when and
3/
1) Why do some people test positive on certain persistence assays and negative on others? How can we use all of the commercially and scientifically available assays to create a unifying test for persistence that helps us to understand when and
3/
January 1, 2026 at 5:54 PM
clinical problems that we face.
1) Why do some people test positive on certain persistence assays and negative on others? How can we use all of the commercially and scientifically available assays to create a unifying test for persistence that helps us to understand when and
3/
1) Why do some people test positive on certain persistence assays and negative on others? How can we use all of the commercially and scientifically available assays to create a unifying test for persistence that helps us to understand when and
3/
A retraction by Oncotarget, but the journal is taking all the credit for my 2020 findings!
"Oncotarget’s Image Forensics analysis identified multiple instances of image manipulations".
What a crappy move from Oncotarget.
HT: @thatsregrettab1.bsky.social
pubpeer.com/publications...
"Oncotarget’s Image Forensics analysis identified multiple instances of image manipulations".
What a crappy move from Oncotarget.
HT: @thatsregrettab1.bsky.social
pubpeer.com/publications...
May 31, 2025 at 10:23 PM
A retraction by Oncotarget, but the journal is taking all the credit for my 2020 findings!
"Oncotarget’s Image Forensics analysis identified multiple instances of image manipulations".
What a crappy move from Oncotarget.
HT: @thatsregrettab1.bsky.social
pubpeer.com/publications...
"Oncotarget’s Image Forensics analysis identified multiple instances of image manipulations".
What a crappy move from Oncotarget.
HT: @thatsregrettab1.bsky.social
pubpeer.com/publications...
So much fun setting up assays with the greenhouse team today!
February 11, 2025 at 10:23 PM
So much fun setting up assays with the greenhouse team today!
Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by @vagar.bsky.social, Fumitaka Inoue, @jshendure.bsky.social and many others as part of ENCODE.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Massively parallel characterization of transcriptional regulatory elements - Nature
Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.
www.nature.com
January 15, 2025 at 5:05 PM
Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by @vagar.bsky.social, Fumitaka Inoue, @jshendure.bsky.social and many others as part of ENCODE.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
They wrote an essay. Scientists do assays @princess-vimentin.bsky.social just sayin’
Proof reading is my superpower
Proof reading is my superpower
September 26, 2026 at 11:23 AM
They wrote an essay. Scientists do assays @princess-vimentin.bsky.social just sayin’
Proof reading is my superpower
Proof reading is my superpower
Does your lab perform killing assays?
TL;DR: we’ve identified a problem that can bias the outcome of killing assays, making antagonism look stronger than it really is.
Adding a simple extra step can mitigate this bias!

Out now at #MicrobioJ www.microbiologyresearch.org/content/jour...
1/n
TL;DR: we’ve identified a problem that can bias the outcome of killing assays, making antagonism look stronger than it really is.
Adding a simple extra step can mitigate this bias!

Out now at #MicrobioJ www.microbiologyresearch.org/content/jour...
1/n
Type VI secretion system activity at lethal antibiotic concentrations leads to overestimation of weapon potency
Competition assays are a mainstay of modern microbiology, offering a simple and cost-effective means to quantify microbe–microbe interactions in vitro. Here, we demonstrate a key weakness of this meth...
www.microbiologyresearch.org
August 31, 2025 at 9:30 PM
Does your lab perform killing assays?
TL;DR: we’ve identified a problem that can bias the outcome of killing assays, making antagonism look stronger than it really is.
Adding a simple extra step can mitigate this bias!

Out now at #MicrobioJ www.microbiologyresearch.org/content/jour...
1/n
TL;DR: we’ve identified a problem that can bias the outcome of killing assays, making antagonism look stronger than it really is.
Adding a simple extra step can mitigate this bias!

Out now at #MicrobioJ www.microbiologyresearch.org/content/jour...
1/n
Grad school was the perfect preparation for maternity leave because I’m really committed to repeating assays at specific timepoints even if they’re in the middle of the night
December 20, 2024 at 6:56 PM
Grad school was the perfect preparation for maternity leave because I’m really committed to repeating assays at specific timepoints even if they’re in the middle of the night
Did some reviews and…. Why do ppl show biophysical assays without the actual data? KD values with no curves or fits. An ITC table without a single raw thermogram. You wouldn’t publish a Western without the blot, but for binding assays we just say “trust me bro”. Free the curves!!
September 16, 2026 at 8:43 AM
Did some reviews and…. Why do ppl show biophysical assays without the actual data? KD values with no curves or fits. An ITC table without a single raw thermogram. You wouldn’t publish a Western without the blot, but for binding assays we just say “trust me bro”. Free the curves!!
Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)
🔗 biorxiv.org/content/10.6...
🔗 biorxiv.org/content/10.6...
January 27, 2026 at 5:03 PM
Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)
🔗 biorxiv.org/content/10.6...
🔗 biorxiv.org/content/10.6...
Too often, non-standard methods in MIC testing impact reproducibility in AMR research. For more reliability: "Antibiotic susceptibility testing using minimum inhibitory concentration (MIC) assays." -> from Laura Piddocks's tweet/X
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Antibiotic susceptibility testing using minimum inhibitory concentration (MIC) assays - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Antibiotic susceptibility testing using minimum inhibitory concentration (MIC) assays
www.nature.com
November 10, 2024 at 11:08 AM
Too often, non-standard methods in MIC testing impact reproducibility in AMR research. For more reliability: "Antibiotic susceptibility testing using minimum inhibitory concentration (MIC) assays." -> from Laura Piddocks's tweet/X
www.nature.com/articles/s44...
www.nature.com/articles/s44...
"The Left's War on Science" nd the "science" in question is racist nonsense based on flimsy extrapolations from methodologically-outdated twin studies, which have failed to be confirmed by modern genetic assays
“Sure your house is burning down, but we wrote a whole book about its leaking faucet.”
July 26, 2025 at 2:43 PM
"The Left's War on Science" nd the "science" in question is racist nonsense based on flimsy extrapolations from methodologically-outdated twin studies, which have failed to be confirmed by modern genetic assays
(Call the same number if you were formally deferred because the screening assays they used to use detected any bloodborne illness but you couldn't get reinstated even with lab confirmation it was a false positive: they have changed the assays they use to ones that are way more accurate.)
August 1, 2025 at 2:37 PM
(Call the same number if you were formally deferred because the screening assays they used to use detected any bloodborne illness but you couldn't get reinstated even with lab confirmation it was a false positive: they have changed the assays they use to ones that are way more accurate.)
Inferring transcription factor activity: use ATAC-seq, reporter assays, or both? link.springer.com/article/10.1...
Systematic comparison of estimates of transcription factor activity by ATAC-seq and multiplexed reporter assays - Molecular Systems Biology
Transcription factors (TFs) are central to gene regulation and play critical roles in development, cellular homeostasis and disease. The ability to accurately measure TF activity is essential to under...
link.springer.com
August 18, 2026 at 9:39 AM
Inferring transcription factor activity: use ATAC-seq, reporter assays, or both? link.springer.com/article/10.1...
Manager was grilling me yesterday bc the tracker says the assays are ready so why haven't I run them yet?
Collaborator today says the assays *aren't* ready and someone else will be running them anyway
And, sorry, I spaced out for a sec, that monitor just flashed a headline about the Supreme Court…
Collaborator today says the assays *aren't* ready and someone else will be running them anyway
And, sorry, I spaced out for a sec, that monitor just flashed a headline about the Supreme Court…
It’s a miracle any non-white, non straight, non-citizen person in America is getting any work done right now—
—While the regime is actively trying to purge us from government, workplaces, universities from its websites, and from society in general.
—While the regime is actively trying to purge us from government, workplaces, universities from its websites, and from society in general.
April 8, 2025 at 6:25 PM
Manager was grilling me yesterday bc the tracker says the assays are ready so why haven't I run them yet?
Collaborator today says the assays *aren't* ready and someone else will be running them anyway
And, sorry, I spaced out for a sec, that monitor just flashed a headline about the Supreme Court…
Collaborator today says the assays *aren't* ready and someone else will be running them anyway
And, sorry, I spaced out for a sec, that monitor just flashed a headline about the Supreme Court…
Retraction @plosone.org for concerns I partially reported in 2015 with additional problems I later posted on @pubpeer.com:
pubpeer.com/publications...
pubpeer.com/publications...
October 23, 2025 at 8:12 PM
Retraction @plosone.org for concerns I partially reported in 2015 with additional problems I later posted on @pubpeer.com:
pubpeer.com/publications...
pubpeer.com/publications...
CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1
February 5, 2025 at 4:38 PM
CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1
ChromSMF preprint is out!🚀
tinyurl.com/ChromSMF
We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting!
In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬
What does this unlock? ⬇️
tinyurl.com/ChromSMF
We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting!
In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬
What does this unlock? ⬇️
March 24, 2026 at 1:30 PM
ChromSMF preprint is out!🚀
tinyurl.com/ChromSMF
We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting!
In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬
What does this unlock? ⬇️
tinyurl.com/ChromSMF
We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting!
In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬
What does this unlock? ⬇️
CRISPR-based Streamlined Highlighting of Infections to Navigate Epidemics (SHINE) assays - 100% specificity. Promising platform for AIV diagnosis and surveillance,
👉 www.sciencedirect.com/science/arti...
👉 www.sciencedirect.com/science/arti...
September 26, 2026 at 2:38 AM
CRISPR-based Streamlined Highlighting of Infections to Navigate Epidemics (SHINE) assays - 100% specificity. Promising platform for AIV diagnosis and surveillance,
👉 www.sciencedirect.com/science/arti...
👉 www.sciencedirect.com/science/arti...