New paper out online today!!
We identify two previously unrecognized transcripts at the BDNF locus, BDNF-DT and BDNF-AS-DT, that are developmentally regulated, coordinated with BDNF expression, and associated with schizophrenia risk.
www.nature.com/articles/s41...
We identify two previously unrecognized transcripts at the BDNF locus, BDNF-DT and BDNF-AS-DT, that are developmentally regulated, coordinated with BDNF expression, and associated with schizophrenia risk.
www.nature.com/articles/s41...
BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus - Molecular Psychiatry
Molecular Psychiatry - BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus
www.nature.com
June 30, 2026 at 11:48 PM
New paper out online today!!
We identify two previously unrecognized transcripts at the BDNF locus, BDNF-DT and BDNF-AS-DT, that are developmentally regulated, coordinated with BDNF expression, and associated with schizophrenia risk.
www.nature.com/articles/s41...
We identify two previously unrecognized transcripts at the BDNF locus, BDNF-DT and BDNF-AS-DT, that are developmentally regulated, coordinated with BDNF expression, and associated with schizophrenia risk.
www.nature.com/articles/s41...
New insights into #depression! Research highlights how #BDNF & #CD4Tcells interact to affect mood
link.springer.com/article/10.1...
link.springer.com/article/10.1...
The impact of BDNF and CD4 + T cell crosstalk on depression - Immunologic Research
Immunologic Research -
link.springer.com
February 11, 2025 at 12:29 PM
New insights into #depression! Research highlights how #BDNF & #CD4Tcells interact to affect mood
link.springer.com/article/10.1...
link.springer.com/article/10.1...
🧪 “We believe this work is important because it suggests exercise may work to improve cognition and memory by improving the abilities of insulin to act on the brain,”
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro‐BDNF in older adults with prediabetes
Short-term exercise training lowered fasting pro-BDNF and increased glucose-stimulated total Akt derived from neuronal extracellular vesicles (nEVs) in relation to peripheral insulin sensitivity amon...
onlinelibrary.wiley.com
February 9, 2025 at 7:39 PM
🧪 “We believe this work is important because it suggests exercise may work to improve cognition and memory by improving the abilities of insulin to act on the brain,”
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Ridiculous rat study claiming male rats exhibited autism like behaviour after prenatal exposure to Covid vaccine has been retracted:
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Retraction Note: Prenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbations - Neurochemical Research
Neurochemical Research -
link.springer.com
July 24, 2025 at 11:14 PM
Ridiculous rat study claiming male rats exhibited autism like behaviour after prenatal exposure to Covid vaccine has been retracted:
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Congrats to Jobert, Anna-Leigh, and Kai on showing how #BDNF amplifies #transcription, coordinates #RNA dynamics, and spatially regulates the #phosphoproteome.
Beautiful cover art too!
@jamessleigh.bsky.social @frattalab.bsky.social @uclqsion.bsky.social
Beautiful cover art too!
@jamessleigh.bsky.social @frattalab.bsky.social @uclqsion.bsky.social
Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons
BDNF promotes axon-regenerative gene expression, RNA metabolism, and kinase signaling in motor neurons.
www.science.org
April 15, 2026 at 5:52 AM
Congrats to Jobert, Anna-Leigh, and Kai on showing how #BDNF amplifies #transcription, coordinates #RNA dynamics, and spatially regulates the #phosphoproteome.
Beautiful cover art too!
@jamessleigh.bsky.social @frattalab.bsky.social @uclqsion.bsky.social
Beautiful cover art too!
@jamessleigh.bsky.social @frattalab.bsky.social @uclqsion.bsky.social
Fascinating news update from @natureportfolio.nature.com
— BDNF brain-derived neurotrophic factor supports neural connections
— People with major depressive disorder have lower blood levels of BDNF
— Over time, some antidepressants seem to increase production & signalling of BDNF
#neurology 🧪
— BDNF brain-derived neurotrophic factor supports neural connections
— People with major depressive disorder have lower blood levels of BDNF
— Over time, some antidepressants seem to increase production & signalling of BDNF
#neurology 🧪
The world’s most popular antidepressant drugs are under fire. Nature reports how scientists need to finish answering basic questions about what SSRIs are doing to help people with depression before they can explain fully questions about withdrawal symptoms. 🧠🩺 🧪
The baffling science of SSRIs: how do they really work?
The world’s most popular antidepressant drugs are under fire. But are they really harder to quit than heroin?
go.nature.com
August 27, 2026 at 10:37 PM
Fascinating news update from @natureportfolio.nature.com
— BDNF brain-derived neurotrophic factor supports neural connections
— People with major depressive disorder have lower blood levels of BDNF
— Over time, some antidepressants seem to increase production & signalling of BDNF
#neurology 🧪
— BDNF brain-derived neurotrophic factor supports neural connections
— People with major depressive disorder have lower blood levels of BDNF
— Over time, some antidepressants seem to increase production & signalling of BDNF
#neurology 🧪
You can go into withdrawal from many things. Esp drugs! Esp psychiatric medications! We could talk about how desensitization develops for the vast majority of G-protein coupled receptor agonists! We could talk about changes to neural pathways and BDNF.
But tbh you don't need to know any of it.
But tbh you don't need to know any of it.
May 8, 2026 at 3:35 PM
You can go into withdrawal from many things. Esp drugs! Esp psychiatric medications! We could talk about how desensitization develops for the vast majority of G-protein coupled receptor agonists! We could talk about changes to neural pathways and BDNF.
But tbh you don't need to know any of it.
But tbh you don't need to know any of it.
BDNF as a Potential Indicator of Physical Exercise Benefits in Fatigue, Pain, Depression and Sleep Disturbances
www.thailandmedical.news/news/bdnf-as...
www.thailandmedical.news/news/bdnf-as...
BDNF as a Potential Indicator of Physical Exercise Benefits in Fatigue, Pain, Depression and Sleep Disturbances - Thailand Medical News
www.thailandmedical.news
February 3, 2025 at 3:43 AM
BDNF as a Potential Indicator of Physical Exercise Benefits in Fatigue, Pain, Depression and Sleep Disturbances
www.thailandmedical.news/news/bdnf-as...
www.thailandmedical.news/news/bdnf-as...
Latest research from my group. We activated BDNF protein expression by disrupting a repressive uORF using a CRISPR base editing strategy: www.sciencedirect.com/science/arti...
#OxfordPaediatrics #IDRMOxford #BDNF #uORF #CRISPR #BaseEditing
#OxfordPaediatrics #IDRMOxford #BDNF #uORF #CRISPR #BaseEditing
Targeted BDNF upregulation via upstream open reading frame disruption
To understand the relative contributions of 5ʹ UTR elements to translation output, we performed a comprehensive analysis of upstream open reading fram…
www.sciencedirect.com
January 6, 2026 at 4:36 PM
Latest research from my group. We activated BDNF protein expression by disrupting a repressive uORF using a CRISPR base editing strategy: www.sciencedirect.com/science/arti...
#OxfordPaediatrics #IDRMOxford #BDNF #uORF #CRISPR #BaseEditing
#OxfordPaediatrics #IDRMOxford #BDNF #uORF #CRISPR #BaseEditing
A pathway that acts as an intrinsic antidepressive mechanism in the brain can become disrupted by chronic, mild stress, shows new work that casts light on the neurological and biochemical origins of #depression.
Learn more in #ScienceSignaling: https://scim.ag/4bRVNbG
Learn more in #ScienceSignaling: https://scim.ag/4bRVNbG
The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gαi1/3 to reduce depressive-like behaviors in mice
A mitochondrial protein indirectly supports antidepressant BDNF signaling in the brain.
scim.ag
April 15, 2026 at 3:02 PM
A pathway that acts as an intrinsic antidepressive mechanism in the brain can become disrupted by chronic, mild stress, shows new work that casts light on the neurological and biochemical origins of #depression.
Learn more in #ScienceSignaling: https://scim.ag/4bRVNbG
Learn more in #ScienceSignaling: https://scim.ag/4bRVNbG
High-intensity exercise briefly boosted BDNF in PTSD patients, unlike low-intensity exercise. However, neither exercise type caused sustained BDNF increases over 12 days.
High-intensity exercise provides short boost to brain protein in PTSD sufferers
High-intensity exercise briefly boosted BDNF in PTSD patients, unlike low-intensity exercise. However, neither exercise type caused sustained BDNF increases over 12 days.
www.psypost.org
February 16, 2025 at 9:26 PM
High-intensity exercise briefly boosted BDNF in PTSD patients, unlike low-intensity exercise. However, neither exercise type caused sustained BDNF increases over 12 days.
"Taurine reverses depressive/anhedonic behaviors induced by chronic stress in rats; normalizes Dopamine, Serotonin, BDNF, FGF-2, and VEGF levels (2017)"
HUMMMMMMM
HUMMMMMMM
September 25, 2026 at 1:14 AM
"Taurine reverses depressive/anhedonic behaviors induced by chronic stress in rats; normalizes Dopamine, Serotonin, BDNF, FGF-2, and VEGF levels (2017)"
HUMMMMMMM
HUMMMMMMM
In a small study, researchers compared 90 minutes of light cycling against just 6 minutes of high-intensity intervals, and measured BDNF levels after each.
The high-intensity intervals increased BDNF by 4 to 5 times more than the 90-minute session.
Five times the effect, in a fraction of the time.
The high-intensity intervals increased BDNF by 4 to 5 times more than the 90-minute session.
Five times the effect, in a fraction of the time.
September 24, 2026 at 4:10 PM
In a small study, researchers compared 90 minutes of light cycling against just 6 minutes of high-intensity intervals, and measured BDNF levels after each.
The high-intensity intervals increased BDNF by 4 to 5 times more than the 90-minute session.
Five times the effect, in a fraction of the time.
The high-intensity intervals increased BDNF by 4 to 5 times more than the 90-minute session.
Five times the effect, in a fraction of the time.
BOOM! Big advance from Zak Campbell's lab (Zak used to be at UTD and moved to U Wisconsin a couple of years ago, big loss for us) on regulation of BDNF translation in nociceptors - www.sciencedirect.com/science/arti...
eEF2K regulates pain through translational control of BDNF
mRNA translation is integral to pain, yet the key regulatory factors and their target mRNAs are unclear. Here, we uncover a mechanism that bridges nox…
www.sciencedirect.com
December 21, 2024 at 1:30 PM
BOOM! Big advance from Zak Campbell's lab (Zak used to be at UTD and moved to U Wisconsin a couple of years ago, big loss for us) on regulation of BDNF translation in nociceptors - www.sciencedirect.com/science/arti...
És azt tudtátok, hogy futás számos előnye mellett „okosabbá” is tesz: növeli a hippokampusz méretét, fokozza az új idegsejtek születését és emeli a BDNF-szintet, ami javítja a memóriát, a fókuszt és a tanulást? Én ma tudtam ezt meg. Miközben otthon felejtettem az ebédem.
December 1, 2025 at 7:59 AM
És azt tudtátok, hogy futás számos előnye mellett „okosabbá” is tesz: növeli a hippokampusz méretét, fokozza az új idegsejtek születését és emeli a BDNF-szintet, ami javítja a memóriát, a fókuszt és a tanulást? Én ma tudtam ezt meg. Miközben otthon felejtettem az ebédem.
That’s four major brain regions activating simultaneously — the exact kind of rich, multi-region stimulation that triggers BDNF release and synaptic strengthening.
There is a protein in your brain called Brain-Derived Neurotrophic Factor, or BDNF.
There is a protein in your brain called Brain-Derived Neurotrophic Factor, or BDNF.
August 14, 2026 at 5:11 AM
That’s four major brain regions activating simultaneously — the exact kind of rich, multi-region stimulation that triggers BDNF release and synaptic strengthening.
There is a protein in your brain called Brain-Derived Neurotrophic Factor, or BDNF.
There is a protein in your brain called Brain-Derived Neurotrophic Factor, or BDNF.
BDNF rocks!!! Most important molecule in the CNS.
February 18, 2026 at 3:17 AM
BDNF rocks!!! Most important molecule in the CNS.
In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:
www.biorxiv.org/content/10.1...
Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.
@uclqsion.bsky.social #aging
www.biorxiv.org/content/10.1...
Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.
@uclqsion.bsky.social #aging
February 2, 2025 at 8:47 AM
In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:
www.biorxiv.org/content/10.1...
Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.
@uclqsion.bsky.social #aging
www.biorxiv.org/content/10.1...
Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.
@uclqsion.bsky.social #aging
Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum - Translational Psychiatry
Translational Psychiatry - Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum
www.nature.com
March 22, 2025 at 5:43 PM
Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A pathway that acts as an intrinsic antidepressive mechanism in the brain can become disrupted by chronic, mild stress, shows new work that casts light on the neurological and biochemical origins of #depression.
Learn more in #ScienceSignaling: https://scim.ag/4bRVNbG
Learn more in #ScienceSignaling: https://scim.ag/4bRVNbG
The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gαi1/3 to reduce depressive-like behaviors in mice
A mitochondrial protein indirectly supports antidepressant BDNF signaling in the brain.
scim.ag
April 1, 2026 at 3:00 PM
A pathway that acts as an intrinsic antidepressive mechanism in the brain can become disrupted by chronic, mild stress, shows new work that casts light on the neurological and biochemical origins of #depression.
Learn more in #ScienceSignaling: https://scim.ag/4bRVNbG
Learn more in #ScienceSignaling: https://scim.ag/4bRVNbG
In honor of a preprint that will be online in the next day or two - for #FluorescenceFriday, some labeled human neural progenitor cells, in which we used CRISPR-based methods to manipulate the human BDNF locus to better understand its function. Image credit to Svitlana Bach. 🔬🧠👩🔬🧪
July 11, 2025 at 3:36 PM
In honor of a preprint that will be online in the next day or two - for #FluorescenceFriday, some labeled human neural progenitor cells, in which we used CRISPR-based methods to manipulate the human BDNF locus to better understand its function. Image credit to Svitlana Bach. 🔬🧠👩🔬🧪
BDNF sliding into my DMs on Slack now - parading around as an eQTL in a new human 🧠 sequencing dataset and I feel like this can't be real life
February 25, 2026 at 1:56 AM
BDNF sliding into my DMs on Slack now - parading around as an eQTL in a new human 🧠 sequencing dataset and I feel like this can't be real life
tfw when some unbiased experiments validate and extend some older findings... given that we acquiesced to the pressure and gave up this work to start the lab's direction over from scratch... I feel justified to be completely petty and say - suck it neurotrophin haters ;)
February 17, 2026 at 4:40 PM
tfw when some unbiased experiments validate and extend some older findings... given that we acquiesced to the pressure and gave up this work to start the lab's direction over from scratch... I feel justified to be completely petty and say - suck it neurotrophin haters ;)
The Holy Grail of Brain Repair: Which BDNF Booster Wins?
Analyze how Semax and elite BDNF peptides stimulate rapid neuroplasticity in research models for animals.
#peptdes #AlzheimersResearch #autismresearch #parkinsons #alsresearch
Analyze how Semax and elite BDNF peptides stimulate rapid neuroplasticity in research models for animals.
#peptdes #AlzheimersResearch #autismresearch #parkinsons #alsresearch
September 25, 2026 at 1:09 AM
The Holy Grail of Brain Repair: Which BDNF Booster Wins?
Analyze how Semax and elite BDNF peptides stimulate rapid neuroplasticity in research models for animals.
#peptdes #AlzheimersResearch #autismresearch #parkinsons #alsresearch
Analyze how Semax and elite BDNF peptides stimulate rapid neuroplasticity in research models for animals.
#peptdes #AlzheimersResearch #autismresearch #parkinsons #alsresearch