🤔🧪Tiny #Quinoline tweaks→💊⚙️breakthrough #Therapies?🌐 #AI-driven halogenation+esterification=🚀 #Bioavailability&🎯 multitarget action!🔬 @mdpiopenaccess.bsky.social #DrugDiscovery #MedChem #Oncology #Neuropharma
📖 www.mdpi.com/1424-8247/18...
📖 www.mdpi.com/1424-8247/18...
August 19, 2025 at 11:04 AM
🤔🧪Tiny #Quinoline tweaks→💊⚙️breakthrough #Therapies?🌐 #AI-driven halogenation+esterification=🚀 #Bioavailability&🎯 multitarget action!🔬 @mdpiopenaccess.bsky.social #DrugDiscovery #MedChem #Oncology #Neuropharma
📖 www.mdpi.com/1424-8247/18...
📖 www.mdpi.com/1424-8247/18...
🤔🧪Tiny #Quinoline tweaks→💊⚙️breakthrough #Therapies?🌐 #AI-driven halogenation+esterification=🚀 #Bioavailability&🎯 multitarget action!🔬 @MDPIOpenAccess @Pharmaceut_MDPI #DrugDiscovery #MedChem #Oncology #Neuropharma
📖 www.mdpi.com/1424-8247/18...
📖 www.mdpi.com/1424-8247/18...
August 8, 2025 at 5:37 AM
🤔🧪Tiny #Quinoline tweaks→💊⚙️breakthrough #Therapies?🌐 #AI-driven halogenation+esterification=🚀 #Bioavailability&🎯 multitarget action!🔬 @MDPIOpenAccess @Pharmaceut_MDPI #DrugDiscovery #MedChem #Oncology #Neuropharma
📖 www.mdpi.com/1424-8247/18...
📖 www.mdpi.com/1424-8247/18...
💥1 #Atom⚛️swap=big wins in #Neuro🧠 #Cancer & #Immunity🌍🧬#Quinoline’s back—smarter, stronger & #BBB-ready🚀🧠 #NMDA🛑💊boosted #Bioavailability & 🎯multi-hits!📄👉 @mdpiopenaccess.bsky.social Preprints #DrugDiscovery #BrainHealth #NextGenTherapies
doi.org/10.20944/pre...
doi.org/10.20944/pre...
doi.org
April 17, 2025 at 5:27 AM
💥1 #Atom⚛️swap=big wins in #Neuro🧠 #Cancer & #Immunity🌍🧬#Quinoline’s back—smarter, stronger & #BBB-ready🚀🧠 #NMDA🛑💊boosted #Bioavailability & 🎯multi-hits!📄👉 @mdpiopenaccess.bsky.social Preprints #DrugDiscovery #BrainHealth #NextGenTherapies
doi.org/10.20944/pre...
doi.org/10.20944/pre...
💥1 #Atom⚛️swap=big wins in #Neuro🧠 #Cancer & #Immunity🌍🧬#Quinoline’s back—smarter, stronger & #BBB-ready🚀🧠 #NMDA🛑💊boosted #Bioavailability & 🎯multi-hits!📄👉 @mdpiopenaccess.bsky.social Preprints #DrugDiscovery #BrainHealth #NextGenTherapies
doi.org/10.20944/pre...
doi.org/10.20944/pre...
doi.org
April 14, 2025 at 5:45 AM
💥1 #Atom⚛️swap=big wins in #Neuro🧠 #Cancer & #Immunity🌍🧬#Quinoline’s back—smarter, stronger & #BBB-ready🚀🧠 #NMDA🛑💊boosted #Bioavailability & 🎯multi-hits!📄👉 @mdpiopenaccess.bsky.social Preprints #DrugDiscovery #BrainHealth #NextGenTherapies
doi.org/10.20944/pre...
doi.org/10.20944/pre...
💥One #Atom⚛️swap!
Big wins in #Neuro🧠 #Cancer & #Immunity 🌍🧬 #Quinoline metabolites are back—smarter, stronger & BBB-ready🚀🔬Think NMDA blocks, better bioavailability & multi-target hits🎯 @mdpiopenaccess.bsky.social #DrugDiscovery #BrainHealth #NextGenTherapies
Dive in 👉 doi.org/10.20944/pre...
Big wins in #Neuro🧠 #Cancer & #Immunity 🌍🧬 #Quinoline metabolites are back—smarter, stronger & BBB-ready🚀🔬Think NMDA blocks, better bioavailability & multi-target hits🎯 @mdpiopenaccess.bsky.social #DrugDiscovery #BrainHealth #NextGenTherapies
Dive in 👉 doi.org/10.20944/pre...
doi.org
April 8, 2025 at 5:47 AM
💥One #Atom⚛️swap!
Big wins in #Neuro🧠 #Cancer & #Immunity 🌍🧬 #Quinoline metabolites are back—smarter, stronger & BBB-ready🚀🔬Think NMDA blocks, better bioavailability & multi-target hits🎯 @mdpiopenaccess.bsky.social #DrugDiscovery #BrainHealth #NextGenTherapies
Dive in 👉 doi.org/10.20944/pre...
Big wins in #Neuro🧠 #Cancer & #Immunity 🌍🧬 #Quinoline metabolites are back—smarter, stronger & BBB-ready🚀🔬Think NMDA blocks, better bioavailability & multi-target hits🎯 @mdpiopenaccess.bsky.social #DrugDiscovery #BrainHealth #NextGenTherapies
Dive in 👉 doi.org/10.20944/pre...
In brief:
🎯Neutrophil Elastase (NE) regulates glucocorticoid (GC) bioavailability through cleavage of CBG
🚚Increased NE in obese adipose facilitates local GC delivery
🐭🚶♂️NE manipulation in mice/humans impacts adipose GC exposure, linking obesity and inflammation to cardiometabolic outcomes
🎯Neutrophil Elastase (NE) regulates glucocorticoid (GC) bioavailability through cleavage of CBG
🚚Increased NE in obese adipose facilitates local GC delivery
🐭🚶♂️NE manipulation in mice/humans impacts adipose GC exposure, linking obesity and inflammation to cardiometabolic outcomes
January 10, 2025 at 2:27 PM
In brief:
🎯Neutrophil Elastase (NE) regulates glucocorticoid (GC) bioavailability through cleavage of CBG
🚚Increased NE in obese adipose facilitates local GC delivery
🐭🚶♂️NE manipulation in mice/humans impacts adipose GC exposure, linking obesity and inflammation to cardiometabolic outcomes
🎯Neutrophil Elastase (NE) regulates glucocorticoid (GC) bioavailability through cleavage of CBG
🚚Increased NE in obese adipose facilitates local GC delivery
🐭🚶♂️NE manipulation in mice/humans impacts adipose GC exposure, linking obesity and inflammation to cardiometabolic outcomes