1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...
www.biorxiv.org
December 30, 2024 at 9:01 PM
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!
September 3, 2025 at 11:53 AM
Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 6, 2024 at 8:39 AM
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
My article in the February issue of @sciam.bsky.social on biomolecular condensates is the cover story, with lovely artwork by Mark Ross.
December 27, 2024 at 12:44 PM
My article in the February issue of @sciam.bsky.social on biomolecular condensates is the cover story, with lovely artwork by Mark Ross.
(1/7)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Accelerating Biomolecular Modeling with AtomWorks and RF3
Deep learning methods trained on protein structure databases have revolutionized biomolecular structure prediction, but developing and training new models remains a considerable challenge. To facilita...
www.biorxiv.org
August 15, 2025 at 5:17 PM
(1/7)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3)
[https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)
Deep learning for proteins tutorial: github.com/Graylab/DL4P...
GitHub - Graylab/DL4Proteins-notebooks: Colab Notebooks covering deep learning tools for biomolecular structure prediction and design
Colab Notebooks covering deep learning tools for biomolecular structure prediction and design - Graylab/DL4Proteins-notebooks
github.com
December 28, 2024 at 3:15 AM
Deep learning for proteins tutorial: github.com/Graylab/DL4P...
Biomolecular condensate starter pack!
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
November 18, 2024 at 9:44 AM
Biomolecular condensate starter pack!
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
go.nature.com
October 28, 2025 at 6:50 PM
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
On personal #Alphafoldology notice - I’ve got my Professorship in Biomolecular Chemistry and Structural Biology today.
June 16, 2025 at 2:13 PM
On personal #Alphafoldology notice - I’ve got my Professorship in Biomolecular Chemistry and Structural Biology today.
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
November 17, 2024 at 4:20 PM
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution
We are excited to present our latest work published in @natcomms.nature.com
www.nature.com/articles/s41...
We are excited to present our latest work published in @natcomms.nature.com
www.nature.com/articles/s41...
Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution - Nature Communications
Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour ...
www.nature.com
May 7, 2025 at 2:43 PM
Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution
We are excited to present our latest work published in @natcomms.nature.com
www.nature.com/articles/s41...
We are excited to present our latest work published in @natcomms.nature.com
www.nature.com/articles/s41...
MIT researchers introduce Boltz-1, a fully open-source model for predicting biomolecular structures
With models like AlphaFold3 limited to academic research, the team built an equivalent alternative, to encourage innovation more broadly
www.eurekalert.org/news-release...
With models like AlphaFold3 limited to academic research, the team built an equivalent alternative, to encourage innovation more broadly
www.eurekalert.org/news-release...
MIT researchers introduce Boltz-1, a fully open-source model for predicting biomolecular structures
Researchers in the MIT Jameel Clinic for Machine Learning in Health developed a fully open-source biomolecular structure prediction model that achieves state-of-the-art performance, at the level of Al...
www.eurekalert.org
December 22, 2024 at 5:33 PM
MIT researchers introduce Boltz-1, a fully open-source model for predicting biomolecular structures
With models like AlphaFold3 limited to academic research, the team built an equivalent alternative, to encourage innovation more broadly
www.eurekalert.org/news-release...
With models like AlphaFold3 limited to academic research, the team built an equivalent alternative, to encourage innovation more broadly
www.eurekalert.org/news-release...
Thrilled to announce that as of this month, I have taken on an additional role at Georgia Tech as an adjunct professor in the Georgia Tech School of Chemical and Biomolecular Engineering. Looking forward to new collaborations and synergies.
July 21, 2025 at 3:33 PM
Thrilled to announce that as of this month, I have taken on an additional role at Georgia Tech as an adjunct professor in the Georgia Tech School of Chemical and Biomolecular Engineering. Looking forward to new collaborations and synergies.
In the cover story of the February issue of @sciam.bsky.social I explain what biomolecular condensates are and why they are transforming cell biology. A short 🧵
(You'll need a subscription to read the article.)
www.scientificamerican.com/article/myst...
(You'll need a subscription to read the article.)
www.scientificamerican.com/article/myst...
Mysterious Blobs in Cells Are Changing the Way We Understand Life
Tiny specks called biomolecular condensates are leading to a new understanding of the cell
www.scientificamerican.com
January 21, 2025 at 5:43 PM
In the cover story of the February issue of @sciam.bsky.social I explain what biomolecular condensates are and why they are transforming cell biology. A short 🧵
(You'll need a subscription to read the article.)
www.scientificamerican.com/article/myst...
(You'll need a subscription to read the article.)
www.scientificamerican.com/article/myst...
The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 25, 2024 at 12:19 PM
The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Great article (in which I am quoted) about biomolecular condensates, the cellular phenomena I work on in my day job! 🧪
www.scientificamerican.com/article/myst...
www.scientificamerican.com/article/myst...
Mysterious Blobs in Cells Are Changing the Way We Understand Life
Tiny specks called biomolecular condensates are leading to a new understanding of the cell
www.scientificamerican.com
January 23, 2025 at 5:30 PM
Great article (in which I am quoted) about biomolecular condensates, the cellular phenomena I work on in my day job! 🧪
www.scientificamerican.com/article/myst...
www.scientificamerican.com/article/myst...
BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design by @yehlincho.bsky.social @martinpacesa.bsky.social @sokrypton.org 🧶🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 7, 2025 at 7:01 AM
BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design by @yehlincho.bsky.social @martinpacesa.bsky.social @sokrypton.org 🧶🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Biomolecular analysis shows that unusual book coverings are made of sealskin, hinting at far-flung trade networks
https://go.nature.com/4lsSBqK
https://go.nature.com/4lsSBqK
Mystery of medieval manuscripts revealed by ancient DNA
Biomolecular analysis shows that unusual book coverings are made of sealskin, hinting at far-flung trade networks.
go.nature.com
April 11, 2025 at 3:50 PM
Biomolecular analysis shows that unusual book coverings are made of sealskin, hinting at far-flung trade networks
https://go.nature.com/4lsSBqK
https://go.nature.com/4lsSBqK
Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!
rdcu.be/e1bBW
rdcu.be/e1bBW
Pre-assembly of biomolecular condensate seeds drives RSV replication
Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.
rdcu.be
January 28, 2026 at 8:38 PM
Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!
rdcu.be/e1bBW
rdcu.be/e1bBW
Job alert! 3 year post doc in my research group at University College London working on Roman Leather via biomolecular archaeology. #ZooMS #stableisotopes
www.jobs.ac.uk/job/DQJ187/r...
www.jobs.ac.uk/job/DQJ187/r...
Research Fellow in Biomolecular Archaeology at UCL
Searching for an academic job? Explore this Research Fellow in Biomolecular Archaeology opening on jobs.ac.uk! Click to view more details and browse other academic jobs.
www.jobs.ac.uk
February 4, 2026 at 8:56 AM
Job alert! 3 year post doc in my research group at University College London working on Roman Leather via biomolecular archaeology. #ZooMS #stableisotopes
www.jobs.ac.uk/job/DQJ187/r...
www.jobs.ac.uk/job/DQJ187/r...
I’ve created a starter pack for #zooarchaeology and #biomolecular archaeology for all periods. Let me know if you want to be added go.bsky.app/Nv8XE4r 🦣🧪🏺🦴🦷
December 1, 2024 at 11:25 AM
I’ve created a starter pack for #zooarchaeology and #biomolecular archaeology for all periods. Let me know if you want to be added go.bsky.app/Nv8XE4r 🦣🧪🏺🦴🦷
💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
Home | Research Group Schmid | University of Basel
schmid.chemie.unibas.ch
July 31, 2025 at 2:34 PM
💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
1/ Pleased to share our review, published today
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
Biomolecular condensates in immune cell fate - Nature Reviews Immunology
Recent studies suggest that biomolecular condensates — membrane-less assemblies of proteins and nucleic acids — are involved in regulating gene expression to ensure proper immune cell development. Thi...
www.nature.com
January 28, 2025 at 4:40 PM
1/ Pleased to share our review, published today
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
We’re excited to release a major update to the Boltz repo: v0.3.0. This release contains several important new features, including our confidence model and memory-efficient inference. Give it a try! github.com/jwohlwend/bo...
GitHub - jwohlwend/boltz: Official repository for the Boltz-1 biomolecular interaction model
Official repository for the Boltz-1 biomolecular interaction model - jwohlwend/boltz
github.com
November 28, 2024 at 4:50 PM
We’re excited to release a major update to the Boltz repo: v0.3.0. This release contains several important new features, including our confidence model and memory-efficient inference. Give it a try! github.com/jwohlwend/bo...
