This study provides mechanistic insights into how NKD2 regulates the differentiation of osteoblasts, adipocytes, and osteoclasts, & #BoneHomeostasis by modulating the Wnt/β-catenin, mTORC1 & NF-kB pathways. #Osteoporosis

#OpenAccess: https://buff.ly/40KUZ3S

Researchers identify NFIA as a key regulator of #BoneHomeostasis, and its loss in mesenchymal progenitors disrupts bone balance by enhancing resorption over formation, linking NFIA deficiency to age-related #osteoporosis. #osteoclastogenesis

#OpenAccess: doi.org/10.1016/j.ge...

“PIDDosome deficiency impairs bone remodeling by increasing osteoclast ploidy and function”

PIDDosome regulates #BoneHomeostasis by regulating OCs polyploidization and their bone-resorbing function independently of the canonical #p53/p21 axis⤵️
nature.com/articles/s41...

Progranulin deficiency contributes to postmenopausal osteoporosis by enhancing ubiquitination of estrogen receptor α.
#Progranulin #Osteoporosis #EstrogenReceptor #Ubiquitination #BoneHomeostasis #PostmenopausalHealth
doi.org/10.1016/j.ge...

Mechanistic insights into how NKD2 regulates the differentiation of osteoblasts, adipocytes, and osteoclasts, as well as #BoneHomeostasis, by modulating the Wnt/β-catenin, mTORC1 & NF-kB pathways. #Osteoporosis #medsky
#MostRead #OpenAccess:
buff.ly/uekaSTl

This review summarizes the physiological role of leptin and associated signaling pathways, its role in regulating #BoneHomeostasis and #osteoarthritis, and discusses its influence on #obesity and #aging associated osteoarthritis. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This study provides mechanistic insights into how NKD2 regulates the differentiation of osteoblasts, adipocytes, and osteoclasts, & #BoneHomeostasis via modulating the Wnt/β-catenin, mTORC1 & NF-kB pathways. #Osteoporosis #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This study provides mechanistic insights into how NKD2 regulates the differentiation of osteoblasts, adipocytes, and osteoclasts, & #BoneHomeostasis by modulating the Wnt/β-catenin, mTORC1 & NF-kB pathways. #Osteoporosis

#OpenAccess: www.sciencedirect.co...

This study provides mechanistic insights into how NKD2 regulates the differentiation of osteoblasts, adipocytes, and osteoclasts, & #BoneHomeostasis by modulating the Wnt/β-catenin, mTORC1 & NF-kB pathways. #Osteoporosis

#OpenAccess: www.sciencedirect.co...