People with Lynch syndrome have a significantly increased risk of developing colorectal cancer and other types of cancer due to a hereditary predisposition. The CAPP2 study had already shown in this high-risk group that acetylsalicylic acid can significantly reduce the long-term risk of colorectal cancer. The study examined a comparatively high daily dose of 600 milligrams. The recently published international CaPP3 study now suggests that even a lower dose of 100 milligrams daily could have a similar cancer-preventive effect while causing fewer side effects, particularly bleeding complications. The research is published in The Lancet Gastroenterology & Hepatology journal.

Our CaPP3 trial has found the best dose of aspirin for preventing bowel cancer. It should help more people benefit from the drug.

Although non-inferiority could not formally be concluded for either 100 mg or 300 mg of aspirin daily by comparison with 600 mg aspirin daily, there was evidence that the 100 mg dose had similar chara...

Nick James, from Gosforth, signed up to the CaPP3 trial - which has found that a daily dose of 75-100mg aspirin cuts risk of bowel cancer

A Newcastle University-led study looks at how the painkiller can help people with Lynch syndrome.

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A little dose goes a long way. CaPP3’s results show that taking as little as 75 to 100mg of aspirin each day can halve the risk of bowel cancer in people with Lynch syndrome, a heritable genetic co…

The trial involved 1,879 people with Lynch syndrome who were given three different-sized doses of the painkiller. The Cancer Prevention Project 3 study (CaPP3), supported by Cancer Research UK, inv…