An important study that provides CCR7-APEX2 proximity labelling mass spectrometry data that is expected to provide new insights into CCR7 signaling partners and pathways #Painresearchcenter #Thomsenlab #CCR7 elifesciences.org/reviewed-pre...
Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration
elifesciences.org
February 10, 2025 at 9:37 PM
An important study that provides CCR7-APEX2 proximity labelling mass spectrometry data that is expected to provide new insights into CCR7 signaling partners and pathways #Painresearchcenter #Thomsenlab #CCR7 elifesciences.org/reviewed-pre...
Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity @cp-immunity.bsky.social @beatricezitti.bsky.social @biology-unige.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
December 21, 2025 at 5:24 PM
Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity @cp-immunity.bsky.social @beatricezitti.bsky.social @biology-unige.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity @cp-immunity.bsky.social @mariakoufaki.bsky.social @santiagozelenay.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
August 4, 2026 at 6:30 PM
CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity @cp-immunity.bsky.social @mariakoufaki.bsky.social @santiagozelenay.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...
Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature
Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...
www.nature.com
May 14, 2025 at 3:52 PM
I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...
In vivo-edited CCR7+IL-7+ DCs reverse T cell exhaustion by promoting T memory stem cell differentiation
@cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
September 30, 2026 at 6:31 PM
In vivo-edited CCR7+IL-7+ DCs reverse T cell exhaustion by promoting T memory stem cell differentiation
@cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
How do regulatory T cells influence autoreactive CD8 T cells? Maeda et al (Science 2014) show, that Tregs can identify autoreactive CD8s in vitro and induce a once-divided CTLA4+CCR7+ phenotype that is anergic to stimulation.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 13, 2024 at 6:41 PM
How do regulatory T cells influence autoreactive CD8 T cells? Maeda et al (Science 2014) show, that Tregs can identify autoreactive CD8s in vitro and induce a once-divided CTLA4+CCR7+ phenotype that is anergic to stimulation.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
PDPN marks lymphatic vessels & CAFs in the TME, but tumor-cell PDPN can also be a biomarker of a plastic lymphatic metastasis–permissive state in TNBC🔬(key fatures of the PDPN state mouse–human conserved). Hypoxia → PDPN⁺ tumour cells → CCR7⁺ lymphatic spread.
BJC: www.nature.com/articles/s41...
BJC: www.nature.com/articles/s41...
Podoplanin-defined tumour plasticity and CCR7-mediated lymphatic metastasis in triple-negative breast cancer - British Journal of Cancer
British Journal of Cancer - Podoplanin-defined tumour plasticity and CCR7-mediated lymphatic metastasis in triple-negative breast cancer
www.nature.com
April 29, 2026 at 12:45 PM
PDPN marks lymphatic vessels & CAFs in the TME, but tumor-cell PDPN can also be a biomarker of a plastic lymphatic metastasis–permissive state in TNBC🔬(key fatures of the PDPN state mouse–human conserved). Hypoxia → PDPN⁺ tumour cells → CCR7⁺ lymphatic spread.
BJC: www.nature.com/articles/s41...
BJC: www.nature.com/articles/s41...
“CCR7 orchestrates the malignant progression of memory B cells in MYC-overexpressing lymphoma”
Learn how CCR7 directs memory-B-cell trafficking from draining LNs to distal LNs and coordinates microenvironmental support to promote progression ⤵️
www.nature.com/articles/s41...
Learn how CCR7 directs memory-B-cell trafficking from draining LNs to distal LNs and coordinates microenvironmental support to promote progression ⤵️
www.nature.com/articles/s41...
CCR7 orchestrates the malignant progression of memory B cells in MYC-overexpressing lymphoma - Cell Death & Differentiation
Cell Death & Differentiation - CCR7 orchestrates the malignant progression of memory B cells in MYC-overexpressing lymphoma
www.nature.com
May 19, 2026 at 10:02 AM
“CCR7 orchestrates the malignant progression of memory B cells in MYC-overexpressing lymphoma”
Learn how CCR7 directs memory-B-cell trafficking from draining LNs to distal LNs and coordinates microenvironmental support to promote progression ⤵️
www.nature.com/articles/s41...
Learn how CCR7 directs memory-B-cell trafficking from draining LNs to distal LNs and coordinates microenvironmental support to promote progression ⤵️
www.nature.com/articles/s41...
Dysregulation of Apolipoprotein O Reprograms CCR7+CD4+T cell Fate in Primary Autoimmune Thrombocytopenia @cp-iscience.bsky.social
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
October 17, 2025 at 4:29 PM
Dysregulation of Apolipoprotein O Reprograms CCR7+CD4+T cell Fate in Primary Autoimmune Thrombocytopenia @cp-iscience.bsky.social
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
And CCR7+ cDCs come to stage! #Ana-MariaLennon from @institutcurie.bsky.social showing dynamic changes in cDC sensing and responsive regulatory programs in tumors
March 27, 2025 at 2:31 PM
And CCR7+ cDCs come to stage! #Ana-MariaLennon from @institutcurie.bsky.social showing dynamic changes in cDC sensing and responsive regulatory programs in tumors
Here's a new co-authored pre-print with Michelle Boyle @burnetinstitute.bsky.social, studying cTfh cells in volunteers infected with P. falciparum, via scRNA-seq and paired TCR-seq. Tfh1 are split based on CCR7, with CCR7+ Tfh1 correlating with antibody responses.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
March 3, 2025 at 9:48 AM
Here's a new co-authored pre-print with Michelle Boyle @burnetinstitute.bsky.social, studying cTfh cells in volunteers infected with P. falciparum, via scRNA-seq and paired TCR-seq. Tfh1 are split based on CCR7, with CCR7+ Tfh1 correlating with antibody responses.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
After traumatic skeletal muscle injury, cDC1 prime clonally diverse, self-reactive Ly49+ HELIOS+ CD8 Tregs that maintain self tolerance by pruning CD62L+CCR7+ naive T cells
doi.org/10.1101/2025...
doi.org/10.1101/2025...
January 15, 2025 at 3:42 AM
After traumatic skeletal muscle injury, cDC1 prime clonally diverse, self-reactive Ly49+ HELIOS+ CD8 Tregs that maintain self tolerance by pruning CD62L+CCR7+ naive T cells
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Structural insights into biased signaling at chemokine receptor CCR7 pubmed.ncbi.nlm.nih.gov/42054364/ #cryoem
May 1, 2026 at 1:04 AM
Structural insights into biased signaling at chemokine receptor CCR7 pubmed.ncbi.nlm.nih.gov/42054364/ #cryoem
Evidence continues to accumulate that dendritic cell activation state is as important as antigens in anti-tumor immunity. A new study confirms CCR7 DCs as key drivers of defense.
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity
Dendritic cells (DCs) can acquire distinct functional states. To examine how different
DC states orchestrate anti-tumor immunity, Koufaki et al. develop mouse models to
label and ablate CCR7+ DCs and ...
www.cell.com
August 5, 2026 at 1:33 AM
Evidence continues to accumulate that dendritic cell activation state is as important as antigens in anti-tumor immunity. A new study confirms CCR7 DCs as key drivers of defense.
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Online now: Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity
Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity
CCR7+ dendritic cells (DCs) are pivotal for antitumor immunity. Zitti, Duval et al. find that intratumoral CCR7+ DCs form perivascular hubs dependent on CCL19-CCR7 signaling. Regulatory T cells (Tregs) restrain immune function within these hubs, and both DC clustering and Treg cell suppression are modulated by anti-PD-1.
dlvr.it
December 19, 2025 at 3:48 PM
Online now: Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity
Nature research paper: Interferon-γ orchestrates leptomeningeal anti-tumour response
https://go.nature.com/4dohxwa
https://go.nature.com/4dohxwa
Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature
Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomeninges.
go.nature.com
May 16, 2025 at 10:17 AM
Nature research paper: Interferon-γ orchestrates leptomeningeal anti-tumour response
https://go.nature.com/4dohxwa
https://go.nature.com/4dohxwa
Analysing paired samples of human blood and thoracic duct lymph, Buggert &al show that human CCR7- non-resident memory CD8 T cells separate into a CX3CR1+ exclusively intravascular, cytotoxic and a non-cytotoxic, lymphatic population.
2020 in @cellpress.bsky.social 🧪⑂
www.cell.com/cell/fulltex...
2020 in @cellpress.bsky.social 🧪⑂
www.cell.com/cell/fulltex...
May 26, 2025 at 1:46 PM
Analysing paired samples of human blood and thoracic duct lymph, Buggert &al show that human CCR7- non-resident memory CD8 T cells separate into a CX3CR1+ exclusively intravascular, cytotoxic and a non-cytotoxic, lymphatic population.
2020 in @cellpress.bsky.social 🧪⑂
www.cell.com/cell/fulltex...
2020 in @cellpress.bsky.social 🧪⑂
www.cell.com/cell/fulltex...
Online now: CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity
CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity
Dendritic cells (DCs) can acquire distinct functional states. To examine how different DC states orchestrate anti-tumor immunity, Koufaki et al. develop mouse models to label and ablate CCR7+ DCs and find that this activation state is essential for tumor control by uniquely priming tumor-specific cytotoxic T lymphocytes (CTLs), sustaining their function and enabling responses to immunotherapy.
dlvr.it
August 4, 2026 at 2:48 PM
Online now: CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity
'While CCR7 is known to promote thymocyte medullary entry and negative selection, our previous studies implicate CCR4 in these processes, raising the question of whether CCR4 and CCR7 play distinct or redundant roles in central tolerance.'
#Immunology #Thymus #Tcells
#Immunology #Thymus #Tcells
CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tole...
Two-photon microscopy, combined with chemotaxis assays, synchronized thymocyte selection studies, and flow cytometry analyses, reveal that CCR4 and CCR7 promote medullary entry and central tolerance o...
elifesciences.org
July 6, 2023 at 9:30 PM
'While CCR7 is known to promote thymocyte medullary entry and negative selection, our previous studies implicate CCR4 in these processes, raising the question of whether CCR4 and CCR7 play distinct or redundant roles in central tolerance.'
#Immunology #Thymus #Tcells
#Immunology #Thymus #Tcells
We see that the progeny of reactivated memory cannot be completely explained by the (CCR7) SCM phenotype vs Temra. But they can generally be explained by this definition
January 12, 2025 at 10:45 AM
We see that the progeny of reactivated memory cannot be completely explained by the (CCR7) SCM phenotype vs Temra. But they can generally be explained by this definition
CCR7+ dendritic cells expressing both IL-23A and IL-12B potentially contribute to psoriasis relapse @natcomms.nature.com
nature.com/articles/s41...
nature.com/articles/s41...
August 16, 2025 at 2:59 AM
CCR7+ dendritic cells expressing both IL-23A and IL-12B potentially contribute to psoriasis relapse @natcomms.nature.com
nature.com/articles/s41...
nature.com/articles/s41...
CaRPOOL: A Pooled Calcium-Recording CRISPR Screening Platform Identifies CCR7 as a Modulator of Cellular Osmomechanosensing https://www.biorxiv.org/content/10.1101/2025.11.27.690909v1
November 29, 2025 at 3:30 AM
CaRPOOL: A Pooled Calcium-Recording CRISPR Screening Platform Identifies CCR7 as a Modulator of Cellular Osmomechanosensing https://www.biorxiv.org/content/10.1101/2025.11.27.690909v1
Podoplanin-Linked Mesenchymal Shift Synergizes with CCR7 driving Lymphatic Metastasis and Tumor Progression in Breast Cancer https://www.biorxiv.org/content/10.1101/2025.03.17.643704v1
March 18, 2025 at 5:50 AM
Podoplanin-Linked Mesenchymal Shift Synergizes with CCR7 driving Lymphatic Metastasis and Tumor Progression in Breast Cancer https://www.biorxiv.org/content/10.1101/2025.03.17.643704v1
Written with @ahernandezb.bsky.social, a wonderful postdoc in my lab!
Many congratulations to @meningojan.bsky.social and @adrienneboire.bsky.social for this amazing publication:
www.nature.com/articles/s41...
Many congratulations to @meningojan.bsky.social and @adrienneboire.bsky.social for this amazing publication:
www.nature.com/articles/s41...
Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature
Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...
www.nature.com
June 27, 2025 at 2:39 PM
Written with @ahernandezb.bsky.social, a wonderful postdoc in my lab!
Many congratulations to @meningojan.bsky.social and @adrienneboire.bsky.social for this amazing publication:
www.nature.com/articles/s41...
Many congratulations to @meningojan.bsky.social and @adrienneboire.bsky.social for this amazing publication:
www.nature.com/articles/s41...