Happy to share the last preprint from the Ivanov lab with CD226+ macrophage subset conserved across several tissues and especially fat, in which they regulate lipid metabolism. They exhibit a rapid turnover from monocytes, and in particular MDP-derived monocytes !
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CD226+ adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism.
Macrophages are innate immune cells present in all tissues, in which they participate in immune responses and maintenance of tissue homeostasis. They develop either from embryonic precursors or from c...
www.biorxiv.org
December 6, 2024 at 6:01 PM
Happy to share the last preprint from the Ivanov lab with CD226+ macrophage subset conserved across several tissues and especially fat, in which they regulate lipid metabolism. They exhibit a rapid turnover from monocytes, and in particular MDP-derived monocytes !
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
iPSC-derived NK cells engineered to overexpress CD226 (DNAM-1) effectively control #AML in xenograft models
ehoonline.biomedcentral.com/articles/10....
ehoonline.biomedcentral.com/articles/10....
July 8, 2025 at 2:23 PM
iPSC-derived NK cells engineered to overexpress CD226 (DNAM-1) effectively control #AML in xenograft models
ehoonline.biomedcentral.com/articles/10....
ehoonline.biomedcentral.com/articles/10....
α-CD226 protects against #T1D in NOD mice. Considerations for future translation tinyurl.com/mu4ykzk5 🔓
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function - Diabetologia
Aims/hypothesis Immunotherapeutics targeting T cells are crucial for inhibiting autoimmune disease progression proximal to disease onset in type 1 diabetes. There is an outstanding need to augment the...
tinyurl.com
December 6, 2024 at 4:07 PM
α-CD226 protects against #T1D in NOD mice. Considerations for future translation tinyurl.com/mu4ykzk5 🔓
CD226+ adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism. https://www.biorxiv.org/content/10.1101/2024.12.03.626330v1
December 5, 2024 at 8:16 PM
CD226+ adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism. https://www.biorxiv.org/content/10.1101/2024.12.03.626330v1
Multiple sclerosis-associated CD226 variant disrupts vitamin D-induced type I Treg differentiation by impairing LFA-1 activation @jci.org
www.jci.org/articles/vie...
www.jci.org/articles/vie...
September 3, 2026 at 1:58 AM
Multiple sclerosis-associated CD226 variant disrupts vitamin D-induced type I Treg differentiation by impairing LFA-1 activation @jci.org
www.jci.org/articles/vie...
www.jci.org/articles/vie...
CD226+ adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism. https://www.biorxiv.org/content/10.1101/2024.12.03.626330v1
CD226+ adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism. https://www.biorxiv.org/content/10.1101/2024.12.03.626330v1
Macrophages are innate immune cells present in all tissues, in which they participate in immune resp
www.biorxiv.org
December 5, 2024 at 8:16 PM
CD226+ adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism. https://www.biorxiv.org/content/10.1101/2024.12.03.626330v1
Overcoming CD226-related immune evasion in AML with CD38 CAR-engineered NK cells
www.cell.com/cell-reports...
www.cell.com/cell-reports...
January 4, 2025 at 7:33 PM
Overcoming CD226-related immune evasion in AML with CD38 CAR-engineered NK cells
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Therapeutic targeting of the T1D-associated costimulatory molecule CD226.
rdcu.be/d2A3k
rdcu.be/d2A3k
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function
rdcu.be
December 6, 2024 at 9:58 AM
Therapeutic targeting of the T1D-associated costimulatory molecule CD226.
rdcu.be/d2A3k
rdcu.be/d2A3k
Preprint from the Rao lab: CD57+ Tem CD8 cells are associated with interstitial lung disease in Systemic Sclerosis. One mechanism seems to be co-stimulatory CD226 interacting with CD155 on damaged epithelial cells.
Sasaki et al 2025 on
www.biorxiv.org/content/10.1...
Sasaki et al 2025 on
www.biorxiv.org/content/10.1...
February 1, 2025 at 6:13 PM
Preprint from the Rao lab: CD57+ Tem CD8 cells are associated with interstitial lung disease in Systemic Sclerosis. One mechanism seems to be co-stimulatory CD226 interacting with CD155 on damaged epithelial cells.
Sasaki et al 2025 on
www.biorxiv.org/content/10.1...
Sasaki et al 2025 on
www.biorxiv.org/content/10.1...
CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages https://www.biorxiv.org/content/10.1101/2025.01.22.634303v1
January 25, 2025 at 4:17 AM
CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages https://www.biorxiv.org/content/10.1101/2025.01.22.634303v1
Tissue-resident γδ T cells and ILC3s represent major cellular contexts in which CD226 is linked to inflammatory transcriptional programs in Crohn's disease
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 3, 2026 at 6:13 PM
Tissue-resident γδ T cells and ILC3s represent major cellular contexts in which CD226 is linked to inflammatory transcriptional programs in Crohn's disease
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Risk factors for multiple sclerosis: expression of a genetic risk variant for MS alters response to vitamin D of a subset of regulatory immune cells.
doi.org/10.1172/JCI2...
@saniya-kari.bsky.social
@inserm.fr @jci.org @cnrsbiologie.bsky.social
@infinitytls.bsky.social
#MS
doi.org/10.1172/JCI2...
@saniya-kari.bsky.social
@inserm.fr @jci.org @cnrsbiologie.bsky.social
@infinitytls.bsky.social
#MS
JCI - Multiple sclerosis-associated CD226 variant disrupts vitamin D-induced type I Treg differentiation by impairing LFA-1 activation
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doi.org
September 11, 2026 at 8:57 AM
Risk factors for multiple sclerosis: expression of a genetic risk variant for MS alters response to vitamin D of a subset of regulatory immune cells.
doi.org/10.1172/JCI2...
@saniya-kari.bsky.social
@inserm.fr @jci.org @cnrsbiologie.bsky.social
@infinitytls.bsky.social
#MS
doi.org/10.1172/JCI2...
@saniya-kari.bsky.social
@inserm.fr @jci.org @cnrsbiologie.bsky.social
@infinitytls.bsky.social
#MS
More evidence that TIGIT is an important player in autoimmunity and independent of its effect on CD226
www.nature.com/articles/s41...
#immunosky
www.nature.com/articles/s41...
#immunosky
TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis - Nature Communications
Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the aut...
www.nature.com
June 2, 2025 at 7:22 AM
More evidence that TIGIT is an important player in autoimmunity and independent of its effect on CD226
www.nature.com/articles/s41...
#immunosky
www.nature.com/articles/s41...
#immunosky
Single-cell transcriptomics to enhance CD19-CAR-T cell function in challenging CNS lymphoma cases. This study presented by @uligerdemann.bsky.social, MD, uncovers CD226 upregulation, offering new insights into overcoming inhibitory brain environments. #ASCO25
May 31, 2025 at 9:22 PM
Single-cell transcriptomics to enhance CD19-CAR-T cell function in challenging CNS lymphoma cases. This study presented by @uligerdemann.bsky.social, MD, uncovers CD226 upregulation, offering new insights into overcoming inhibitory brain environments. #ASCO25
Exclusive: Formation Bio has licensed its first drug since raising $372M — an anti-CD226 antibody from IMIDomics — and plans two more deals in 2025 as it builds out its pipeline.
Exclusive: Formation licenses first drug since $372M raise, eyes more deals in 2025
Formation Bio licenses first-in-class anti-CD226 antibody from IMIDomics for IBD treatment, marking first drug acquisition since $372M Series D raise in 2023.
endpoints.news
July 29, 2025 at 5:43 PM
Exclusive: Formation Bio has licensed its first drug since raising $372M — an anti-CD226 antibody from IMIDomics — and plans two more deals in 2025 as it builds out its pipeline.
Exclusive: Formation Bio raised a $372M Series D last year.
Later today, the New York biopharma will announce its first licensing deal since raising that money — bringing in a CD226 antibody from the Spanish biotech IMIDomics.
My latest for @endpts.com: endpoints.news/exclusive-fo...
Later today, the New York biopharma will announce its first licensing deal since raising that money — bringing in a CD226 antibody from the Spanish biotech IMIDomics.
My latest for @endpts.com: endpoints.news/exclusive-fo...
Exclusive: Formation licenses first drug since $372M raise, eyes more deals in 2025
Formation Bio licenses first-in-class anti-CD226 antibody from IMIDomics for IBD treatment, marking first drug acquisition since $372M Series D raise in 2023.
endpoints.news
July 29, 2025 at 12:20 PM
Exclusive: Formation Bio raised a $372M Series D last year.
Later today, the New York biopharma will announce its first licensing deal since raising that money — bringing in a CD226 antibody from the Spanish biotech IMIDomics.
My latest for @endpts.com: endpoints.news/exclusive-fo...
Later today, the New York biopharma will announce its first licensing deal since raising that money — bringing in a CD226 antibody from the Spanish biotech IMIDomics.
My latest for @endpts.com: endpoints.news/exclusive-fo...
CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages
CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages
Shinkawa et al. identify effector and dysfunctional states among lung CD8+ T cells during chronic tuberculosis in C57BL/6 mice. The most differentially expressed gene between the two states is CD226, which costimulates recognition of infected macrophages. Loss of CD226 expression correlates with development of CD8+ T cell exhaustion during tuberculosis.
dlvr.it
September 7, 2025 at 12:36 PM
CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages
CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages
www.cell.com/cell-reports... @cp-cellreports.bsky.social
www.cell.com/cell-reports... @cp-cellreports.bsky.social
September 1, 2025 at 5:37 PM
CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages
www.cell.com/cell-reports... @cp-cellreports.bsky.social
www.cell.com/cell-reports... @cp-cellreports.bsky.social
α-CD226 protects against #T1D in NOD mice - this could have implications for future translational research #DiabetesResearch #Endocrinology
α-CD226 protects against #T1D in NOD mice. Considerations for future translation tinyurl.com/mu4ykzk5 🔓
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function - Diabetologia
Aims/hypothesis Immunotherapeutics targeting T cells are crucial for inhibiting autoimmune disease progression proximal to disease onset in type 1 diabetes. There is an outstanding need to augment the...
tinyurl.com
December 9, 2024 at 10:31 AM
α-CD226 protects against #T1D in NOD mice - this could have implications for future translational research #DiabetesResearch #Endocrinology
8/n From 22 paired patient samples (pre/post chemo)📊 we found that macrophage-dominated signaling is a key feature post-chemo, aligning with our spatial findings. Wondering what was the strongest induced interaction? NECTIN2 binding to CD226, & the inhibitory receptors CD96 & TIGIT on CD8+ T cells.
December 10, 2024 at 11:48 AM
8/n From 22 paired patient samples (pre/post chemo)📊 we found that macrophage-dominated signaling is a key feature post-chemo, aligning with our spatial findings. Wondering what was the strongest induced interaction? NECTIN2 binding to CD226, & the inhibitory receptors CD96 & TIGIT on CD8+ T cells.
- Immune activation and sex-based differences
Proportionally more memory B cells at the cost of naive B cells.
More naive CD8 T cells and T cells expressing the activity markers PD-1 or CXCR5, less CD226. CD4 T cells were similar on markers assessed.
5/8
Proportionally more memory B cells at the cost of naive B cells.
More naive CD8 T cells and T cells expressing the activity markers PD-1 or CXCR5, less CD226. CD4 T cells were similar on markers assessed.
5/8
February 21, 2024 at 6:13 PM
- Immune activation and sex-based differences
Proportionally more memory B cells at the cost of naive B cells.
More naive CD8 T cells and T cells expressing the activity markers PD-1 or CXCR5, less CD226. CD4 T cells were similar on markers assessed.
5/8
Proportionally more memory B cells at the cost of naive B cells.
More naive CD8 T cells and T cells expressing the activity markers PD-1 or CXCR5, less CD226. CD4 T cells were similar on markers assessed.
5/8
The multiple sclerosis associated CD226 risk variant alters vitamin D-induced human type I regulatory T cell differentiation by impairing LFA-1 activation #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-5475102/latest
https://www.researchsquare.com/article/rs-5475102/latest
February 27, 2025 at 9:24 AM
The multiple sclerosis associated CD226 risk variant alters vitamin D-induced human type I regulatory T cell differentiation by impairing LFA-1 activation #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-5475102/latest
https://www.researchsquare.com/article/rs-5475102/latest
@thermofishersci.bsky.social's resource, RRID:AB_1724031, was just reported to be used in the paper. Thanks for making your methods matter! #reproducibility #OpenScience #reproducibility
CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages
doi.org
September 4, 2025 at 7:00 AM
@thermofishersci.bsky.social's resource, RRID:AB_1724031, was just reported to be used in the paper. Thanks for making your methods matter! #reproducibility #OpenScience #reproducibility
A paper using RRID:CVCL_0064 (from CLS) was just published in Cell Reports see "Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells". Thank you for making your methods matter! #RRID #accelerateopenscience
doi.org
January 8, 2025 at 1:06 PM
A paper using RRID:CVCL_0064 (from CLS) was just published in Cell Reports see "Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells". Thank you for making your methods matter! #RRID #accelerateopenscience
RRID:AB_1107780 from @bioxcell.bsky.social was used by authors in their None paper. Thanks for making your methods matter! #OpenScience #STMpublishing #ReproducibleResearch
Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226+ B cells in type 1 diabetes
doi.org
September 20, 2025 at 7:00 AM
RRID:AB_1107780 from @bioxcell.bsky.social was used by authors in their None paper. Thanks for making your methods matter! #OpenScience #STMpublishing #ReproducibleResearch