Schwere #Überschwemmung aufgrund #sintflutartigerStürme im Dorf Meures in Haute-Marne, #Frankreich
20.07.2024
Video: CD52, Meteo Express
20.07.2024
Video: CD52, Meteo Express
Disaster News
Serious flood due to torrential storms in the village of Meures in Haute-Marne, France 🇫🇷 (20.07.2024)
Video: CD52, Meteo Express
Subscribe to @Disaster_News
t.me
July 21, 2024 at 6:08 PM
Schwere #Überschwemmung aufgrund #sintflutartigerStürme im Dorf Meures in Haute-Marne, #Frankreich
20.07.2024
Video: CD52, Meteo Express
20.07.2024
Video: CD52, Meteo Express
Pete Hegseth has the Pentagon behaving like a commodities trader trying to corner the market. No one can figure out what this is about. www.ft.com/content/cd52...
Pentagon steps up stockpiling of critical minerals with $1bn buying spree
Trump administration challenges Chinese dominance of supply chain for metals essential to defence industry
www.ft.com
October 13, 2025 at 2:59 AM
Pete Hegseth has the Pentagon behaving like a commodities trader trying to corner the market. No one can figure out what this is about. www.ft.com/content/cd52...
4/5 and indeed it is! @silviadandrea.bsky.social brilliant work 🌟 showed that hypersialylation not only shapes the CD52 conf, but that it also determines the selection of HMGB1-Box B vs Box A, two structurally identical domains, with subtle but key mutations that confer CD52 binding selectivity
February 27, 2025 at 5:05 PM
4/5 and indeed it is! @silviadandrea.bsky.social brilliant work 🌟 showed that hypersialylation not only shapes the CD52 conf, but that it also determines the selection of HMGB1-Box B vs Box A, two structurally identical domains, with subtle but key mutations that confer CD52 binding selectivity
My Marantz CD52 is still going well.
March 22, 2026 at 7:17 AM
My Marantz CD52 is still going well.
Here the authors propose T cell-derived sCD52 as a therapeutic target to mitigate #obesity-associated #MASLD and glucose intolerance www.sciencedirect.com/science/arti...
Protective role of soluble CD52 in obesity-associated steatotic liver disease and glucose dysregulation in mice.
Soluble CD52 (sCD52) derived from activated CD4+ T cells regulates T cell immunity under autoimmune conditions; however, its role in obesity-associate…
www.sciencedirect.com
November 5, 2025 at 12:05 PM
Here the authors propose T cell-derived sCD52 as a therapeutic target to mitigate #obesity-associated #MASLD and glucose intolerance www.sciencedirect.com/science/arti...
Fantastic article!
By molecularly targeting the abnormal immune responses of this child with Omenn syndrome, using a combo of ruxolitinib, mepolizumab (anti-IL5), and alemtuzumab (anti-CD52), this team saved the 👶🏼's 🫀, allowing them to go to life-saving stem cell transplant.
TRANSLATIONAL SCIENCE!💪🏼
By molecularly targeting the abnormal immune responses of this child with Omenn syndrome, using a combo of ruxolitinib, mepolizumab (anti-IL5), and alemtuzumab (anti-CD52), this team saved the 👶🏼's 🫀, allowing them to go to life-saving stem cell transplant.
TRANSLATIONAL SCIENCE!💪🏼
June 23, 2025 at 6:48 PM
Fantastic article!
By molecularly targeting the abnormal immune responses of this child with Omenn syndrome, using a combo of ruxolitinib, mepolizumab (anti-IL5), and alemtuzumab (anti-CD52), this team saved the 👶🏼's 🫀, allowing them to go to life-saving stem cell transplant.
TRANSLATIONAL SCIENCE!💪🏼
By molecularly targeting the abnormal immune responses of this child with Omenn syndrome, using a combo of ruxolitinib, mepolizumab (anti-IL5), and alemtuzumab (anti-CD52), this team saved the 👶🏼's 🫀, allowing them to go to life-saving stem cell transplant.
TRANSLATIONAL SCIENCE!💪🏼
particular study, the universal CAR T-cells came from the white blood cells of healthy donors. The engineering steps utilized custom RNA, mRNA, and a lentiviral vector in an automated system researchers previously refined.
January 1, 2026 at 5:15 PM
particular study, the universal CAR T-cells came from the white blood cells of healthy donors. The engineering steps utilized custom RNA, mRNA, and a lentiviral vector in an automated system researchers previously refined.
That Moderna mRNA melanoma vaccine looks like a bit of a gamechanger on cancer treatment. Potentially one of the breakthroughs of the decade www.ft.com/content/cd52...
Moderna pins hopes on mRNA ‘game-changer’ for cancer vaccines
Technology behind blockbuster Covid jabs is yielding promising results in oncology treatment
www.ft.com
August 20, 2026 at 9:27 AM
That Moderna mRNA melanoma vaccine looks like a bit of a gamechanger on cancer treatment. Potentially one of the breakthroughs of the decade www.ft.com/content/cd52...
All set up for EVO 2023!
Come find me at table B22, across from the pillar that has CD52 on it.
Come find me at table B22, across from the pillar that has CD52 on it.
August 3, 2023 at 7:33 PM
All set up for EVO 2023!
Come find me at table B22, across from the pillar that has CD52 on it.
Come find me at table B22, across from the pillar that has CD52 on it.
Multi-omics integration reveals risk-associated gene expression signatures, identifying CD52 as a potential therapeutic target for high-risk JMML.
Anti-CD52 treatment depletes JMML stem cells and disrupts disease propagation in a JMML PDX model.
Anti-CD52 treatment depletes JMML stem cells and disrupts disease propagation in a JMML PDX model.
December 6, 2025 at 12:59 AM
Multi-omics integration reveals risk-associated gene expression signatures, identifying CD52 as a potential therapeutic target for high-risk JMML.
Anti-CD52 treatment depletes JMML stem cells and disrupts disease propagation in a JMML PDX model.
Anti-CD52 treatment depletes JMML stem cells and disrupts disease propagation in a JMML PDX model.
✨ New research alert!
How do glycans shape protein-protein interactions?
Groundbreaking work from @elisafadda.bsky.social & team shows that CD52 activity depends on hypersialylation, driving selective binding to HMGB1.
Out now in JBC! 🔗 doi.org/10.1016/j.jb...
How do glycans shape protein-protein interactions?
Groundbreaking work from @elisafadda.bsky.social & team shows that CD52 activity depends on hypersialylation, driving selective binding to HMGB1.
Out now in JBC! 🔗 doi.org/10.1016/j.jb...
February 28, 2025 at 4:28 PM
✨ New research alert!
How do glycans shape protein-protein interactions?
Groundbreaking work from @elisafadda.bsky.social & team shows that CD52 activity depends on hypersialylation, driving selective binding to HMGB1.
Out now in JBC! 🔗 doi.org/10.1016/j.jb...
How do glycans shape protein-protein interactions?
Groundbreaking work from @elisafadda.bsky.social & team shows that CD52 activity depends on hypersialylation, driving selective binding to HMGB1.
Out now in JBC! 🔗 doi.org/10.1016/j.jb...
3/5 In active CD52 O- and N-glycans appear to be hypersialylated... 🤔 Could this affect CD52 binding to the pro-inflammatory HMGB1 (P09429), where the complex is required to interact with SIGLEC10? (see also doi.org/10.1073/pnas...)
February 27, 2025 at 4:58 PM
3/5 In active CD52 O- and N-glycans appear to be hypersialylated... 🤔 Could this affect CD52 binding to the pro-inflammatory HMGB1 (P09429), where the complex is required to interact with SIGLEC10? (see also doi.org/10.1073/pnas...)
2/5 Human CD52 (P31358) is a 12 aa peptide with broad immunosuppressive properties with quite large O- and N-linked glycans relative to its length... We characterised the CD52 sugars in detail as these are *crucial* to activity. How and why that is was the mystery to solve!
February 27, 2025 at 4:48 PM
2/5 Human CD52 (P31358) is a 12 aa peptide with broad immunosuppressive properties with quite large O- and N-linked glycans relative to its length... We characterised the CD52 sugars in detail as these are *crucial* to activity. How and why that is was the mystery to solve!
This paper still irritates me - harvesting marrow from one-day-old neonates (human!)
www.cell.com/developmenta...
www.cell.com/developmenta...
Temporal molecular program of human hematopoietic stem and progenitor cells after birth
Zhang et al. provided an integral transcriptomic analysis of HSPCs, defined their dynamics in post-natal steady-state hematopoiesis, and refined the heterogeneity of MPPs by CD52 expression. Neonate bone-marrow-derived HSCs exhibited higher reconstruction capability than cord blood HSCs. This resource will help understand hematopoiesis in development and disease.
www.cell.com
December 14, 2024 at 1:25 AM
This paper still irritates me - harvesting marrow from one-day-old neonates (human!)
www.cell.com/developmenta...
www.cell.com/developmenta...
CD52 Antibody Market Size, Trends & Forecast 2035 - Wiseguy | WiseGuyReports www.wiseguyreports.com/reports/cd52...
CD52 Antibody Market Size, Trends & Forecast 2035 - Wiseguy
The CD52 Antibody Market is expected to grow from 2,640 USD Million in 2025 to 5 USD Billion by 2035. The CD52 Antibody Market CAGR (growth rate) is expected to be around 6.6% | Wiseguy Reports
www.wiseguyreports.com
September 17, 2026 at 9:56 AM
CD52 Antibody Market Size, Trends & Forecast 2035 - Wiseguy | WiseGuyReports www.wiseguyreports.com/reports/cd52...
The Phase I results of the first 11 patients, treated at Great Ormond Street and King's College Hospital, have just been published in the New England Journal of Medicine.
YES, it is PEER-REVIEWED.
• www.nejm.org/doi/full/10....
🧪🧵⬇️
YES, it is PEER-REVIEWED.
• www.nejm.org/doi/full/10....
🧪🧵⬇️
January 1, 2026 at 5:04 PM
The Phase I results of the first 11 patients, treated at Great Ormond Street and King's College Hospital, have just been published in the New England Journal of Medicine.
YES, it is PEER-REVIEWED.
• www.nejm.org/doi/full/10....
🧪🧵⬇️
YES, it is PEER-REVIEWED.
• www.nejm.org/doi/full/10....
🧪🧵⬇️
Anti-CD52 therapy of rheumatic diseases: Revisited in the era of immune reset
Checking your browser - reCAPTCHA
pubmed.ncbi.nlm.nih.gov
April 24, 2026 at 11:35 PM
Anti-CD52 therapy of rheumatic diseases: Revisited in the era of immune reset
The U.S. #military depends heavily on Chinese rare earths. New restrictions could hit #defense #supply chains hard, from #jet engines to precision #weapons. #Washington is scrambling to stockpile and diversify.
www.ft.com/content/cd52...
www.ft.com/content/cd52...
Pentagon steps up stockpiling of critical minerals with $1bn buying spree
Trump administration challenges Chinese dominance of supply chain for metals essential to defence industry
www.ft.com
October 12, 2025 at 10:06 AM
The U.S. #military depends heavily on Chinese rare earths. New restrictions could hit #defense #supply chains hard, from #jet engines to precision #weapons. #Washington is scrambling to stockpile and diversify.
www.ft.com/content/cd52...
www.ft.com/content/cd52...
"The share price reaction stunned Wall Street as it is rare for a large biotech group to move so dramatically."
"Another looming uncertainty for Moderna is the degree of political hostility it may have to overcome when bringing products to market."
www.ft.com/content/cd52...
"Another looming uncertainty for Moderna is the degree of political hostility it may have to overcome when bringing products to market."
www.ft.com/content/cd52...
Moderna pins hopes on mRNA ‘game-changer’ for cancer vaccines
Technology behind blockbuster Covid jabs is yielding promising results in oncology treatment
www.ft.com
August 20, 2026 at 8:29 AM
"The share price reaction stunned Wall Street as it is rare for a large biotech group to move so dramatically."
"Another looming uncertainty for Moderna is the degree of political hostility it may have to overcome when bringing products to market."
www.ft.com/content/cd52...
"Another looming uncertainty for Moderna is the degree of political hostility it may have to overcome when bringing products to market."
www.ft.com/content/cd52...
"52nd Annual Telluride Bluegrass Festival welcomes back its best" Bringing it all back home https://www.telluridenews.com/news/article_e84c07e4-cd52-11ef-8673-a77a97ef1327.html #FolkMusic #Bluegrass
February 1, 2025 at 10:52 PM
"52nd Annual Telluride Bluegrass Festival welcomes back its best" Bringing it all back home https://www.telluridenews.com/news/article_e84c07e4-cd52-11ef-8673-a77a97ef1327.html #FolkMusic #Bluegrass
🔥 Lu Home Cordeiro, Lisbon — 492€ invece di 1575€ (-69%) per il 04 Sep. https://hotel-oracle.com/oracolo/booking_com_lu_home_cordeiro?deal=a9b168c8-cd52-4d49-b319-710a980d3b06 #HotelOracle #ViaggiScontati
August 29, 2026 at 8:30 PM
🔥 Lu Home Cordeiro, Lisbon — 492€ invece di 1575€ (-69%) per il 04 Sep. https://hotel-oracle.com/oracolo/booking_com_lu_home_cordeiro?deal=a9b168c8-cd52-4d49-b319-710a980d3b06 #HotelOracle #ViaggiScontati
Not used an actual CD in years, my old Marantz CD52 MK2 Signature Edition with a modified clock was amazing back in the day though
August 18, 2024 at 8:15 AM
Not used an actual CD in years, my old Marantz CD52 MK2 Signature Edition with a modified clock was amazing back in the day though
4/n Hypersialylation of the CD52 glycopeptide determines selection and binding to the receptor through the O-glycan and binding to Siglec-10 through the N-glycan [https://doi.org/10.1016/j.jbc.2025.108350] and [https://doi.org/10.1101/2025.06.10.658867]
November 27, 2025 at 6:24 PM
4/n Hypersialylation of the CD52 glycopeptide determines selection and binding to the receptor through the O-glycan and binding to Siglec-10 through the N-glycan [https://doi.org/10.1016/j.jbc.2025.108350] and [https://doi.org/10.1101/2025.06.10.658867]
DSHB's resource, RRID:AB_2314866, was just reported to be used in "Single-cell sequencing exposes mast cell-derived CD52's anti-tumor action in breast cancer through the IL-6/JAK/STAT3 axis". Thank you for making your methods matter! #methodsmatter #RRID
doi.org
April 13, 2025 at 7:00 AM
DSHB's resource, RRID:AB_2314866, was just reported to be used in "Single-cell sequencing exposes mast cell-derived CD52's anti-tumor action in breast cancer through the IL-6/JAK/STAT3 axis". Thank you for making your methods matter! #methodsmatter #RRID