Plenary at @hypertensioncanada.bsky.social with @drjmluther.bsky.social on new drugs

He starts of with the really old drugs!

#CHC25

This is a fantastic table of all BP drug classes approval over time

We have come a long way

@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25

How about the siRNA (hot off the press from yesterday's @jama.com )

Zilebesiran summary evidence

@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25

Rahul @rahulchanchlani.bsky.social starts off with a bang

Hypertension in Children

Congrats for the young Investigator too!

@hypertensioncanada.bsky.social #CHC25

huge knowledge gaps in pediatric hypertension

from pubmed.ncbi.nlm.nih.gov/35570999/ in @kireports.bsky.social

@rahulchanchlani.bsky.social at @hypertensioncanada.bsky.social #CHC25

And his conclusions!

Excellent overview of really old to the rapidly emerging field of hypertension drugs

@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25

The details of the existing ASIs in development

Note the selectivity of Bax/Lorun/Vica -drostats

But also the half life, Bax > Lorun > Vica

@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25

After covering Aprocitentan (see www.nephjc.com/news/aprocit...)

@drjmluther.bsky.social moves on to Aldo synthase inhibitors

This is his take on the potential role of ASIs

#NephJC chat on Lorundrostat: www.nephjc.com/news/advance...

#CHC25 @hypertensioncanada.bsky.social

diastolic hypertension and risk of aortic dissection - note the relative risk scales!

@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25

Up next on our 2025 calendar is @CHILLCON1!

Take advantage of our 10% pre-order discount at irongatescenery.co.uk. But hurry, this offer ends March 19th.

To claim your discount, use code: CHC25 at checkout and select the delivery option 'Pick up at Chillcon'.

The summary of the data on ASIs so far

@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25

Sold out for 3 years in a row, the Canadian Hydrogen Convention is North America's largest hydrogen convention! ✔️

Secure your spot today to connect with industry leaders!

Register today: hubs.la/Q033cX3b0

#CHC25