Actual world first!
Beta test of Neos mouse driver for C64OS.
Due to Commodores unfathomable dualing of the LMB and the data strobe compared to its msx sibling, there are compromises and issues to be worked around, but we've* got basic functionally. 📹👇
*Greg is doing the work, I'm just pestering him
Beta test of Neos mouse driver for C64OS.
Due to Commodores unfathomable dualing of the LMB and the data strobe compared to its msx sibling, there are compromises and issues to be worked around, but we've* got basic functionally. 📹👇
*Greg is doing the work, I'm just pestering him
February 13, 2026 at 7:18 PM
Actual world first!
Beta test of Neos mouse driver for C64OS.
Due to Commodores unfathomable dualing of the LMB and the data strobe compared to its msx sibling, there are compromises and issues to be worked around, but we've* got basic functionally. 📹👇
*Greg is doing the work, I'm just pestering him
Beta test of Neos mouse driver for C64OS.
Due to Commodores unfathomable dualing of the LMB and the data strobe compared to its msx sibling, there are compromises and issues to be worked around, but we've* got basic functionally. 📹👇
*Greg is doing the work, I'm just pestering him
New paper alert! We ID resides of CIA targeting complex that recruit clients - in contradiction to what was predicted from previous studies, we find it is the cia1-cia2 interface, not cia1 on its own, that mediates the interaction.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
A Conserved Cia1–Cia2 Interface Mediates Client Recruitment in the Cytosolic Iron–Sulfur Cluster Assembly Pathway
The cytosolic iron–sulfur cluster assembly (CIA) targeting complex maturates over 30 cytosolic and nuclear Fe–S proteins, raising the question of how a single complex recognizes such a diverse set of ...
pubs.acs.org
September 19, 2025 at 12:53 AM
New paper alert! We ID resides of CIA targeting complex that recruit clients - in contradiction to what was predicted from previous studies, we find it is the cia1-cia2 interface, not cia1 on its own, that mediates the interaction.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
So excited to get this work out there! We have been working hard to "crack the CIA code" - more to come soon!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motif
The cytosolic iron-sulfur cluster assembly (CIA) targeting complex is responsible for maturation of cytosolic and nuclear iron-sulfur enzymes, numbering >30 proteins critical for fundamental processes...
www.biorxiv.org
March 27, 2025 at 11:49 AM
So excited to get this work out there! We have been working hard to "crack the CIA code" - more to come soon!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Role of CIA2 and CIL in the regulation of chloroplast photomorphogenesis in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.11.24.690140v1
November 26, 2025 at 7:01 PM
Role of CIA2 and CIL in the regulation of chloroplast photomorphogenesis in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.11.24.690140v1
What? I thought you were working on a utility to change the init in the SID files to point to a replacement CIA1 or CIA2 (NMI) programmable interrupt??
October 26, 2025 at 4:09 AM
What? I thought you were working on a utility to change the init in the SID files to point to a replacement CIA1 or CIA2 (NMI) programmable interrupt??
The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motif https://www.biorxiv.org/content/10.1101/2025.03.25.645274v1
March 26, 2025 at 3:45 AM
The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motif https://www.biorxiv.org/content/10.1101/2025.03.25.645274v1
The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motif https://www.biorxiv.org/content/10.1101/2025.03.25.645274v1
March 26, 2025 at 3:45 AM
The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motif https://www.biorxiv.org/content/10.1101/2025.03.25.645274v1
achei paia dms o oráculo traindo o ligonz, acho q poderiam plmns incluir ele nesse ngc de cia2
September 15, 2024 at 9:35 PM
achei paia dms o oráculo traindo o ligonz, acho q poderiam plmns incluir ele nesse ngc de cia2
C64 Repair Twist: The Fault Was CIA 2 — Not the Character ROM
#Commodore64 #C64 #C64Repair #RetroComputing #VintageComputers #C64Troubleshooting #CIA2 #HardwareRepair #RetroRepair
theoasisbbs.com/c64-repair-t...
#Commodore64 #C64 #C64Repair #RetroComputing #VintageComputers #C64Troubleshooting #CIA2 #HardwareRepair #RetroRepair
theoasisbbs.com/c64-repair-t...
C64 Repair Twist: The Fault Was CIA 2 — Not the Character ROM - The Oasis BBS
Watch this C64 repair unfold as a display fault leads to a surprising culprit — CIA 2. See how the troubleshooting process revealed the real problem.
theoasisbbs.com
April 10, 2025 at 1:15 PM
C64 Repair Twist: The Fault Was CIA 2 — Not the Character ROM
#Commodore64 #C64 #C64Repair #RetroComputing #VintageComputers #C64Troubleshooting #CIA2 #HardwareRepair #RetroRepair
theoasisbbs.com/c64-repair-t...
#Commodore64 #C64 #C64Repair #RetroComputing #VintageComputers #C64Troubleshooting #CIA2 #HardwareRepair #RetroRepair
theoasisbbs.com/c64-repair-t...
Day 21 of listening to new game music every day. I did Kingdom Valley, Sunset Heights, and Chaos Island Act 2 from Shadow Generations. Technically, I heard them in game first, since I have been playing that game lately. The first two are solid, though for CIa2 it's fine, besides the awesome intro.
May 9, 2025 at 3:08 AM
Day 21 of listening to new game music every day. I did Kingdom Valley, Sunset Heights, and Chaos Island Act 2 from Shadow Generations. Technically, I heard them in game first, since I have been playing that game lately. The first two are solid, though for CIa2 it's fine, besides the awesome intro.
A paper from the Perlstein lab is on BioRxiv!
www.biorxiv.org/content/10.1...
Check out what we (and by we I mean my labmates) worked so hard on and got to learn about how proteins interact in the pathway that develops and sends iron-sulfur clusters to so many important proteins!
www.biorxiv.org/content/10.1...
Check out what we (and by we I mean my labmates) worked so hard on and got to learn about how proteins interact in the pathway that develops and sends iron-sulfur clusters to so many important proteins!
The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motif
The cytosolic iron-sulfur cluster assembly (CIA) targeting complex is responsible for maturation of cytosolic and nuclear iron-sulfur enzymes, numbering >30 proteins critical for fundamental processes...
www.biorxiv.org
March 27, 2025 at 11:14 PM
A paper from the Perlstein lab is on BioRxiv!
www.biorxiv.org/content/10.1...
Check out what we (and by we I mean my labmates) worked so hard on and got to learn about how proteins interact in the pathway that develops and sends iron-sulfur clusters to so many important proteins!
www.biorxiv.org/content/10.1...
Check out what we (and by we I mean my labmates) worked so hard on and got to learn about how proteins interact in the pathway that develops and sends iron-sulfur clusters to so many important proteins!
仲間を見捨てないゾウリムシの助け合い行動
www.youtube.com/watch?v=cia2...
www.youtube.com/watch?v=cia2...
February 16, 2024 at 5:55 PM
仲間を見捨てないゾウリムシの助け合い行動
www.youtube.com/watch?v=cia2...
www.youtube.com/watch?v=cia2...
The answer?
Nar1 engages the CIA targeting complex through a bipartite binding mechanism:
• a conserved electrostatic interface anchors Nar1 to a conserved acidic face of Cia1
• Nar1's divergent targeting complex recognition motif exploits the client recruitment site at the Cia1-Cia2 interface
Nar1 engages the CIA targeting complex through a bipartite binding mechanism:
• a conserved electrostatic interface anchors Nar1 to a conserved acidic face of Cia1
• Nar1's divergent targeting complex recognition motif exploits the client recruitment site at the Cia1-Cia2 interface
March 9, 2026 at 12:51 PM
The answer?
Nar1 engages the CIA targeting complex through a bipartite binding mechanism:
• a conserved electrostatic interface anchors Nar1 to a conserved acidic face of Cia1
• Nar1's divergent targeting complex recognition motif exploits the client recruitment site at the Cia1-Cia2 interface
Nar1 engages the CIA targeting complex through a bipartite binding mechanism:
• a conserved electrostatic interface anchors Nar1 to a conserved acidic face of Cia1
• Nar1's divergent targeting complex recognition motif exploits the client recruitment site at the Cia1-Cia2 interface
February 17, 2026 at 12:17 PM
Role of CIA2 and CIL in the regulation of chloroplast photomorphogenesis in Arabidopsis www.biorxiv.org/content/10.1...
Role of CIA2 and CIL in the regulation of chloroplast photomorphogenesis in Arabidopsis
Abstract: Chloroplast development plays a crucial role in plant de-etiolation, a process in which plants switch from growth in darkness to light-driven development, known as photomorphogenesis. This s...
www.biorxiv.org
November 26, 2025 at 9:51 PM
Role of CIA2 and CIL in the regulation of chloroplast photomorphogenesis in Arabidopsis www.biorxiv.org/content/10.1...
Role of CIA2 and CIL in the regulation of chloroplast photomorphogenesis in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.11.24.690140v1
November 26, 2025 at 7:01 PM
Role of CIA2 and CIL in the regulation of chloroplast photomorphogenesis in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.11.24.690140v1