Epigenetics Update - SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin www.nature.com/articles/s41...
Cem Meydan, Ari Melnick, & @darkobar.bsky.social in Nature.com
#Epigenetics #Chromatin #CTCF #Cohesin #SWISNF
---
Discover the breakthrough at epigenometech.com
Cem Meydan, Ari Melnick, & @darkobar.bsky.social in Nature.com
#Epigenetics #Chromatin #CTCF #Cohesin #SWISNF
---
Discover the breakthrough at epigenometech.com
November 4, 2026 at 12:34 PM
Epigenetics Update - SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin www.nature.com/articles/s41...
Cem Meydan, Ari Melnick, & @darkobar.bsky.social in Nature.com
#Epigenetics #Chromatin #CTCF #Cohesin #SWISNF
---
Discover the breakthrough at epigenometech.com
Cem Meydan, Ari Melnick, & @darkobar.bsky.social in Nature.com
#Epigenetics #Chromatin #CTCF #Cohesin #SWISNF
---
Discover the breakthrough at epigenometech.com
November 1, 2026 at 8:09 PM
Ci sono #vetrine di serie A
E vetrine di serie B
Di queste non parla nessuno 🤷
Che poi un opposizione seria su questo dovrebbe fare molto rumore!
Contro chi parla sempre di sicurezza, ma sa solo criminalizzare i giovani!
A #Roma Est, 15 #bombe in tre mesi | lavialibera share.google/DVsdObC1QGYe...
E vetrine di serie B
Di queste non parla nessuno 🤷
Che poi un opposizione seria su questo dovrebbe fare molto rumore!
Contro chi parla sempre di sicurezza, ma sa solo criminalizzare i giovani!
A #Roma Est, 15 #bombe in tre mesi | lavialibera share.google/DVsdObC1QGYe...
A Roma Est continuano a esplodere bombe: 15 da settembre. Dietro, l'ombra dei clan che si riorganizzano
share.google
November 2, 2026 at 10:22 PM
Epigenetics Update - Evolution of CTCF underlies the establishment of loop extrusion as a predominant chromatin folding mechanism in vertebrates www.biorxiv.org/content/10.6...
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
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epigenometech.com
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
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epigenometech.com
November 2, 2026 at 7:28 AM
Epigenetics Update - Evolution of CTCF underlies the establishment of loop extrusion as a predominant chromatin folding mechanism in vertebrates www.biorxiv.org/content/10.6...
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
---
epigenometech.com
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
---
epigenometech.com
A settembre la Russia ha ottenuto un nuovo record: 54.400 perdite (soldati russi morti o storpiati) in un mese
Almeno 12 mila a settimana, più di 1.700 al giorno, 70 all'ora (è la stima minima) [Bloomberg]
E questo per una perdita netta di territori pari a circa 160 km² [ISW]
Almeno 12 mila a settimana, più di 1.700 al giorno, 70 all'ora (è la stima minima) [Bloomberg]
E questo per una perdita netta di territori pari a circa 160 km² [ISW]
November 3, 2026 at 9:55 PM
In Russia la stazione di stoccaggio petrolifero di Samara, 71 serbatoi per un totale di 1,6 milioni di metri cubi di petrolio, brucia ininterrottamente ormai da due giorni, e questa è la gravità della situazione a stasera:
November 3, 2026 at 9:52 PM
CERTO, PUTIN STA VINCENDO 40.000 soldati americani morti in 15 anni di guerra in Vietnam, 54.000 soldati russi morti in Ucraina nel solo mese di ottobre e oltre un milione in 4 anni di guerra.
November 3, 2026 at 9:50 PM
Beyond thrilled that the first paper from our lab is out today in @nature.com! We show that SWI/SNF loss results in gain-of-function for CTCF and cohesin, reshaping the 3D genome, and an unexpected switch between chromatin remodeling complexes.
Full thread below.
www.nature.com/articles/s41...
Full thread below.
www.nature.com/articles/s41...
SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin - Nature
Loss of function of canonical BAF induces gain of CTCF and cohesin binding that alters 3D genome architecture and reprograms transcription.
www.nature.com
October 28, 2026 at 5:05 PM
Beyond thrilled that the first paper from our lab is out today in @nature.com! We show that SWI/SNF loss results in gain-of-function for CTCF and cohesin, reshaping the 3D genome, and an unexpected switch between chromatin remodeling complexes.
Full thread below.
www.nature.com/articles/s41...
Full thread below.
www.nature.com/articles/s41...
La meglio gioventù. #chetempochefa | Intervista #sayf | Video https://nove.tv/che-tempo-che-fa-puntata-1-novembre-2026-intervista-sayf-video
@spettacoli
#music #tv #CTCF #genova
@spettacoli
#music #tv #CTCF #genova
November 3, 2026 at 6:28 AM
La meglio gioventù. #chetempochefa | Intervista #sayf | Video https://nove.tv/che-tempo-che-fa-puntata-1-novembre-2026-intervista-sayf-video
@spettacoli
#music #tv #CTCF #genova
@spettacoli
#music #tv #CTCF #genova
SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin - Nature
November 2, 2026 at 3:44 AM
SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin - Nature
Really exciting work!!
SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin - Nature
Loss of function of canonical BAF induces gain of CTCF and cohesin binding that alters 3D genome architecture and reprograms transcription.
www.nature.com
October 29, 2026 at 3:52 PM
Really exciting work!!
NAD Metabolism Drives CTCF-Cohesin Chromatin Regulation in EBV-Transformed B-Cells https://www.biorxiv.org/content/10.64898/2026.11.01.763250v1
November 3, 2026 at 2:17 AM
NAD Metabolism Drives CTCF-Cohesin Chromatin Regulation in EBV-Transformed B-Cells https://www.biorxiv.org/content/10.64898/2026.11.01.763250v1
NAD Metabolism Drives CTCF-Cohesin Chromatin Regulation in EBV-Transformed B-Cells https://www.biorxiv.org/content/10.64898/2026.11.01.763250v1
November 3, 2026 at 2:17 AM
NAD Metabolism Drives CTCF-Cohesin Chromatin Regulation in EBV-Transformed B-Cells https://www.biorxiv.org/content/10.64898/2026.11.01.763250v1
Il ritorno a #CTCF del prof Antonio Scurati, in occasione dell'uscita del suo ultimo libro! 👏🏻📒
Cc @spettacoli@diggita.com @televisione @spettacoli
https://youtu.be/_W2alIRASUo?si=0x7Lf319AbWoxX8r
Cc @spettacoli@diggita.com @televisione @spettacoli
https://youtu.be/_W2alIRASUo?si=0x7Lf319AbWoxX8r
November 2, 2026 at 9:18 PM
Il ritorno a #CTCF del prof Antonio Scurati, in occasione dell'uscita del suo ultimo libro! 👏🏻📒
Cc @spettacoli@diggita.com @televisione @spettacoli
https://youtu.be/_W2alIRASUo?si=0x7Lf319AbWoxX8r
Cc @spettacoli@diggita.com @televisione @spettacoli
https://youtu.be/_W2alIRASUo?si=0x7Lf319AbWoxX8r
Is gain of CTCF a direct response? Acute ARID1A loss in embryonic stem cells or SWI/SNF inhibition in cancer cells opened CTCF sites in a few hours.
ChIP showed increased CTCF and decreased ARID1A binding at the same sites, supporting direct antagonism on chromatin.
5/n
ChIP showed increased CTCF and decreased ARID1A binding at the same sites, supporting direct antagonism on chromatin.
5/n
October 28, 2026 at 5:05 PM
Is gain of CTCF a direct response? Acute ARID1A loss in embryonic stem cells or SWI/SNF inhibition in cancer cells opened CTCF sites in a few hours.
ChIP showed increased CTCF and decreased ARID1A binding at the same sites, supporting direct antagonism on chromatin.
5/n
ChIP showed increased CTCF and decreased ARID1A binding at the same sites, supporting direct antagonism on chromatin.
5/n
Next we asked: What helps CTCF gain when cBAF is lost?
Surprisingly, PBAF. CTCF interacts with this distinct SWI/SNF complex that is recruited to sites gaining CTCF. We confirmed this interaction in several cancer cell lines from different tissue-of-origin.
7/n
Surprisingly, PBAF. CTCF interacts with this distinct SWI/SNF complex that is recruited to sites gaining CTCF. We confirmed this interaction in several cancer cell lines from different tissue-of-origin.
7/n
October 28, 2026 at 5:05 PM
Next we asked: What helps CTCF gain when cBAF is lost?
Surprisingly, PBAF. CTCF interacts with this distinct SWI/SNF complex that is recruited to sites gaining CTCF. We confirmed this interaction in several cancer cell lines from different tissue-of-origin.
7/n
Surprisingly, PBAF. CTCF interacts with this distinct SWI/SNF complex that is recruited to sites gaining CTCF. We confirmed this interaction in several cancer cell lines from different tissue-of-origin.
7/n
CRV Science Labs ⚗️
🧬 How the Absence of Hox/ParaHox Clusters, Minimal Wnt Polarity, and CTCF-Negative Chromatin Loops Support the Ctenophora-First Hypothesis — Synthesizing 1.64 Mb across 32 Development and Untouched Reser…
https://crvscience.com/labs/discoveries/ctenophora-hox-wnt-chromatin-tier3
🧬 How the Absence of Hox/ParaHox Clusters, Minimal Wnt Polarity, and CTCF-Negative Chromatin Loops Support the Ctenophora-First Hypothesis — Synthesizing 1.64 Mb across 32 Development and Untouched Reser…
https://crvscience.com/labs/discoveries/ctenophora-hox-wnt-chromatin-tier3
CRV Science Labs ⚗️
🧬 How the Absence of Hox/ParaHox Clusters, Minimal Wnt Polarity, and CTCF-Negative Chromatin Loops Support the Ctenophora-First Hypothesis — Synthesizing 1.64 Mb across 32 Development and Untouched Reserve cohorts (64 metazoan and holozoan taxa) demonstrates that Ctenophora and …
crvscience.com
November 3, 2026 at 12:10 PM
CRV Science Labs ⚗️
🧬 How the Absence of Hox/ParaHox Clusters, Minimal Wnt Polarity, and CTCF-Negative Chromatin Loops Support the Ctenophora-First Hypothesis — Synthesizing 1.64 Mb across 32 Development and Untouched Reser…
https://crvscience.com/labs/discoveries/ctenophora-hox-wnt-chromatin-tier3
🧬 How the Absence of Hox/ParaHox Clusters, Minimal Wnt Polarity, and CTCF-Negative Chromatin Loops Support the Ctenophora-First Hypothesis — Synthesizing 1.64 Mb across 32 Development and Untouched Reser…
https://crvscience.com/labs/discoveries/ctenophora-hox-wnt-chromatin-tier3
4/ Finally, not all SB hopping is local. Up to 50% of transposons integrate on other chromosomes, but this fraction depends on the cargo: promoters ‘like’ to hop to other chromosomes, while transposons containing CTCF binding sites prefer to reintegrate on the launch chromosome.
November 4, 2026 at 10:34 AM
4/ Finally, not all SB hopping is local. Up to 50% of transposons integrate on other chromosomes, but this fraction depends on the cargo: promoters ‘like’ to hop to other chromosomes, while transposons containing CTCF binding sites prefer to reintegrate on the launch chromosome.
Tutti gli ospiti del Tavolo di domani sera!
#CTCF 🐠
Cc @televisione @spettacoli@diggita.com @spettacoli
"Il Tavolo di Che tempo che fa" con Fabio Fazio su NOVE: ospiti Carlo Conti, Max Angioni, Nek, Roberto Saviano, Francesco Costa | MagTv […]
#CTCF 🐠
Cc @televisione @spettacoli@diggita.com @spettacoli
"Il Tavolo di Che tempo che fa" con Fabio Fazio su NOVE: ospiti Carlo Conti, Max Angioni, Nek, Roberto Saviano, Francesco Costa | MagTv […]
Original post on mastodon.uno
mastodon.uno
November 3, 2026 at 4:15 PM
Tutti gli ospiti del Tavolo di domani sera!
#CTCF 🐠
Cc @televisione @spettacoli@diggita.com @spettacoli
"Il Tavolo di Che tempo che fa" con Fabio Fazio su NOVE: ospiti Carlo Conti, Max Angioni, Nek, Roberto Saviano, Francesco Costa | MagTv […]
#CTCF 🐠
Cc @televisione @spettacoli@diggita.com @spettacoli
"Il Tavolo di Che tempo che fa" con Fabio Fazio su NOVE: ospiti Carlo Conti, Max Angioni, Nek, Roberto Saviano, Francesco Costa | MagTv […]
Why would cells benefit from CTCF and PBAF gain upon cBAF loss? Faster proliferation.
CTCF over-expression alone reproduces the growth advantage of ARID1A loss. Deleting the PBAF subunit ARID2 removes that advantage in ARID1A-mutant cells.
9/n
CTCF over-expression alone reproduces the growth advantage of ARID1A loss. Deleting the PBAF subunit ARID2 removes that advantage in ARID1A-mutant cells.
9/n
October 28, 2026 at 5:05 PM
Why would cells benefit from CTCF and PBAF gain upon cBAF loss? Faster proliferation.
CTCF over-expression alone reproduces the growth advantage of ARID1A loss. Deleting the PBAF subunit ARID2 removes that advantage in ARID1A-mutant cells.
9/n
CTCF over-expression alone reproduces the growth advantage of ARID1A loss. Deleting the PBAF subunit ARID2 removes that advantage in ARID1A-mutant cells.
9/n
Do we see a parallel in patients?
In pan-cancer analyses, patients with alterations in both ARID1A and CTCF have better overall survival than those with ARID1A alterations alone. Also, high CTCF expression is associated with worse survival.
11/n
In pan-cancer analyses, patients with alterations in both ARID1A and CTCF have better overall survival than those with ARID1A alterations alone. Also, high CTCF expression is associated with worse survival.
11/n
October 28, 2026 at 5:05 PM
Do we see a parallel in patients?
In pan-cancer analyses, patients with alterations in both ARID1A and CTCF have better overall survival than those with ARID1A alterations alone. Also, high CTCF expression is associated with worse survival.
11/n
In pan-cancer analyses, patients with alterations in both ARID1A and CTCF have better overall survival than those with ARID1A alterations alone. Also, high CTCF expression is associated with worse survival.
11/n
This is also true in mice. Embryonic fibroblasts proliferate faster after Arid1a loss, and genetically deleting both Ctcf and Arid1a restores normal growth.
Interestingly, in our mouse lymphoma model, CTCF-site opening appears before overt disease and persists in tumors.
10/n
Interestingly, in our mouse lymphoma model, CTCF-site opening appears before overt disease and persists in tumors.
10/n
October 28, 2026 at 5:05 PM
This is also true in mice. Embryonic fibroblasts proliferate faster after Arid1a loss, and genetically deleting both Ctcf and Arid1a restores normal growth.
Interestingly, in our mouse lymphoma model, CTCF-site opening appears before overt disease and persists in tumors.
10/n
Interestingly, in our mouse lymphoma model, CTCF-site opening appears before overt disease and persists in tumors.
10/n
"Sono preoccupata per Luciana, più passa il tempo e più si sveglia presto"
Maria de Filippi che chiama così a ufo le trasmissioni degli altri mi mancava! 😂
E comunque ha anticipato che presto sarà ospite a #CTCF quindi questo è uno SCOOP enorme! 💥💥💥
Cc @spettacoli@diggita.com @televisione […]
Maria de Filippi che chiama così a ufo le trasmissioni degli altri mi mancava! 😂
E comunque ha anticipato che presto sarà ospite a #CTCF quindi questo è uno SCOOP enorme! 💥💥💥
Cc @spettacoli@diggita.com @televisione […]
Original post on mastodon.uno
mastodon.uno
November 3, 2026 at 6:45 PM
"Sono preoccupata per Luciana, più passa il tempo e più si sveglia presto"
Maria de Filippi che chiama così a ufo le trasmissioni degli altri mi mancava! 😂
E comunque ha anticipato che presto sarà ospite a #CTCF quindi questo è uno SCOOP enorme! 💥💥💥
Cc @spettacoli@diggita.com @televisione […]
Maria de Filippi che chiama così a ufo le trasmissioni degli altri mi mancava! 😂
E comunque ha anticipato che presto sarà ospite a #CTCF quindi questo è uno SCOOP enorme! 💥💥💥
Cc @spettacoli@diggita.com @televisione […]