Battery modules for our next validation vehicles are coming together quickly thanks to our partners at CTNS. 🔋
November 24, 2025 at 7:42 PM
Battery modules for our next validation vehicles are coming together quickly thanks to our partners at CTNS. 🔋
Beautiful battery modules from our partners at CTNS, ready to be installed into the battery frame. 🔋 We will announce our battery cell supplier at CES 2025!
December 5, 2024 at 7:40 PM
Beautiful battery modules from our partners at CTNS, ready to be installed into the battery frame. 🔋 We will announce our battery cell supplier at CES 2025!
I am excited to share our new preprint! Led by @laylanassar.bsky.social , we have found a new JIP4-dependent mechanism that controls the efflux of cystine from lysosomes. Our findings have implications for both lysosome biology and human disease: doi.org/10.1101/2025...
JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux
Lysosomes break down macromolecules, clear cellular waste and recycle nutrients such as cystine. We describe a novel mechanism whereby JIP4 regulates lysosomal cystine storage by controlling the abundance of cystinosin (CTNS), the transporter responsible for lysosomal cystine efflux. To this end, JIP4, previously characterized as a motor adaptor and kinase signaling scaffold, suppresses TMEM55B-dependent ubiquitylation of CTNS. Loss of JIP4 reduces CTNS protein levels, leading to lysosomal cystine accumulation and lysosomal storage defects that phenocopy loss of CTNS in both human cells and the renal proximal tubules of JIP4 knockout mice. These phenotypes mirror cystinosis, the lysosomal storage disease caused by CTNS loss-of-function. Our findings thus reveal a fundamental process that controls the efflux of lysosomal cystine and has relevance to understanding human disease arising from JIP4 mutations. ### Competing Interest Statement The authors have declared no competing interest. NIH, AG085824, AG062210, R35GM150619 Michael J. Fox Foundation, https://ror.org/03arq3225, ASAP-000580
doi.org
June 9, 2025 at 1:35 PM
I am excited to share our new preprint! Led by @laylanassar.bsky.social , we have found a new JIP4-dependent mechanism that controls the efflux of cystine from lysosomes. Our findings have implications for both lysosome biology and human disease: doi.org/10.1101/2025...
- Putin décrète le blocus sur le blé 🇺🇦ien transitant par la Mer noire (rendant la sécurité alimentaire de ctns pays précaire)
- les 🇺🇦 contournent le blocus
- pour un cessez-le-feu Putin exige la sécurisat° de la Mer noire
A cx qui nous disent que la Ruzzie a gagné la guerre, ça vous inspire quoi ?
- les 🇺🇦 contournent le blocus
- pour un cessez-le-feu Putin exige la sécurisat° de la Mer noire
A cx qui nous disent que la Ruzzie a gagné la guerre, ça vous inspire quoi ?
March 19, 2025 at 6:05 AM
- Putin décrète le blocus sur le blé 🇺🇦ien transitant par la Mer noire (rendant la sécurité alimentaire de ctns pays précaire)
- les 🇺🇦 contournent le blocus
- pour un cessez-le-feu Putin exige la sécurisat° de la Mer noire
A cx qui nous disent que la Ruzzie a gagné la guerre, ça vous inspire quoi ?
- les 🇺🇦 contournent le blocus
- pour un cessez-le-feu Putin exige la sécurisat° de la Mer noire
A cx qui nous disent que la Ruzzie a gagné la guerre, ça vous inspire quoi ?
#QueerWriters CTNS, or Complicated Traumatic Neurosis Syndrome, is a form of neurodivergence resulting from layers of trauma. Kaedan’s resulted from many different forms of trauma, a lot of it related to Inarora’s gestational parent.
#Pride #WriteSky #WritingCommunity
#Pride #WriteSky #WritingCommunity
June 29, 2025 at 4:42 PM
#QueerWriters CTNS, or Complicated Traumatic Neurosis Syndrome, is a form of neurodivergence resulting from layers of trauma. Kaedan’s resulted from many different forms of trauma, a lot of it related to Inarora’s gestational parent.
#Pride #WriteSky #WritingCommunity
#Pride #WriteSky #WritingCommunity
REVIEW 1144 | ODAs ENTHÜLLT HINWEIS ZUR ERSTEN WELT? 🤯
Schaut unbedingt rein:
▶️ youtu.be/G5UT_1-cTNs
🔁 Reposten wäre mega!
#ONEPIECE #ONEPIECE1144
Schaut unbedingt rein:
▶️ youtu.be/G5UT_1-cTNs
🔁 Reposten wäre mega!
#ONEPIECE #ONEPIECE1144
March 30, 2025 at 6:30 PM
REVIEW 1144 | ODAs ENTHÜLLT HINWEIS ZUR ERSTEN WELT? 🤯
Schaut unbedingt rein:
▶️ youtu.be/G5UT_1-cTNs
🔁 Reposten wäre mega!
#ONEPIECE #ONEPIECE1144
Schaut unbedingt rein:
▶️ youtu.be/G5UT_1-cTNs
🔁 Reposten wäre mega!
#ONEPIECE #ONEPIECE1144
ITS INABILITY TO ANSWER THESE QUESTIONS IS EXACTLY WHY WE DO NOT WANT AI OR THESE MASSIVE DATA CTns THAT WILL BE CONTROLLED BY THE FASCIST BILLIONAIRES WHO R WKING HARD TO DESTROY AMERICA,OUR DEMOCRACY & create a fascist enslaved rule over us all! That’s why all these prisons & Ctrs R secret!
I asked Grok AI this question three times and it refused, after searching to answer
June 1, 2026 at 8:03 PM
ITS INABILITY TO ANSWER THESE QUESTIONS IS EXACTLY WHY WE DO NOT WANT AI OR THESE MASSIVE DATA CTns THAT WILL BE CONTROLLED BY THE FASCIST BILLIONAIRES WHO R WKING HARD TO DESTROY AMERICA,OUR DEMOCRACY & create a fascist enslaved rule over us all! That’s why all these prisons & Ctrs R secret!
Over 100 different mutations in the #CTNS gene have been found, this is the genetic difference that causes #Cystinosis.
Source: Orphanet Journal of Rare Diseases, 🔗 in bio.
Source: Orphanet Journal of Rare Diseases, 🔗 in bio.
May 26, 2025 at 3:02 PM
Over 100 different mutations in the #CTNS gene have been found, this is the genetic difference that causes #Cystinosis.
Source: Orphanet Journal of Rare Diseases, 🔗 in bio.
Source: Orphanet Journal of Rare Diseases, 🔗 in bio.
je viens seulement de terminer que g déjà envie de l’oublier pour rewatch, jsp si c lié au fait que je m’identifie trop à ctns perso ou que je l’ai regardé pendant que je travaillais aussi dans un supermarché, mais ct tellement bien😔
j’ai finis superstore hier…. que faire de ma vie désormais ?
February 7, 2025 at 10:20 AM
je viens seulement de terminer que g déjà envie de l’oublier pour rewatch, jsp si c lié au fait que je m’identifie trop à ctns perso ou que je l’ai regardé pendant que je travaillais aussi dans un supermarché, mais ct tellement bien😔
(ds gglebooks, ctns ouvrages sont bloqués qu'on ouvrirait sur nos propres plateformes), et la nature des ayants-droits (copyright vs droit d'auteur).
Ctnes bib peuvent ds ctnes condit°s numériser stricto sensu, pour raisons de conservat° et/ou pour faciliter l'accès aux psnes handicapées. 2/4
Ctnes bib peuvent ds ctnes condit°s numériser stricto sensu, pour raisons de conservat° et/ou pour faciliter l'accès aux psnes handicapées. 2/4
February 15, 2025 at 11:25 AM
(ds gglebooks, ctns ouvrages sont bloqués qu'on ouvrirait sur nos propres plateformes), et la nature des ayants-droits (copyright vs droit d'auteur).
Ctnes bib peuvent ds ctnes condit°s numériser stricto sensu, pour raisons de conservat° et/ou pour faciliter l'accès aux psnes handicapées. 2/4
Ctnes bib peuvent ds ctnes condit°s numériser stricto sensu, pour raisons de conservat° et/ou pour faciliter l'accès aux psnes handicapées. 2/4
Supermarkets have taken over high streets, driving out small shops, including bakeries, pharmacies CTNs and others. They've cut staffing to the bone. Yet Economists, the high priests of Capitalism, constantly complain about the tax burden on the Corporations.
November 25, 2025 at 8:19 PM
Supermarkets have taken over high streets, driving out small shops, including bakeries, pharmacies CTNs and others. They've cut staffing to the bone. Yet Economists, the high priests of Capitalism, constantly complain about the tax burden on the Corporations.
Christians that voted for Trump: Sheep or goats?
Seems pretty obvious
@parkroseperma.bsky.social
www.youtube.com/watch?v=ctNs...
Seems pretty obvious
@parkroseperma.bsky.social
www.youtube.com/watch?v=ctNs...
Christians Tr*mpers Should Understand Why Folks Are Cutting Them Off
YouTube video by Parkrose Permaculture
www.youtube.com
December 5, 2024 at 2:48 PM
Christians that voted for Trump: Sheep or goats?
Seems pretty obvious
@parkroseperma.bsky.social
www.youtube.com/watch?v=ctNs...
Seems pretty obvious
@parkroseperma.bsky.social
www.youtube.com/watch?v=ctNs...
Game #35 of 2025: Spider-Man Remastered CTNS: Turf Wars DLC 🔥
May 20, 2025 at 7:14 PM
Game #35 of 2025: Spider-Man Remastered CTNS: Turf Wars DLC 🔥
Nephropathic cystinosis is a lysosomal storage disease due to biallelic pathogenic variants in the CTNS gene encoding the cystine transport protein cystinosin. Read this Review of long-term outcomes in nephropathic cystinosis. Open Access.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
May 19, 2025 at 7:21 PM
Nephropathic cystinosis is a lysosomal storage disease due to biallelic pathogenic variants in the CTNS gene encoding the cystine transport protein cystinosin. Read this Review of long-term outcomes in nephropathic cystinosis. Open Access.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
It's Seed Gathering Season! 🧡🎉 #SeedGatheringSeason
Join us for 31 days of autumnal goodness! Learn how to grow trees from seeds in our Seed Gathering Masterclass, learn all about Community Tree Nurseries (CTNs) and how you can get involved, and stay tuned for competitions and more!
Join us for 31 days of autumnal goodness! Learn how to grow trees from seeds in our Seed Gathering Masterclass, learn all about Community Tree Nurseries (CTNs) and how you can get involved, and stay tuned for competitions and more!
September 22, 2025 at 11:03 AM
It's Seed Gathering Season! 🧡🎉 #SeedGatheringSeason
Join us for 31 days of autumnal goodness! Learn how to grow trees from seeds in our Seed Gathering Masterclass, learn all about Community Tree Nurseries (CTNs) and how you can get involved, and stay tuned for competitions and more!
Join us for 31 days of autumnal goodness! Learn how to grow trees from seeds in our Seed Gathering Masterclass, learn all about Community Tree Nurseries (CTNs) and how you can get involved, and stay tuned for competitions and more!
Over 140 mutations in CTNS are linked to #cystinosis, with severe mutations causing infantile (nephropathic) forms.
Interpretation: Scientists see tons of #geneticdifferences cause cystinosis: bigger changes = a more severe form.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
Interpretation: Scientists see tons of #geneticdifferences cause cystinosis: bigger changes = a more severe form.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
June 6, 2025 at 3:02 PM
Over 140 mutations in CTNS are linked to #cystinosis, with severe mutations causing infantile (nephropathic) forms.
Interpretation: Scientists see tons of #geneticdifferences cause cystinosis: bigger changes = a more severe form.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
Interpretation: Scientists see tons of #geneticdifferences cause cystinosis: bigger changes = a more severe form.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
youtube.com/watch?v=ctNs...
Ooo.. Those fake-ety right-wing Christians will hate this.
Ooo.. Those fake-ety right-wing Christians will hate this.
youtube.com
December 4, 2024 at 7:31 AM
youtube.com/watch?v=ctNs...
Ooo.. Those fake-ety right-wing Christians will hate this.
Ooo.. Those fake-ety right-wing Christians will hate this.
The CTNS gene encodes #cystinosin, a protein responsible for transporting #cystine out of #lysosomes.
Interpretation: This gene provides instructions for how to clean up the cell; the mutation "breaks" this cleanup system.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
Interpretation: This gene provides instructions for how to clean up the cell; the mutation "breaks" this cleanup system.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
June 5, 2025 at 3:02 PM
The CTNS gene encodes #cystinosin, a protein responsible for transporting #cystine out of #lysosomes.
Interpretation: This gene provides instructions for how to clean up the cell; the mutation "breaks" this cleanup system.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
Interpretation: This gene provides instructions for how to clean up the cell; the mutation "breaks" this cleanup system.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
Yesterday at the CES 2025 in Las Vegas, Aptera signed a contract with CTNS and LG Energy Solutions.
January 9, 2025 at 4:13 PM
Yesterday at the CES 2025 in Las Vegas, Aptera signed a contract with CTNS and LG Energy Solutions.
#Cystinosis is a rare genetic disorder caused by mutations in the #CTNS gene, leading to cystine buildup in lysosomes.
Interpretation: A rare inherited condition where cystine collects in tiny cell parts, damaging organs over time.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
Interpretation: A rare inherited condition where cystine collects in tiny cell parts, damaging organs over time.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
June 4, 2025 at 3:03 PM
#Cystinosis is a rare genetic disorder caused by mutations in the #CTNS gene, leading to cystine buildup in lysosomes.
Interpretation: A rare inherited condition where cystine collects in tiny cell parts, damaging organs over time.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
Interpretation: A rare inherited condition where cystine collects in tiny cell parts, damaging organs over time.
Source: American Journal of Physiology-Renal Physiology, 🔗 in bio.
NEW from @johnfoxe.bsky.social A behavioral and electrophysiological investigation of conflict monitoring in cystinosis (CTNS gene mutations) using the flanker paradigm.
doi.org/10.3389/fnep... #URochesterResearch @urneuroscience.bsky.social
doi.org/10.3389/fnep... #URochesterResearch @urneuroscience.bsky.social
Frontiers | A behavioral and electrophysiological investigation of conflict monitoring in cystinosis (CTNS gene mutations) using the flanker paradigm
Cystinosis, a rare lysosomal storage disease, is characterized by cystine crystallization and accumulation within tissues and organs, including the kidneys a...
doi.org
April 29, 2026 at 4:06 PM
NEW from @johnfoxe.bsky.social A behavioral and electrophysiological investigation of conflict monitoring in cystinosis (CTNS gene mutations) using the flanker paradigm.
doi.org/10.3389/fnep... #URochesterResearch @urneuroscience.bsky.social
doi.org/10.3389/fnep... #URochesterResearch @urneuroscience.bsky.social
The #CTNS gene is at the heart of cystinosis. When it doesn’t work, cystine can’t escape cell lysosomes, leading to harmful buildup. 🧬 (Source: Orphanet Journal of Rare Diseases, 🔗 in bio.)
Simply put, cells in Oliver's body don't take out the trash, it piles up to form no-good-very-bad crystals.
Simply put, cells in Oliver's body don't take out the trash, it piles up to form no-good-very-bad crystals.
May 2, 2025 at 1:02 PM
The #CTNS gene is at the heart of cystinosis. When it doesn’t work, cystine can’t escape cell lysosomes, leading to harmful buildup. 🧬 (Source: Orphanet Journal of Rare Diseases, 🔗 in bio.)
Simply put, cells in Oliver's body don't take out the trash, it piles up to form no-good-very-bad crystals.
Simply put, cells in Oliver's body don't take out the trash, it piles up to form no-good-very-bad crystals.
