#DBfeature #LatestResearch 🐣
Gene knockout in chick reveals a new in vivo role for Cxcl14 during trigeminal ganglion development
By Hugo Urrutia, Junpeng Gao, Marianne Bronner
doi.org/10.1016/j.ydbio.2026.06.001
Gene knockout in chick reveals a new in vivo role for Cxcl14 during trigeminal ganglion development
By Hugo Urrutia, Junpeng Gao, Marianne Bronner
doi.org/10.1016/j.ydbio.2026.06.001
July 16, 2026 at 8:43 AM
#DBfeature #LatestResearch 🐣
Gene knockout in chick reveals a new in vivo role for Cxcl14 during trigeminal ganglion development
By Hugo Urrutia, Junpeng Gao, Marianne Bronner
doi.org/10.1016/j.ydbio.2026.06.001
Gene knockout in chick reveals a new in vivo role for Cxcl14 during trigeminal ganglion development
By Hugo Urrutia, Junpeng Gao, Marianne Bronner
doi.org/10.1016/j.ydbio.2026.06.001
Airway Epithelium-derived CXCL14 Promotes Eosinophil Accumulation in Allergic Airway Inflammation https://buff.ly/3WU3mbe
TA: @MSUPedsPulm @msupedspulm.bsky.social #PedsPulm
TA: @MSUPedsPulm @msupedspulm.bsky.social #PedsPulm
Airway Epithelium-derived CXCL14 Promotes Eosinophil Accumulation in Allergic Airway Inflammation - PubMed
CXCL14 (C-X-C motif chemokine ligand 14) is expressed in the airway epithelial cells of patients with asthma. However, the mechanisms of CXCL14 secretion and its effects on asthma pathogenesis remain…
buff.ly
February 18, 2025 at 4:30 PM
Airway Epithelium-derived CXCL14 Promotes Eosinophil Accumulation in Allergic Airway Inflammation https://buff.ly/3WU3mbe
TA: @MSUPedsPulm @msupedspulm.bsky.social #PedsPulm
TA: @MSUPedsPulm @msupedspulm.bsky.social #PedsPulm
Airway Epithelium–derived CXCL14 Promotes Eosinophil Accumulation in Allergic Airway Inflammation
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/272ur54k
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/272ur54k
February 4, 2025 at 8:50 PM
Airway Epithelium–derived CXCL14 Promotes Eosinophil Accumulation in Allergic Airway Inflammation
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/272ur54k
@atscommunity.bsky.social #medsky
🔗 tinyurl.com/272ur54k
What are Markers of arterial adventitial fibroblast?
PDGFRA
DPEP1
3 fibroblast subsets
CD55+
LOX+
CXCL14+
CD55+ adventitial fibroblasts are enriched in thoracic aorta & carotid artery, but rare in other large arteries
#CardiovascRes 2023
academic.oup.com/cardiovascre...
PDGFRA
DPEP1
3 fibroblast subsets
CD55+
LOX+
CXCL14+
CD55+ adventitial fibroblasts are enriched in thoracic aorta & carotid artery, but rare in other large arteries
#CardiovascRes 2023
academic.oup.com/cardiovascre...
January 28, 2026 at 8:43 PM
What are Markers of arterial adventitial fibroblast?
PDGFRA
DPEP1
3 fibroblast subsets
CD55+
LOX+
CXCL14+
CD55+ adventitial fibroblasts are enriched in thoracic aorta & carotid artery, but rare in other large arteries
#CardiovascRes 2023
academic.oup.com/cardiovascre...
PDGFRA
DPEP1
3 fibroblast subsets
CD55+
LOX+
CXCL14+
CD55+ adventitial fibroblasts are enriched in thoracic aorta & carotid artery, but rare in other large arteries
#CardiovascRes 2023
academic.oup.com/cardiovascre...
How is the inner ear axonal circuitry established?
If you want to hear about it, check out our new bioRxiv preprint, where we reveal the importance of pioneer axons and we identify the chemokine Cxcl14 as a novel instructive guidance cue. www.biorxiv.org/content/10.6...
@bertaalsinalab.bsky.social
If you want to hear about it, check out our new bioRxiv preprint, where we reveal the importance of pioneer axons and we identify the chemokine Cxcl14 as a novel instructive guidance cue. www.biorxiv.org/content/10.6...
@bertaalsinalab.bsky.social
www.biorxiv.org
May 27, 2026 at 9:35 AM
How is the inner ear axonal circuitry established?
If you want to hear about it, check out our new bioRxiv preprint, where we reveal the importance of pioneer axons and we identify the chemokine Cxcl14 as a novel instructive guidance cue. www.biorxiv.org/content/10.6...
@bertaalsinalab.bsky.social
If you want to hear about it, check out our new bioRxiv preprint, where we reveal the importance of pioneer axons and we identify the chemokine Cxcl14 as a novel instructive guidance cue. www.biorxiv.org/content/10.6...
@bertaalsinalab.bsky.social
p21/Rb-activated SMAD/STAT/NFκB-dependent secretome activates a reversible immunoclearance program
Fibroblast in vitro
Hepatocyte in vivo
Senescence-independent😎
CXCL14
IGFBP3
ADAM15
SSC5D
APP
FN1
Prosaposin
@science.org 2021
www.science.org/doi/10.1126/...
Fibroblast in vitro
Hepatocyte in vivo
Senescence-independent😎
CXCL14
IGFBP3
ADAM15
SSC5D
APP
FN1
Prosaposin
@science.org 2021
www.science.org/doi/10.1126/...
October 8, 2025 at 11:28 AM
p21/Rb-activated SMAD/STAT/NFκB-dependent secretome activates a reversible immunoclearance program
Fibroblast in vitro
Hepatocyte in vivo
Senescence-independent😎
CXCL14
IGFBP3
ADAM15
SSC5D
APP
FN1
Prosaposin
@science.org 2021
www.science.org/doi/10.1126/...
Fibroblast in vitro
Hepatocyte in vivo
Senescence-independent😎
CXCL14
IGFBP3
ADAM15
SSC5D
APP
FN1
Prosaposin
@science.org 2021
www.science.org/doi/10.1126/...
February 22, 2025 at 11:54 AM
The authors included RRIDs in their in Cells paper! RRIDs improve reproducibility in scientific research. #OpenScience #reproducibility #accelerateopenscience
CXCL14 Inhibits Colon Cancer Progression by Modulating Tumor Cell Invasion and Immune Microenvironment
Read the full paper: CXCL14 Inhibits Colon Cancer Progression by Modulating Tumor Cell Invasion and Immune Microenvironment
doi.org
June 7, 2026 at 7:04 AM
The authors included RRIDs in their in Cells paper! RRIDs improve reproducibility in scientific research. #OpenScience #reproducibility #accelerateopenscience
Airway Epithelium–derived CXCL14 Promotes Eosinophil Accumulation in Allergic Airway Inflammation
@atscommunity.bsky.social #medsky
🔗 shorturl.at/PUvdw
@atscommunity.bsky.social #medsky
🔗 shorturl.at/PUvdw
February 19, 2025 at 6:53 PM
Airway Epithelium–derived CXCL14 Promotes Eosinophil Accumulation in Allergic Airway Inflammation
@atscommunity.bsky.social #medsky
🔗 shorturl.at/PUvdw
@atscommunity.bsky.social #medsky
🔗 shorturl.at/PUvdw
❗OUT NOW! In a translational research collaboration between @bqbiomedmolub.bsky.social & @irsantpau.bsky.social we identify ⬇️circulating #CXCL14 as a subclinical cardiovascular disease biomarker in people living with #HIV on #antiretroviraltherapy💊🫀
Open access here ➡️ doi.org/10.1016/j.ej...
Open access here ➡️ doi.org/10.1016/j.ej...
July 28, 2025 at 4:03 PM
❗OUT NOW! In a translational research collaboration between @bqbiomedmolub.bsky.social & @irsantpau.bsky.social we identify ⬇️circulating #CXCL14 as a subclinical cardiovascular disease biomarker in people living with #HIV on #antiretroviraltherapy💊🫀
Open access here ➡️ doi.org/10.1016/j.ej...
Open access here ➡️ doi.org/10.1016/j.ej...
Astrocyte immunosuppressive activity in glioblastoma depends on ZEB1 and is counteracted by CXCL14 #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.05.10.724074v1
https://www.biorxiv.org/content/10.64898/2026.05.10.724074v1
May 13, 2026 at 4:00 PM
Astrocyte immunosuppressive activity in glioblastoma depends on ZEB1 and is counteracted by CXCL14 #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.05.10.724074v1
https://www.biorxiv.org/content/10.64898/2026.05.10.724074v1
RRIDs were included in this None paper. We value the author's support of reproducibility. #methodsmatter #STMpublishing #OpenScience
Reduced circulating levels of CXCL14 are associated with cardiovascular damage in people living with HIV
doi.org
July 30, 2025 at 7:00 AM
RRIDs were included in this None paper. We value the author's support of reproducibility. #methodsmatter #STMpublishing #OpenScience
The authors included RRIDs in their The FASEB Journal paper! Thanks for making your methods matter! #methodsmatter #accelerateopenscience #reproducibility
CXCL14 Chemokine Exacerbates Acute Viral Hepatitis in Coronavirus MHV‐Infected Mice and Is Associated With Human Acute Viral Hepatitis
doi.org
May 29, 2025 at 7:00 AM
The authors included RRIDs in their The FASEB Journal paper! Thanks for making your methods matter! #methodsmatter #accelerateopenscience #reproducibility
If you are want to know how pioneer axons reach new born hair cells, check this new preprint from the lab identifying the chemokine Cxcl14 as a new guidance cue.
A wonderful work led by Mireia Rumbo, @mireiarumbo.bluesky.social
doi.org/10.64898/202...
doi.org/10.64898/202...
A wonderful work led by Mireia Rumbo, @mireiarumbo.bluesky.social
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org
May 29, 2026 at 11:41 AM
If you are want to know how pioneer axons reach new born hair cells, check this new preprint from the lab identifying the chemokine Cxcl14 as a new guidance cue.
A wonderful work led by Mireia Rumbo, @mireiarumbo.bluesky.social
doi.org/10.64898/202...
doi.org/10.64898/202...
A wonderful work led by Mireia Rumbo, @mireiarumbo.bluesky.social
doi.org/10.64898/202...
doi.org/10.64898/202...
That’s a good question. In the preprint we present data that in our view suggest rhythmic GP340 mediated entry of S aureus into mammalian epithelial cells. See also Tsujihana et al 2022 for a CXCL14 mediated immune rhythm. But if S aureus itself has a clock is unpublished.
May 11, 2025 at 8:30 PM
That’s a good question. In the preprint we present data that in our view suggest rhythmic GP340 mediated entry of S aureus into mammalian epithelial cells. See also Tsujihana et al 2022 for a CXCL14 mediated immune rhythm. But if S aureus itself has a clock is unpublished.
We also show that the chemokine Cxcl14 is expressed in otic hair cells and hindbrain entry points, coinciding in time with axons targeting those regions. When abrogated, pioneer axons show navigation and targeting defects, indicating that the chemokine is a novel inner ear guidance cue. 3/3
May 27, 2026 at 9:35 AM
We also show that the chemokine Cxcl14 is expressed in otic hair cells and hindbrain entry points, coinciding in time with axons targeting those regions. When abrogated, pioneer axons show navigation and targeting defects, indicating that the chemokine is a novel inner ear guidance cue. 3/3
RRIDs were included in this in Communications Biology paper. Thanks for making your methods matter! #BetterScience #accelerateopenscience #RRID
Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2 - Communications Biology
This study reveals that the proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2; these results provide a rational basis for the future development of idiopathic pulmonary fibrosis therapies.
doi.org
September 21, 2026 at 7:00 AM
RRIDs were included in this in Communications Biology paper. Thanks for making your methods matter! #BetterScience #accelerateopenscience #RRID
Authors used C57BL/6J from #InternationalMouseSt in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #RRID
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #RRID
Leptin Receptor+ cells create a perisinusoidal niche for thrombopoiesis in the bone marrow by synthesizing CXCL14
www.biorxiv.org
July 12, 2026 at 12:05 PM
Authors used C57BL/6J from #InternationalMouseSt in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #RRID
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #STMpublishing #RRID
CXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide- and Dexamethasone-Induced Muscle Atrophy in Cultured Myotubes and Mouse Models
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
CXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide‐ and Dexamethasone‐Induced Muscle Atrophy in Cultured Myotubes and Mouse Models
Background
Skeletal muscle mass is regulated by secretory factors derived from myofibers and muscle-resident cells. Identifying these factors and understanding their mechanisms is critical for comba.....
onlinelibrary.wiley.com
October 14, 2025 at 4:35 PM
CXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide- and Dexamethasone-Induced Muscle Atrophy in Cultured Myotubes and Mouse Models
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Online Now: COPD reshapes the tumor microenvironment of NSCLC and enhances anti-PD-1 therapy response
COPD reshapes the tumor microenvironment of NSCLC and enhances anti-PD-1 therapy response
Chen et al. show that COPD reshapes the lung epithelium in NSCLC, expanding CXCL14+ basal-like tumor cells. These cells recruit macrophages producing CXCL9 through the CXCL14-CXCR4 axis, creating an immune-permissive niche that enhances the anti-PD-1 inhibitor response.
dlvr.it
February 16, 2026 at 1:24 PM
Online Now: COPD reshapes the tumor microenvironment of NSCLC and enhances anti-PD-1 therapy response
Leptin Receptor+ cells create a perisinusoidal niche for thrombopoiesis in the bone marrow by synthesizing CXCL14 https://www.biorxiv.org/content/10.64898/2026.01.27.702029v1
January 28, 2026 at 10:31 AM
Leptin Receptor+ cells create a perisinusoidal niche for thrombopoiesis in the bone marrow by synthesizing CXCL14 https://www.biorxiv.org/content/10.64898/2026.01.27.702029v1
Engineered CXCL14-Fc fusion proteins improve the poor stability and short half-life of native CXCL14. By linking CXCL14 to an Fc domain, they gain prolonged exposure and enhanced activity, enabling sustained immunomodulation and tumour-suppressive effects across multiple cancers.
[Credit: Hadasit]
[Credit: Hadasit]
November 22, 2025 at 1:17 PM
Engineered CXCL14-Fc fusion proteins improve the poor stability and short half-life of native CXCL14. By linking CXCL14 to an Fc domain, they gain prolonged exposure and enhanced activity, enabling sustained immunomodulation and tumour-suppressive effects across multiple cancers.
[Credit: Hadasit]
[Credit: Hadasit]
Astrocyte immunosuppressive activity in glioblastoma depends on ZEB1 and is counteracted by CXCL14 https://www.biorxiv.org/content/10.64898/2026.05.10.724074v1
May 13, 2026 at 7:47 AM
Astrocyte immunosuppressive activity in glioblastoma depends on ZEB1 and is counteracted by CXCL14 https://www.biorxiv.org/content/10.64898/2026.05.10.724074v1
The Cxcl14 chemokine defines pioneer axon guidance and early circuit assembly in the inner ear https://www.biorxiv.org/content/10.64898/2026.05.21.726833v1
May 22, 2026 at 8:30 AM
The Cxcl14 chemokine defines pioneer axon guidance and early circuit assembly in the inner ear https://www.biorxiv.org/content/10.64898/2026.05.21.726833v1
The Cxcl14 chemokine defines pioneer axon guidance and early circuit assembly in the inner ear https://www.biorxiv.org/content/10.64898/2026.05.21.726833v1
May 22, 2026 at 8:30 AM
The Cxcl14 chemokine defines pioneer axon guidance and early circuit assembly in the inner ear https://www.biorxiv.org/content/10.64898/2026.05.21.726833v1