A Cellular Trio Drives Pancreatic #Cancer - Associated #Cachexia
Crosstalk between subpopulations of pancreatic cancer cells, macrophages, and fibroblasts contribute to the wasting syndrome and may help identify biomarkers for the condition.
#Health #Science
Crosstalk between subpopulations of pancreatic cancer cells, macrophages, and fibroblasts contribute to the wasting syndrome and may help identify biomarkers for the condition.
#Health #Science
A Cellular Trio Drives Pancreatic Cancer-Associated Cachexia | The Scientist
Crosstalk between subpopulations of pancreatic cancer cells, macrophages, and fibroblasts contribute to the wasting syndrome and may help identify biomarkers for the condition.
www.the-scientist.com
November 13, 2026 at 10:43 AM
A Cellular Trio Drives Pancreatic #Cancer - Associated #Cachexia
Crosstalk between subpopulations of pancreatic cancer cells, macrophages, and fibroblasts contribute to the wasting syndrome and may help identify biomarkers for the condition.
#Health #Science
Crosstalk between subpopulations of pancreatic cancer cells, macrophages, and fibroblasts contribute to the wasting syndrome and may help identify biomarkers for the condition.
#Health #Science
A Cellular Trio Drives Pancreatic Cancer-Associated Cachexia | The Scientist
Crosstalk between subpopulations of pancreatic cancer cells, macrophages, and fibroblasts contribute to the wasting syndrome and may help identify biomarkers for the condition.
www.the-scientist.com
November 13, 2026 at 10:43 AM
More intriguing Promethion-powered science from Dr. I Chio & colleagues at Columbia - an iron-dependent methionine redox pathway drives adipose browning & cancer cachexia! 🧪 www.nature.com/articles/s43...
An iron-regulated methionine redox axis governs adipose browning and cancer cachexia - Nature Cancer
Chio and colleagues describe an iron-dependent pathway with a role in the induction of cancer cachexia-linked events such as adipose browning and identify methionine sulfoxide reductase A as an import...
www.nature.com
November 13, 2026 at 5:02 PM
More intriguing Promethion-powered science from Dr. I Chio & colleagues at Columbia - an iron-dependent methionine redox pathway drives adipose browning & cancer cachexia! 🧪 www.nature.com/articles/s43...
Hosny et al. generated a human stem-cell heart model of cancer cachexia, reporting the Atrogin-1/calcineurin A/NFAT axis as a key molecular pathway that drives heart muscle wasting and dysfunction and could serve as a therapeutic target: doi.org/10.1172/jci....
November 12, 2026 at 5:08 PM
Hosny et al. generated a human stem-cell heart model of cancer cachexia, reporting the Atrogin-1/calcineurin A/NFAT axis as a key molecular pathway that drives heart muscle wasting and dysfunction and could serve as a therapeutic target: doi.org/10.1172/jci....
Elucidating cancer cachexia–mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle: insight.jci.org/articles/vie...
JCI Insight - Elucidating cancer cachexia–mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle
Research ArticleCardiologyOncology Open Access | 10.1172/jci.insight.203276
insight.jci.org
November 12, 2026 at 5:08 PM
Elucidating cancer cachexia–mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle: insight.jci.org/articles/vie...
Open Access UCL Research: Systematic review of randomised controlled trials and network meta-analysis in the prevention and treatment of cachexia in people with pancreatic cancer discovery.ucl.ac.uk/id/eprint/10...
Systematic review of randomised controlled trials and network meta-analysis in the prevention and treatment of cachexia in people with pancreatic cancer
-
UCL Discovery
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
discovery.ucl.ac.uk
November 12, 2026 at 8:25 AM
Open Access UCL Research: Systematic review of randomised controlled trials and network meta-analysis in the prevention and treatment of cachexia in people with pancreatic cancer discovery.ucl.ac.uk/id/eprint/10...
Shared Information ...as per NORML
norml.org/laws/medical...
#harborhemp
#CBDEducation
#CBDWellness
#cbdlife
#cannabislegalization
#marijuanaismedicine
#cbd #hemp #usa #uk #canada #australia
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#harborhemp
#CBDEducation
#CBDWellness
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Washington Medical Marijuana Law
Status Operational Law Signed: 1998 QUALIFYING CONDITIONS Cachexia Cancer Crohn’s disease Glaucoma Hepatitis C HIV…
norml.org
November 10, 2026 at 6:50 AM
Shared Information ...as per NORML
norml.org/laws/medical...
#harborhemp
#CBDEducation
#CBDWellness
#cbdlife
#cannabislegalization
#marijuanaismedicine
#cbd #hemp #usa #uk #canada #australia
norml.org/laws/medical...
#harborhemp
#CBDEducation
#CBDWellness
#cbdlife
#cannabislegalization
#marijuanaismedicine
#cbd #hemp #usa #uk #canada #australia
【「前悪液質」血液透析例の特徴は？/Nephrology】Nov.08
日本、維持血液透析109例 [中央値70歳] 横断解析——
・46%に悪液質、21％が前悪液質。
・「前悪液質」例では「比悪液質」に比べ「最高有仕事率」が低
値。
・一方、「最高酸素摂取量」には差なし。
抄録🔗 qr.paps.jp/xKoSp
日本、維持血液透析109例 [中央値70歳] 横断解析——
・46%に悪液質、21％が前悪液質。
・「前悪液質」例では「比悪液質」に比べ「最高有仕事率」が低
値。
・一方、「最高酸素摂取量」には差なし。
抄録🔗 qr.paps.jp/xKoSp
Association Between Cachexia, Defined Using the Asian Working Group for Cachexia 2023 Criteria, and Exercise Capacity in Patients Undergoing Haemodialysis
This study found that the prevalence of pre-cachexia and cachexia, defined using the Asian Working Group for Cachexia 2023 criteria, was 45.9% and 33.0%, respectively, among haemodialysis patients. C....
qr.paps.jp
November 9, 2026 at 9:54 PM
【「前悪液質」血液透析例の特徴は？/Nephrology】Nov.08
日本、維持血液透析109例 [中央値70歳] 横断解析——
・46%に悪液質、21％が前悪液質。
・「前悪液質」例では「比悪液質」に比べ「最高有仕事率」が低
値。
・一方、「最高酸素摂取量」には差なし。
抄録🔗 qr.paps.jp/xKoSp
日本、維持血液透析109例 [中央値70歳] 横断解析——
・46%に悪液質、21％が前悪液質。
・「前悪液質」例では「比悪液質」に比べ「最高有仕事率」が低
値。
・一方、「最高酸素摂取量」には差なし。
抄録🔗 qr.paps.jp/xKoSp
💻 Upcoming #VirtualSeminar:
📅 November 19 at 1 PM (ET)
"Bone Marrow Reprogramming and Neutrophil Extravasation in Cancer Cachexia: Looking Beyond the Tumor"
Dr. Louisa Tichy (Wake Forest Med)
➡️ Register https://loom.ly/LColRYk
#ASIPwebinar #pathobiology
📅 November 19 at 1 PM (ET)
"Bone Marrow Reprogramming and Neutrophil Extravasation in Cancer Cachexia: Looking Beyond the Tumor"
Dr. Louisa Tichy (Wake Forest Med)
➡️ Register https://loom.ly/LColRYk
#ASIPwebinar #pathobiology
November 11, 2026 at 2:06 PM
💻 Upcoming #VirtualSeminar:
📅 November 19 at 1 PM (ET)
"Bone Marrow Reprogramming and Neutrophil Extravasation in Cancer Cachexia: Looking Beyond the Tumor"
Dr. Louisa Tichy (Wake Forest Med)
➡️ Register https://loom.ly/LColRYk
#ASIPwebinar #pathobiology
📅 November 19 at 1 PM (ET)
"Bone Marrow Reprogramming and Neutrophil Extravasation in Cancer Cachexia: Looking Beyond the Tumor"
Dr. Louisa Tichy (Wake Forest Med)
➡️ Register https://loom.ly/LColRYk
#ASIPwebinar #pathobiology
In STEP 1 (semaglutide, 68 weeks, DEXA), roughly 30-40% of total weight lost was fat-free mass — versus about 25% for caloric restriction alone.
A scale cannot tell you which tissue left.
Source: J Cachexia Sarcopenia Muscle, doi 10.1002/jcsm.70147. Research context only.
A scale cannot tell you which tissue left.
Source: J Cachexia Sarcopenia Muscle, doi 10.1002/jcsm.70147. Research context only.
November 10, 2026 at 1:03 PM
In STEP 1 (semaglutide, 68 weeks, DEXA), roughly 30-40% of total weight lost was fat-free mass — versus about 25% for caloric restriction alone.
A scale cannot tell you which tissue left.
Source: J Cachexia Sarcopenia Muscle, doi 10.1002/jcsm.70147. Research context only.
A scale cannot tell you which tissue left.
Source: J Cachexia Sarcopenia Muscle, doi 10.1002/jcsm.70147. Research context only.
So I suspect there's many more pwME in precarious health no one knows about as it's too dangerous to risk hospital until there's no choice.
(Just to note: I was vv.lucky my cachexia(?) resolved – still don't know why, stopping/restarting supps prob culprit – but if not I would've ended up there.)
(Just to note: I was vv.lucky my cachexia(?) resolved – still don't know why, stopping/restarting supps prob culprit – but if not I would've ended up there.)
November 8, 2026 at 8:42 PM
So I suspect there's many more pwME in precarious health no one knows about as it's too dangerous to risk hospital until there's no choice.
(Just to note: I was vv.lucky my cachexia(?) resolved – still don't know why, stopping/restarting supps prob culprit – but if not I would've ended up there.)
(Just to note: I was vv.lucky my cachexia(?) resolved – still don't know why, stopping/restarting supps prob culprit – but if not I would've ended up there.)
#CancerCachexia arises from interconnected metabolic and inflammatory disruptions.
This review explores tumor-host cross-talk and systemic metabolic remodeling, highlighting therapeutic strategies to mitigate cachexia.
#STTT #OpenAccess: doi.org/10.1038/s413...
#PrecisionMedicine
This review explores tumor-host cross-talk and systemic metabolic remodeling, highlighting therapeutic strategies to mitigate cachexia.
#STTT #OpenAccess: doi.org/10.1038/s413...
#PrecisionMedicine
November 6, 2026 at 6:30 AM
#CancerCachexia arises from interconnected metabolic and inflammatory disruptions.
This review explores tumor-host cross-talk and systemic metabolic remodeling, highlighting therapeutic strategies to mitigate cachexia.
#STTT #OpenAccess: doi.org/10.1038/s413...
#PrecisionMedicine
This review explores tumor-host cross-talk and systemic metabolic remodeling, highlighting therapeutic strategies to mitigate cachexia.
#STTT #OpenAccess: doi.org/10.1038/s413...
#PrecisionMedicine
Feeding mice more fat to counter cachexia backfired, leaving a puzzle.
Lung tumors in mice can trigger cachexia by directly communicating with neurons to alter eating behavior, and a high-fat diet worsened cachexia rather than reducing it.
#Nutrition
doi.org/10.1158/2159-8290.cd-nw2026-0081
Lung tumors in mice can trigger cachexia by directly communicating with neurons to alter eating behavior, and a high-fat diet worsened cachexia rather than reducing it.
#Nutrition
doi.org/10.1158/2159-8290.cd-nw2026-0081
Lung Tumors Hack Nervous System to Drive Cachexia.
Cancer Discovery · Covered by 1 news source.
jclub.com.au
November 6, 2026 at 12:28 AM
Feeding mice more fat to counter cachexia backfired, leaving a puzzle.
Lung tumors in mice can trigger cachexia by directly communicating with neurons to alter eating behavior, and a high-fat diet worsened cachexia rather than reducing it.
#Nutrition
doi.org/10.1158/2159-8290.cd-nw2026-0081
Lung tumors in mice can trigger cachexia by directly communicating with neurons to alter eating behavior, and a high-fat diet worsened cachexia rather than reducing it.
#Nutrition
doi.org/10.1158/2159-8290.cd-nw2026-0081
Reprogramming Muscle Proteostasis in Cancer Cachexia: Transcriptional Mechanisms and Therapeutic Opportunities
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com
November 4, 2026 at 4:58 PM
Reprogramming Muscle Proteostasis in Cancer Cachexia: Transcriptional Mechanisms and Therapeutic Opportunities
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A mouse model of metastasis-induced breast cancer cachexia with non-cachectic controls bearing isogenic primary tumors https://www.biorxiv.org/content/10.64898/2026.10.28.762598v1
November 3, 2026 at 6:49 PM
A mouse model of metastasis-induced breast cancer cachexia with non-cachectic controls bearing isogenic primary tumors https://www.biorxiv.org/content/10.64898/2026.10.28.762598v1
A mouse model of metastasis-induced breast cancer cachexia with non-cachectic controls bearing isogenic primary tumors https://www.biorxiv.org/content/10.64898/2026.10.28.762598v1
November 3, 2026 at 6:49 PM
A mouse model of metastasis-induced breast cancer cachexia with non-cachectic controls bearing isogenic primary tumors https://www.biorxiv.org/content/10.64898/2026.10.28.762598v1
A 53-year-old man presented with 5-month hx of progressive bilateral lower limb weakness, myalgia, & weight loss. Exam revealed cachexia, abdominal distension, and weakness of hip & knee flexors. No rash, synovitis or arthritis were detected.
continues
continues
November 6, 2026 at 12:54 PM
A 53-year-old man presented with 5-month hx of progressive bilateral lower limb weakness, myalgia, & weight loss. Exam revealed cachexia, abdominal distension, and weakness of hip & knee flexors. No rash, synovitis or arthritis were detected.
continues
continues
NUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF-κB Signaling Pathway
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
NUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF‐κB Signaling Pathway
NUB1 mediates skeletal muscle atrophy in lung cancer cachexia. Upregulated NUB1 recruits IκBα and S5a, triggering IκBα degradation and NF‑κB nuclear translocation. Activated NF‑κB elevates Atrogin1 a...
advanced.onlinelibrary.wiley.com
November 1, 2026 at 4:42 PM
NUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF-κB Signaling Pathway
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Experts caution cancer cachexia an urgent issue
00:03
Many people might think it is normal to experience weight loss and weakness during cancer treatment, but medical experts yesterday warned that it could also be “cancer cachexia,” and that insufficient muscle mass can even cause treatment to […]
00:03
Many people might think it is normal to experience weight loss and weakness during cancer treatment, but medical experts yesterday warned that it could also be “cancer cachexia,” and that insufficient muscle mass can even cause treatment to […]
Original post on pbs.idv.tw
pbs.idv.tw
October 31, 2026 at 4:03 PM
Experts caution cancer cachexia an urgent issue
00:03
Many people might think it is normal to experience weight loss and weakness during cancer treatment, but medical experts yesterday warned that it could also be “cancer cachexia,” and that insufficient muscle mass can even cause treatment to […]
00:03
Many people might think it is normal to experience weight loss and weakness during cancer treatment, but medical experts yesterday warned that it could also be “cancer cachexia,” and that insufficient muscle mass can even cause treatment to […]
Mice with cancer-related wasting had about 30% greater grip strength after antibody treatment than untreated mice. The candidate’s safety and efficacy in humans remain unproven. doi.org/hcqqtq
Antibody candidate could help preserve appetite and muscle strength in patients with cancer
In cancer cachexia, patients continue to lose weight, muscle and fat even when they eat. A KAIST research team has developed a therapeutic candidate that blocks a signal responsible for appetite suppression, weight loss and excessive energy expenditure.
medicalxpress.com
October 29, 2026 at 5:40 PM
Mice with cancer-related wasting had about 30% greater grip strength after antibody treatment than untreated mice. The candidate’s safety and efficacy in humans remain unproven. doi.org/hcqqtq
Wasting is essential: cachexia is driven by a wound-healing adaptation https://www.biorxiv.org/content/10.64898/2026.10.23.761459v1
October 27, 2026 at 6:02 PM
Wasting is essential: cachexia is driven by a wound-healing adaptation https://www.biorxiv.org/content/10.64898/2026.10.23.761459v1
Wasting is essential: cachexia is driven by a wound-healing adaptation https://www.biorxiv.org/content/10.64898/2026.10.23.761459v1
October 27, 2026 at 6:02 PM
Wasting is essential: cachexia is driven by a wound-healing adaptation https://www.biorxiv.org/content/10.64898/2026.10.23.761459v1