CardioShift: Resolving cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes from high-throughput single-cell imaging https://www.biorxiv.org/content/10.64898/2026.10.31.763029v1
November 3, 2026 at 9:30 PM
CardioShift: Resolving cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes from high-throughput single-cell imaging https://www.biorxiv.org/content/10.64898/2026.10.31.763029v1
Single-cell transcriptomics identified C0 Atcayos⁺ cardiomyocytes that communicate with fibroblasts through Bmp6 & Fgf1 signaling pathways, providing new insights into #MyocardialFibrosis after #IschemiaReperfusionInjury. #medsky #Cardiology
#BIOI #OpenAccess: doi.org/10.15212/bio...
#BIOI #OpenAccess: doi.org/10.15212/bio...
November 2, 2026 at 11:57 AM
Single-cell transcriptomics identified C0 Atcayos⁺ cardiomyocytes that communicate with fibroblasts through Bmp6 & Fgf1 signaling pathways, providing new insights into #MyocardialFibrosis after #IschemiaReperfusionInjury. #medsky #Cardiology
#BIOI #OpenAccess: doi.org/10.15212/bio...
#BIOI #OpenAccess: doi.org/10.15212/bio...
CardioShift: Resolving cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes from high-throughput single-cell imaging https://www.biorxiv.org/content/10.64898/2026.10.31.763029v1
November 3, 2026 at 9:30 PM
CardioShift: Resolving cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes from high-throughput single-cell imaging https://www.biorxiv.org/content/10.64898/2026.10.31.763029v1
CardioShift: Resolving cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes from high-throughput single-cell imaging #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.10.31.763029v1
https://www.biorxiv.org/content/10.64898/2026.10.31.763029v1
November 3, 2026 at 11:00 PM
CardioShift: Resolving cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes from high-throughput single-cell imaging #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.10.31.763029v1
https://www.biorxiv.org/content/10.64898/2026.10.31.763029v1
Can mechanical forces disrupt cardiac rhythms? Wang et al. model how periodic forces entrain, destabilize, or split calcium oscillations in cardiomyocytes, potentially triggering bursting-like dynamics beyond a critical threshold. buff.ly/MmQMd1F
A mechanochemical model for frequency entrainment and bursting transitions in cardiac calcium oscillations
Rhythmic contraction of cardiomyocytes is driven by self-sustained intracellular calcium oscillations. While these oscillations are typically attributed to intrinsic calcium cycling, increasing…
buff.ly
November 4, 2026 at 5:31 PM
Can mechanical forces disrupt cardiac rhythms? Wang et al. model how periodic forces entrain, destabilize, or split calcium oscillations in cardiomyocytes, potentially triggering bursting-like dynamics beyond a critical threshold. buff.ly/MmQMd1F
Join the next L-BIIG meeting!
13 Nov 2026 | 12:00-13:00 GMT
Morgan Gridley (UCL) – Airyscan imaging of synapses
Ben Reilly O'Donnell (Imperial College London) – Dynamic multimodal imaging combining SICM microscopy with mechanical stretch of adult rat cardiomyocytes
🔗 www.ucl.ac.uk/research-inn...
13 Nov 2026 | 12:00-13:00 GMT
Morgan Gridley (UCL) – Airyscan imaging of synapses
Ben Reilly O'Donnell (Imperial College London) – Dynamic multimodal imaging combining SICM microscopy with mechanical stretch of adult rat cardiomyocytes
🔗 www.ucl.ac.uk/research-inn...
London BioImage Interest Group
The London BioImage Interest Group (L-BIIG) connects researchers and technical specialists working on biological image acquisition and analysis across London institutions.
www.ucl.ac.uk
November 2, 2026 at 7:57 AM
Join the next L-BIIG meeting!
13 Nov 2026 | 12:00-13:00 GMT
Morgan Gridley (UCL) – Airyscan imaging of synapses
Ben Reilly O'Donnell (Imperial College London) – Dynamic multimodal imaging combining SICM microscopy with mechanical stretch of adult rat cardiomyocytes
🔗 www.ucl.ac.uk/research-inn...
13 Nov 2026 | 12:00-13:00 GMT
Morgan Gridley (UCL) – Airyscan imaging of synapses
Ben Reilly O'Donnell (Imperial College London) – Dynamic multimodal imaging combining SICM microscopy with mechanical stretch of adult rat cardiomyocytes
🔗 www.ucl.ac.uk/research-inn...
DGD Volume 68, Issue 9 was released!!
https://doi.org/10.1111/dgd.70059
Cover: The relationship between RNA‐binding protein expression and the proliferative capacity of mouse cardiomyocytes. A positive correlation is observed between the KH_1 domain‐containing gene expression and cardiomyocyte prol…
https://doi.org/10.1111/dgd.70059
Cover: The relationship between RNA‐binding protein expression and the proliferative capacity of mouse cardiomyocytes. A positive correlation is observed between the KH_1 domain‐containing gene expression and cardiomyocyte prol…
November 3, 2026 at 11:45 PM
DGD Volume 68, Issue 9 was released!!
https://doi.org/10.1111/dgd.70059
Cover: The relationship between RNA‐binding protein expression and the proliferative capacity of mouse cardiomyocytes. A positive correlation is observed between the KH_1 domain‐containing gene expression and cardiomyocyte prol…
https://doi.org/10.1111/dgd.70059
Cover: The relationship between RNA‐binding protein expression and the proliferative capacity of mouse cardiomyocytes. A positive correlation is observed between the KH_1 domain‐containing gene expression and cardiomyocyte prol…
MCT1 also resides in the inner mitochondrial membrane of mouse and human cardiomyocytes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MCT1-dependent mitochondrial lactate import sustains cardiac metabolism - Nature
In mouse myocardium, glucose oxidation persists in the absence of the mitochondrial pyruvate carrier, with mitochondrial MCT1 importing lactate into mitochondria and LDHB oxidizing it to pyruvate and ...
www.nature.com
October 28, 2026 at 10:44 PM
MCT1 also resides in the inner mitochondrial membrane of mouse and human cardiomyocytes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In 2019, @berterolab.bsky.social, Fields et al. discovered an mRNA that appears to do just this. In cardiomyocytes, nascent TTN RNA organizes a compartment that concentrates the splicing factor RBM20 and brings together loci from multiple chromosomes. An "RNA Factory" scaffolded on a pre-mRNA!
October 28, 2026 at 6:14 AM
In 2019, @berterolab.bsky.social, Fields et al. discovered an mRNA that appears to do just this. In cardiomyocytes, nascent TTN RNA organizes a compartment that concentrates the splicing factor RBM20 and brings together loci from multiple chromosomes. An "RNA Factory" scaffolded on a pre-mRNA!
This approach yielded exceptionally precise biotinylation in both WT and ∆RBM20 cardiomyocytes: just two biotin foci—corresponding to the two alleles of TTN.
In the context of two meters of folded DNA, O-MAP can home in and affinity-tag a single-locus nuclear compartment.
In the context of two meters of folded DNA, O-MAP can home in and affinity-tag a single-locus nuclear compartment.
October 28, 2026 at 6:15 AM
This approach yielded exceptionally precise biotinylation in both WT and ∆RBM20 cardiomyocytes: just two biotin foci—corresponding to the two alleles of TTN.
In the context of two meters of folded DNA, O-MAP can home in and affinity-tag a single-locus nuclear compartment.
In the context of two meters of folded DNA, O-MAP can home in and affinity-tag a single-locus nuclear compartment.
We were particularly interested in QKI and SAFB, which are critical regulators of RNA splicing and chromatin organization. Both were strongly enriched in the TTN factory, with striking colocalization observed in cultured cardiomyocytes and human fetal heart tissue.
October 28, 2026 at 6:19 AM
We were particularly interested in QKI and SAFB, which are critical regulators of RNA splicing and chromatin organization. Both were strongly enriched in the TTN factory, with striking colocalization observed in cultured cardiomyocytes and human fetal heart tissue.
Cav1.3-C-terminus Restores Electrical and Contractile Functions in hiPSC-derived Cardiomyocytes Model of Heart Failure https://www.biorxiv.org/content/10.64898/2026.10.27.762268v1
October 28, 2026 at 8:31 PM
Cav1.3-C-terminus Restores Electrical and Contractile Functions in hiPSC-derived Cardiomyocytes Model of Heart Failure https://www.biorxiv.org/content/10.64898/2026.10.27.762268v1
Cav1.3-C-terminus Restores Electrical and Contractile Functions in hiPSC-derived Cardiomyocytes Model of Heart Failure https://www.biorxiv.org/content/10.64898/2026.10.27.762268v1
October 28, 2026 at 8:31 PM
Cav1.3-C-terminus Restores Electrical and Contractile Functions in hiPSC-derived Cardiomyocytes Model of Heart Failure https://www.biorxiv.org/content/10.64898/2026.10.27.762268v1
Cav1.3-C-terminus Restores Electrical and Contractile Functions in hiPSC-derived Cardiomyocytes Model of Heart Failure #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.10.27.762268v1
https://www.biorxiv.org/content/10.64898/2026.10.27.762268v1
October 28, 2026 at 11:00 PM
Cav1.3-C-terminus Restores Electrical and Contractile Functions in hiPSC-derived Cardiomyocytes Model of Heart Failure #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.10.27.762268v1
https://www.biorxiv.org/content/10.64898/2026.10.27.762268v1
I want to write a book called biology is BS all about exceptions. Did you know about a quarter of your cardiomyocytes are not diploid? Mitosis is BS. Did you know E. coli only share about 40% of their core genes? Species are BS. Did you know your cells swap mitochondria? Cells are BS
I always said biology is the only science with exceptions to every "rule".
When I was a student moving from engineering to biology, I often heard that I was moving to a ‘soft science.’ Whereas physics and chemistry and mathematics had ground truth rules that were true no matter what, biology seemed like anarchy by comparison.
October 28, 2026 at 11:49 AM
I want to write a book called biology is BS all about exceptions. Did you know about a quarter of your cardiomyocytes are not diploid? Mitosis is BS. Did you know E. coli only share about 40% of their core genes? Species are BS. Did you know your cells swap mitochondria? Cells are BS
この異形な見た目の画像は、単離培養された心筋細胞の免疫蛍光染色像です。
心筋細胞同士が互いの張力をもとに筋節を配列しようとしているところです。
異形な見た目の正体は、組織を形成しようとする心筋細胞の逞しい生命力を捉えたものでした。
(画像は自身の過去の研究で取得)
Rat isolated cardiomyocytes
🩷 Z-line (anti-αActinin)
💚 M-line (anti-Titin)
💙 Nucleus (Hoechst)
Image size: ~100μm x 100μm
#Halloween #ハロウィン #Heart #SciArt #STEAM
心筋細胞同士が互いの張力をもとに筋節を配列しようとしているところです。
異形な見た目の正体は、組織を形成しようとする心筋細胞の逞しい生命力を捉えたものでした。
(画像は自身の過去の研究で取得)
Rat isolated cardiomyocytes
🩷 Z-line (anti-αActinin)
💚 M-line (anti-Titin)
💙 Nucleus (Hoechst)
Image size: ~100μm x 100μm
#Halloween #ハロウィン #Heart #SciArt #STEAM
October 31, 2026 at 1:33 AM
この異形な見た目の画像は、単離培養された心筋細胞の免疫蛍光染色像です。
心筋細胞同士が互いの張力をもとに筋節を配列しようとしているところです。
異形な見た目の正体は、組織を形成しようとする心筋細胞の逞しい生命力を捉えたものでした。
(画像は自身の過去の研究で取得)
Rat isolated cardiomyocytes
🩷 Z-line (anti-αActinin)
💚 M-line (anti-Titin)
💙 Nucleus (Hoechst)
Image size: ~100μm x 100μm
#Halloween #ハロウィン #Heart #SciArt #STEAM
心筋細胞同士が互いの張力をもとに筋節を配列しようとしているところです。
異形な見た目の正体は、組織を形成しようとする心筋細胞の逞しい生命力を捉えたものでした。
(画像は自身の過去の研究で取得)
Rat isolated cardiomyocytes
🩷 Z-line (anti-αActinin)
💚 M-line (anti-Titin)
💙 Nucleus (Hoechst)
Image size: ~100μm x 100μm
#Halloween #ハロウィン #Heart #SciArt #STEAM
RRIDs were included in this in Nature Cardiovascular Research paper. We value the author's support of reproducibility. #ReproducibleResearch #reproducibility #STMpublishing
Cardiomyocyte-expressed TGFβ programs early heart maturation and adult myocyte identity - Nature Cardiovascular Research
Minerath et al. show that cardiomyocyte-derived TGFβ orchestrates a developmental signaling network that is essential for heart maturation. By communicating with non-myocytes, TGFβ promotes cardiomyocyte identity, whereas its loss disrupts fibroblast maturation and activates skeletal muscle gene programs in cardiomyocytes.
doi.org
October 30, 2026 at 7:08 AM
RRIDs were included in this in Nature Cardiovascular Research paper. We value the author's support of reproducibility. #ReproducibleResearch #reproducibility #STMpublishing
and further exacerbates insuli
🫀 #Cardiomyocyte Injury and Pyroptosis: Accumulation of BCAAs heightens both acute and chronic myocardial injury, deteriorates cardiac function, and activates pyroptosis in cardiomyocytes via NLRP3/ASC/Caspase-1 signaling pathways.
🫀 #Cardiomyocyte Injury and Pyroptosis: Accumulation of BCAAs heightens both acute and chronic myocardial injury, deteriorates cardiac function, and activates pyroptosis in cardiomyocytes via NLRP3/ASC/Caspase-1 signaling pathways.
October 28, 2026 at 4:40 AM
and further exacerbates insuli
🫀 #Cardiomyocyte Injury and Pyroptosis: Accumulation of BCAAs heightens both acute and chronic myocardial injury, deteriorates cardiac function, and activates pyroptosis in cardiomyocytes via NLRP3/ASC/Caspase-1 signaling pathways.
🫀 #Cardiomyocyte Injury and Pyroptosis: Accumulation of BCAAs heightens both acute and chronic myocardial injury, deteriorates cardiac function, and activates pyroptosis in cardiomyocytes via NLRP3/ASC/Caspase-1 signaling pathways.
They used human cardiac spheroids made of cardiomyocytes and fibroblasts to characterize the response to cardiac injury in this model (no proliferation, rather fibrotic response).
paper: journals.biologists.com/dmm/article/...
movie: Movie 1 from the paper
paper: journals.biologists.com/dmm/article/...
movie: Movie 1 from the paper
Development of a laser injury model using human cardiac spheroids
Summary: We report the establishment of a human cardiac microtissue injury model using focal laser ablation to investigate cardiomyocyte–fibroblast interactions during reparative and regenerative proc...
journals.biologists.com
October 29, 2026 at 1:34 PM
They used human cardiac spheroids made of cardiomyocytes and fibroblasts to characterize the response to cardiac injury in this model (no proliferation, rather fibrotic response).
paper: journals.biologists.com/dmm/article/...
movie: Movie 1 from the paper
paper: journals.biologists.com/dmm/article/...
movie: Movie 1 from the paper
What drives atrial arrhythmias in #TakotsuboSyndrome?
Patient-specific iPSC-derived cardiomyocytes reveal that catecholaminergic stress and PDE4 dysregulation underlie arrhythmogenic calcium defects. @jlugiessen.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#CardiovascularResearch
Patient-specific iPSC-derived cardiomyocytes reveal that catecholaminergic stress and PDE4 dysregulation underlie arrhythmogenic calcium defects. @jlugiessen.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#CardiovascularResearch
October 27, 2026 at 11:49 AM
What drives atrial arrhythmias in #TakotsuboSyndrome?
Patient-specific iPSC-derived cardiomyocytes reveal that catecholaminergic stress and PDE4 dysregulation underlie arrhythmogenic calcium defects. @jlugiessen.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#CardiovascularResearch
Patient-specific iPSC-derived cardiomyocytes reveal that catecholaminergic stress and PDE4 dysregulation underlie arrhythmogenic calcium defects. @jlugiessen.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#CardiovascularResearch
Dissecting diastolic stiffness. New study by Shahid et al. (rupress.org/jgp/article/...) reveals sex-based differences in the contributors to diastolic stress in #cardiomyocytes from heart failure with preserved ejection fraction model mice. In Research News: rupress.org/jgp/article/...
#HFpEF
#HFpEF
October 26, 2026 at 1:31 PM
Dissecting diastolic stiffness. New study by Shahid et al. (rupress.org/jgp/article/...) reveals sex-based differences in the contributors to diastolic stress in #cardiomyocytes from heart failure with preserved ejection fraction model mice. In Research News: rupress.org/jgp/article/...
#HFpEF
#HFpEF
#cardiomyocytes
#ExtracellularMatrixScaffold
#PilarFerrer
#GelHealHeart
organdetox.substack.com/p/a-doctoral...
#ExtracellularMatrixScaffold
#PilarFerrer
#GelHealHeart
organdetox.substack.com/p/a-doctoral...
A doctoral student in Argentina built a gel that helps the heart repair itself after a heart attack. Here's what her research reveals about the one problem every cardiologist has been unable to solve.
There’s a 25-year-old biologist named Pilar Ferrer working in Argentina right now.
organdetox.substack.com
October 26, 2026 at 4:10 AM
A paper using RRID:AB_2536381 from @thermofishersci.bsky.social was just published in iScience. We value the author's support of reproducibility. #OpenResearch #methodsmatter #ReproducibleResearch
Generation of hypoimmunogenic cardiomyocytes from human induced pluripotent stem cells with TAPBP knockout
Read the full paper: Generation of hypoimmunogenic cardiomyocytes from human induced pluripotent stem cells with TAPBP knockout
doi.org
October 23, 2026 at 7:00 AM
A paper using RRID:AB_2536381 from @thermofishersci.bsky.social was just published in iScience. We value the author's support of reproducibility. #OpenResearch #methodsmatter #ReproducibleResearch
My talk from the Early Career Symposium (@alleninstitute.org, @isscr.org, and the Society for Developmental Biology) is now online! 🫀
I present our approach to studying maturation and proliferation of hPSC-derived cardiomyocytes, toward modeling human cardiac regeneration.
me-l.co/qyk996qb
I present our approach to studying maturation and proliferation of hPSC-derived cardiomyocytes, toward modeling human cardiac regeneration.
me-l.co/qyk996qb
Stem Dev Symposium/ Ariel Waisman
YouTube video by allen institute
www.youtube.com
October 21, 2026 at 1:06 PM
My talk from the Early Career Symposium (@alleninstitute.org, @isscr.org, and the Society for Developmental Biology) is now online! 🫀
I present our approach to studying maturation and proliferation of hPSC-derived cardiomyocytes, toward modeling human cardiac regeneration.
me-l.co/qyk996qb
I present our approach to studying maturation and proliferation of hPSC-derived cardiomyocytes, toward modeling human cardiac regeneration.
me-l.co/qyk996qb
🏆 Congrats to #SPM40 doctoral candidate Jing Zeng (ChariteBerlin) on the Best Student Award at #ITEC2026 in Leipzig!
Her poster used AFM micro-rheology to probe the viscoelastic properties of beating human iPSC-derived cardiomyocytes 🫀
@ibecbarcelona.eu #HorizonEU
Her poster used AFM micro-rheology to probe the viscoelastic properties of beating human iPSC-derived cardiomyocytes 🫀
@ibecbarcelona.eu #HorizonEU
October 21, 2026 at 10:37 AM
🏆 Congrats to #SPM40 doctoral candidate Jing Zeng (ChariteBerlin) on the Best Student Award at #ITEC2026 in Leipzig!
Her poster used AFM micro-rheology to probe the viscoelastic properties of beating human iPSC-derived cardiomyocytes 🫀
@ibecbarcelona.eu #HorizonEU
Her poster used AFM micro-rheology to probe the viscoelastic properties of beating human iPSC-derived cardiomyocytes 🫀
@ibecbarcelona.eu #HorizonEU