#CellTypeAnnotation

SIMS
Scalable, Interpretable Machine learning for Single cell
github.com/braingeneers...

TabNet attention-based
Temperature scaling of trained network
Automated gene intersection

vs Seurat scANVI scVI Scnym Scibet SingleR scBERT

#CellGenomics 2025
www.cell.com/cell-genomic...

popV/popular Vote

Automated #CellTypeAnnotation

Measures of Intrinsic & Extrinsic Uncertainty
Extrinsic: agreement of 8 prediction algorithms
Intrinsic: classifier score of each algorithm

RF SVM Celltypist OnClass KNN+Scanorama/BBKNN/scVI/scanVI

#NatGenet 2024
www.nature.com/articles/s41...