#CellularSenescence
LightNews LightNews
oelsallabi.bsky.social
Excited to dive into fascinating science on cellular senescence! @yicsac.bsky.social @icsasenescence.bsky.social
#CellularSenescence #Aging #ICSA2025 #yICSA”
September 16, 2025 at 3:04 PM
demarialab.bsky.social
Last Friday, Alessio Piccolantonio (@apiccolantonio.bsky.social) from our lab presented his PhD project at his first ERIBA seminar, exploring the role of cellular senescence in systemic sclerosis🔬🧬🧫 #Science #Research#CellBiology #Aging #CellularSenescence
February 7, 2025 at 1:31 PM
haoyin.bsky.social
Casein kinase 2 inhibitor, TBB as a novel #Senolytic

TBB quenches DDR in senescent cells▶️
⏫unrepaired DNA damage
⏫Apoptosis

in Zmpste24 KO🐭
extends lifespan (18->24 wk)
⏫trabecular bone vol
⏬#CellularSenescence in kidney spleen

#CellDeathDis 2024
www.nature.com/articles/s41...
January 6, 2025 at 12:34 AM
demarialab.bsky.social
Farewell to @magnusberglind.bsky.social 👋
After two months in our lab, it was great having you around. We really enjoyed you being part of the team, both for your work and the fun moments.
Good luck with what’s next, we’re sure you’ll do great 🚀 #labteam #cellularsenescence #aging
August 22, 2025 at 2:14 PM
aging-us.bsky.social
🔆 #PaperSpotlight:
A new #research paper was #published on May 15: “Extracellular vesicles released by senescent myoblasts affect recipient cells via miRNA-target interactions.” @mcmasteruniversity.bsky.social

🔗 doi.org/10.18632/aging.206379

#aging #quote #cellularsenescence #metabolism #muscle
June 3, 2026 at 3:37 PM
febsopenbio.bsky.social
📣 Looking for a new Review to read this week?

Overview of molecular signatures of senescence and associated resources: pros and cons

➡️ buff.ly/QjHFhzr

#Senescence #CellularSenescence #Ageing
October 27, 2025 at 11:03 AM
engbioirc.bsky.social
Great talks and discussions at our ECR Meet yesterday with Andrew Baker on #CellularSenescence🧫& Yash Mishra Journey from PhD Student to Cellcraft Co-Founder #CultivatedMeat🥩 Join us at next meet 17 March with Mariel Alem-Fonseca & Nadia Radzman details here 👉 www.tickettailor.com/events/engin...
February 18, 2025 at 9:54 AM
jsantoyo.bsky.social
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases. #Chromatin #GenomeInstability #CellularSenescence #Ageing #Genomics #BioSky #SciSky 🧪
www.nature.com/articles/s41...
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases - Nature Reviews Molecular Cell Biology
Heterochromatin loss, telomere attrition and DNA damage induce cellular senescence by eliciting genome instability and innate immunity responses, thereby promoting ageing and age-related diseases. Thi...
www.nature.com
November 16, 2024 at 3:10 PM
itmat.bsky.social
Novel #MouseModel allows study of #Senolytic mechanisms linked to specific cell types doi.org/10.1016/j.jc... @kaestner_klaus #LiverDisease #AgingResearch #CellularSenescence #TranslationalScience
Redirecting
doi.org
August 25, 2026 at 6:48 PM
oelsallabi.bsky.social
Loved the mix of science, good conversations, and familiar faces. Already looking forward to the next one!

#PhDLife #CellularSenescence #KarolinskaInstitute #yICSA #ResearchCommunity #Gratitude
May 18, 2025 at 5:07 PM
oelsallabi.bsky.social
Really grateful for the chance to share my journey across Europe and the U.S.
looking forward to it!

#ICSA #cellularsenescence #agingresearch #academia #senolytics #geroscience
yicsac.bsky.social yicsac.bsky.social @yicsac.bsky.social · Jan 5
🎙️ We’re excited to start 2026 with our first @yicsac.bsky.social webinar featuring @oelsallabi.bsky.social , Postdoctoral Researcher at the University “G. d’Annunzio” 🇮🇹
🧬 Cellular senescence, ovarian aging & senotherapeutics
👉 Register: us06web.zoom.us/meeting/regi...
#yICSAWebinarSeries #Senescence
January 5, 2026 at 5:51 PM
genesndiseases.bsky.social
This recent review explores #CellularSenescence in #IntervertebralDiscDegeneration, summarizing detection methods, #RegulatoryMechanisms, & therapies to inhibit #Senescence, & also addresses the challenges in #Clinical applications. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...
October 13, 2025 at 12:43 PM
enhancedgenomics.bsky.social
@akispapantonis.bsky.social seminar, moderated by @stefanschoenfelder.bsky.social : Senescent cells repurpose proteins to cluster CTCF, rewiring genome architecture.
Recording: www.youtube.com/watch?v=6NtH...
Next "3D Regulatory Genome" speaker coming soon!
#CellularSenescence #GenomeRegulation
May 13, 2025 at 1:02 PM
buckinstitute.org
Many age-related diseases involve fibrosis. Study in @geroscience.bsky.social shows mechanical forces shape #cellularsenescence and related secretory phenotypes. Researchers in Winer lab ID’d unique high-stiffness-driven secretory protein profiles link.springer.com/article/10.1...
Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts - GeroScience
Cells are subjected to dynamic mechanical environments which impart forces and induce cellular responses. In age-related conditions like pulmonary fibrosis, there is both an increase in tissue stiffne...
link.springer.com
January 23, 2025 at 7:12 PM
aging-us.bsky.social
📈 #TrendingWithImpact:
A new #research paper was #published on September 8, titled “Runx1 overexpression induces early onset of intervertebral disc degeneration.”

🔗 doi.org/10.18632/agi...

#aging #quote #cellularsenescence #runx1 #openaccess #publishing
October 16, 2025 at 3:22 PM
aging-us.bsky.social
🎥 #AgingShort:
Abstract #video about the #research paper, titled “Extracellular vesicles released by senescent myoblasts affect recipient cells via miRNA-target interactions.”
@mcmasteruniversity.bsky.social

🔗 doi.org/10.18632/agi...

#aging #PaperSpotlight #cellularsenescence #metabolism #muscle
June 3, 2026 at 3:28 PM
genesndiseases.bsky.social
This review highlights the central role of #CellularSenescence in #IntervertebralDiscDegeneration, exploring its mechanisms, diagnostic approaches, and emerging anti-senescence therapies aimed at restoring disc homeostasis & alleviating low back pain.
Read: doi.org/10.1016/j.ge...
May 20, 2026 at 3:30 PM
agingcongress.bsky.social
Call for Abstracts

p62 loss drives TIF-IA buildup, nucleolar change, and SASP inflammation

Key discoveries shaping our understanding of aging and longevity submit your abstract below:

agingcongress.com/edition2/abs...

#CellularSenescence#Proteostasis #Autophagy #Nucleolus #SASP
January 2, 2026 at 4:14 AM
aging-us.bsky.social
🎥 #AgingShort:
Abstract #video about the #research paper, "Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during senescence induction." @buckinstitute.org

🔗 doi.org/10.18632/aging.206299

#aging #PaperSpotlight #cellularsenescence #oa #publishing
September 22, 2025 at 6:45 PM
jthoracdis.bsky.social
🔬 COPD lungs may age 10-20 years faster due to oxidative stress. With no current drugs targeting the COPD inflammatory pattern, Prof. Barnes highlighted #senolytics (like Bcl-xL inhibitors) as potential therapies to clear senescent cells. 💊 #RespiratoryMedicine #CellularSenescence
September 10, 2026 at 7:46 AM
demarialab.bsky.social
🔥Exciting science at ERIBA seminar! 🔥
Our Postdoc @jamilnehme.bsky.social presented his research on cell fate decisions in response to damage and the broader implications for health and disease. Inspiring insights into life’s resilience!
#aging #cellularsenescence #science
September 26, 2025 at 7:57 AM
longevitytech.bsky.social
Experimental therapy cut precancerous skin lesions by 46%, offering a glimpse of how longevity science could reshape disease treatment.

Link as first comment.

#longevity #geroscience #skinhealth #cellularsenescence #clinicaltrials
Researchers in lab coats analyze a vial of substance related to Rubedo's early success in treating age-related skin disease. The mood is focused and professional.
June 2, 2026 at 5:26 PM
handle.invalid
Discover how zombie #cells drive #aging and #disease, and explore emerging #senolytictherapies that may reverse the damage. Visit now to learn more.

Visit BlogPost 🔗: www.healthandfitnessposts.site/2025/04/Cell...

#cellularsenescence #zombiecells #senolytics #antiaging #longevity #AgeingWell
Cellular Senescence Explained: How Zombie Cells Accelerate Aging and How to Fight Back!
Learn how zombie cells drive aging & disease. Discover senescence, its risks, and senolytics—therapies aiming to clear these aging cells.
www.healthandfitnessposts.site
April 9, 2025 at 1:55 PM
medchemexpress.bsky.social
🔸Targeting this pathway or applying senolytic strategies significantly reduces tumor burden in preclinical models

🌟ABT-737, a widely used #BH3 mimetic was cited in this paper
www.medchemexpress.com/abt-737.html
🔗Read the full paper: www.nature.com/articles/s43...
#Bcl2 #CellularSenescence #ABT737
ABT-737 | Bcl-2 Family Inhibitor/BH3 Mimetic | MedChemExpress
ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and…
www.medchemexpress.com
April 9, 2026 at 4:02 PM
alicefrolov.bsky.social
New visualization: Molecular Signatures Distinguish Distinct Senescence Programs

#CellularSenescence #SASP #Senescence #CellBiology #DataVizualization #MolecularBiology #Aging #Oncology
New visualization: Molecular Signatures Distinguish Distinct Senescence Programs I am sharing a parallel-coordinates rendering intended to communicate how distinct senescence induction modes diverge across a set of hallmark molecular axes. The subtitle, "Simulated multi-parametric profiling of senescence subtypes across seven hallmark axes," is deliberate: the data plotted here are simulated and constructed to reflect literature-grounded trends rather than any single empirical dataset. The figure is meant as a conceptual synthesis for discussion, not as a source of quantitative parameters. Each polyline traces one senescence program across seven axes: p16INK4a/Rb pathway engagement, p21CIP1/p53 axis activity, SASP amplitude (NF-kB/C-EBPbeta-driven), SA-beta-galactosidase intensity, persistent DNA damage response (gamma-H2AX foci), lysosomal/autophagic remodeling, and cell-cycle arrest stability. The compared programs include replicative senescence, oncogene-induced senescence (OIS), therapy-induced senescence (TIS), and stress/DNA-damage-induced senescence. The intended reading is that no single marker uniquely resolves subtype identity, whereas the combined multi-axis trajectory does. OIS is depicted with pronounced DDR and high SASP amplitude alongside strong p16 engagement, consistent with hyperreplicative stress. Replicative senescence shows telomere-attrition-driven DDR with comparatively moderate SASP. TIS is rendered with elevated p21/p53 activity and variable, often blunted, SASP depending on the therapeutic modality. The crossing pattern of polylines emphasizes axis-dependent divergence rather than a monotonic severity gradient. My aim in circulating this is to solicit critique on axis selection and on whether additional dimensions, for example mitochondrial dysfunction, cGAS-STING signaling, or nuclear lamina remodeling, would materially improve subtype separation.
August 17, 2026 at 5:01 PM