chromothripsis
September 25, 2026 at 1:11 PM
chromothripsis
This is a nice review on chromothripsis (aka chromosomal shattering) when a single catastrophic event is associated with lots of genomic rearrangements
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chromothripsis in cancer - Nature Reviews Cancer
Chromothripsis is an extreme form of chromosome instability that causes the acquisition of multiple genomic aberrations. Simovic-Lorenz and Ernst discuss mechanistic models of chromothripsis and outli...
www.nature.com
November 20, 2024 at 2:09 PM
This is a nice review on chromothripsis (aka chromosomal shattering) when a single catastrophic event is associated with lots of genomic rearrangements
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New Online! p53 keeps a transcription–replication balance that prevents chromothripsis
p53 keeps a transcription–replication balance that prevents chromothripsis
Nature Reviews Molecular Cell Biology, Published online: 28 September 2026; doi:10.1038/s41580-026-01031-6p53 loss induces global increase of transcription that causes nucleotide shortage and replication stress, thereby driving formation of DNA double-strand breaks and chromothripsis.
dlvr.it
September 28, 2026 at 11:12 AM
New Online! p53 keeps a transcription–replication balance that prevents chromothripsis
# REVIEW 🚨
Simovic-Lorenz & Ernst from @dkfz.bsky.social discuss mechanisms of #chromothripsis, its impact on cancer and vulnerabilities of chromothriptic tumours.
📖 ⬇️
Simovic-Lorenz & Ernst from @dkfz.bsky.social discuss mechanisms of #chromothripsis, its impact on cancer and vulnerabilities of chromothriptic tumours.
📖 ⬇️
Chromothripsis in cancer - Nature Reviews Cancer
go.nature.com
February 14, 2025 at 6:17 PM
# REVIEW 🚨
Simovic-Lorenz & Ernst from @dkfz.bsky.social discuss mechanisms of #chromothripsis, its impact on cancer and vulnerabilities of chromothriptic tumours.
📖 ⬇️
Simovic-Lorenz & Ernst from @dkfz.bsky.social discuss mechanisms of #chromothripsis, its impact on cancer and vulnerabilities of chromothriptic tumours.
📖 ⬇️
five chromothripsis, six chromothripsisises
July 30, 2025 at 8:27 PM
five chromothripsis, six chromothripsisises
Chromothripsis in cancer. #Chromothripsis #Cancer #GenomicRearrangements #ChromosomalShattering #Genomics #NatureReviewsCancer #BioSky #SciSky 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chromothripsis in cancer - Nature Reviews Cancer
Chromothripsis is an extreme form of chromosome instability that causes the acquisition of multiple genomic aberrations. Simovic-Lorenz and Ernst discuss mechanistic models of chromothripsis and outli...
www.nature.com
November 16, 2024 at 11:54 AM
Chromothripsis in cancer. #Chromothripsis #Cancer #GenomicRearrangements #ChromosomalShattering #Genomics #NatureReviewsCancer #BioSky #SciSky 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#Chromothripsis leads to the acquisition of multiple genomic aberrations.
Now out in Nat Rev Cancer:
1) A #Review from Simovic-Lorenz & Aurelie Ernst, @dkfz.bsky.social, covering mechanistic models of chromothripsis & its role in cancer and progression.
👉 bit.ly/4fy8pFo
Now out in Nat Rev Cancer:
1) A #Review from Simovic-Lorenz & Aurelie Ernst, @dkfz.bsky.social, covering mechanistic models of chromothripsis & its role in cancer and progression.
👉 bit.ly/4fy8pFo
November 21, 2024 at 11:14 AM
#Chromothripsis leads to the acquisition of multiple genomic aberrations.
Now out in Nat Rev Cancer:
1) A #Review from Simovic-Lorenz & Aurelie Ernst, @dkfz.bsky.social, covering mechanistic models of chromothripsis & its role in cancer and progression.
👉 bit.ly/4fy8pFo
Now out in Nat Rev Cancer:
1) A #Review from Simovic-Lorenz & Aurelie Ernst, @dkfz.bsky.social, covering mechanistic models of chromothripsis & its role in cancer and progression.
👉 bit.ly/4fy8pFo
🧬🔬@science.org #Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes | Science www.science.org/doi/10.1126/...
Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes
Genome instability, including chromothripsis, is a hallmark of cancer. Cancer cells frequently contain micronuclei—small, nucleus-like structures formed by chromosome missegregation—that are susceptib...
www.science.org
December 12, 2025 at 10:07 PM
🧬🔬@science.org #Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes | Science www.science.org/doi/10.1126/...
Cool paper in Cancer Discovery @theaacr.bsky.social from last week. My @mskdeptofmed.bsky.social colleague Charlie Rudin and MSK collaborators, led by Natasha Rekhtman, explore an unusual subset of small cell lung cancers that happen in people who never smoked cig aacrjournals.org/cancerdiscov....
Chromothripsis-Mediated Small Cell Lung Carcinoma
This study describes an exceptional, alternative pathway of SCLC pathogenesis via chromothripsis and ecDNA in the absence of RB1 and TP53 mutations or smoking mutagenesis, defining a novel tumor type ...
aacrjournals.org
January 21, 2025 at 10:37 PM
Cool paper in Cancer Discovery @theaacr.bsky.social from last week. My @mskdeptofmed.bsky.social colleague Charlie Rudin and MSK collaborators, led by Natasha Rekhtman, explore an unusual subset of small cell lung cancers that happen in people who never smoked cig aacrjournals.org/cancerdiscov....
Thank you @gabriellebrewer.bsky.social for highlighting our work in Nature Reviews Cancer, led by grad student @justeng95.bsky.social.
Check out the original paper in Cell here:
www.cell.com/cell/fulltex...
Here's a summary thread from "the other site": x.com/PeterLyLab/s...
Check out the original paper in Cell here:
www.cell.com/cell/fulltex...
Here's a summary thread from "the other site": x.com/PeterLyLab/s...
November 21, 2024 at 4:23 PM
Thank you @gabriellebrewer.bsky.social for highlighting our work in Nature Reviews Cancer, led by grad student @justeng95.bsky.social.
Check out the original paper in Cell here:
www.cell.com/cell/fulltex...
Here's a summary thread from "the other site": x.com/PeterLyLab/s...
Check out the original paper in Cell here:
www.cell.com/cell/fulltex...
Here's a summary thread from "the other site": x.com/PeterLyLab/s...
The new issue is out!! 👉 cell.com/cell/current
Featuring the engineering of source-sink relations to
create climate-smart crops, how ongoing chromothripsis drives tumor evolution across sarcomas and carcinomas, and the intercellular propagation of pyroptosis!
📷: Jake Watson
Featuring the engineering of source-sink relations to
create climate-smart crops, how ongoing chromothripsis drives tumor evolution across sarcomas and carcinomas, and the intercellular propagation of pyroptosis!
📷: Jake Watson
January 23, 2025 at 4:40 PM
The new issue is out!! 👉 cell.com/cell/current
Featuring the engineering of source-sink relations to
create climate-smart crops, how ongoing chromothripsis drives tumor evolution across sarcomas and carcinomas, and the intercellular propagation of pyroptosis!
📷: Jake Watson
Featuring the engineering of source-sink relations to
create climate-smart crops, how ongoing chromothripsis drives tumor evolution across sarcomas and carcinomas, and the intercellular propagation of pyroptosis!
📷: Jake Watson
Our February issue is LIVE! 🌟 🤩
It features articles on:
- Chromothripsis in cancer
- AR signaling in non-prostate cancers
- Genetic predisposition to childhood cancers
- Long-term adverse effects of childhood cancer therapy
https://bit.ly/3E8OM...
It features articles on:
- Chromothripsis in cancer
- AR signaling in non-prostate cancers
- Genetic predisposition to childhood cancers
- Long-term adverse effects of childhood cancer therapy
https://bit.ly/3E8OM...
January 29, 2025 at 1:44 PM
Our February issue is LIVE! 🌟 🤩
It features articles on:
- Chromothripsis in cancer
- AR signaling in non-prostate cancers
- Genetic predisposition to childhood cancers
- Long-term adverse effects of childhood cancer therapy
https://bit.ly/3E8OM...
It features articles on:
- Chromothripsis in cancer
- AR signaling in non-prostate cancers
- Genetic predisposition to childhood cancers
- Long-term adverse effects of childhood cancer therapy
https://bit.ly/3E8OM...
🧬 #ResearchWatch: Loss–Translocation–Amplification #Chromothripsis Drives #Osteosarcoma Evolution, a summary of the study by @jevalleinclan.bsky.social, Solange De Noon, Adrienne Flanagan, Isidro Cortes-Ciriano, and colleagues @ucl.ac.uk @ebi.embl.org @uclnews.bsky.social
doi.org/10.1158/2159...
doi.org/10.1158/2159...
Loss–Translocation–Amplification Chromothripsis Drives Osteosarcoma Evolution
Main Finding: High-grade osteosarcomas frequently exhibit a loss–translocation–amplification (LTA) pattern of chromothripsis that inactivates TP53 and amplifies oncogenes.Concept: Ongoing chromothrips...
doi.org
February 6, 2025 at 5:00 PM
🧬 #ResearchWatch: Loss–Translocation–Amplification #Chromothripsis Drives #Osteosarcoma Evolution, a summary of the study by @jevalleinclan.bsky.social, Solange De Noon, Adrienne Flanagan, Isidro Cortes-Ciriano, and colleagues @ucl.ac.uk @ebi.embl.org @uclnews.bsky.social
doi.org/10.1158/2159...
doi.org/10.1158/2159...
Look up chromothripsis--this happens in some cancer cells when chromosome segregation goes awry and chromosomes end in micronuclei
June 18, 2025 at 6:34 PM
Look up chromothripsis--this happens in some cancer cells when chromosome segregation goes awry and chromosomes end in micronuclei
Two new @natureportfolio.bsky.social publications:
1️⃣ Multi-omic profiling of medulloblastoma characterizes subclonal variation of chromothripsis (doi.org/10.1038/s414...)
2️⃣ Spatio-temporal profiling explores mechanisms of treatment resistance (doi.org/10.1038/s414...)
Thanks to all involved! 🙌
1️⃣ Multi-omic profiling of medulloblastoma characterizes subclonal variation of chromothripsis (doi.org/10.1038/s414...)
2️⃣ Spatio-temporal profiling explores mechanisms of treatment resistance (doi.org/10.1038/s414...)
Thanks to all involved! 🙌
December 10, 2024 at 10:24 AM
Two new @natureportfolio.bsky.social publications:
1️⃣ Multi-omic profiling of medulloblastoma characterizes subclonal variation of chromothripsis (doi.org/10.1038/s414...)
2️⃣ Spatio-temporal profiling explores mechanisms of treatment resistance (doi.org/10.1038/s414...)
Thanks to all involved! 🙌
1️⃣ Multi-omic profiling of medulloblastoma characterizes subclonal variation of chromothripsis (doi.org/10.1038/s414...)
2️⃣ Spatio-temporal profiling explores mechanisms of treatment resistance (doi.org/10.1038/s414...)
Thanks to all involved! 🙌
$BNGO - Bionano
13-Nov-2024
Scientists are increasingly taking note of Optical Genome Mappings's unique ability to detect chromothripsis.
1/4
13-Nov-2024
Scientists are increasingly taking note of Optical Genome Mappings's unique ability to detect chromothripsis.
1/4
November 21, 2024 at 12:30 AM
$BNGO - Bionano
13-Nov-2024
Scientists are increasingly taking note of Optical Genome Mappings's unique ability to detect chromothripsis.
1/4
13-Nov-2024
Scientists are increasingly taking note of Optical Genome Mappings's unique ability to detect chromothripsis.
1/4
Thursday, we were joined by Isidro Cortés-Ciriano, PhD, on OsteoBites to discuss, "Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution".
Watch the full episode here: www.youtube.com/watch?v=H1kV...
#MIBAgents #MakeItBetter #osteosarcoma #OsteoBites #podcast
Watch the full episode here: www.youtube.com/watch?v=H1kV...
#MIBAgents #MakeItBetter #osteosarcoma #OsteoBites #podcast
OsteoBites: Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution
YouTube video by Osteosarcoma: MIB Agents Osteosarcoma Alliance
www.youtube.com
December 8, 2025 at 9:20 PM
Thursday, we were joined by Isidro Cortés-Ciriano, PhD, on OsteoBites to discuss, "Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution".
Watch the full episode here: www.youtube.com/watch?v=H1kV...
#MIBAgents #MakeItBetter #osteosarcoma #OsteoBites #podcast
Watch the full episode here: www.youtube.com/watch?v=H1kV...
#MIBAgents #MakeItBetter #osteosarcoma #OsteoBites #podcast
🚨🚨Paper out! 🚨🚨
Delighted to share our work, now published in @natgenet.nature.com 🧬!
shorturl.at/94s5S
We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n
Illustration: Hratch Arbach
🧵👇
Delighted to share our work, now published in @natgenet.nature.com 🧬!
shorturl.at/94s5S
We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n
Illustration: Hratch Arbach
🧵👇
June 10, 2025 at 3:26 PM
🚨🚨Paper out! 🚨🚨
Delighted to share our work, now published in @natgenet.nature.com 🧬!
shorturl.at/94s5S
We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n
Illustration: Hratch Arbach
🧵👇
Delighted to share our work, now published in @natgenet.nature.com 🧬!
shorturl.at/94s5S
We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n
Illustration: Hratch Arbach
🧵👇
2) A #Researchhighlight (by yours truly) of a study from the @peterlylab.bsky.social that identified the FA pathway as a driver of chromothripsis.
👉 bit.ly/3OizHUk
👉 bit.ly/3OizHUk
Fanconi anaemia pathway induces chromosome shattering - Nature Reviews Cancer
Engel et al. conducted a genetic screen in which they identified the Fanconi anaemia (FA) pathway as a driver of chromothripsis, complex genomic rearrangements and generation of extrachromosomal DNA.
bit.ly
November 21, 2024 at 11:15 AM
2) A #Researchhighlight (by yours truly) of a study from the @peterlylab.bsky.social that identified the FA pathway as a driver of chromothripsis.
👉 bit.ly/3OizHUk
👉 bit.ly/3OizHUk
