#ClinMicroRev
LightNews LightNews
asm.org
The traditional landscape of dermatophyte infections has changed over the past decade. In #ClinMicroRev: an overview of currently recognized dermatophyte species, complexes & genera, describing phylogenetic, ecological, and biochemical relatedness. asm.social/36x
KOH wet mounts of nail tissue containing dermatophyte hyphae with arthroconidia, stained with Parker Ink (A and B), viewed under a light microscope, and calcofluor white (C), viewed using a fluorescence microscope with ultra-violet light. Images in panels A and B: Sarah Kidd, School of Biological Sciences, Adelaide University.
September 28, 2026 at 5:58 PM
asm.org
Scrub typhus, caused by Orientia tsutsugamushi, remains a major cause of acute undifferentiated febrile illness with an expanding global footprint. Learn about its clinical signatures, immunopathogenesis and diagnostic implications in #ClinMicroRev: asm.social/35d
Trombiculid life cycle and stylostome-mediated feeding. The life cycle comprises free-living soil stages and a single parasitic larval stage. The chigger injects saliva to digest host tissues, and the saliva solidifies with host exudates to form a hardened feeding tube, the stylostome.
September 15, 2026 at 1:57 PM
asm.org
#MicrobiologyMonday: Phages help promote wound healing by reducing concentrations of pathogenic bacteria, disrupting biofilms in wounds and downregulating the production of inflammatory mediators. Get the full story in #ClinMicroRev: asm.social/2Yr
Multifactorial roles of natural and engineered bacteriophages in wound healing. Schematic representation of bacteriophage activities in infected skin wounds. Effects attributed to natural phages include selective bacterial targeting and lysis, biofilm dispersal, preservation of the commensal microbiome, and downregulation of pro-inflammatory mediators (e.g., IL-6, IL-8, NF-κB, ROS), collectively supporting immune modulation and restoration of a reparative wound microenvironment. Engineered phage-based approaches are represented by phage display-derived constructs for targeted infection prevention and phage-based scaffolds supporting tissue regeneration. Together, these mechanisms highlight the dual therapeutic potential of natural and engineered bacteriophages in infected wound management.
June 15, 2026 at 2:05 PM
asm.org
#MicrobiologyMonday: Jorge Lobo’s disease is a chronic fungal infection that preferentially affects cooler areas of the body. This thermal preference may help explain why lesions remain cutaneous and do not typically disseminate. #ClinMicroRev: asm.social/2WD
Light and electron microscopy of Paracoccidioides lobogeorgii. Pleomorphic clinical presentations of Jorge Lobo’s disease.
May 18, 2026 at 3:44 PM
asm.org
Pathogen genomics is increasingly being implemented in clinical microbiology. Discover the factors that represent barriers to, and potential enablers of, this implementation, including the availability of funding and genomics-trained staff. #ClinMicroRev: asm.social/2VH
Applications of genomics in clinical microbiology.
May 5, 2026 at 5:08 PM
asm.org
Since its first isolation in 1935, several thousand Clostridioides difficile isolates have been collected & analyzed. In #ClinMicroRev: an overview of the current C. difficile population structure, including a summary of the 5 main clades. Read now: asm.social/2TC
GrapeTree phylogenies of the Enterobase Clostridioides strains. Each phylogeny was generated using all strains present within Enterobase (accessed 25June 2025) and the “Create MLST GrapeTree” function with the MSTree V2 algorithm.
April 14, 2026 at 6:09 PM
asm.org
Liposomal amphotericin B (L-AmB) is a broad-spectrum antifungal agent with a more favorable safety profile than conventional amphotericins. What are the clinical situations in which it might be most useful? This #ClinMicroRev article offers insights: asm.social/2RV
Mechanism of action of different classes of antifungals. AmB is Amphotericin B; cAmB is the encochleated form of Amphotericin B; L-AmB is liposomal Amphotericin B. Created in BioRender. Giuliano, S. (2025)
March 30, 2026 at 11:22 AM
asm.org
Certain chronic diseases can increase the risk of invasive fungal infections. However, how fungal infections contribute to the development or exacerbation of chronic diseases is less clear. This #ClinMicroRev article explores what we know: asm.social/2R8
Factors contributing to chronic disease states associated with fungal infections: pathogen factors (i.e., organismspecific characteristics of disease-causingfungi), host factors (i.e., intrinsic biological characteristics of an infected organism), and clinical factors (external healthcare- and diagnosis-related elements) mayall contribute to an increased likelihood of fungal infection resulting in a chronic disease state.
March 19, 2026 at 3:44 PM
asm.org
#MicrobiologyMonday: Inquilinus limosus is a nonfermentative gram-negative rod & emerging pathogen, particularly in chronic respiratory disease. This #ClinMicroRev article summarizes what we know & still need to learn about this underestimated organism: asm.social/2Lm
Fig 1 Culture of an Inquilinus limosus strain isolated from the respiratory tract of cystic fibrosis patient. The strain was plated on five commercial agar media and incubated for 24 hours to 72 hours at 35°C.
January 12, 2026 at 4:44 PM
asm.org
Despite the success of existing anti-TB drugs in controlling transmission, significant challenges remain. Future strategies should explore the potential of cell-based therapies, suggests this #ClinMicroRev article: asm.social/2L5
Application of cells and cytokines in TB and DR-TB.
January 8, 2026 at 7:34 PM
asm.org
How does Salmonella survive in the gut? This #ClinMicroRev article shines light on the environmental and physiological factors that influence survival of resistant Salmonella under infection-related conditions in the gut. Read now: asm.social/2JM
Fig 1 Salmonella survival inside the host cells using different pathogenicity island genes.
December 16, 2025 at 4:36 PM
asm.org
In #ClinMicroRev: a review of the global epidemiology of drug-resistant tuberculosis (DR-TB), the strategic context of its transmissibility, prevention, diagnosis and treatment, plus an analysis quantifying the global post DR-TB disease health burden. asm.social/2GW
The TB treatment pipeline. (A) TB drug development pipeline (regardless of TB drug susceptibility), adapted from the Stop TB Partnership Working Group on New TB Drugs with permission; regimen combinations under trial are not presented here. *Trial on DS-TB only but has potential in vitro activity against DR-TB strains. (B) Individualized advanced therapeutic and precision medicine approaches with potential to revolutionize DR-TB treatment.
November 18, 2025 at 6:03 PM
asm.org
In #ClinMicroRev, researchers highlight a major bias in perceptions of mycobacterial infection transmission and suggest broadening the field to include research on environmental non-tuberculous mycobacteria. Get the full story: asm.social/2DZ
Schematic illustration of the different potential, that is, null and alternative, hypotheses for explaining non-tuberculous and tuberculous mycobacteria transmission to humans and animals, based on an extensive scientific literature search and a comprehensive analysis of mycobacterial disease transmission.
October 13, 2025 at 6:57 PM
asm.org
#MicrobiologyMonday: Proteus spp. are frequent causes of urinary tract and bloodstream infections. Several new Proteus spp. have been described, but their pathogenic potential is unclear. Get an update on these ubiquitous bacteria in #ClinMicroRev: asm.social/2AS
Swarming phenotypes of different Proteus isolates on blood agar. Shown is the phenotype of colonies after 24 h. (A) Non-swarming isolate of P. hauseri sampled from dog feces, (B) bull’s-eye pattern of swarming P. terrae sampled from water, (C and E) root-like structures seen in swarming P. terrae sampled from water, (D) P. terrae sampled from dog feces swarming irregularly, and (F) unilateral, thin swarming layer produced by P. terrae isolate from dog feces.
September 15, 2025 at 4:48 PM
asm.org
Human toxocariasis is a zoonotic parasitic infection caused by the larvae of dog & cat roundworms. A comprehensive review in #ClinMicroRev analyzes existing research to provide a detailed and updated understanding of this globally important infection. asm.social/2vi
Toxocara spp. egg. Reprinted from reference 27 (CDC DPDx).
July 17, 2025 at 5:41 PM
asm.org
This new #ClinMicroRev review offers an in-depth, focused assessment of contemporary serologic and antigen detection methods for the common dimorphic fungal pathogens, and summarizes utilization guidance for these methods. Read the review: asm.social/2rI
(A) Histoplasma immunodiffusion. Well G contains H. capsulatum antigen; Wells A and D contain positive control antisera; Well E is the negative control; Wells B, C, and F are patient samples, of which Well C is positive for the M-band. (B) Immunodiffusion cartoon showing a band of identity (a), a band of nonidentity (b), and a band of partial identity (c).
June 5, 2025 at 6:12 PM
asm.org
How effective are probiotics? Emerging evidence supports the efficacy of specific probiotic strains and combinations in treating a wide range of disorders, from gut and liver diseases to dermatological conditions. Get the full story in #ClinMicroRev: asm.social/2oX
Probiotic mechanisms against H. pylori and C. difficile infection and epithelial cell damage in the human gut. (a) Lactobacillus spp. and Bifidobacterium spp. inhibit H. pylori adhesion to gastric epithelial cells by suppressing adhesin and urease expression in vitro and in vivo. (b) Probiotics produce protease that may degrade C. difficile toxins. (c) Probiotic-secreted antibacterial peptides, such as bacteriocin and reuterin, inhibit C. difficile proliferation. (d) Bifidobacterium longum-produced lactate inhibits C. difficile ATP synthesis by reducing NAD+ required for proton gradient generation. (e) B. longum-produced proline up-regulates NAD+, repressing butyrate-induced toxin production. (f) Amuc_1409, secreted by Akkermansia muciniphila, enhances intestinal stem cell regeneration, improving barrier integrity (40). Created with BioRender.
May 6, 2025 at 7:09 PM
asm.org
#MicrobiologyMonday: Bacillus Calmette-Guérin (BCG), a non-virulent strain of Mycobacterium bovis, is used to treat non-muscle-invasive bladder cancer. Why some patients are resistant is unclear, but the bladder microbiota may play a role. #ClinMicroRev journals.asm.org/doi/10.1128/...
Relationship between bladder microbiota and BCG immunotherapy
March 24, 2025 at 2:39 PM
asm.org
Transplant recipients require lifelong, multimodal immunosuppression to prevent rejection. This #ClinMicroRev article explores the concept of “immunosuppressant imprecision,” which focuses on metabolic/microbial effects of immunosuppressive therapies. asm.social/2jO
Interactions of gut metabolome with host immunity.
March 13, 2025 at 7:11 PM
asm.org
Xenotransplantation—transplantation of organs, tissues or cells between species—could help address the shortage of human organs for patients with end-stage organ failure. How should infectious risks be managed? This #ClinMicroRev article offers insights. asm.social/2hU
Timeline of potential infections after pig-to-human organ xenotransplantation. Standard immunosuppression for organ transplantation is associated with a predictable pattern of human infections over time based on the intensity of immune deficits and epidemiological exposures. A similar pattern of infectious risk is expected following xenotransplantation. Introduction of newer immunosuppressive agents for induction or maintenance therapy (e.g., costimulatory blockade, cytokine inhibition, complement inhibitors) is expected to alter the risk of various infections over time.
February 18, 2025 at 8:17 PM
asm.org
Henipaviruses, like Hendra virus and Nipah virus, were first identified 30 years ago and have since been associated with over 30 outbreaks of disease in humans. Learn about henipavirus epidemiology, ecology, disease and more in #ClinMicroRev: journals.asm.org/doi/10.1128/...
Reported henipavirus outbreaks in different countries from 1994 to 2022. Summary of geographic locations and year of report for henipavirus outbreaks involving human cases for Hendra virus (yellow—Australia), Nipah virus strain Malaysia (red—Malaysia, Singapore, and the Philippines), and Nipah virus strain Bangladesh (blue—India and Bangladesh).
January 14, 2025 at 1:24 PM