I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com.
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway
Nature Reviews Molecular Cell Biology - Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and...
rdcu.be
March 25, 2025 at 12:37 PM
I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com.
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multi-scale Molecular Imaging of Human Cells reveals COPI and COPII Vesicles at ER Exit Sites
Trafficking from the endoplasmic reticulum to the Golgi apparatus comprises the first steps toward the correct localization of 30% of eukaryotic proteins. Coat protein complexes COPII and COPI are inv...
www.biorxiv.org
August 4, 2025 at 11:35 AM
Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Ploaie, cărți, cafea cu gheață, lume grăbită, zgomot de copii în jur, gânduri ordonate :)
#tranquilflowoflife #justobserving #enjoySaturday
#tranquilflowoflife #justobserving #enjoySaturday
February 7, 2026 at 5:45 PM
Ploaie, cărți, cafea cu gheață, lume grăbită, zgomot de copii în jur, gânduri ordonate :)
#tranquilflowoflife #justobserving #enjoySaturday
#tranquilflowoflife #justobserving #enjoySaturday
Interesting preprint from the Boyce lab! Sec23IP (protein linking COPII inner and outer coats) is regulated by O-GlcNAcylation. Site-specific modification of its disordered domain controls O-GlcNAcylation, Sec31A recruitment, COPII assembly, and ER exit site function.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 22, 2025 at 12:23 PM
Interesting preprint from the Boyce lab! Sec23IP (protein linking COPII inner and outer coats) is regulated by O-GlcNAcylation. Site-specific modification of its disordered domain controls O-GlcNAcylation, Sec31A recruitment, COPII assembly, and ER exit site function.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Interesting new preprint from Cecile Gauthier-Rouviere! Flotillins link endolysosomes to ERES, recruiting COPII and ATG8 to drive secretory autophagy and extracellular vesicle release. Anew role for COPII in unconventional secretion!
www.researchsquare.com/article/rs-1...
www.researchsquare.com/article/rs-1...
August 12, 2026 at 7:04 AM
Interesting new preprint from Cecile Gauthier-Rouviere! Flotillins link endolysosomes to ERES, recruiting COPII and ATG8 to drive secretory autophagy and extracellular vesicle release. Anew role for COPII in unconventional secretion!
www.researchsquare.com/article/rs-1...
www.researchsquare.com/article/rs-1...
STING signaling modulation by COPII cargo recognition www.sciencedirect.com/science/arti...
STING signaling modulation by COPII cargo recognition
Stimulator of interferon genes (STING) activation requires coat protein complex II (COPII)-mediated endoplasmic reticulum (ER) exit, but the mechanism…
www.sciencedirect.com
March 31, 2026 at 3:53 PM
STING signaling modulation by COPII cargo recognition www.sciencedirect.com/science/arti...
Exciting cryoET structure of the COPII coat from the Zanetti lab.
rdcu.be/dZuzf
rdcu.be/dZuzf
Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes
Nature Structural & Molecular Biology - The authors reconstituted coat protein complex II vesicles from native membranes and used cryo-electron tomography and subtomogram averaging to reveal...
rdcu.be
November 7, 2024 at 11:25 PM
Exciting cryoET structure of the COPII coat from the Zanetti lab.
rdcu.be/dZuzf
rdcu.be/dZuzf
Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
July 30, 2025 at 3:28 PM
Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
New Online! COPII meets autophagy at the ER membrane
COPII meets autophagy at the ER membrane
Nature Reviews Molecular Cell Biology, Published online: 30 June 2026; doi:10.1038/s41580-026-00997-7This study shows that neutral lipids regulate endoplasmic reticulum (ER) membrane curvature and bendability during ER-phagy, and finds that a COPII protein helps couple ER cargo to the autophagy receptor.
dlvr.it
June 30, 2026 at 1:32 PM
New Online! COPII meets autophagy at the ER membrane
This turns out to be a lot harder than the above cartoon makes it look. In a cell, dozens of proteins are needed and they have a complicated choreography that's only partially understood.
In 1998 Schekman's lab at UC Berkeley was able to reconstitute formation of a COPII carrier (PMID 9568718).
/6
In 1998 Schekman's lab at UC Berkeley was able to reconstitute formation of a COPII carrier (PMID 9568718).
/6
February 6, 2026 at 6:59 PM
This turns out to be a lot harder than the above cartoon makes it look. In a cell, dozens of proteins are needed and they have a complicated choreography that's only partially understood.
In 1998 Schekman's lab at UC Berkeley was able to reconstitute formation of a COPII carrier (PMID 9568718).
/6
In 1998 Schekman's lab at UC Berkeley was able to reconstitute formation of a COPII carrier (PMID 9568718).
/6
ICYMI: New Online! COPII meets autophagy at the ER membrane
COPII meets autophagy at the ER membrane
Nature Reviews Molecular Cell Biology, Published online: 30 June 2026; doi:10.1038/s41580-026-00997-7This study shows that neutral lipids regulate endoplasmic reticulum (ER) membrane curvature and bendability during ER-phagy, and finds that a COPII protein helps couple ER cargo to the autophagy receptor.
dlvr.it
July 3, 2026 at 1:33 PM
ICYMI: New Online! COPII meets autophagy at the ER membrane
Excited to share a new story that transformed how we think about membrane domains in the ER!
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export
Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...
rdcu.be
January 24, 2026 at 8:20 PM
Excited to share a new story that transformed how we think about membrane domains in the ER!
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
1/9
Glad to be part of this study from Meir Aridor! COPII assembles at ER exit sites when the ERGIC/Golgi is close by!
p125A links COPII outer coat assembly to PI4P-rich Golgi membranes, coordinating tunnel-based collagen secretion from the ER to the ERGIC/cis-Golgi.
www.biorxiv.org/content/10.1...
p125A links COPII outer coat assembly to PI4P-rich Golgi membranes, coordinating tunnel-based collagen secretion from the ER to the ERGIC/cis-Golgi.
www.biorxiv.org/content/10.1...
May 13, 2025 at 11:34 AM
Glad to be part of this study from Meir Aridor! COPII assembles at ER exit sites when the ERGIC/Golgi is close by!
p125A links COPII outer coat assembly to PI4P-rich Golgi membranes, coordinating tunnel-based collagen secretion from the ER to the ERGIC/cis-Golgi.
www.biorxiv.org/content/10.1...
p125A links COPII outer coat assembly to PI4P-rich Golgi membranes, coordinating tunnel-based collagen secretion from the ER to the ERGIC/cis-Golgi.
www.biorxiv.org/content/10.1...
#KiddyShop #Banz #ProtectiaAuzului #CastiAntifonice #Bebelusi #Copii #Artificii #Meciuri #Nunti #EvenimenteCuCopii #AuzSanatos
September 27, 2026 at 5:16 PM
Luna Cancerului la Copii: 3 proiecte Horizon Europe pentru tratamente inovatoare
🔗 https://grantpress.ro/2026/09/25/luna-cancerului-la-copii-3-proiecte-horizon-europe-pentru-tratamente-inovatoare/
🔗 https://grantpress.ro/2026/09/25/luna-cancerului-la-copii-3-proiecte-horizon-europe-pentru-tratamente-inovatoare/
September 25, 2026 at 10:35 AM
Luna Cancerului la Copii: 3 proiecte Horizon Europe pentru tratamente inovatoare
🔗 https://grantpress.ro/2026/09/25/luna-cancerului-la-copii-3-proiecte-horizon-europe-pentru-tratamente-inovatoare/
🔗 https://grantpress.ro/2026/09/25/luna-cancerului-la-copii-3-proiecte-horizon-europe-pentru-tratamente-inovatoare/
Cei mai buni parinti sunt cei care nu au copii.
November 14, 2023 at 7:37 AM
Cei mai buni parinti sunt cei care nu au copii.
How can a vesicle forming coat drive non-vesicular traffic?
Here is the case of COPII.
p125A (Sec23ip) couples COPII coat assembly with donor-acceptor membrane organization to facilitate tunnel-based traffic. www.biorxiv.org/content/10.1...
Here is the case of COPII.
p125A (Sec23ip) couples COPII coat assembly with donor-acceptor membrane organization to facilitate tunnel-based traffic. www.biorxiv.org/content/10.1...
May 13, 2025 at 12:15 PM
How can a vesicle forming coat drive non-vesicular traffic?
Here is the case of COPII.
p125A (Sec23ip) couples COPII coat assembly with donor-acceptor membrane organization to facilitate tunnel-based traffic. www.biorxiv.org/content/10.1...
Here is the case of COPII.
p125A (Sec23ip) couples COPII coat assembly with donor-acceptor membrane organization to facilitate tunnel-based traffic. www.biorxiv.org/content/10.1...
Sequential restriction of SNARE-mediated fusion by the COPII inner coat and SNARE chaperones www.biorxiv.org/content/10.6...
www.biorxiv.org
February 5, 2026 at 4:27 PM
Sequential restriction of SNARE-mediated fusion by the COPII inner coat and SNARE chaperones www.biorxiv.org/content/10.6...
It was a pleasure to invite and handle this Review! Give it a read if you're interested in COPII or the secretory pathway 😎
New #Review 🥳
@dr-downes.bsky.social and @giuliazanetti.bsky.social discuss recent findings on how #COPII particles assemble and recognise their cargo as part of the #SecretoryPathway
🔗 go.nature.com/3XJHHmy
@dr-downes.bsky.social and @giuliazanetti.bsky.social discuss recent findings on how #COPII particles assemble and recognise their cargo as part of the #SecretoryPathway
🔗 go.nature.com/3XJHHmy
Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway - Nature Reviews Molecular Cell Biology
Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and facilitating their transport to the Golgi. This Revi...
go.nature.com
April 2, 2025 at 5:39 AM
It was a pleasure to invite and handle this Review! Give it a read if you're interested in COPII or the secretory pathway 😎
The proteins are manufactured at the endomplasmic reticulum (ER), then they are packaged for transport by COPII, a protein complex that deforms cargo-loaded membrane to make carriers, which can be little round vesicles or sausage-shaped tubes.
2/
2/
February 6, 2026 at 6:41 PM
The proteins are manufactured at the endomplasmic reticulum (ER), then they are packaged for transport by COPII, a protein complex that deforms cargo-loaded membrane to make carriers, which can be little round vesicles or sausage-shaped tubes.
2/
2/
Alice Weidel, șefa AfD, e lesbiană, căsătorită cu o imigrantă din Sri Lanka, au împreună doi copii adoptați și nu trăiește în Germania, ci în Elveția. Practic este tot ceea ce un "suveranist" urăște din toată inima.
February 20, 2025 at 7:26 PM
Alice Weidel, șefa AfD, e lesbiană, căsătorită cu o imigrantă din Sri Lanka, au împreună doi copii adoptați și nu trăiește în Germania, ci în Elveția. Practic este tot ceea ce un "suveranist" urăște din toată inima.
😮 Exciting study from G. Zanetti's lab exploring COPII assembly on reconstituted membrane carriers and microsomes by #CryoET: rdcu.be/dZK8M ❄️🔬
Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes
Nature Structural & Molecular Biology - The authors reconstituted coat protein complex II vesicles from native membranes and used cryo-electron tomography and subtomogram averaging to reveal...
rdcu.be
November 10, 2024 at 9:56 PM
😮 Exciting study from G. Zanetti's lab exploring COPII assembly on reconstituted membrane carriers and microsomes by #CryoET: rdcu.be/dZK8M ❄️🔬