Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?
April 8, 2026 at 4:04 AM
Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?
Nature research paper: Covariation MS uncovers a protein that controls cysteine catabolism
go.nature.com/47HyIYO
go.nature.com/47HyIYO
Covariation MS uncovers a protein that controls cysteine catabolism - Nature
A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
go.nature.com
September 21, 2025 at 3:27 PM
Nature research paper: Covariation MS uncovers a protein that controls cysteine catabolism
go.nature.com/47HyIYO
go.nature.com/47HyIYO
Time to see if this cures me
October 2, 2024 at 5:41 PM
Time to see if this cures me
Why is #cysteine amino acid so toxic to cells?
www.rockefeller.edu/news/40469-c...
— intracellular cysteine stored as glutathione
— excess cysteine frees iron from ferritin
— excess iron in mitochondria damages iron-sulfur proteins
— mitochondria fail
— cell death
#health #supplement #aging
www.rockefeller.edu/news/40469-c...
— intracellular cysteine stored as glutathione
— excess cysteine frees iron from ferritin
— excess iron in mitochondria damages iron-sulfur proteins
— mitochondria fail
— cell death
#health #supplement #aging
The Rockefeller University » Why high levels of the amino acid cysteine are toxic to cells
The findings explain why the cell prefers glutathione, and may lead to new therapies for certain types of neurodegeneration and cancers.
www.rockefeller.edu
September 19, 2026 at 10:59 PM
Why is #cysteine amino acid so toxic to cells?
www.rockefeller.edu/news/40469-c...
— intracellular cysteine stored as glutathione
— excess cysteine frees iron from ferritin
— excess iron in mitochondria damages iron-sulfur proteins
— mitochondria fail
— cell death
#health #supplement #aging
www.rockefeller.edu/news/40469-c...
— intracellular cysteine stored as glutathione
— excess cysteine frees iron from ferritin
— excess iron in mitochondria damages iron-sulfur proteins
— mitochondria fail
— cell death
#health #supplement #aging
Check out our latest work out today in @natmetabolism.nature.com in which we describe a new metabotype (metabolic phenotype): excess cysteine stress. We discovered novel cysteine conjugates and show how pyruvate modulates free intracellular cysteine levels. Grateful for an awesome team!!
April 7, 2026 at 9:30 PM
Check out our latest work out today in @natmetabolism.nature.com in which we describe a new metabotype (metabolic phenotype): excess cysteine stress. We discovered novel cysteine conjugates and show how pyruvate modulates free intracellular cysteine levels. Grateful for an awesome team!!
Don't shoot the messenger, okay?!
March 16, 2025 at 3:25 PM
Don't shoot the messenger, okay?!
The human zinc-binding cysteine proteome
congrats to @nilsburger.bsky.social !!
www.cell.com/cell/fulltex...
congrats to @nilsburger.bsky.social !!
www.cell.com/cell/fulltex...
The human zinc-binding cysteine proteome
A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.
www.cell.com
January 1, 2025 at 1:44 PM
The human zinc-binding cysteine proteome
congrats to @nilsburger.bsky.social !!
www.cell.com/cell/fulltex...
congrats to @nilsburger.bsky.social !!
www.cell.com/cell/fulltex...
Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...
The human zinc-binding cysteine proteome
A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.
www.cell.com
December 31, 2024 at 4:21 PM
Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...
Cysteine excess triggers mitochondrial iron cell death 🧪
www.nature.com/articles/s42...
@atanas-g-atanasov.bsky.social
@gmpinglish.bsky.social
@mljtpa.bsky.social
@jngljane.bsky.social
@flipturns.bsky.social
@mfamyfuerza.bsky.social
@carnegielemon.deferredreality.com
@neurowithmelike.bsky.social
www.nature.com/articles/s42...
@atanas-g-atanasov.bsky.social
@gmpinglish.bsky.social
@mljtpa.bsky.social
@jngljane.bsky.social
@flipturns.bsky.social
@mfamyfuerza.bsky.social
@carnegielemon.deferredreality.com
@neurowithmelike.bsky.social
Cysteine excess triggers a mitochondrial iron-dependent cell death - Nature Metabolism
Using a genome-wide CRISPR screen, the authors demonstrate that excess cysteine drives mitochondrial iron accumulation and iron–sulfur cluster failure, triggering a distinct iron-dependent cell death ...
www.nature.com
September 19, 2026 at 10:59 PM
Ever wondered what the lonely histone H3C110 does? We found that it’s lost in many fungi. Adding it back boosts histone H3 copper reductase activity, rescues iron defects and modulates lifespan, suggesting an evolutionary tradeoff between these effects.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in Saccharomyces cerevisiae
Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in yeast.
www.science.org
April 11, 2025 at 9:43 PM
Ever wondered what the lonely histone H3C110 does? We found that it’s lost in many fungi. Adding it back boosts histone H3 copper reductase activity, rescues iron defects and modulates lifespan, suggesting an evolutionary tradeoff between these effects.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
🐟🥫 Cysteine cuts mercury in tuna
A new study found that soaking canned tuna in a simple cysteine solution during storage can reduce mercury levels by up to 35%.
🔗 doi.org/10.1002/gch2...
#SciComm #FoodSafety 🧪
A new study found that soaking canned tuna in a simple cysteine solution during storage can reduce mercury levels by up to 35%.
🔗 doi.org/10.1002/gch2...
#SciComm #FoodSafety 🧪
New Insight into Mercury Removal from Fish Meat Using a Single‐Component Solution Containing cysteine
A novel method for reducing methylmercury in fish meat during storage is developed, using a single-component aqueous cysteine solution. This approach achieves up to 35% mercury reduction in albacore ...
doi.org
March 25, 2025 at 9:31 AM
🐟🥫 Cysteine cuts mercury in tuna
A new study found that soaking canned tuna in a simple cysteine solution during storage can reduce mercury levels by up to 35%.
🔗 doi.org/10.1002/gch2...
#SciComm #FoodSafety 🧪
A new study found that soaking canned tuna in a simple cysteine solution during storage can reduce mercury levels by up to 35%.
🔗 doi.org/10.1002/gch2...
#SciComm #FoodSafety 🧪
🧪🧬 New preprint!
What if the same biosensor could reveal how cysteine is regulated across life domains?
We introduce Cystector, a genetically encoded fluorescent biosensor for real-time cysteine monitoring in living cells.
www.biorxiv.org/content/10.6...
🧵A thread ⬇️
What if the same biosensor could reveal how cysteine is regulated across life domains?
We introduce Cystector, a genetically encoded fluorescent biosensor for real-time cysteine monitoring in living cells.
www.biorxiv.org/content/10.6...
🧵A thread ⬇️
February 9, 2026 at 11:56 AM
🧪🧬 New preprint!
What if the same biosensor could reveal how cysteine is regulated across life domains?
We introduce Cystector, a genetically encoded fluorescent biosensor for real-time cysteine monitoring in living cells.
www.biorxiv.org/content/10.6...
🧵A thread ⬇️
What if the same biosensor could reveal how cysteine is regulated across life domains?
We introduce Cystector, a genetically encoded fluorescent biosensor for real-time cysteine monitoring in living cells.
www.biorxiv.org/content/10.6...
🧵A thread ⬇️
"Scientists discovered a surprising backup system that lets mammalian cells make the essential amino acid cysteine even when the pathways once considered indispensable are disabled. The same survival mechanism may help cancer cells resist treatment . . ."
Scientists discover an “impossible” cellular survival pathway that could help fight cancer
Scientists discovered a surprising backup system that lets mammalian cells make the essential amino acid cysteine even when the pathways once considered indispensable are disabled. The same survival m...
www.sciencedaily.com
September 25, 2026 at 12:27 PM
"Scientists discovered a surprising backup system that lets mammalian cells make the essential amino acid cysteine even when the pathways once considered indispensable are disabled. The same survival mechanism may help cancer cells resist treatment . . ."
New work from our own Chouchani Lab finds that LRRC58 is the substrate adaptor of an E3 ubiquitin ligase that mediates proteasomal degradation of CDO1, the rate-limiting enzyme of the catabolic shunt of cysteine to taurine in response to altered Cysteine levels. www.nature.com/articles/s41...
Covariation MS uncovers a protein that controls cysteine catabolism - Nature
A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
www.nature.com
September 17, 2025 at 5:48 PM
New work from our own Chouchani Lab finds that LRRC58 is the substrate adaptor of an E3 ubiquitin ligase that mediates proteasomal degradation of CDO1, the rate-limiting enzyme of the catabolic shunt of cysteine to taurine in response to altered Cysteine levels. www.nature.com/articles/s41...
New exciting work from the Chouchani Lab @harvardcellbio.bsky.social
reports a global analysis of the zinc binding cysteine proteome. www.cell.com/cell/fulltex...
reports a global analysis of the zinc binding cysteine proteome. www.cell.com/cell/fulltex...
The human zinc-binding cysteine proteome
A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.
www.cell.com
January 1, 2025 at 3:00 AM
New exciting work from the Chouchani Lab @harvardcellbio.bsky.social
reports a global analysis of the zinc binding cysteine proteome. www.cell.com/cell/fulltex...
reports a global analysis of the zinc binding cysteine proteome. www.cell.com/cell/fulltex...
Cysteine depletion triggers adipose tissue thermogenesis and weight loss
www.nature.com/articles/s42...
a new paper
www.nature.com/articles/s42...
a new paper
Cysteine depletion triggers adipose tissue thermogenesis and weight loss - Nature Metabolism
The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.
www.nature.com
June 8, 2025 at 5:42 AM
Cysteine depletion triggers adipose tissue thermogenesis and weight loss
www.nature.com/articles/s42...
a new paper
www.nature.com/articles/s42...
a new paper
Covariation MS uncovers a protein that controls cysteine catabolism
www.nature.com/articles/s41...
Beautiful work from Ed Chouchani!
www.nature.com/articles/s41...
Beautiful work from Ed Chouchani!
Covariation MS uncovers a protein that controls cysteine catabolism - Nature
A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
www.nature.com
September 17, 2025 at 4:15 PM
Covariation MS uncovers a protein that controls cysteine catabolism
www.nature.com/articles/s41...
Beautiful work from Ed Chouchani!
www.nature.com/articles/s41...
Beautiful work from Ed Chouchani!
First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Covariation MS uncovers a protein that controls cysteine catabolism - Nature
A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
www.nature.com
September 17, 2025 at 7:24 PM
First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chemical #priming of #hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves #flooding tolerance
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance
Abstract. Extreme flooding driven by climate change demands strategies to enhance plant tolerance to low-oxygen stress. We investigated the ability of bioa
academic.oup.com
September 21, 2026 at 2:37 PM
Chemical #priming of #hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves #flooding tolerance
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
academic.oup.com/plphys/artic...
#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1
www.nature.com/articles/s42...
www.nature.com/articles/s42...
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1 - Nature Metabolism
Zangari et al. show that d-cysteine targets NFS1, thus affecting Fe–S cluster biogenesis and impairing tumour growth.
www.nature.com
August 15, 2025 at 10:02 AM
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1
www.nature.com/articles/s42...
www.nature.com/articles/s42...
𝐓𝐰𝐨 𝐬𝐭𝐮𝐝𝐢𝐞𝐬, 𝐨𝐧𝐞 𝐬𝐭𝐨𝐫𝐲: 𝐜𝐨𝐩𝐩𝐞𝐫, 𝐜𝐲𝐬𝐭𝐞𝐢𝐧𝐞 𝐚𝐧𝐝 𝐫𝐞𝐝𝐨𝐱 𝐚𝐝𝐚𝐩𝐭𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝑴. 𝒕𝒖𝒃𝒆𝒓𝒄𝒖𝒍𝒐𝒔𝒊𝒔
Our new @mbio.bsky.social paper shows that copper reaches intracellular M. tuberculosis and strongly induces CysK2, a cysteine synthase linking copper sensing to redox adaptation and persistence.
📖 shorturl.at/PSDbk
Our new @mbio.bsky.social paper shows that copper reaches intracellular M. tuberculosis and strongly induces CysK2, a cysteine synthase linking copper sensing to redox adaptation and persistence.
📖 shorturl.at/PSDbk
September 13, 2026 at 7:48 AM
𝐓𝐰𝐨 𝐬𝐭𝐮𝐝𝐢𝐞𝐬, 𝐨𝐧𝐞 𝐬𝐭𝐨𝐫𝐲: 𝐜𝐨𝐩𝐩𝐞𝐫, 𝐜𝐲𝐬𝐭𝐞𝐢𝐧𝐞 𝐚𝐧𝐝 𝐫𝐞𝐝𝐨𝐱 𝐚𝐝𝐚𝐩𝐭𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝑴. 𝒕𝒖𝒃𝒆𝒓𝒄𝒖𝒍𝒐𝒔𝒊𝒔
Our new @mbio.bsky.social paper shows that copper reaches intracellular M. tuberculosis and strongly induces CysK2, a cysteine synthase linking copper sensing to redox adaptation and persistence.
📖 shorturl.at/PSDbk
Our new @mbio.bsky.social paper shows that copper reaches intracellular M. tuberculosis and strongly induces CysK2, a cysteine synthase linking copper sensing to redox adaptation and persistence.
📖 shorturl.at/PSDbk