- In advance of this manuscript, you might also see this manuscript from our team using similar intraoperative 3D printing (biodressing) technology In an intriguing study published in the Archives of Plastic Surgery, researchers Hyeonmin Yoon and Woojin Song have continued with a novel approach to limb salvage in the treatment of diabetic foot ulcers (DFUs) In advance of this manuscript, you might also see this manuscript from our team using similar intraoperative 3D printing (biodressing) technology In an intriguing study published in the Archives of Plastic Surgery, researchers Hyeonmin Yoon and Woojin Song have continued with a novel approach to limb salvage in the treatment of diabetic foot ulcers (DFUs) In advance of this manuscript, you might also see this manuscript from our team using similar intraoperative 3D printing (biodressing) technology In an intriguing study published in the Archives of Plastic Surgery, researchers Hyeonmin Yoon and Woojin Song have continued with a novel approach to limb salvage in the treatment of diabetic foot ulcers (DFUs) - -

PolarityBio's pivotal COVER DFUS II trial results will be presented on 16 October, ahead of the FDA's March 2027 PDUFA date for SkinTE.

- A new multicenter randomized controlled trial (RCT) from our combined team, published in the International Wound Journal, has reported that a borate-based bioactive glass fiber matrix (BBGFM) appears to significantly improve healing outcomes in people with chronic, non-healing non-infected, non-ischemic full-thickness diabetic foot ulcers (DFUs). Study Design The trial enrolled 148 participants across 14 U.S. A new multicenter randomized controlled trial (RCT) from our combined team, published in the International Wound Journal, has reported that a borate-based bioactive glass fiber matrix (BBGFM) appears to significantly improve healing outcomes in people with chronic, non-healing non-infected, non-ischemic full-thickness diabetic foot ulcers (DFUs). Study Design The trial enrolled 148 participants across 14 U.S. A new multicenter randomized controlled trial (RCT) from our combined team, published in the International Wound Journal, has reported that a borate-based bioactive glass fiber matrix (BBGFM) appears to significantly improve healing outcomes in people with chronic, non-healing non-infected, non-ischemic full-thickness diabetic foot ulcers (DFUs). Study Design The trial enrolled 148 participants across 14 U.S. - -

- More efforts to better elucidate treatment of pro-inflammatory mild infections/colonization that may be impeding healing Abstract Diabetic foot ulcers (DFUs) are a serious complication from diabetes mellitus, with a huge economic, social and psychological impact on the patients’ life. One of the main reasons why DFUs are so difficult to heal is related to the presence More efforts to better elucidate treatment of pro-inflammatory mild infections/colonization that may be impeding healing Abstract Diabetic foot ulcers (DFUs) are a serious complication from diabetes mellitus, with a huge economic, social and psychological impact on the patients’ life. One of the main reasons why DFUs are so difficult to heal is related to the presence More efforts to better elucidate treatment of pro-inflammatory mild infections/colonization that may be impeding healing Abstract Diabetic foot ulcers (DFUs) are a serious complication from diabetes mellitus, with a huge economic, social and psychological impact on the patients’ life. One of the main reasons why DFUs are so difficult to heal is related to the presence - -

- A recent cohort study published in Diabetologia by Naomi Holman, Arthur C. Yelland, Bob Young, Jonathan Valabhji, William Jeffcoate, and Fran Game highlights the alarming short-term mortality rates in individuals presenting with new diabetes-related foot ulcers (DFUs). The study analyzed data from 71,000 people registered in the National Diabetes Foot Care Audit (NDFA) in England A recent cohort study published in Diabetologia by Naomi Holman, Arthur C. Yelland, Bob Young, Jonathan Valabhji, William Jeffcoate, and Fran Game highlights the alarming short-term mortality rates in individuals presenting with new diabetes-related foot ulcers (DFUs). The study analyzed data from 71,000 people registered in the National Diabetes Foot Care Audit (NDFA) in England A recent cohort study published in Diabetologia by Naomi Holman, Arthur C. Yelland, Bob Young, Jonathan Valabhji, William Jeffcoate, and Fran Game highlights the alarming short-term mortality rates in individuals presenting with new diabetes-related foot ulcers (DFUs). The study analyzed data from 71,000 people registered in the National Diabetes Foot Care Audit (NDFA) in England - -

- Excellent work from our Mancunian colleagues. Highlights •An insole system continuously monitors daily plantar pressure for 18 months.•Personalised pressure feedback reduces foot pressure in feet at high-risk of ulcers.•Pressure feedback induced a learning response. Abstract Aims High plantar pressure is a major risk factor in the development of diabetic foot ulcers (DFUs) and recent evidence Excellent work from our Mancunian colleagues. Highlights •An insole system continuously monitors daily plantar pressure for 18 months.•Personalised pressure feedback reduces foot pressure in feet at high-risk of ulcers.•Pressure feedback induced a learning response. Abstract Aims High plantar pressure is a major risk factor in the development of diabetic foot ulcers (DFUs) and recent evidence Excellent work from our Mancunian colleagues. Highlights •An insole system continuously monitors daily plantar pressure for 18 months.•Personalised pressure feedback reduces foot pressure in feet at high-risk of ulcers.•Pressure feedback induced a learning response. Abstract Aims High plantar pressure is a major risk factor in the development of diabetic foot ulcers (DFUs) and recent evidence - -

- Diabetic foot ulcers (DFUs) are a significant global health concern, affecting a substantial number of individuals with diabetes. These ulcers often present challenges in achieving healing, leading to prolonged non-healing and, in some cases, necessitating amputation. However, a recent study by Liu et al. (2024) offers a promising new approach to managing DFUs[1]. The Study Diabetic foot ulcers (DFUs) are a significant global health concern, affecting a substantial number of individuals with diabetes. These ulcers often present challenges in achieving healing, leading to prolonged non-healing and, in some cases, necessitating amputation. However, a recent study by Liu et al. (2024) offers a promising new approach to managing DFUs[1]. The Study Diabetic foot ulcers (DFUs) are a significant global health concern, affecting a substantial number of individuals with diabetes. These ulcers often present challenges in achieving healing, leading to prolonged non-healing and, in some cases, necessitating amputation. However, a recent study by Liu et al. (2024) offers a promising new approach to managing DFUs[1]. The Study - -

:Diabetic foot ulcers (DFUs) are often polymicrobial infections, necessitating antibiotic therapy. However, the high prevalence of antibiotic misuse and the growing issue of antibiotic resistance in low- and middle-income countries (LMICs) exacerbate the challenges in managing these ulcers, contributing to the risk of lower-limb amputations.Objectives:This systematic review reported the bacterial profile and antibiotic resistance patterns associated with DFUs in LMICs.Design:A systematic review and meta-analysis.Data sources and methods:A comprehensive search was conducted in PubMed, SCOPUS, and Web of Science to retrieve relevant articles, which were screened according to predefined selection criteria. Publication bias was assessed with a funnel plot and Egger’s regression test. A meta-analysis was conducted in RStudio version 4.5.2, using the random-effects model. Meta-regression and sensitivity analysis were conducted to assess the sources of heterogeneity and robustness of the included studies, respectively.Results:The most frequently isolated bacteria were Staphylococcus aureus (22.64%), Escherichia coli (12.37%), Pseudomonas aeruginosa (8.49%), Klebsiella pneumoniae (5.19%), P. mirabilis (4.61%), and Coagulase-negative Staphylococci (4.86%). The prevalence of key antibiotic-resistant bacteria was as follows: Methicillin-resistant S. aureus (38.65%), Extended-spectrum beta-lactamase (ESBL)-producing E. coli (50.74%), and ESBL-producing K. pneumoniae (41.54%). S. aureus demonstrated the highest resistance to penicillin (96.87% (93.30; 99.32)), azithromycin (76.42% (64.54; 86.65)), and cefoxitin (68.19% (46.83; 86.67)). E. coli showed the highest resistance to ampicillin (86.60% (77.14; 94.18)) and cotrimoxazole (69.27% (57.35; 80.18)).Conclusion:Pathogenic bacteria isolated from DFUs in LMICs exhibit high rates of antibiotic and multidrug resistance. Alternative therapies, such as phage therapy, should be explored as potential treatments for DFUs to mitigate the impact of antibiotic resistance and decrease the rate of diabetes-related amputations.Trial registration:Open Science Framework (OSF) registry, available at https://doi.org/10.17605/OSF.IO/DPX9F.

- For patients battling both diabetes and cancer, even a small foot wound can carry devastating consequences. Chemotherapy, radiation, immunotherapy, and stem cell transplants all compromise immunity and circulation. Add diabetes to the mix, and the risk of diabetic foot ulcers (DFUs) and amputations rises dramatically. What’s more, even minor foot infections can force oncologists to For patients battling both diabetes and cancer, even a small foot wound can carry devastating consequences. Chemotherapy, radiation, immunotherapy, and stem cell transplants all compromise immunity and circulation. Add diabetes to the mix, and the risk of diabetic foot ulcers (DFUs) and amputations rises dramatically. What’s more, even minor foot infections can force oncologists to For patients battling both diabetes and cancer, even a small foot wound can carry devastating consequences. Chemotherapy, radiation, immunotherapy, and stem cell transplants all compromise immunity and circulation. Add diabetes to the mix, and the risk of diabetic foot ulcers (DFUs) and amputations rises dramatically. What’s more, even minor foot infections can force oncologists to - -

- Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes, often leading to lower extremity amputations. Traditional treatments, while varied, do not always prevent the progression of these ulcers, particularly in more advanced stages. However, a recent study published by Liu et al. offers hope through a novel surgical technique known as modified Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes, often leading to lower extremity amputations. Traditional treatments, while varied, do not always prevent the progression of these ulcers, particularly in more advanced stages. However, a recent study published by Liu et al. offers hope through a novel surgical technique known as modified Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes, often leading to lower extremity amputations. Traditional treatments, while varied, do not always prevent the progression of these ulcers, particularly in more advanced stages. However, a recent study published by Liu et al. offers hope through a novel surgical technique known as modified - -

- The use of Information Communication Technology Tools in Diabetic Foot Ulcers Prevention Programs: A Scoping Review Background Information Communication Technology (ICT) tools are an integral part of day-to-day human activities. However, evidence of how ICT tools are used to engage individuals with diabetes to prevent diabetic foot ulcers (DFUs) is limited. This review aims to The use of Information Communication Technology Tools in Diabetic Foot Ulcers Prevention Programs: A Scoping Review Background Information Communication Technology (ICT) tools are an integral part of day-to-day human activities. However, evidence of how ICT tools are used to engage individuals with diabetes to prevent diabetic foot ulcers (DFUs) is limited. This review aims to The use of Information Communication Technology Tools in Diabetic Foot Ulcers Prevention Programs: A Scoping Review Background Information Communication Technology (ICT) tools are an integral part of day-to-day human activities. However, evidence of how ICT tools are used to engage individuals with diabetes to prevent diabetic foot ulcers (DFUs) is limited. This review aims to - -

- A recent meta-analysis, published in Wound Repair and Regeneration, systematically examined healing rates for diabetic neuropathic foot ulcers (DFUs) in patients receiving standard-of-care treatments. The study, led by Tyler Coye and a distinguished group of co-authors, including long-time research partner Lawrence A. Lavery, underscores a critical need for improved strategies in DFU management. Key Findings The analysis A recent meta-analysis, published in Wound Repair and Regeneration, systematically examined healing rates for diabetic neuropathic foot ulcers (DFUs) in patients receiving standard-of-care treatments. The study, led by Tyler Coye and a distinguished group of co-authors, including long-time research partner Lawrence A. Lavery, underscores a critical need for improved strategies in DFU management. Key Findings The analysis A recent meta-analysis, published in Wound Repair and Regeneration, systematically examined healing rates for diabetic neuropathic foot ulcers (DFUs) in patients receiving standard-of-care treatments. The study, led by Tyler Coye and a distinguished group of co-authors, including long-time research partner Lawrence A. Lavery, underscores a critical need for improved strategies in DFU management. Key Findings The analysis - -

Background: Diabetic foot ulcers (DFUs) are often polymicrobial infections, necessitating antibiotic therapy. However, the high prevalence of antibiotic misuse ...

- In advance of this manuscript, you might also see this manuscript from our team using similar intraoperative 3D printing (biodressing) technology In an intriguing study published in the Archives of Plastic Surgery, researchers Hyeonmin Yoon and Woojin Song have continued with a novel approach to limb salvage in the treatment of diabetic foot ulcers (DFUs) In advance of this manuscript, you might also see this manuscript from our team using similar intraoperative 3D printing (biodressing) technology In an intriguing study published in the Archives of Plastic Surgery, researchers Hyeonmin Yoon and Woojin Song have continued with a novel approach to limb salvage in the treatment of diabetic foot ulcers (DFUs) In advance of this manuscript, you might also see this manuscript from our team using similar intraoperative 3D printing (biodressing) technology In an intriguing study published in the Archives of Plastic Surgery, researchers Hyeonmin Yoon and Woojin Song have continued with a novel approach to limb salvage in the treatment of diabetic foot ulcers (DFUs) - -

- David G. Armstrong, DPM, MD, PhD, Keck School of Medicine at the University of Southern California, discusses his recently published study "Nutrition Interventions in Adults with Diabetic Foot Ulcers" in which he shares the importance of having flexibility with nutritional intervention when treating diabetic foot ulcers (click through for video). More information here about DFUs: David G. Armstrong, DPM, MD, PhD, Keck School of Medicine at the University of Southern California, discusses his recently published study "Nutrition Interventions in Adults with Diabetic Foot Ulcers" in which he shares the importance of having flexibility with nutritional intervention when treating diabetic foot ulcers (click through for video). More information here about DFUs: David G. Armstrong, DPM, MD, PhD, Keck School of Medicine at the University of Southern California, discusses his recently published study "Nutrition Interventions in Adults with Diabetic Foot Ulcers" in which he shares the importance of having flexibility with nutritional intervention when treating diabetic foot ulcers (click through for video). More information here about DFUs: - -

- Intriguing work from Xu and coworkers showing a continued march toward improvement in AI Models. As the input improves, output will follow! Abstract Diabetic foot ulcers (DFUs) are one of the most common complications of diabetes. Identifying the presence of infection and ischemia in DFU is important for ulcer examination and treatment planning. Recently, the Intriguing work from Xu and coworkers showing a continued march toward improvement in AI Models. As the input improves, output will follow! Abstract Diabetic foot ulcers (DFUs) are one of the most common complications of diabetes. Identifying the presence of infection and ischemia in DFU is important for ulcer examination and treatment planning. Recently, the Intriguing work from Xu and coworkers showing a continued march toward improvement in AI Models. As the input improves, output will follow! Abstract Diabetic foot ulcers (DFUs) are one of the most common complications of diabetes. Identifying the presence of infection and ischemia in DFU is important for ulcer examination and treatment planning. Recently, the - -

- A new multicenter randomized controlled trial (RCT) from our combined team, published in the International Wound Journal, has reported that a borate-based bioactive glass fiber matrix (BBGFM) appears to significantly improve healing outcomes in people with chronic, non-healing non-infected, non-ischemic full-thickness diabetic foot ulcers (DFUs). Study Design The trial enrolled 148 participants across 14 U.S. A new multicenter randomized controlled trial (RCT) from our combined team, published in the International Wound Journal, has reported that a borate-based bioactive glass fiber matrix (BBGFM) appears to significantly improve healing outcomes in people with chronic, non-healing non-infected, non-ischemic full-thickness diabetic foot ulcers (DFUs). Study Design The trial enrolled 148 participants across 14 U.S. A new multicenter randomized controlled trial (RCT) from our combined team, published in the International Wound Journal, has reported that a borate-based bioactive glass fiber matrix (BBGFM) appears to significantly improve healing outcomes in people with chronic, non-healing non-infected, non-ischemic full-thickness diabetic foot ulcers (DFUs). Study Design The trial enrolled 148 participants across 14 U.S. - -

- Important and subtle work from Gustav Jarl and coworkers in Sweden and Australia. It speaks to the trend to be doing things with our patients and not to them. Background: Non-removable knee-high devices are the gold-standard offloading treatments to heal plantar diabetic foot ulcers (DFUs). These devices are underused in practice for a variety of reasons. Important and subtle work from Gustav Jarl and coworkers in Sweden and Australia. It speaks to the trend to be doing things with our patients and not to them. Background: Non-removable knee-high devices are the gold-standard offloading treatments to heal plantar diabetic foot ulcers (DFUs). These devices are underused in practice for a variety of reasons. Important and subtle work from Gustav Jarl and coworkers in Sweden and Australia. It speaks to the trend to be doing things with our patients and not to them. Background: Non-removable knee-high devices are the gold-standard offloading treatments to heal plantar diabetic foot ulcers (DFUs). These devices are underused in practice for a variety of reasons. - -