#DMMPerspective
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dmmjournal.bsky.social
Excited to see Ewa Snaar-Jagalska talk today at #ZDM19? Check out her recent #DMMPerspective article with Gabriel Forn-Cuní, Bruno Lopes-Bastos, David Langenau & Liz Patton on the evolution of #zebrafish models of #cancer

doi.org/10.1242/dmm....

@zdmsociety.bsky.social
September 29, 2026 at 9:38 AM
dmmjournal.bsky.social
Bats can carry deadly viruses without getting sick. Now, Ng & Wang give a timely & fascinating #DMMPerspective on the possible translation of discoveries from bats to humans, in the context of treating and preventing #infectiousdiseases. 🦇🧫 doi.org/10.1242/dmm....
Translational value of bat research to humans. (A-D) Investigating emerging infectious disease (A), inflammation (B), longevity (C), metabolism (D).
November 4, 2025 at 5:21 PM
dmmjournal.bsky.social
A new #DMMPerspective from Wenqing Xu & @aleprigio.bsky.social explores increasing evidence of #neurodevelopmental aspects in #HuntingtonsDisease & early interventions that might lead to prevention or delay of the disease pathology

journals.biologists.com/dmm/article/...
Diagram illustrating altered neurodevelopment in Huntington’s disease (HD) and proposed early interventions. The top row shows a healthy brain trajectory: wild-type huntingtin (wtHTT) supports normal development from a healthy developing brain to a healthy adult brain. The bottom row shows HD trajectory: presence of mutant huntingtin (mHTT) leads to an aberrant developing brain and later regional brain atrophy. Below, two intervention strategies to preserve developmental compensation are shown: Cell-autonomous approaches target stress response mechanisms (CHCHD2, DRP1, ATM, HSF1, other factors) to preserve mitochondrial health; Non-cell-autonomous approaches support intercellular communication, with compensation by cerebellum, healthy cells, and glial cells.
November 21, 2025 at 7:03 PM
dmmjournal.bsky.social
In this #DMMPerspective, Diane Sepich & co discuss how pre-clinical models of adolescent idiopathic scoliosis (AIS) are urgently needed to speed etiologic and therapeutic discoveries, even if they do not perfectly recapitulate all aspects of the disease.

doi.org/10.1242/dmm....

#scoliosis
Adolescent idiopathic scoliosis (AIS) is a spine growth disorder caused by interplay (depicted as puzzle pieces) of the effects of genetics, sex hormones and mechanical stress on the spine during rapid growth. Missing pieces represent our current lack of understanding of AIS etiology.
October 6, 2025 at 8:18 AM
dmmjournal.bsky.social
In this #DMMPerspective, Claire Adams, Duncan Rutherford, Gareth Jones & Gwo-tzer Ho provide an overview of mitochondrial and metabolic aberrations come across in #InflammatoryBowelDisease and discuss potential immunometabolic therapies as emerging novel approaches for #IBD.

bit.ly/414MhxY
Headshots of Claire E. Adams, Duncan G. Rutherford, Gareth R. Jones and Gwo-tzer Ho (left to right)
November 27, 2024 at 8:12 AM