Background: Increasingly, individuals are seeking treatment for sexual health concerns through direct-to-consumer (DTC) telehealth platforms, and there is ongoing debate about whether such platforms can deliver safe and effective care. Objective: The objective of this study was to examine how men who sought sexual health treatment through a large national DTC telehealth platform viewed the quality and safety of their care, and how these perceptions differed from those of men who sought other types of treatment through the platform. Methods: We conducted a retrospective analysis of data gathered from an online survey sent to individuals who accessed treatment through the DTC telehealth platform. Individuals completed the survey between June 30, 2025, and July 3, 2025. The survey consisted of 4 sets of items that asked respondents about their perceptions of the quality and safety of the care they accessed. We used descriptive statistics to summarize individuals’ responses to survey items and chi-square tests to compare the responses of those who accessed sexual health treatment with those who accessed other types of treatment. Results: The survey was completed by 497 men who accessed sexual health treatment and 512 men who accessed other types of treatment through the platform. Among sexual health participants, 397 of 497 (≥80%) reported favorable impressions of the quality and safety of care across most survey items. Sexual health participants were more likely than nonsexual health participants to view the online intake as similar to an in-person appointment (²=12.4;