#FirstLove #DendriticCellPower! Fernandes Rodrigues, Wu, Colonna &co show @CellCellPress that Rorgt DCs, not ILC3s, are fundamental to maintain gut Tregs, preventing Th2 cell expansion & #food #allergy! www.cell.com/cell/fulltex...
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens
Deleting a regulatory element in the Rorc gene depletes RORγt+ dendritic cells from
the intestine in mice, leading to a reduction of regulatory T cells and impaired oral
tolerance to antigens. This wo...
www.cell.com
April 4, 2025 at 10:54 AM
#FirstLove #DendriticCellPower! Fernandes Rodrigues, Wu, Colonna &co show @CellCellPress that Rorgt DCs, not ILC3s, are fundamental to maintain gut Tregs, preventing Th2 cell expansion & #food #allergy! www.cell.com/cell/fulltex...
#WeekendRead! #DendriticCellPower! @reisesousalab.bsky.social @drjonlim.bsky.social &co show @natimmunol.nature.com that cDC1s exploit DNGR1 to crosspresent #tumor #neoantigens derived from F-actin binding proteins protecting against tumorigenesis but favoring cancer immunoediting!
Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology
Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...
doi.org
January 3, 2026 at 4:13 PM
#WeekendRead! #DendriticCellPower! @reisesousalab.bsky.social @drjonlim.bsky.social &co show @natimmunol.nature.com that cDC1s exploit DNGR1 to crosspresent #tumor #neoantigens derived from F-actin binding proteins protecting against tumorigenesis but favoring cancer immunoediting!
#WeekendRead! #DendriticCellPower #FirstLove! Wang Zou &co show @nature.com that #NotAllSTATsAreEqual & STAT3 restrains anti-tumor DC functions driven by STAT5. STAT3 degraders protect against advanced, metastatic, & immunecheckpoint blockade-resistant cancers! www.nature.com/articles/s41...
STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity - Nature
Immune checkpoint blockade activates T cell immunity by reprogramming the STAT3 and STAT5 transcriptional pathways in dendritic cells, and STAT3 degradation is effective for treating tumours...
www.nature.com
May 18, 2025 at 3:46 PM
#WeekendRead! #DendriticCellPower #FirstLove! Wang Zou &co show @nature.com that #NotAllSTATsAreEqual & STAT3 restrains anti-tumor DC functions driven by STAT5. STAT3 degraders protect against advanced, metastatic, & immunecheckpoint blockade-resistant cancers! www.nature.com/articles/s41...