- Antiarythmiques : amiodarone, disopyramide, hydroquinidine, quinidine, sotalol
- Antidépresseurs : citalopram et escitalopram
- Antiémétiques : dompéridone
- Antihistaminiques : méquitazine, mizolastine
- Antiparasitaires : chloroquine, halofantrine, luméfantrine ⤵️
- Antidépresseurs : citalopram et escitalopram
- Antiémétiques : dompéridone
- Antihistaminiques : méquitazine, mizolastine
- Antiparasitaires : chloroquine, halofantrine, luméfantrine ⤵️
October 23, 2025 at 4:42 PM
- Antiarythmiques : amiodarone, disopyramide, hydroquinidine, quinidine, sotalol
- Antidépresseurs : citalopram et escitalopram
- Antiémétiques : dompéridone
- Antihistaminiques : méquitazine, mizolastine
- Antiparasitaires : chloroquine, halofantrine, luméfantrine ⤵️
- Antidépresseurs : citalopram et escitalopram
- Antiémétiques : dompéridone
- Antihistaminiques : méquitazine, mizolastine
- Antiparasitaires : chloroquine, halofantrine, luméfantrine ⤵️
Is #Aficamten Plus #Disopyramide More Effective Than Aficamten Alone in obstructive HCM?
#CardioSky #JACCHF
www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @jimjanuzzi.bsky.social @robmentz.bsky.social @hvanspall.bsky.social @vietheartpa.bsky.social @load-dependent.bsky.social
#CardioSky #JACCHF
www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @jimjanuzzi.bsky.social @robmentz.bsky.social @hvanspall.bsky.social @vietheartpa.bsky.social @load-dependent.bsky.social
May 9, 2025 at 3:30 AM
Is #Aficamten Plus #Disopyramide More Effective Than Aficamten Alone in obstructive HCM?
#CardioSky #JACCHF
www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @jimjanuzzi.bsky.social @robmentz.bsky.social @hvanspall.bsky.social @vietheartpa.bsky.social @load-dependent.bsky.social
#CardioSky #JACCHF
www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @jimjanuzzi.bsky.social @robmentz.bsky.social @hvanspall.bsky.social @vietheartpa.bsky.social @load-dependent.bsky.social
Which 1️⃣ of the following is the best recommendation?
A. Mavacamten w/ obstructive HCM
B. Mavacamten w/ nonobstructive HCM
C. Surgical myectomy w/ obstructive HCM
D. Disopyramide w/ obstructive HCM
E. None of the above
Read the case details & comment below! 👇
#CardioSky #MedSky #ACCEd
A. Mavacamten w/ obstructive HCM
B. Mavacamten w/ nonobstructive HCM
C. Surgical myectomy w/ obstructive HCM
D. Disopyramide w/ obstructive HCM
E. None of the above
Read the case details & comment below! 👇
#CardioSky #MedSky #ACCEd
December 12, 2024 at 3:58 PM
Which 1️⃣ of the following is the best recommendation?
A. Mavacamten w/ obstructive HCM
B. Mavacamten w/ nonobstructive HCM
C. Surgical myectomy w/ obstructive HCM
D. Disopyramide w/ obstructive HCM
E. None of the above
Read the case details & comment below! 👇
#CardioSky #MedSky #ACCEd
A. Mavacamten w/ obstructive HCM
B. Mavacamten w/ nonobstructive HCM
C. Surgical myectomy w/ obstructive HCM
D. Disopyramide w/ obstructive HCM
E. None of the above
Read the case details & comment below! 👇
#CardioSky #MedSky #ACCEd
Ibutilide is a niche drug but I love it
there is a risk of TdP but that's minimized if you're aggressive with IV magnesium
in non-intubated pts it often chemically cardioverts them avoiding need for DCCV
if it fails to chemically cardiovert, it augments DCCV efficacy
emcrit.org/ibcc/antiarr...
there is a risk of TdP but that's minimized if you're aggressive with IV magnesium
in non-intubated pts it often chemically cardioverts them avoiding need for DCCV
if it fails to chemically cardiovert, it augments DCCV efficacy
emcrit.org/ibcc/antiarr...
Antiarrhythmics
CONTENTS Class 0: HCN channel modulators Ivabradine Class 1: Voltage-gated Na channel blockers 1a: Intermediate dissociation kinetics Procainamide Quinidine Disopyramide 1b: Fast dissociation kinetics...
emcrit.org
February 12, 2025 at 2:19 AM
Ibutilide is a niche drug but I love it
there is a risk of TdP but that's minimized if you're aggressive with IV magnesium
in non-intubated pts it often chemically cardioverts them avoiding need for DCCV
if it fails to chemically cardiovert, it augments DCCV efficacy
emcrit.org/ibcc/antiarr...
there is a risk of TdP but that's minimized if you're aggressive with IV magnesium
in non-intubated pts it often chemically cardioverts them avoiding need for DCCV
if it fails to chemically cardiovert, it augments DCCV efficacy
emcrit.org/ibcc/antiarr...
#EHJCVI 🫀 What are the effects of disopyramide and mavacamten on myocardial mechanics? Only mavacamten reduced LV mechanical dispersion and GWW, while improving GWE in obstructive HCM. LVMD <72 ms at follow-up is useful to predict VT or SCA ⚡ doi.org/10.1093/ehjc... #MedSky @jgrapsa.bsky.social
November 15, 2025 at 6:06 PM
#EHJCVI 🫀 What are the effects of disopyramide and mavacamten on myocardial mechanics? Only mavacamten reduced LV mechanical dispersion and GWW, while improving GWE in obstructive HCM. LVMD <72 ms at follow-up is useful to predict VT or SCA ⚡ doi.org/10.1093/ehjc... #MedSky @jgrapsa.bsky.social
8/Mavacamten: A Game-Changer. First-in-class cardiac myosin inhibitor:
• Reduces contractility and obstruction
• Improves symptoms and QOL
LVEF must be monitored (REMS requirement).
• Reduces contractility and obstruction
• Improves symptoms and QOL
LVEF must be monitored (REMS requirement).
September 30, 2025 at 5:42 PM
8/Mavacamten: A Game-Changer. First-in-class cardiac myosin inhibitor:
• Reduces contractility and obstruction
• Improves symptoms and QOL
LVEF must be monitored (REMS requirement).
• Reduces contractility and obstruction
• Improves symptoms and QOL
LVEF must be monitored (REMS requirement).
6/Ryan’s diagnosis of oHCM:
• IVS = 17 mm
• SAM of MV
• Resting gradient = 21 mm Hg
• Provoked = 75 mm Hg
His symptoms are also having a negative effect on him. More than 50% of patients with HCM said their symptoms have a severe or moderate impact on their daily activities.
• IVS = 17 mm
• SAM of MV
• Resting gradient = 21 mm Hg
• Provoked = 75 mm Hg
His symptoms are also having a negative effect on him. More than 50% of patients with HCM said their symptoms have a severe or moderate impact on their daily activities.
November 10, 2025 at 4:13 PM
6/Ryan’s diagnosis of oHCM:
• IVS = 17 mm
• SAM of MV
• Resting gradient = 21 mm Hg
• Provoked = 75 mm Hg
His symptoms are also having a negative effect on him. More than 50% of patients with HCM said their symptoms have a severe or moderate impact on their daily activities.
• IVS = 17 mm
• SAM of MV
• Resting gradient = 21 mm Hg
• Provoked = 75 mm Hg
His symptoms are also having a negative effect on him. More than 50% of patients with HCM said their symptoms have a severe or moderate impact on their daily activities.
5/Mavacamten, an allosteric, reversible inhibitor selective for cardiac myosin, is the first agent designed specifically to treat oHCM. We’ve been using agents (ie, beta blockers, calcium channel blockers, disopyramide) designed for other purposes to alleviate oHCM symptoms.
January 7, 2025 at 6:46 PM
5/Mavacamten, an allosteric, reversible inhibitor selective for cardiac myosin, is the first agent designed specifically to treat oHCM. We’ve been using agents (ie, beta blockers, calcium channel blockers, disopyramide) designed for other purposes to alleviate oHCM symptoms.
#EHJCVI 🫀 How to choose between 2nd line therapies for HOCM ? 🤔 Mavacamten, but not disopyramide, ⬇️ LV mechanical dispersion and GWW, while ⬆️ GWE in a cohort of 120 #HCM pts ⚡Those under #CMI also showed fewer arrhythmic events. Read more: doi.org/10.1093/ehjc... #MedSky
January 22, 2026 at 8:10 PM
#EHJCVI 🫀 How to choose between 2nd line therapies for HOCM ? 🤔 Mavacamten, but not disopyramide, ⬇️ LV mechanical dispersion and GWW, while ⬆️ GWE in a cohort of 120 #HCM pts ⚡Those under #CMI also showed fewer arrhythmic events. Read more: doi.org/10.1093/ehjc... #MedSky
Three antiarrhythmic drugs out of stock: DHSC
Key Summary Three antiarrhythmic drugs will be out of stock at different stages over the coming months. They are propafenone (arythmol) 150mg tablets, disopyramide ( rythmodan) 100mg capsules and disopyramide (rythmodan retard) 250mg. DHSC has…
Key Summary Three antiarrhythmic drugs will be out of stock at different stages over the coming months. They are propafenone (arythmol) 150mg tablets, disopyramide ( rythmodan) 100mg capsules and disopyramide (rythmodan retard) 250mg. DHSC has…
Three antiarrhythmic drugs out of stock: DHSC
Key Summary Three antiarrhythmic drugs will be out of stock at different stages over the coming months. They are propafenone (arythmol) 150mg tablets, disopyramide ( rythmodan) 100mg capsules and disopyramide (rythmodan retard) 250mg. DHSC has suggested alternatives and precautions to be taken . Three antiarrhythmic drugs will be out of stock at different stages over the coming months, the Department of Health and Social Care (DHSC) has announced in two medicine supply notifications. In two separate Tier 2 (medium impact) notifications issued on June 22, DHSC announced that propafenone (arythmol) 150mg tablets, disopyramide (rythmodan) 100mg capsules and disopyramide (rythmodan retard) 250mg modified-release tablets will be affected by supply issues. Disopyramide ( Rythmodan) 100mg capsules will be in out of stock from late June 2026 until early April 2027. Disopyramide ( Rythmodan Retard) 250mg modified release (MR) tablets will be out of stock from late June until late July 2026 and can support a partial uplift in demand once available. The imports of disopyramide 250mg MR tablets and disopyramide 100mg capsules are in limited supply and cannot support an uplift in demand. Propafenone ( Arythmol) 150mg tablets are out of stock until late July 2026. Propafenone (Arythmol) 300mg tablets remain available and can support a limited increase in demand. However, DHSC said that they should not be halved to deliver a 150mg dose. Flecainide 50mg and 100mg tablets remain available to support the shift. The medicine regulator has advised to take into account medical and treatment history, previous hypersensitivity and adverse reactions, and ensure patients are counseled on the appropriate dose. All three affected medications are class 1c antiarrhythmic drugs used to prevent irregular heartbeats, such as atrial fibrillation, from recurring in patients who do not have structural heart disease. As part of its guidance, the DHSC stated that clinicians should not initiate new patients on propafenone 150mg tablets until the supply issue has been fully resolved.
news-area.com
June 25, 2026 at 12:58 AM
Three antiarrhythmic drugs out of stock: DHSC
Key Summary Three antiarrhythmic drugs will be out of stock at different stages over the coming months. They are propafenone (arythmol) 150mg tablets, disopyramide ( rythmodan) 100mg capsules and disopyramide (rythmodan retard) 250mg. DHSC has…
Key Summary Three antiarrhythmic drugs will be out of stock at different stages over the coming months. They are propafenone (arythmol) 150mg tablets, disopyramide ( rythmodan) 100mg capsules and disopyramide (rythmodan retard) 250mg. DHSC has…
6/Ryan’s diagnosis of oHCM:
• IVS = 17 mm
• SAM of MV
• Resting gradient = 21 mm Hg
• Provoked = 75 mm Hg
His symptoms are also having a negative effect on him. More than 50% of patients with HCM said their symptoms have a severe or moderate impact on their daily activities.
• IVS = 17 mm
• SAM of MV
• Resting gradient = 21 mm Hg
• Provoked = 75 mm Hg
His symptoms are also having a negative effect on him. More than 50% of patients with HCM said their symptoms have a severe or moderate impact on their daily activities.
November 6, 2025 at 5:10 PM
6/Ryan’s diagnosis of oHCM:
• IVS = 17 mm
• SAM of MV
• Resting gradient = 21 mm Hg
• Provoked = 75 mm Hg
His symptoms are also having a negative effect on him. More than 50% of patients with HCM said their symptoms have a severe or moderate impact on their daily activities.
• IVS = 17 mm
• SAM of MV
• Resting gradient = 21 mm Hg
• Provoked = 75 mm Hg
His symptoms are also having a negative effect on him. More than 50% of patients with HCM said their symptoms have a severe or moderate impact on their daily activities.
This week's #drugshortages
▶️ Arythmol 150mg tablets (propafenone)
▶️ Kelhale 50 microgram and 100 microgram per puff inhalers (beclometasone)
▶️ Rythmodan (disopyramide)
For more information, see the MIMS Drug Shortages tracker
buff.ly/U4AmhZO
▶️ Arythmol 150mg tablets (propafenone)
▶️ Kelhale 50 microgram and 100 microgram per puff inhalers (beclometasone)
▶️ Rythmodan (disopyramide)
For more information, see the MIMS Drug Shortages tracker
buff.ly/U4AmhZO
June 24, 2026 at 10:00 AM
This week's #drugshortages
▶️ Arythmol 150mg tablets (propafenone)
▶️ Kelhale 50 microgram and 100 microgram per puff inhalers (beclometasone)
▶️ Rythmodan (disopyramide)
For more information, see the MIMS Drug Shortages tracker
buff.ly/U4AmhZO
▶️ Arythmol 150mg tablets (propafenone)
▶️ Kelhale 50 microgram and 100 microgram per puff inhalers (beclometasone)
▶️ Rythmodan (disopyramide)
For more information, see the MIMS Drug Shortages tracker
buff.ly/U4AmhZO
Les tensions d’approvisionnement en Rythmodan 250 mg LP, comprimé enrobé (disopyramide), se poursuivent.
Rythmodan 100 mg ou spécialités étrangères : l’ANSM adapte ses recommandations face aux tensions
L’importation d’une spécialité néerlandaise avait déjà été autorisée en mars. C’est désormais le cas d’une autre, belge. En cas d’indisponibilité de Rythmodan 250 mg LP, les pharmaciens peuvent continuer à dispenser Rythmodan 100 mg, gélule, sans...
www.lequotidiendumedecin.fr
May 29, 2025 at 11:05 AM
Les tensions d’approvisionnement en Rythmodan 250 mg LP, comprimé enrobé (disopyramide), se poursuivent.