#OncSky #DrugDevelopment ⬇️⬇️⬇️
Wow—one of the most impressive bench-to-bedside stories you’re ever going to see out today @Nature
Spatial proteomics of potentially fatal toxic epidermal necrolysis/Stevens-Johnson Syndrome drug reactions identifies JAK/STAT pathway inhibition as effective therapy!
www.nature.com/articles/s41...
Spatial proteomics of potentially fatal toxic epidermal necrolysis/Stevens-Johnson Syndrome drug reactions identifies JAK/STAT pathway inhibition as effective therapy!
www.nature.com/articles/s41...
November 24, 2024 at 2:20 AM
#OncSky #DrugDevelopment ⬇️⬇️⬇️
A very cool thing about getting older in medicine: eventually you see a dreaded disease of your early career succumb to science. Once you witness it a few times, nothing will seem impossible to you in the same way ever again. #MedSky #DrugDevelopment
February 27, 2025 at 4:39 AM
A very cool thing about getting older in medicine: eventually you see a dreaded disease of your early career succumb to science. Once you witness it a few times, nothing will seem impossible to you in the same way ever again. #MedSky #DrugDevelopment
📣 NEW study compares #LongCovidKids to kids fully recovered from #COVID19 & uninfected controls: kids w/ #LongCovid have impaired neutrophil function w/ ⬇️ superoxide activity & phagocytosis. Symptoms correlated w/ defect. #MedSky #IDSky #PedSky #DrugDevelopment
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 27, 2024 at 3:33 PM
📣 NEW study compares #LongCovidKids to kids fully recovered from #COVID19 & uninfected controls: kids w/ #LongCovid have impaired neutrophil function w/ ⬇️ superoxide activity & phagocytosis. Symptoms correlated w/ defect. #MedSky #IDSky #PedSky #DrugDevelopment
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🧪 The importance of #NIH in #DrugDevelopment
99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...
Comparison of Research Spending on New Drug Approvals by the NIH vs the Pharmaceutical Industry
This cross-sectional study examines National Institutes of Health and pharmaceutical industry investments in recent drug approvals.
jamanetwork.com
March 10, 2025 at 3:20 PM
🧪 The importance of #NIH in #DrugDevelopment
A father's quest to save his daughter from a ultra-rare genetic disorder is transforming how the FDA approaches gene therapy development. The Wilse…
#Drugdevelopment #Genetherapy #NGLY1deficiency #Patientadvocacy #Precisionmedicine
#Drugdevelopment #Genetherapy #NGLY1deficiency #Patientadvocacy…
#Drugdevelopment #Genetherapy #NGLY1deficiency #Patientadvocacy #Precisionmedicine
#Drugdevelopment #Genetherapy #NGLY1deficiency #Patientadvocacy…
Patient Advocacy Reshapes Rare Disease Research
A father's quest to save his daughter from a ultra-rare genetic disorder is transforming how the FDA approaches gene therapy development. The Wilse…
#Drugdevelopment #Genetherapy #NGLY1deficiency #Patientadvocacy #Precisionmedicine
news.gmj.ge
September 25, 2026 at 9:27 PM
A father's quest to save his daughter from a ultra-rare genetic disorder is transforming how the FDA approaches gene therapy development. The Wilse…
#Drugdevelopment #Genetherapy #NGLY1deficiency #Patientadvocacy #Precisionmedicine
#Drugdevelopment #Genetherapy #NGLY1deficiency #Patientadvocacy…
#Drugdevelopment #Genetherapy #NGLY1deficiency #Patientadvocacy #Precisionmedicine
#Drugdevelopment #Genetherapy #NGLY1deficiency #Patientadvocacy…
Excited to join BlueSky! Will share insights in #intestine #stemcells #cancer #organoids #drugdevelopment and others. Blue image credentials: Luminal surface of the small intestine, Anne Rios. Goblet cells red, enterocytes blue
December 1, 2024 at 2:18 PM
Excited to join BlueSky! Will share insights in #intestine #stemcells #cancer #organoids #drugdevelopment and others. Blue image credentials: Luminal surface of the small intestine, Anne Rios. Goblet cells red, enterocytes blue
#SABCS24 I’ll be speaking on Designing Patient-Centric #clinicaltrials. Join us Tues 12/10 2:30-4p CST! Thanks to my #bcsm #advocacy friends who weighed in. People w/ cancer & caregivers, what makes you join a trial (or not)? #PatientExperience
bit.ly/4iknAnl
#OncoAlert #OncSky #DrugDevelopment
bit.ly/4iknAnl
#OncoAlert #OncSky #DrugDevelopment
December 9, 2024 at 2:08 PM
#SABCS24 I’ll be speaking on Designing Patient-Centric #clinicaltrials. Join us Tues 12/10 2:30-4p CST! Thanks to my #bcsm #advocacy friends who weighed in. People w/ cancer & caregivers, what makes you join a trial (or not)? #PatientExperience
bit.ly/4iknAnl
#OncoAlert #OncSky #DrugDevelopment
bit.ly/4iknAnl
#OncoAlert #OncSky #DrugDevelopment
#MedSky #IDSky
📢 Prospective cohort study (CO-FLOW) of adults hospitalized for #COVID19 finds only 1 in 8 fully recovered at 3m, & only 1 in 4 at 3y. More than half had ⬇️ memory & concentration at 3y. This is #LongCovid. HUGE unmet #DrugDevelopment need.
www.thelancet.com/action/showP...
📢 Prospective cohort study (CO-FLOW) of adults hospitalized for #COVID19 finds only 1 in 8 fully recovered at 3m, & only 1 in 4 at 3y. More than half had ⬇️ memory & concentration at 3y. This is #LongCovid. HUGE unmet #DrugDevelopment need.
www.thelancet.com/action/showP...
July 11, 2025 at 5:21 AM
#MedSky #IDSky
📢 Prospective cohort study (CO-FLOW) of adults hospitalized for #COVID19 finds only 1 in 8 fully recovered at 3m, & only 1 in 4 at 3y. More than half had ⬇️ memory & concentration at 3y. This is #LongCovid. HUGE unmet #DrugDevelopment need.
www.thelancet.com/action/showP...
📢 Prospective cohort study (CO-FLOW) of adults hospitalized for #COVID19 finds only 1 in 8 fully recovered at 3m, & only 1 in 4 at 3y. More than half had ⬇️ memory & concentration at 3y. This is #LongCovid. HUGE unmet #DrugDevelopment need.
www.thelancet.com/action/showP...
#Science #Entrepeneurship #Company #StartUp #Founding #DrugDiscovery #DrugDevelopment #ChemSky #ChemBio
(7/7)
(7/7)
May 21, 2026 at 4:04 PM
Nanotechnology to Enhance Mitochondria & Heal the Brain | Rob Etherington & Mark Mortenson Interview
youtu.be/Xn9Shp2ssNo
#MultipleSclerosis #Parkinsons #DrugDevelopment #mitochondria #brain #Nanomedicine #neuroscience #neurology #Aging #NAD
youtu.be/Xn9Shp2ssNo
#MultipleSclerosis #Parkinsons #DrugDevelopment #mitochondria #brain #Nanomedicine #neuroscience #neurology #Aging #NAD
youtu.be
January 5, 2025 at 4:48 PM
Nanotechnology to Enhance Mitochondria & Heal the Brain | Rob Etherington & Mark Mortenson Interview
youtu.be/Xn9Shp2ssNo
#MultipleSclerosis #Parkinsons #DrugDevelopment #mitochondria #brain #Nanomedicine #neuroscience #neurology #Aging #NAD
youtu.be/Xn9Shp2ssNo
#MultipleSclerosis #Parkinsons #DrugDevelopment #mitochondria #brain #Nanomedicine #neuroscience #neurology #Aging #NAD
#MedSky
The EMA, the #regulatory equivalent to FDA for the European Union, has moved from Twitter to BlueSky:
@ema.europa.eu.
They’re a great source of info on #publichealth, #drugdevelopment, & more.
The EMA, the #regulatory equivalent to FDA for the European Union, has moved from Twitter to BlueSky:
@ema.europa.eu.
They’re a great source of info on #publichealth, #drugdevelopment, & more.
a man is looking at his cell phone with a follow button in the background .
ALT: a man is looking at his cell phone with a follow button in the background .
media.tenor.com
January 28, 2025 at 5:14 PM
#MedSky
The EMA, the #regulatory equivalent to FDA for the European Union, has moved from Twitter to BlueSky:
@ema.europa.eu.
They’re a great source of info on #publichealth, #drugdevelopment, & more.
The EMA, the #regulatory equivalent to FDA for the European Union, has moved from Twitter to BlueSky:
@ema.europa.eu.
They’re a great source of info on #publichealth, #drugdevelopment, & more.
Dive into the world of #drugdevelopment w/ C-Path's #YouTube channel! Subscribe now for access to on-demand content including meetings, webinars, interviews, and more. Stay informed, stay inspired! Subscribe here: https://f.mtr.cool/ovp6irbmfh
September 25, 2026 at 7:32 PM
Dive into the world of #drugdevelopment w/ C-Path's #YouTube channel! Subscribe now for access to on-demand content including meetings, webinars, interviews, and more. Stay informed, stay inspired! Subscribe here: https://f.mtr.cool/ovp6irbmfh
#MedSky🧪 #Academicsky This are excellent & Useful Core Metabolic Roadmap for #clinicalreserch & #Drugdevelopment
🎯Core Metabolic Roadmap
How to get the molecules that are needed, when they’re needed.
Source & High resolution:
Bibel, B., & The bumbling biochemist. (2024). Core Metabolic Roadmap. Zenodo.
zenodo.org/records/1336...
How to get the molecules that are needed, when they’re needed.
Source & High resolution:
Bibel, B., & The bumbling biochemist. (2024). Core Metabolic Roadmap. Zenodo.
zenodo.org/records/1336...
December 4, 2024 at 6:33 AM
#MedSky🧪 #Academicsky This are excellent & Useful Core Metabolic Roadmap for #clinicalreserch & #Drugdevelopment
#MedSky🧪 #IDsky #ImmunoSky #NeuroSky #Drugdevelopment #Drugdiscovery Age & disease-associated stressors that drive inflammation, reactive oxygen species, toxic protein accumulation, metabolic dysregulation or #DNAdamage may cause #senescence in many cell types, incl neurons .
November 15, 2024 at 7:22 AM
#MedSky🧪 #IDsky #ImmunoSky #NeuroSky #Drugdevelopment #Drugdiscovery Age & disease-associated stressors that drive inflammation, reactive oxygen species, toxic protein accumulation, metabolic dysregulation or #DNAdamage may cause #senescence in many cell types, incl neurons .
New presentation: hbiostat.org/talks/rcteff... #StatsSky #Statistics #clinicaltrial #rct #drugdevelopment #pharma
Important Considerations in Trial Design for Flexibility & Efficiency
hbiostat.org
May 5, 2026 at 1:17 PM
New presentation: hbiostat.org/talks/rcteff... #StatsSky #Statistics #clinicaltrial #rct #drugdevelopment #pharma
🧠✨ New nanoparticle therapy reverses Parkinson’s in mice
A wireless deep brain stimulation system has been developed that uses gold nanoparticles & light to clear harmful proteins & restore dopamine neurons, improving motor function.
🔗 www.science.org/doi/10.1126/...
#Parkinsons #SciComm 🧪 🧬
A wireless deep brain stimulation system has been developed that uses gold nanoparticles & light to clear harmful proteins & restore dopamine neurons, improving motor function.
🔗 www.science.org/doi/10.1126/...
#Parkinsons #SciComm 🧪 🧬
A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson’s disease
Nanoparticle-mediated wireless system reverses Parkinson’s disease.
www.science.org
January 19, 2025 at 5:46 PM
Read the full paper here (no paywall). Congrats to the authors on this important non clinical & clinical insight into #LongCovid & #NeuroCovid!
#MedSky #IDSky #NeuroSky #PsychSky #COVID19 #Advocacy #DrugDevelopment 👀
www.cell.com/action/showP...
www.cell.com/action/showP...
#MedSky #IDSky #NeuroSky #PsychSky #COVID19 #Advocacy #DrugDevelopment 👀
www.cell.com/action/showP...
www.cell.com/action/showP...
www.cell.com
November 29, 2024 at 5:09 PM
Read the full paper here (no paywall). Congrats to the authors on this important non clinical & clinical insight into #LongCovid & #NeuroCovid!
#MedSky #IDSky #NeuroSky #PsychSky #COVID19 #Advocacy #DrugDevelopment 👀
www.cell.com/action/showP...
www.cell.com/action/showP...
#MedSky #IDSky #NeuroSky #PsychSky #COVID19 #Advocacy #DrugDevelopment 👀
www.cell.com/action/showP...
www.cell.com/action/showP...
#MedSky #OncSky #IDSky #DrugDevelopment #MedEd
If you want to get up to speed on the #microbiome in #cancer literature, this review is an excellent summary.
jamanetwork.com/journals/jam...
If you want to get up to speed on the #microbiome in #cancer literature, this review is an excellent summary.
jamanetwork.com/journals/jam...
The Microbiome and Cancer: A Review
This review in the Translational Science series summarizes current evidence regarding the human microbiome and cancer, including how the microbiota in the gut and other anatomical locations affect can...
jamanetwork.com
May 13, 2025 at 2:28 AM
#MedSky #OncSky #IDSky #DrugDevelopment #MedEd
If you want to get up to speed on the #microbiome in #cancer literature, this review is an excellent summary.
jamanetwork.com/journals/jam...
If you want to get up to speed on the #microbiome in #cancer literature, this review is an excellent summary.
jamanetwork.com/journals/jam...
15 PhDs, 11 countries, 1 goal: Rethinking immunotherapy!
@luberod.bsky.social leads #UNLIMITED, a newly EU-funded Marie Skłodowska-Curie Actions #MSCA Doctoral Network on lipid #immunometabolism with €4.5m for cutting-edge science!! Congratulationss!
#immunology
#bioinformatics
#drugdevelopment
@luberod.bsky.social leads #UNLIMITED, a newly EU-funded Marie Skłodowska-Curie Actions #MSCA Doctoral Network on lipid #immunometabolism with €4.5m for cutting-edge science!! Congratulationss!
#immunology
#bioinformatics
#drugdevelopment
April 15, 2025 at 1:05 PM
15 PhDs, 11 countries, 1 goal: Rethinking immunotherapy!
@luberod.bsky.social leads #UNLIMITED, a newly EU-funded Marie Skłodowska-Curie Actions #MSCA Doctoral Network on lipid #immunometabolism with €4.5m for cutting-edge science!! Congratulationss!
#immunology
#bioinformatics
#drugdevelopment
@luberod.bsky.social leads #UNLIMITED, a newly EU-funded Marie Skłodowska-Curie Actions #MSCA Doctoral Network on lipid #immunometabolism with €4.5m for cutting-edge science!! Congratulationss!
#immunology
#bioinformatics
#drugdevelopment
My first-author PhD paper is out in @naturecomms.bsky.social: A “double trouble” approach—combining membrane disruption with a key cellular pathway—dramatically limits bacterial #resistance. Discover “Exploring the principles behind antibiotics with limited resistance” #AMR #DrugDevelopment #MEvoSky
🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...
Exploring the principles behind antibiotics with limited resistance - Nature Communications
This study shows that only those dual-targeting antibiotics limit resistance in Gram-negative pathogens that also target the membrane of the bacteria. This mechanism provides a basis for designing fut...
www.nature.com
February 25, 2025 at 11:02 AM
My first-author PhD paper is out in @naturecomms.bsky.social: A “double trouble” approach—combining membrane disruption with a key cellular pathway—dramatically limits bacterial #resistance. Discover “Exploring the principles behind antibiotics with limited resistance” #AMR #DrugDevelopment #MEvoSky
Dive into the world of #drugdevelopment w/ C-Path's #YouTube channel! Subscribe now for access to on-demand content including meetings, webinars, interviews, and more. Stay informed, stay inspired! Subscribe here: https://f.mtr.cool/xtrquziko5
September 24, 2026 at 7:32 PM
Dive into the world of #drugdevelopment w/ C-Path's #YouTube channel! Subscribe now for access to on-demand content including meetings, webinars, interviews, and more. Stay informed, stay inspired! Subscribe here: https://f.mtr.cool/xtrquziko5
🧵 [6/6]
A potent antibiotic… with some cytotoxicity. The road to optimization has just begun.
🌐 #DrugDevelopment #Pharmacology #Glycopeptides @arnieoflovers.bsky.social @mariposa17.bsky.social @jchilton666.bsky.social @alokjha09.bsky.social @sole25.bsky.social @michaeldonoian.bsky.social
A potent antibiotic… with some cytotoxicity. The road to optimization has just begun.
🌐 #DrugDevelopment #Pharmacology #Glycopeptides @arnieoflovers.bsky.social @mariposa17.bsky.social @jchilton666.bsky.social @alokjha09.bsky.social @sole25.bsky.social @michaeldonoian.bsky.social
August 22, 2025 at 12:02 PM
🧵 [6/6]
A potent antibiotic… with some cytotoxicity. The road to optimization has just begun.
🌐 #DrugDevelopment #Pharmacology #Glycopeptides @arnieoflovers.bsky.social @mariposa17.bsky.social @jchilton666.bsky.social @alokjha09.bsky.social @sole25.bsky.social @michaeldonoian.bsky.social
A potent antibiotic… with some cytotoxicity. The road to optimization has just begun.
🌐 #DrugDevelopment #Pharmacology #Glycopeptides @arnieoflovers.bsky.social @mariposa17.bsky.social @jchilton666.bsky.social @alokjha09.bsky.social @sole25.bsky.social @michaeldonoian.bsky.social
#Medsky🧪 #IDsky #virosky #drugdevelopment #immunosky #publichealth The 1st generation of #mRNAvaccines for #COVID were instrumental in curbing the ongoing #COVID19pandemic. However, they failed to elicit broad & durable immunity, essential for long-term protection against viral variants.
www.newscientist.com/article/2500...
#mRNA
#VaccineScience #HealthScience #CellularReality #MolecularReality #NonEquilibriumThermodynamics
#mRNA
#VaccineScience #HealthScience #CellularReality #MolecularReality #NonEquilibriumThermodynamics
Why the next generation of mRNA vaccines is set to be even better
Scientists are designing mRNA vaccines to produce virus-like nanoparticles, which should lead to a more robust immune response with even fewer side effects than either of these immunisation approaches...
www.newscientist.com
October 16, 2025 at 5:02 AM
#Medsky🧪 #IDsky #virosky #drugdevelopment #immunosky #publichealth The 1st generation of #mRNAvaccines for #COVID were instrumental in curbing the ongoing #COVID19pandemic. However, they failed to elicit broad & durable immunity, essential for long-term protection against viral variants.
STARTING SOON!
Tues 11/19/24 9:30-10:30a EST: US & EU #regulatory colleagues discuss #PedOnc & #AYACSM challenges in #cancer #DrugDevelopment.
cc @GRASPtweets @OncoAlert @ASCO @AmerAcadPeds
#leusm #sarcoma #btsm #lymsm #advocacy #OncSky #PedSky
Reg here for free: surveymonkey.com/r/5TNRXV5
Tues 11/19/24 9:30-10:30a EST: US & EU #regulatory colleagues discuss #PedOnc & #AYACSM challenges in #cancer #DrugDevelopment.
cc @GRASPtweets @OncoAlert @ASCO @AmerAcadPeds
#leusm #sarcoma #btsm #lymsm #advocacy #OncSky #PedSky
Reg here for free: surveymonkey.com/r/5TNRXV5
November 19, 2024 at 2:10 PM
STARTING SOON!
Tues 11/19/24 9:30-10:30a EST: US & EU #regulatory colleagues discuss #PedOnc & #AYACSM challenges in #cancer #DrugDevelopment.
cc @GRASPtweets @OncoAlert @ASCO @AmerAcadPeds
#leusm #sarcoma #btsm #lymsm #advocacy #OncSky #PedSky
Reg here for free: surveymonkey.com/r/5TNRXV5
Tues 11/19/24 9:30-10:30a EST: US & EU #regulatory colleagues discuss #PedOnc & #AYACSM challenges in #cancer #DrugDevelopment.
cc @GRASPtweets @OncoAlert @ASCO @AmerAcadPeds
#leusm #sarcoma #btsm #lymsm #advocacy #OncSky #PedSky
Reg here for free: surveymonkey.com/r/5TNRXV5