#Medsky🧪 #IDsky #drugsdevelopment #immunosky #publichealth Mortality, prevalence , burden of #infectiousdiseases & Unmet needs in #vaccine development @natrevdrugdiscov.nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Unmet needs in vaccine development
Discover the world’s best science and medicine | Nature.com
www.nature.com
July 10, 2025 at 6:01 PM
#Medsky🧪 #IDsky #drugsdevelopment #immunosky #publichealth Mortality, prevalence , burden of #infectiousdiseases & Unmet needs in #vaccine development @natrevdrugdiscov.nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
#Medsky🧪 #Drugdelivery #drugsdevelopment #academisky Complex Innovative Trial Design Meeting Program update
www.fda.gov/drugs/develo...
www.fda.gov/drugs/develo...
Complex Innovative Trial Design Meeting Program
Complex Innovative Designs
www.fda.gov
March 25, 2025 at 1:38 PM
#Medsky🧪 #Drugdelivery #drugsdevelopment #academisky Complex Innovative Trial Design Meeting Program update
www.fda.gov/drugs/develo...
www.fda.gov/drugs/develo...
MedSky🧪#Drugsdevelopment Various #immunecheckpointinhibitors are approved as adjuvant therapies for high-risk #melanoma (stage IIB–IV), but disease recurrence remains common.
February 23, 2024 at 7:01 AM
MedSky🧪#Drugsdevelopment Various #immunecheckpointinhibitors are approved as adjuvant therapies for high-risk #melanoma (stage IIB–IV), but disease recurrence remains common.
#Medsky🧪 #IDsky #pharmsky #drugsdevelopment #publichealth @aaas.org #obeldesivir ‘That could be a game changer’: an antiviral pill gets first test for #Ebola prevention www.science.org/content/arti...
‘That could be a game changer’: an antiviral pill gets first test for Ebola prevention
Researchers are preparing to launch an unprecedented trial to protect people exposed to Ebola in the DRC and Uganda
www.science.org
June 1, 2026 at 10:31 AM
#Medsky🧪 #IDsky #pharmsky #drugsdevelopment #publichealth @aaas.org #obeldesivir ‘That could be a game changer’: an antiviral pill gets first test for #Ebola prevention www.science.org/content/arti...
#Medsky🧪 #Drugsdevelopment What’s the worst that could happen? There's a growing concern that AI tools used to help produce innovative drugs could also make it easier to create new threats @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
AI can design viruses, toxins and other bioweapons. How worried should we be?
Scientists are debating whether to limit biological AI software to ward off threats.
www.nature.com
May 13, 2026 at 10:33 AM
#Medsky🧪 #Drugsdevelopment What’s the worst that could happen? There's a growing concern that AI tools used to help produce innovative drugs could also make it easier to create new threats @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
MedSky🧪 IDSky #PublicHealth #ClinicalTrial #Drugsdevelopment
An investigational messenger RNA (mRNA)–based vaccine designed to protect against both influenza & #COVID19 induced virus-specific #immuneresponses in people who received it
jamanetwork.com/journals/jam...
An investigational messenger RNA (mRNA)–based vaccine designed to protect against both influenza & #COVID19 induced virus-specific #immuneresponses in people who received it
jamanetwork.com/journals/jam...
Combined COVID-19, Flu Vaccine Candidate Headed to Phase 3 Trials
An investigational messenger RNA (mRNA)–based vaccine designed to protect against both influenza and COVID-19 induced virus-specific immune responses in people
jamanetwork.com
November 16, 2023 at 4:52 AM
MedSky🧪 IDSky #PublicHealth #ClinicalTrial #Drugsdevelopment
An investigational messenger RNA (mRNA)–based vaccine designed to protect against both influenza & #COVID19 induced virus-specific #immuneresponses in people who received it
jamanetwork.com/journals/jam...
An investigational messenger RNA (mRNA)–based vaccine designed to protect against both influenza & #COVID19 induced virus-specific #immuneresponses in people who received it
jamanetwork.com/journals/jam...
MedSky🧪 #IDSky #Drugsdiscovery #Drugsdevelopment #Immunopharmacology Summarize the latest advancements in the #clinicaldevelopment of #antivirals against infections by #SARSCoV2 and its variants.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Clinical development of antivirals against SARS-CoV-2 and its variants
The unceasing global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) calls for the development of novel therapeutics. Although …
www.sciencedirect.com
March 24, 2024 at 8:34 PM
MedSky🧪 #IDSky #Drugsdiscovery #Drugsdevelopment #Immunopharmacology Summarize the latest advancements in the #clinicaldevelopment of #antivirals against infections by #SARSCoV2 and its variants.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
#Medsky #oncosky #Drugsdevelopment #publichealthThe hormone erythropoietin is best known as a performance-enhancing drug & is banned from professional and college sports for its ability to boost endurance. But cheating athletes aren’t the only dubious characters using it to gain an advantage and
April 25, 2025 at 11:07 AM
#Medsky #oncosky #Drugsdevelopment #publichealthThe hormone erythropoietin is best known as a performance-enhancing drug & is banned from professional and college sports for its ability to boost endurance. But cheating athletes aren’t the only dubious characters using it to gain an advantage and
MedSky🧪IDSky #Drugsdiscovery #Drugsdevelopment Up the Nose and Down the Windpipe May Be the Path to New & Improved #COVID19Vaccines How these experimental #mucosalvaccines stack up against #mRNAvaccines and what’s in the pipeline ?
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
The Next Generation of COVID-19 Vaccines May be Inhaled
This Medical News story discusses experimental mucosal COVID-19 vaccines.
jamanetwork.com
December 7, 2023 at 6:24 AM
MedSky🧪IDSky #Drugsdiscovery #Drugsdevelopment Up the Nose and Down the Windpipe May Be the Path to New & Improved #COVID19Vaccines How these experimental #mucosalvaccines stack up against #mRNAvaccines and what’s in the pipeline ?
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
MedSky🧪 #IDSky #Viralimmunology #Clinical_ID #Drugsdevelopment perspectives #publichealth @aaas Where do we go wrong ? Pfizer’s antiviral #Paxlovid may not help as many people as hoped. The combo drug was granted emergency use authorization in 2021 in 🇺🇸
April 9, 2024 at 1:21 PM
MedSky🧪 #IDSky #Viralimmunology #Clinical_ID #Drugsdevelopment perspectives #publichealth @aaas Where do we go wrong ? Pfizer’s antiviral #Paxlovid may not help as many people as hoped. The combo drug was granted emergency use authorization in 2021 in 🇺🇸
#MedSky🧪 #IDSky #ImmunoSky #Viralimmunology #Drugsdevelopment Overview the role of #interferons in host immunity & Viral infection : from virus-host crosstalk to prophylactic and therapeutic potential in #SARSCoV2 infection.
January 15, 2024 at 7:08 AM
#MedSky🧪 #IDSky #ImmunoSky #Viralimmunology #Drugsdevelopment Overview the role of #interferons in host immunity & Viral infection : from virus-host crosstalk to prophylactic and therapeutic potential in #SARSCoV2 infection.
#MedSky🧪 #IDSky #Publichealth #Immunopharmacology #Clinical_ID #Drugsdevelopment Summary #Antivirals for #COVID19 Therapeutic Options Alt #Paxlovid
x.com/castltraston...
x.com/castltraston...
May 29, 2024 at 5:34 AM
#MedSky🧪 #IDSky #Publichealth #Immunopharmacology #Clinical_ID #Drugsdevelopment Summary #Antivirals for #COVID19 Therapeutic Options Alt #Paxlovid
x.com/castltraston...
x.com/castltraston...
MedSky🧪#IDSky #Microbiology #Drugsdevelopment where are we with Clinical development of #antivirals against #SARSCoV2 & its variants ?
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
January 22, 2024 at 11:35 PM
MedSky🧪#IDSky #Microbiology #Drugsdevelopment where are we with Clinical development of #antivirals against #SARSCoV2 & its variants ?
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
MedSky🧪 #Drugsdevelopment perspective .Safety failures are an important factor in low drug development success rates. Human genetic evidence can select drug targets causal in disease and enrich for successful programs.
Human genetic evidence enriched for side effects of approved drugs https://www.medrxiv.org/content/10.1101/2023.12.12.23299869v1
Human genetic evidence enriched for side effects of approved drugs https://www.medrxiv.org/content/10.1101/2023.12.12.23299869v1
Safety failures are an important factor in low drug development success rates. Human genetic evidenc
www.medrxiv.org
December 14, 2023 at 3:43 AM
MedSky🧪 #Drugsdevelopment perspective .Safety failures are an important factor in low drug development success rates. Human genetic evidence can select drug targets causal in disease and enrich for successful programs.
MedSky🧪 #Drugsdelivery #Drugsdevelopment #IDsky RNA Vaccines .A step at the time in educating the immune system @ImmunityCP
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
December 16, 2023 at 10:52 PM
MedSky🧪 #Drugsdelivery #Drugsdevelopment #IDsky RNA Vaccines .A step at the time in educating the immune system @ImmunityCP
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
MedSky🧪IDSky #immunoSky #Drugsdevelopment #Drugsdiscovery Overview & Summaries of the clinical development of #antivirals targeting various factors to inhibit #SARSCoV2 infection, including both viral factors & host factors.
December 4, 2023 at 6:53 PM
MedSky🧪IDSky #immunoSky #Drugsdevelopment #Drugsdiscovery Overview & Summaries of the clinical development of #antivirals targeting various factors to inhibit #SARSCoV2 infection, including both viral factors & host factors.
MedSky🧪#IDSky #Drugsdevelopment #HIVvaccine #clinicaltrial in Africa halted after disappointing initial results. African-led trial ended a year early as researchers conclude there is ‘little or no chance’ new combination vaccines cut #HIV risk
www.theguardian.com/global-devel...
www.theguardian.com/global-devel...
HIV vaccine trial in Africa halted after disappointing initial results
African-led trial ended a year early as researchers conclude there is ‘little or no chance’ new combination vaccines cut HIV risk
www.theguardian.com
December 11, 2023 at 1:19 PM
MedSky🧪#IDSky #Drugsdevelopment #HIVvaccine #clinicaltrial in Africa halted after disappointing initial results. African-led trial ended a year early as researchers conclude there is ‘little or no chance’ new combination vaccines cut #HIV risk
www.theguardian.com/global-devel...
www.theguardian.com/global-devel...
#MedSky🧪#IDSky #ImmunoSky #Drugsdevelopment Understanding Retroviral Life Cycle and its Genomic RNA Packaging
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
MMTV RNA packaging requires an extended long-range interaction for productive Gag binding to packaging signals
The role of long-range interactions (LRI) in retroviral RNA packaging is unclear. This study found that a specific packaging signal (Psi) structure, maintained by an extended LRI, is crucial for effic...
journals.plos.org
October 4, 2024 at 1:10 PM
#MedSky🧪#IDSky #ImmunoSky #Drugsdevelopment Understanding Retroviral Life Cycle and its Genomic RNA Packaging
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
#Immunopharmacology #Drugsdiscovery Brief introduction of C-type lectin-like receptor 2: Roles & #drugsdevelopment that targeting #COVID19 , #Tumour , #DVT & the other diseases related #thrombosis thrombosisjournal.biomedcentral.com/articles/10....
C-type lectin-like receptor 2: roles and drug target - Thrombosis Journal
C-type lectin-like receptor-2 (CLEC-2) is a member of the C-type lectin superfamily of cell surface receptors. The first confirmed endogenous and exogenous ligands of CLEC-2 are podoplanin and rhodocy...
thrombosisjournal.biomedcentral.com
April 17, 2024 at 9:15 PM
#Immunopharmacology #Drugsdiscovery Brief introduction of C-type lectin-like receptor 2: Roles & #drugsdevelopment that targeting #COVID19 , #Tumour , #DVT & the other diseases related #thrombosis thrombosisjournal.biomedcentral.com/articles/10....
MedSky🧪#Cancerbiology #Drugsdiscovery #Drugsdevelopment Understanding of targetable protein lipidation pathways in Cancer & mechanisms, dysregulation and emerging drug targets
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 1, 2024 at 11:13 AM
MedSky🧪#Cancerbiology #Drugsdiscovery #Drugsdevelopment Understanding of targetable protein lipidation pathways in Cancer & mechanisms, dysregulation and emerging drug targets
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MedSky🧪#Drugsdelivery #Drugsdevelopment #Immunooncology Overview of NK-cell therapy & Advantages for targeting NK cells in cancer
academic.oup.com/immunotherap...
academic.oup.com/immunotherap...
Harnessing natural killer cell effector function against cancer
Summary. Natural killer (NK) cells are cytotoxic innate lymphoid cells that participate in anti-tumour and anti-viral immune responses. Their ability to rapidly
academic.oup.com
February 15, 2024 at 4:50 AM
MedSky🧪#Drugsdelivery #Drugsdevelopment #Immunooncology Overview of NK-cell therapy & Advantages for targeting NK cells in cancer
academic.oup.com/immunotherap...
academic.oup.com/immunotherap...
MedSky🧪#IDSky #Drugsdevelopment #Clinicaltrial Evaluate the Efficacy and Safety of SIM0417 /Oral #Simnotrelvir Orally Co-Administered With #Ritonavir in Symptomatic Adult Participants With Mild to Moderate #COVID19
www.nejm.org/doi/10.1056/...
www.nejm.org/doi/10.1056/...
Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19 | NEJM
Original Article from The New England Journal of Medicine — Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19
www.nejm.org
January 23, 2024 at 7:24 AM
MedSky🧪#IDSky #Drugsdevelopment #Clinicaltrial Evaluate the Efficacy and Safety of SIM0417 /Oral #Simnotrelvir Orally Co-Administered With #Ritonavir in Symptomatic Adult Participants With Mild to Moderate #COVID19
www.nejm.org/doi/10.1056/...
www.nejm.org/doi/10.1056/...
MedSky🧪IDSky #Mucosalimmunity #COVID19 #Drugsdevelopment the studies show that how and where vaccines are delivered can have a profound effect on the immunity generated and the protection conferred.
December 20, 2023 at 3:39 PM
MedSky🧪IDSky #Mucosalimmunity #COVID19 #Drugsdevelopment the studies show that how and where vaccines are delivered can have a profound effect on the immunity generated and the protection conferred.