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A empresa galega Altia European Services, con sede en Oleiros, asinou na recta final de 2024 un contrato co European Investment Bank Group (EIBG, composto principalmente polo EIB e o EIF) para desenvolver un Portal de Clientes do Grupo (PCG) común e integrado e, desta forma, ofrecer unha solución dixital para as interaccións e servizos con clientes, intermediarios financeiros, mandatarios e socios do EIBG. A duración do contrato esténdese ata finais de 2025.

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Scientific Reports - Chain formation mediated by Escherichia coli immunoglobulin-binding proteins EibD and EibG depends on expression levels and localization of proteins

Bacteria frequently colonize host and environmental surfaces under fluid flow. Chain-like adherence pattern (CLAP) is an EibG-mediated surface colonization phenotype of certain Shiga toxin-producing Escherichia coli (STEC) that lack the locus of enterocyte effacement (LEE). EibG, an immunoglobulin-binding oligomeric coiled-coil adhesin, drives CLAP, but the temporal dynamics and genetic diversity underlying chain formation remain unclear. Here, we use live-cell time-lapse imaging to show that chains arise from single cells that elongate and divide without separation. Under flow, chains resist detachment and undergo shear-dependent fragmentation at cell-cell junctions, releasing viable clonal units that disperse downstream. Comparative genomics reveals substantial diversity among EibG-related adhesins and identifies distinct lineages, including chain-like adhesins ( cla ) that mediate CLAP while lacking IgG binding. Screening of 1,354 LEE-negative STEC genomes from England shows that claB is present in 95.6% of strains from major LEE-negative STEC serotypes, highlighting its epidemiological prevalence. Targeted mutagenesis demonstrates that chain formation and IgG binding are mediated by distinct structural domains, revealing the modular functional architecture of these adhesins. In a mouse infection model, deletion of eibG reduced lethality, indicating that EibG contributes to virulence. Collectively, these findings establish CLAP as a dynamic, surface-associated strategy of LEE-negative STEC and reveal previously unrecognized diversification among adhesins that drive this behavior. ### Competing Interest Statement The authors have declared no competing interest. Japan Science and Technology Agency, https://ror.org/00097mb19, JST BOOST JPMJBS2419 to Y.K. Tokyo Metropolitan University, https://ror.org/00ws30h19, MIYAKO-MIRAI Project to Y.K. Japan Agency for Medical Research and Development, https://ror.org/004rtk039, 25fk0108702h0002 and 22fk0108611j0002 to S.I. Japan Society for the Promotion of Science, https://ror.org/00hhkn466, JP25K22566 and JP24K02282 to S.I., JP24KJ1131 to N.A.U.

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