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Our study overview is outlined in Fig. 1a. We obtained longitudinal EMBs from 49 adult and 13 pediatric HT recipients. Median recipient age at time of HT was 52 years (27% female) for adults and 6 years (62% female) for children. Complete donor/recipient characteristics are presented in Table 1. Biopsies were collected at a median of 313 and 407 days post-HT for EMBs during rejection and following immunomodulatory therapies, respectively (Supplementary Fig. 1). Among biopsies demonstrating rejection, 67.7% comprised of acute cellular rejection (ACR), 11.3% antibody-mediated rejection (AMR) and 21% mixed rejection (both ACR and AMR). Consistent with clinical practice, we observed a broad range of immunomodulatory therapies (corticosteroids, 50%; cytolytic T cell-targeted therapies, 11.3%; B cell-targeted therapies, 21%; combination cytolytic/B cell therapy, 16.1%; no therapy, 1.6%; Fig. 1b). Compositional and spatial landscape of acute rejection highlights functionally relevant cell types post-HT To better understand cell types driving allograft rejection, we evaluated compositional differences between the three types of rejection and following antirejection therapies. Across all samples, we measured 10,343,560 high-quality transcripts among 162,638 cells comprising 28 cell types (Fig. 1c–e and Extended Data Figs. 1–8). Beyond canonical cardiac cell types, we identified POSTN+ activated fibroblasts, myofibroblasts, BMX+ activated endothelial...

وزير الزراعة يبحث مع مجموعة EMBS تعزيز سلامة الغذاء وتطوير التنمية الريفيةبحث وزير الزراعة المهندس "باسل السويدان" اليوم مع رئيس مجلس إدارة مجموعة EMBS للهندسة الإدارية والجودة المهندسة "إسراء هيثم" والوفد المرافق لها، دور وزارة الزراعة في تعزيز سلامة الغذاء وتطوير سلاسل التوريد الغذائي، وآليات التعاون في هذا المجال.وأكد الوزير حرص الوزارة على إيصال منتج زراعي نظيف وآمن وخالٍ من الأثر المتبقي، من خلال العمل على تعديل التشريعات والقوانين الناظمة لاستيراد المبيدات والأسمدة والأدوية البيطرية، وخلق...