🩸Facts about Acute Hepatic Porphyria:
Investigational treatments, iron supplementation in EPP1 and XLEPP, and limitations of urine PBG screening.
#EPP #XLEPP #EPP1 #Dersimelagon #Bitopertin #Afamelanotide #MC1R #GlyT1 #ALAS2 #PPIX #Porphyria #Hematology #HemeOnc #MedEd #HemeHub
Investigational treatments, iron supplementation in EPP1 and XLEPP, and limitations of urine PBG screening.
#EPP #XLEPP #EPP1 #Dersimelagon #Bitopertin #Afamelanotide #MC1R #GlyT1 #ALAS2 #PPIX #Porphyria #Hematology #HemeOnc #MedEd #HemeHub
November 1, 2026 at 5:05 AM
🩸Facts about Acute Hepatic Porphyria:
Investigational treatments, iron supplementation in EPP1 and XLEPP, and limitations of urine PBG screening.
#EPP #XLEPP #EPP1 #Dersimelagon #Bitopertin #Afamelanotide #MC1R #GlyT1 #ALAS2 #PPIX #Porphyria #Hematology #HemeOnc #MedEd #HemeHub
Investigational treatments, iron supplementation in EPP1 and XLEPP, and limitations of urine PBG screening.
#EPP #XLEPP #EPP1 #Dersimelagon #Bitopertin #Afamelanotide #MC1R #GlyT1 #ALAS2 #PPIX #Porphyria #Hematology #HemeOnc #MedEd #HemeHub
🩸Facts about Acute Hepatic Porphyria:
EPP1 and XLEPP genetics, afamelanotide’s mechanism of action, improved light tolerance, and treatment limitations in children.
#EPP #XLEPP #Porphyria #Afamelanotide #MC1R #Hematology #HemeOnc #MedEd #HemeHub
EPP1 and XLEPP genetics, afamelanotide’s mechanism of action, improved light tolerance, and treatment limitations in children.
#EPP #XLEPP #Porphyria #Afamelanotide #MC1R #Hematology #HemeOnc #MedEd #HemeHub
October 30, 2026 at 5:09 PM
🩸Facts about Acute Hepatic Porphyria:
EPP1 and XLEPP genetics, afamelanotide’s mechanism of action, improved light tolerance, and treatment limitations in children.
#EPP #XLEPP #Porphyria #Afamelanotide #MC1R #Hematology #HemeOnc #MedEd #HemeHub
EPP1 and XLEPP genetics, afamelanotide’s mechanism of action, improved light tolerance, and treatment limitations in children.
#EPP #XLEPP #Porphyria #Afamelanotide #MC1R #Hematology #HemeOnc #MedEd #HemeHub
Our findings suggest that EPP1 serves as a key molecular bridge between plasma membrane signaling and downstream responses doing root nodule symbiosis, helping to close a long-standing gap in the field.
Congratulations to everyone involved in this work!
Congratulations to everyone involved in this work!
October 2, 2025 at 6:51 AM
Our findings suggest that EPP1 serves as a key molecular bridge between plasma membrane signaling and downstream responses doing root nodule symbiosis, helping to close a long-standing gap in the field.
Congratulations to everyone involved in this work!
Congratulations to everyone involved in this work!
We’re thrilled to share our latest preprint!
In this study we provide a mechanistic insight into how the protein EPP1 (first identified in Rose et al., 2012) functions in partnership with SYMRK.
www.biorxiv.org/content/10.1...
In this study we provide a mechanistic insight into how the protein EPP1 (first identified in Rose et al., 2012) functions in partnership with SYMRK.
www.biorxiv.org/content/10.1...
EPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis
Legume symbiosis with nitrogen-fixing bacteria is controlled by a cascade of signaling events leading to root nodule development. While plant cell-surface receptors initiate this process, the link bet...
www.biorxiv.org
October 2, 2025 at 6:51 AM
We’re thrilled to share our latest preprint!
In this study we provide a mechanistic insight into how the protein EPP1 (first identified in Rose et al., 2012) functions in partnership with SYMRK.
www.biorxiv.org/content/10.1...
In this study we provide a mechanistic insight into how the protein EPP1 (first identified in Rose et al., 2012) functions in partnership with SYMRK.
www.biorxiv.org/content/10.1...
Dr. Demento used to play that song
www.youtube.com/watch?v=ePp1...
www.youtube.com/watch?v=ePp1...
Fleshapoids Nuke the Whales
YouTube video by MrSkummie
www.youtube.com
July 18, 2026 at 1:30 AM
Dr. Demento used to play that song
www.youtube.com/watch?v=ePp1...
www.youtube.com/watch?v=ePp1...
Together with new data in RNS from our colleagues @nikolajabel.bsky.social et al. doi.org/10.1101/2025..., we hope close the gap in our understanding of the common symbiosis pathway for plant endosymbioses! 7/7
October 6, 2025 at 1:44 PM
Together with new data in RNS from our colleagues @nikolajabel.bsky.social et al. doi.org/10.1101/2025..., we hope close the gap in our understanding of the common symbiosis pathway for plant endosymbioses! 7/7
We propose that EPP1 has been a core component of AMS signaling since the origin of land plants as we know them 🌱🍄 6/7
doi.org
October 6, 2025 at 1:36 PM
We propose that EPP1 has been a core component of AMS signaling since the origin of land plants as we know them 🌱🍄 6/7
Here we show abolition of AMS in epp1 mutants in the flowering plant Petunia and in the liverwort Marchantia. We also find that EPP1 is directly phosphorylated by the SYMRK receptor and that the epp1 phenotype can be complemented by an autoactive version of the kinase CCaMK 5/7
October 6, 2025 at 1:36 PM
Here we show abolition of AMS in epp1 mutants in the flowering plant Petunia and in the liverwort Marchantia. We also find that EPP1 is directly phosphorylated by the SYMRK receptor and that the epp1 phenotype can be complemented by an autoactive version of the kinase CCaMK 5/7
Knowing EPP1 belongs to the short list of genes conserved across land plants in species with the ability to form endosymbiosis and convergently lost in the ones having lost this ability, we decided switch model plants to test the function of EPP1 in Arbuscular Mycorrhiza Symbiosis (AMS). 4/7
October 6, 2025 at 1:36 PM
Knowing EPP1 belongs to the short list of genes conserved across land plants in species with the ability to form endosymbiosis and convergently lost in the ones having lost this ability, we decided switch model plants to test the function of EPP1 in Arbuscular Mycorrhiza Symbiosis (AMS). 4/7
Previously, Early Phosphorylated Protein 1 (EPP1) was suggested to play an essential role in Root Nodule Symbiosis but the high copy number of EPP1 genes in Medicago (4!) limited our ability to study its function doi.org/10.1093/pcp/... doi.org/10.1111/nph.... . 3/7
A Novel Positive Regulator of the Early Stages of Root Nodule Symbiosis Identified by Phosphoproteomics
Abstract. Signals and signaling pathways underlying the symbiosis between legumes and rhizobia have been studied extensively over the past decades. In a pr
doi.org
October 6, 2025 at 1:36 PM
Previously, Early Phosphorylated Protein 1 (EPP1) was suggested to play an essential role in Root Nodule Symbiosis but the high copy number of EPP1 genes in Medicago (4!) limited our ability to study its function doi.org/10.1093/pcp/... doi.org/10.1111/nph.... . 3/7
So happy to see the latest preprint of the team out! www.biorxiv.org/content/10.1...
The continuation of a long standing project started by @oswaldovaldesl.bsky.social in @jeanmichelane.bsky.social‘s lab. 1/7 🧵
The continuation of a long standing project started by @oswaldovaldesl.bsky.social in @jeanmichelane.bsky.social‘s lab. 1/7 🧵
EPP1 is an ancestral component of the plant Common Symbiosis Pathway
The success of plants on land has been enabled by mutualistic intracellular associations with microbes for 450 million years ([Delaux and Schornack 2021][1]). Because of their intracellular nature, th...
www.biorxiv.org
October 6, 2025 at 1:36 PM
So happy to see the latest preprint of the team out! www.biorxiv.org/content/10.1...
The continuation of a long standing project started by @oswaldovaldesl.bsky.social in @jeanmichelane.bsky.social‘s lab. 1/7 🧵
The continuation of a long standing project started by @oswaldovaldesl.bsky.social in @jeanmichelane.bsky.social‘s lab. 1/7 🧵
~12 years after we coined it EPP1 with @oswaldovaldesl.bsky.social one afternoon when we were postdoc with @jeanmichelane.bsky.social!
Congrats @melaniekrich.bsky.social @tatiana-vernie.bsky.social et al. for the hard work!
EPP1 is the fourth member of the Common Symbiosis Pathway 🍄🌱!
Congrats @melaniekrich.bsky.social @tatiana-vernie.bsky.social et al. for the hard work!
EPP1 is the fourth member of the Common Symbiosis Pathway 🍄🌱!
So happy to see the latest preprint of the team out! www.biorxiv.org/content/10.1...
The continuation of a long standing project started by @oswaldovaldesl.bsky.social in @jeanmichelane.bsky.social‘s lab. 1/7 🧵
The continuation of a long standing project started by @oswaldovaldesl.bsky.social in @jeanmichelane.bsky.social‘s lab. 1/7 🧵
EPP1 is an ancestral component of the plant Common Symbiosis Pathway
The success of plants on land has been enabled by mutualistic intracellular associations with microbes for 450 million years ([Delaux and Schornack 2021][1]). Because of their intracellular nature, th...
www.biorxiv.org
October 6, 2025 at 3:44 PM
~12 years after we coined it EPP1 with @oswaldovaldesl.bsky.social one afternoon when we were postdoc with @jeanmichelane.bsky.social!
Congrats @melaniekrich.bsky.social @tatiana-vernie.bsky.social et al. for the hard work!
EPP1 is the fourth member of the Common Symbiosis Pathway 🍄🌱!
Congrats @melaniekrich.bsky.social @tatiana-vernie.bsky.social et al. for the hard work!
EPP1 is the fourth member of the Common Symbiosis Pathway 🍄🌱!
www.biorxiv.org/content/10.1...
and
www.biorxiv.org/content/10.1...
Two papers to tell us more about mysterious EPP1, a protein required for symbiosis. Well done @tatiana-vernie.bsky.social and all co-authors.
and
www.biorxiv.org/content/10.1...
Two papers to tell us more about mysterious EPP1, a protein required for symbiosis. Well done @tatiana-vernie.bsky.social and all co-authors.
EPP1 is an ancestral component of the plant Common Symbiosis Pathway
The success of plants on land has been enabled by mutualistic intracellular associations with microbes for 450 million years ([Delaux and Schornack 2021][1]). Because of their intracellular nature, th...
www.biorxiv.org
October 6, 2025 at 1:01 PM
www.biorxiv.org/content/10.1...
and
www.biorxiv.org/content/10.1...
Two papers to tell us more about mysterious EPP1, a protein required for symbiosis. Well done @tatiana-vernie.bsky.social and all co-authors.
and
www.biorxiv.org/content/10.1...
Two papers to tell us more about mysterious EPP1, a protein required for symbiosis. Well done @tatiana-vernie.bsky.social and all co-authors.
EPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis | bioRxiv
EPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis | bioRxiv
Legume symbiosis with nitrogen-fixing bacteria is controlled by a cascade of signaling events leading to root nodule development. While plant cell-surface receptors initiate this process, the link between receptors and cytoplasmic signaling components remains unclear. Here we identify Early Phosphorylated Protein 1 (EPP1) as a central mediator of this pathway. EPP1 is recruited to the activated SYMRK receptor, where it is phosphorylated on a key serine residue, an event essential and sufficient to propagate symbiotic signaling. We provide structural and functional validation of the SYMRK-EPP1 signaling complex and demonstrate that EPP1 is required for root nodule formation. Synthetic engineering of the SYMRK-EPP1 interaction bypasses the need for symbiotic bacteria to initiate the pathway and triggers nodule organogenesis. These findings establish EPP1 as a crucial cytoplasmic component between receptor activation and intracellular signaling, advancing our understanding of nitrogen-fixing symbiosis.
sco.lt
October 5, 2025 at 8:14 PM
EPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis | bioRxiv
Fantastic work from @pierremarcdelaux.bsky.social annd col. expanding the basic genetic toolkit enabling symbiotic interactions in plants www.biorxiv.org/content/10.1...
EPP1 is an ancestral component of the plant Common Symbiosis Pathway
The success of plants on land has been enabled by mutualistic intracellular associations with microbes for 450 million years (Delaux and Schornack 2021). Because of their intracellular nature, the est...
www.biorxiv.org
October 3, 2025 at 7:30 AM
Fantastic work from @pierremarcdelaux.bsky.social annd col. expanding the basic genetic toolkit enabling symbiotic interactions in plants www.biorxiv.org/content/10.1...
"The coaster was built back in the 90s. You may remember it as its former name, Flight Deck."
www.youtube.com/watch?v=EPP1...
www.youtube.com/watch?v=EPP1...
Canada’s Wonderland gave this rollercoaster a makeover. We tried it out
YouTube video by CBC News Toronto
www.youtube.com
July 24, 2026 at 11:21 PM
"The coaster was built back in the 90s. You may remember it as its former name, Flight Deck."
www.youtube.com/watch?v=EPP1...
www.youtube.com/watch?v=EPP1...
www.biorxiv.org/content/10.1...
Great story in collaboration with @pierremarcdelaux.bsky.social and @jeanmichelane.bsky.social groups. EPP1 story continues after many years of collaborations with Pierre-Marc and Jean-Michel!!!
Great story in collaboration with @pierremarcdelaux.bsky.social and @jeanmichelane.bsky.social groups. EPP1 story continues after many years of collaborations with Pierre-Marc and Jean-Michel!!!
EPP1 is an ancestral component of the plant Common Symbiosis Pathway
The success of plants on land has been enabled by mutualistic intracellular associations with microbes for 450 million years (Delaux and Schornack 2021). Because of their intracellular nature, the est...
www.biorxiv.org
October 2, 2025 at 8:11 PM
www.biorxiv.org/content/10.1...
Great story in collaboration with @pierremarcdelaux.bsky.social and @jeanmichelane.bsky.social groups. EPP1 story continues after many years of collaborations with Pierre-Marc and Jean-Michel!!!
Great story in collaboration with @pierremarcdelaux.bsky.social and @jeanmichelane.bsky.social groups. EPP1 story continues after many years of collaborations with Pierre-Marc and Jean-Michel!!!
Vintage 1973 Reel to Reel Tape RCA EPP1 0283-C 💛
Vintage 1973 Reel to Reel Tape RCA EPP1 0283-C
Farwell, Minnesota
www.ebay.com
May 1, 2025 at 7:17 PM
Vintage 1973 Reel to Reel Tape RCA EPP1 0283-C 💛
EPP1 is an ancestral component of the plant Common SymbiosisPathway https://www.biorxiv.org/content/10.1101/2025.09.30.679610v1
October 2, 2025 at 3:03 PM
EPP1 is an ancestral component of the plant Common SymbiosisPathway https://www.biorxiv.org/content/10.1101/2025.09.30.679610v1
EPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis https://www.biorxiv.org/content/10.1101/2025.09.29.679184v1
October 1, 2025 at 11:03 PM
EPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis https://www.biorxiv.org/content/10.1101/2025.09.29.679184v1
10tの時でええと思うんよな。後EPP1回でいいと思う
October 20, 2025 at 7:46 PM
10tの時でええと思うんよな。後EPP1回でいいと思う
EPP1 is an ancestral component of the plant Common SymbiosisPathway https://www.biorxiv.org/content/10.1101/2025.09.30.679610v1
October 2, 2025 at 3:03 PM
EPP1 is an ancestral component of the plant Common SymbiosisPathway https://www.biorxiv.org/content/10.1101/2025.09.30.679610v1
EPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis https://www.biorxiv.org/content/10.1101/2025.09.29.679184v1
October 1, 2025 at 11:03 PM
EPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis https://www.biorxiv.org/content/10.1101/2025.09.29.679184v1