But most important is our finding that, not unlike early-stage cancer, the molecular and cellular hallmarks of IPF, a LETHAL disease, occur before loss of pulmonary functions or symptoms, highlighting the urgent need for early detection
#EarlyIPFIsIPF
www.biorxiv.org/content/10.6...

snRNASeq of Early IPF lungs reveals emergence of aberrant basaloid cells & alveolar intermediate epithelial states & marked loss of AT2 and AT1 cells in early IPF.
These changes associate with subsequent disease progression 🙀
#EarlyIPFisIPF www.biorxiv.org/content/10.6...