#Engasertib
No therapies are licensed to treat hereditary hemorrhagic telangiectasia, despite the considerable disease burden. Research findings with the AKT1 and AKT2 inhibitor engasertib are summarized in a new Quick Take video. nej.md/43PdHc1

#MedSky #Hematology
December 2, 2025 at 2:02 PM
From the #Transfusion Evidence Alert:

Engasertib versus Placebo for Bleeding in Hereditary Hemorrhagic Telangiectasia
by Al-Samkari et al.
www.transfusionevidencelibrary.com/articles/412...
#MedSky
January 28, 2026 at 1:43 PM
Daily Mosnodenvir as Dengue Prophylaxis nej.md/48eUJwJ

CRISPR-Cas9 Targeting ANGPTL3 nej.md/43doGvu

Engasertib in Hereditary Hemorrhagic Telangiectasia nej.md/4pz9RMC

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November 27, 2025 at 2:29 PM
Engasertib, inhibidor de la AKT, reduce la frecuencia y duración de las epistaxis en pacientes con telangiectasia hemorrágica hereditaria firstwordpharma.com/story/6713688
firstwordpharma.com
November 28, 2025 at 12:40 PM
In patients with hereditary hemorrhagic telangiectasia, treatment with engasertib reduced nosebleed frequency and duration over 12 weeks, with mild reversible rash as the most common drug-related side effect. Full trial results: nej.md/4pz9RMC

#MedSky #Hematology
November 26, 2025 at 11:00 PM
A new oral AKT inhibitor, engasertib, reduced nosebleed frequency and duration in hereditary hemorrhagic telangiectasia during a recent placebo-controlled trial, with a favorable safety profile.
Drug developed for inherited bleeding disorder shows promising trial results
Hereditary hemorrhagic telangiectasia (HHT) is the second most common inherited bleeding disorder worldwide, affecting one in 3,800 persons.
medicalxpress.com
November 26, 2025 at 10:00 PM
Vaderis Therapeutics Secures $152 Million in Series B Financing for Engasertib and Launches Phase 3 HEROIC Study#USA#Lincolnshire#HHT#engasertib#Vaderis
Vaderis Therapeutics Secures $152 Million in Series B Financing for Engasertib and Launches Phase 3 HEROIC Study
Vaderis Therapeutics has successfully closed a $152 million Series B financing round, launching the Phase 3 HEROIC study for engasertib aimed at treating HHT.
third-news.com
August 11, 2026 at 11:19 AM
Vaderis Therapeutics Secures $152 Million in Financing and Begins HEROIC Study for HHT Treatment#USA#Lincolnshire#HHT#Vaderis_Therapeutics#engasertib
Vaderis Therapeutics Secures $152 Million in Financing and Begins HEROIC Study for HHT Treatment
Vaderis Therapeutics has successfully raised $152 million in Series B funding, enabling the start of the HEROIC Phase 3 study for engasertib, targeting hereditary hemorrhagic telangiectasia.
third-news.com
August 11, 2026 at 11:12 AM
Vaderis raised $152M to push a repurposed cancer drug into Phase 3 for a rare bleeding disorder with no approved treatments.
Vaderis gets $152M to run Phase 3 of rare bleeding disorder treatment
Vaderis Therapeutics raised a Series B to run a Phase 3 study of its AKT inhibitor engasertib in a rare blood disorder called hereditary hemorrhagic telangiectasia.
endpoints.news
August 11, 2026 at 1:32 PM
June 25, 2026 at 2:00 AM
A #clinicaltrial of #VaderisTherapeutics' AKT inhibitor engasertib suggests it could be the first effective treatment for #hereditaryhaemorrhagictelangiectasia (HHT), the second most common #inheritedbleedingdisorder.
Vaderis drug lends hope to patients with bleeding disease HHT
A trial of Vaderis' AKT inhibitor engasertib finds it could be the first effective treatment for rare disease hereditary haemorrhagic telangiectasia.
buff.ly
November 27, 2025 at 4:00 PM
Feed: "Medical News, Health News Latest, Medical News Today - Medical Dialogues |"
By: Dr. Shravani Dali on Wednesday, December 3, 2025
Engasertib Shows Favorable Safety Profile and Reduces Epistaxis in hereditary hemorrhagic telegenctasia: Study
Hereditary hemorrhagic telangiectasia (HHT) can cause recurrent, severe epistaxis, as well as anemia and reduced quality of life. The disease remains without licensed therapies worldwide.In this...
medicaldialogues.in
December 4, 2025 at 3:13 AM