#EngramCells
LightNews LightNews
plosbiology.org
Long-term memories become imprecise as animals age, but what are the neural mechanisms? This study shows that increased #dopamine signaling during #memory consolidation causes memory #EngramCells to respond to inappropriate cues, inducing memory generalization @plosbiology.org 🧪 plos.io/4v62VtD
Top: Putative engram cells were identified as GFP (cFos) signals in the indicated mushroom body cell body region dorsal to the calyx 24 hours after spaced training of UAS-mCD8-GFP; kayak-Gal4/Tubp-Gal80ts flies. pERK signals observed after odor exposure 24 hours after training were used to identify cells activated during memory recall tests. Bottom: Schematic for optogenetic reactivation of engram cells. Channelrhodopsin-YFP (ChR2-YFP) was expressed in putative engram cells using the same strategy of expressing GFP above. Twenty-four hours after spaced training, flies were tested for their preference of blue light (which activates channelrhodopsin) vs. green light.
April 2, 2026 at 8:55 AM
plosbiology.org
Long-term memories become imprecise as animals age, but what are the neural mechanisms? This study shows that increased #dopamine signaling during #memory consolidation causes memory #EngramCells to respond to inappropriate cues, inducing memory generalization @plosbiology.org 🧪 plos.io/4v62VtD
Top: Putative engram cells were identified as GFP (cFos) signals in the indicated mushroom body cell body region dorsal to the calyx 24 hours after spaced training of UAS-mCD8-GFP; kayak-Gal4/Tubp-Gal80ts flies. pERK signals observed after odor exposure 24 hours after training were used to identify cells activated during memory recall tests. Bottom: Schematic for optogenetic reactivation of engram cells. Channelrhodopsin-YFP (ChR2-YFP) was expressed in putative engram cells using the same strategy of expressing GFP above. Twenty-four hours after spaced training, flies were tested for their preference of blue light (which activates channelrhodopsin) vs. green light.
April 2, 2026 at 4:25 PM
earthdotcom.bsky.social
Earth’s first bacteria used oxygen about one billion years earlier than we thought: Bacteria used oxygen far earlier than expected, reshaping views on early life, evolution, and photosynthesis origins.

#MemoryEngram #Neuroscience #BrainCells #MemoryFormation #EngramCells #EarthDotCom #EarthSnap
Earth's first bacteria used oxygen about one billion years earlier than we thought
Bacteria used oxygen far earlier than expected, reshaping views on early life, evolution, and photosynthesis origins.
www.earth.com
April 7, 2025 at 11:22 AM
plosbiology.org
Long-term memories become imprecise as animals age, but what are the neural mechanisms? This study shows that increased #dopamine signaling during #memory consolidation causes memory #EngramCells to respond to inappropriate cues, inducing memory generalization @plosbiology.org 🧪 plos.io/4v62VtD
Top: Putative engram cells were identified as GFP (cFos) signals in the indicated mushroom body cell body region dorsal to the calyx 24 hours after spaced training of UAS-mCD8-GFP; kayak-Gal4/Tubp-Gal80ts flies. pERK signals observed after odor exposure 24 hours after training were used to identify cells activated during memory recall tests. Bottom: Schematic for optogenetic reactivation of engram cells. Channelrhodopsin-YFP (ChR2-YFP) was expressed in putative engram cells using the same strategy of expressing GFP above. Twenty-four hours after spaced training, flies were tested for their preference of blue light (which activates channelrhodopsin) vs. green light.
April 2, 2026 at 12:55 PM
earthdotcom.bsky.social
How does the human brain create and retrieve memories? Scientists figured it out: Memory formation hinges on connections between groups of engram cells, which are neurons thought to capture and store distinct experiences.

#MemoryEngram #Neuroscience #BrainCells #Memory #EngramCells #EarthDotCom
How does the human brain create and retrieve memories? Scientists figured it out
memory formation hinges on connections between groups of engram cells, which are neurons thought to capture and store distinct experiences.
www.earth.com
April 7, 2025 at 11:18 AM