New Salk research reveals how the cancer drug entinostat works inside pancreatic cancer cells.

The findings point to new combination treatment strategies and a way to deliver the drug directly to tumors.

www.salk.edu/news-release...

Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression
doi.org/10.3389/fimm...

At #ASCO25 this morning, Tracy Rose, MD, MPH, will present at the poster session: (Poster 403) Pathologic response and safety of neoadjuvant pembrolizumab with or without entinostat in muscle-invasive urothelial cancer (MIUC).

⌚️: 9 a.m. - 12 p.m. CT
📍: Hall A

🔬By using innovative combinations of mathematical modeling and clinical trials, she is working to "prime" tumors, making them responsive to immunotherapy and giving patients new hope.

🔬 www.nature.com/articles/s43...

Kaduk and Rai: Structure of entinostat Form B, C21H20N4O3, derived using laboratory powder diffraction data and density functional techniques ##PowderDiffraction##Entinostat##RietveldRefinement... ##IUCrhttps://journals.iucr.org/paper?S2056989025007406

- Virusimprint durch molekulare Signaturen von EBV, HIV, HSV

Therapieansätze (zumindest in silico)
- HDAC-Hemmer (z.B. Entinostat, Vorinostat; interessant v. a. weil epigenetischer Ansatz)
- Östrogen-Antagonisten (Fulvestrant)
➡️ Evtl.
3/4

- A viral imprint reflected in molecular signatures of EBV, HIV and HSV

Potential therapeutic strategies (at least in silico):

- HDAC inhibitors (e.g. Entinostat, Vorinostat) — particularly interesting due to their epigenetic mechanisms
3/4

A paper using RRID:Addgene_12259 was just published in Frontiers in Immunology see "Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression". RRIDs like this improve reproducibility in scientific research. #accelerateopenscience

RRID:CVCL_0434 was used by the authors of the Neoplasia paper "Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat". RRIDs like this improve reproducibility in scientific research. #ReproducibleResearch #OpenScience

Blocking HDACs turned down pancreatic tumors’ DNA repair genes, making DNA-damaging treatments significantly more effective. A nanoparticle form of entinostat also reduced toxicity in preclinical models.

Sequencing analysis reveals evidence of immune activation in advanced HER2 negative breast cancer responders treated with the combination of entinostat

La NMPA de China aprueba la comercialización de Entinostat Tablets

📩 info@dengyuemed.com
🔗https://dengyuepharma.com

#Entinostat #EntinostatTablets #Jingzhuda
#CáncerDeMama #CáncerDeMamaMetastásico
#HRpositivo #HER2negativo
#InhibidorHDAC #TerapiaDirigida

www.linkedin.com/pulse/entino...

Pancreatic cancer cells are built to survive. New Lustgarten-funded research from @salkinstitute.bsky.social scientists explores how entinostat may help weaken that defense and make cancer cells more vulnerable to treatment: bit.ly/4v7wud4

PXD055268 🚨

A novel nontoxic combination of ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma

🚨 New dataset alert! 🚨