If you fancy human ephys, come hear our talks at SfN! Nov 16, 1-4pm
Going to #SfN2026? Come to our Nanosymposium on Nov 16, WCC Rm143, 1-4PM (@qasimetal.bsky.social). We have an excellent lineup of short talks showcasing what recordings from the human brain reveal about how we navigate, learn, remember, balance reward, and make sense of language and other people.
November 11, 2026 at 8:58 PM
If you fancy human ephys, come hear our talks at SfN! Nov 16, 1-4pm
Interdisciplinary work got us there! Using FEM we looked at change in brain activity between 2 & 7 mnth post-stroke (LH and RH). #Ephys is wonderful: temporal resolution and direct nature of signal in relation to underlying *neuronal* activity. studies do either comprehension or production 3/6
November 13, 2026 at 10:53 AM
Interdisciplinary work got us there! Using FEM we looked at change in brain activity between 2 & 7 mnth post-stroke (LH and RH). #Ephys is wonderful: temporal resolution and direct nature of signal in relation to underlying *neuronal* activity. studies do either comprehension or production 3/6
What a way to kick off #SfN26! Our Neural Dynamics accelerator packed the house for a satellite workshop on our pipelines for ephys, calcium imaging & whole brain imaging data. Thanks to all speakers, organizers & early risers!
In DC? Find the Allen Institute team at Booth 305!
In DC? Find the Allen Institute team at Booth 305!
November 14, 2026 at 8:48 PM
What a way to kick off #SfN26! Our Neural Dynamics accelerator packed the house for a satellite workshop on our pipelines for ephys, calcium imaging & whole brain imaging data. Thanks to all speakers, organizers & early risers!
In DC? Find the Allen Institute team at Booth 305!
In DC? Find the Allen Institute team at Booth 305!
R2deep is a limited 2026 special edition. It’s in production now and planned to ship at the end of 2026. Details and pre-order: 3dneuro.com/products/cus... #Neuropixels #ephys
November 14, 2026 at 12:48 PM
R2deep is a limited 2026 special edition. It’s in production now and planned to ship at the end of 2026. Details and pre-order: 3dneuro.com/products/cus... #Neuropixels #ephys
Headed to #SfN26? Find SpikeGadgets at booth #2336, Nov 14-18 in Washington, D.C.
High-channel-count in vivo ephys for freely moving animals: wireless datalogging with Neuropixels support, headstages for mice to primates, and closed-loop stimulation.
Bring your recording questions!
High-channel-count in vivo ephys for freely moving animals: wireless datalogging with Neuropixels support, headstages for mice to primates, and closed-loop stimulation.
Bring your recording questions!
November 12, 2026 at 8:07 PM
Headed to #SfN26? Find SpikeGadgets at booth #2336, Nov 14-18 in Washington, D.C.
High-channel-count in vivo ephys for freely moving animals: wireless datalogging with Neuropixels support, headstages for mice to primates, and closed-loop stimulation.
Bring your recording questions!
High-channel-count in vivo ephys for freely moving animals: wireless datalogging with Neuropixels support, headstages for mice to primates, and closed-loop stimulation.
Bring your recording questions!
It ships with an ephys plugin. Run spike sorting from the app: pick a sorter and a stretch of the recording, press Run, inspect the templates. Includes our implementation of Kilosort4 (Pachitariu et al.) and other sorters.
#spikesorting #neuroscience #rustlang
#spikesorting #neuroscience #rustlang
November 9, 2026 at 6:54 PM
It ships with an ephys plugin. Run spike sorting from the app: pick a sorter and a stretch of the recording, press Run, inspect the templates. Includes our implementation of Kilosort4 (Pachitariu et al.) and other sorters.
#spikesorting #neuroscience #rustlang
#spikesorting #neuroscience #rustlang
Hi ! I don't post on here often, but our newest preprint is out. The idea was closed loop ephys with in vitro cultures, but rather than using them as compute we wanted to see if we could train them to behave differently. It worked !
Paper, code, and thoughts below.
Paper, code, and thoughts below.
November 4, 2026 at 6:34 PM
Hi ! I don't post on here often, but our newest preprint is out. The idea was closed loop ephys with in vitro cultures, but rather than using them as compute we wanted to see if we could train them to behave differently. It worked !
Paper, code, and thoughts below.
Paper, code, and thoughts below.
🚨 3-year postdoctoral position with myself, Emma Cahill and Paul Chadderton studying PFC circuit development using slice ephys, optogenetics, high-throughput behavioural tracking and in vivo analysis of neural activity.
Please share and get in touch if interested
www.bristol.ac.uk/jobs/find/de...
Please share and get in touch if interested
www.bristol.ac.uk/jobs/find/de...
Details | Working at Bristol | University of Bristol
www.bristol.ac.uk
October 29, 2026 at 4:58 PM
🚨 3-year postdoctoral position with myself, Emma Cahill and Paul Chadderton studying PFC circuit development using slice ephys, optogenetics, high-throughput behavioural tracking and in vivo analysis of neural activity.
Please share and get in touch if interested
www.bristol.ac.uk/jobs/find/de...
Please share and get in touch if interested
www.bristol.ac.uk/jobs/find/de...
Using Neuropixels or want to upskill? Check out our free and open Neuropixels resources including:
⚙️ Design files for our modular insertion system
🎯 Methods for MRI-guided targeting
☁️ Cloud-based spike sorting
🖥️ Open ephys GUI
Access these tools and more: https://bit.ly/4e0Uklh
⚙️ Design files for our modular insertion system
🎯 Methods for MRI-guided targeting
☁️ Cloud-based spike sorting
🖥️ Open ephys GUI
Access these tools and more: https://bit.ly/4e0Uklh
October 28, 2026 at 4:39 PM
Using Neuropixels or want to upskill? Check out our free and open Neuropixels resources including:
⚙️ Design files for our modular insertion system
🎯 Methods for MRI-guided targeting
☁️ Cloud-based spike sorting
🖥️ Open ephys GUI
Access these tools and more: https://bit.ly/4e0Uklh
⚙️ Design files for our modular insertion system
🎯 Methods for MRI-guided targeting
☁️ Cloud-based spike sorting
🖥️ Open ephys GUI
Access these tools and more: https://bit.ly/4e0Uklh
Even your goats have an ephys cage???
October 24, 2026 at 1:22 PM
Even your goats have an ephys cage???
We're in the dog days of grant submissions, but still managed to coach the roton to his first cell.
October 22, 2026 at 11:51 PM
We're in the dog days of grant submissions, but still managed to coach the roton to his first cell.
Happy to announce our project on intracranial ephys artifacts is finally out 🙈
doi.org/10.1523/JNEUROSCI.0295-26.2026
It all began with an observation, are neurons across an entire array synchronizing at 1/30 ms resolution in cortex? Identical waveforms? Revolutionary if true, but...
Blueprint!🧵
doi.org/10.1523/JNEUROSCI.0295-26.2026
It all began with an observation, are neurons across an entire array synchronizing at 1/30 ms resolution in cortex? Identical waveforms? Revolutionary if true, but...
Blueprint!🧵
October 21, 2026 at 3:20 PM
Happy to announce our project on intracranial ephys artifacts is finally out 🙈
doi.org/10.1523/JNEUROSCI.0295-26.2026
It all began with an observation, are neurons across an entire array synchronizing at 1/30 ms resolution in cortex? Identical waveforms? Revolutionary if true, but...
Blueprint!🧵
doi.org/10.1523/JNEUROSCI.0295-26.2026
It all began with an observation, are neurons across an entire array synchronizing at 1/30 ms resolution in cortex? Identical waveforms? Revolutionary if true, but...
Blueprint!🧵
So! Whiten your band-passed ephys signals at sampling resolution prior to any further analysis, to minimize the issues caused by crosstalk. Even if we do not know where it happens.
Always be critical about any (sub)millisecond correlations!
Always be critical about any (sub)millisecond correlations!
October 21, 2026 at 3:20 PM
So! Whiten your band-passed ephys signals at sampling resolution prior to any further analysis, to minimize the issues caused by crosstalk. Even if we do not know where it happens.
Always be critical about any (sub)millisecond correlations!
Always be critical about any (sub)millisecond correlations!
And well, surprise, surprise, that is what we see. Spike coincidences are higher wherever the background ephys signal correlation is also higher.
It seems crosstalk is the reason for the suspiciously synchronized neurons.
So, what can we do? Not all coincidences are bad, only some of them...
It seems crosstalk is the reason for the suspiciously synchronized neurons.
So, what can we do? Not all coincidences are bad, only some of them...
October 21, 2026 at 3:20 PM
And well, surprise, surprise, that is what we see. Spike coincidences are higher wherever the background ephys signal correlation is also higher.
It seems crosstalk is the reason for the suspiciously synchronized neurons.
So, what can we do? Not all coincidences are bad, only some of them...
It seems crosstalk is the reason for the suspiciously synchronized neurons.
So, what can we do? Not all coincidences are bad, only some of them...
Tomorrow (Oct 20) I’m giving an online tutorial on ephys quality control with bombcell, part of @openlab.bsky.social’s Neural Data Analysis with Open-Source Tools series.
Also featuring: @spikeinterface.bsky.social, @pynapple.bsky.social and NeMoS.
Free registration: nenckiopenlab.org/neuraldata/
Also featuring: @spikeinterface.bsky.social, @pynapple.bsky.social and NeMoS.
Free registration: nenckiopenlab.org/neuraldata/
Neural Data Analysis with Open-Source Tools
From Raw Signals to Behavior-Linked Activity How do we move from raw extracellular recordings to interpretable neural activity linked to behavior? This hands-on workshop series introduces an open-s…
nenckiopenlab.org
October 19, 2026 at 2:28 PM
Tomorrow (Oct 20) I’m giving an online tutorial on ephys quality control with bombcell, part of @openlab.bsky.social’s Neural Data Analysis with Open-Source Tools series.
Also featuring: @spikeinterface.bsky.social, @pynapple.bsky.social and NeMoS.
Free registration: nenckiopenlab.org/neuraldata/
Also featuring: @spikeinterface.bsky.social, @pynapple.bsky.social and NeMoS.
Free registration: nenckiopenlab.org/neuraldata/
Another public dataset for studying intrinsic ephys of engram cells (ex-vivo CA3 mice slices 24h after encoding).
entrepot.recherche.data.gouv.fr/dataset.xhtm...
From paper: "Early changes in the properties of CA3 engram cells explored with a novel viral tool" elifesciences.org/reviewed-pre...
entrepot.recherche.data.gouv.fr/dataset.xhtm...
From paper: "Early changes in the properties of CA3 engram cells explored with a novel viral tool" elifesciences.org/reviewed-pre...
entrepot.recherche.data.gouv.fr
October 19, 2026 at 6:14 PM
Another public dataset for studying intrinsic ephys of engram cells (ex-vivo CA3 mice slices 24h after encoding).
entrepot.recherche.data.gouv.fr/dataset.xhtm...
From paper: "Early changes in the properties of CA3 engram cells explored with a novel viral tool" elifesciences.org/reviewed-pre...
entrepot.recherche.data.gouv.fr/dataset.xhtm...
From paper: "Early changes in the properties of CA3 engram cells explored with a novel viral tool" elifesciences.org/reviewed-pre...
DREADDs friends, what concentration of DCZ do you use for slice ephys?
October 14, 2026 at 5:51 PM
DREADDs friends, what concentration of DCZ do you use for slice ephys?
Also your post reminded of this paper I ran into a few weeks ago on the topic of ephys and emergence. Just sharing for the vibes. royalsocietypublishing.org/rstb/article...
From damage response to action potentials: early evolution of neural and contractile modules in stem eukaryotes
Abstract. Eukaryotic cells convert external stimuli into membrane depolarization, which in turn triggers effector responses such as secretion and contracti
royalsocietypublishing.org
October 4, 2026 at 7:57 PM
Also your post reminded of this paper I ran into a few weeks ago on the topic of ephys and emergence. Just sharing for the vibes. royalsocietypublishing.org/rstb/article...
Public datasets to get cortical neuron waveforms to build a ephys waveform evolution tracker:
(1) Allen Institute Visual Coding dataset (brain-map.org/our-research...) which can be accessed via Python (allensdk.readthedocs.io/en/latest/vi...) or MATLAB (www.mathworks.com/matlabcentra...)
🧵
(1) Allen Institute Visual Coding dataset (brain-map.org/our-research...) which can be accessed via Python (allensdk.readthedocs.io/en/latest/vi...) or MATLAB (www.mathworks.com/matlabcentra...)
🧵
Ophys/Ephys Calibration Data
Optical physiology and electrophysiology calibration datasets. Validate calcium imaging with simultaneous electrical recordings for accurate analysis.
brain-map.org
October 4, 2026 at 6:37 PM
Public datasets to get cortical neuron waveforms to build a ephys waveform evolution tracker:
(1) Allen Institute Visual Coding dataset (brain-map.org/our-research...) which can be accessed via Python (allensdk.readthedocs.io/en/latest/vi...) or MATLAB (www.mathworks.com/matlabcentra...)
🧵
(1) Allen Institute Visual Coding dataset (brain-map.org/our-research...) which can be accessed via Python (allensdk.readthedocs.io/en/latest/vi...) or MATLAB (www.mathworks.com/matlabcentra...)
🧵
(2) Steinmetz Lab Neuropixels Ultra for all experiments (figshare.com/articles/dat...) and one experiment with the raw data available (github.com/jenniferColo...). Sidenote: For anyone that wants gorgeous ephys data for art's sake take a look.
Detailed neuronal waveforms across brain regions recorded with Neuropixels 'Ultra'
Spatiotemporal waveforms of ~6,000 neurons recorded across cortex, hippocampus, thalamus, striatum, and midbrain areas in awake mice, along with spike times.Associated with Ye, Shelton, et al. (2025) Neuron, in press. (preprint here)
figshare.com
October 4, 2026 at 6:49 PM
(2) Steinmetz Lab Neuropixels Ultra for all experiments (figshare.com/articles/dat...) and one experiment with the raw data available (github.com/jenniferColo...). Sidenote: For anyone that wants gorgeous ephys data for art's sake take a look.
Something like this but for intrinsic ephys dynamics like the AP afterpotential amongst other things.
"Single cortical neurons as deep artificial neural networks"
pubmed.ncbi.nlm.nih.gov/34380016/
"Single cortical neurons as deep artificial neural networks"
pubmed.ncbi.nlm.nih.gov/34380016/
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pubmed.ncbi.nlm.nih.gov
October 3, 2026 at 1:38 AM
Something like this but for intrinsic ephys dynamics like the AP afterpotential amongst other things.
"Single cortical neurons as deep artificial neural networks"
pubmed.ncbi.nlm.nih.gov/34380016/
"Single cortical neurons as deep artificial neural networks"
pubmed.ncbi.nlm.nih.gov/34380016/
The new issue revealed is an meaningful connection between intrinsic ephys data as a transnational deep learning NN to a structural causal model. It is not so much a data hunger problem.
October 3, 2026 at 1:20 AM
The new issue revealed is an meaningful connection between intrinsic ephys data as a transnational deep learning NN to a structural causal model. It is not so much a data hunger problem.
Those two public datasets I had previously share have ephys of engram encoding (hypothetical factual) and recognition/recall (hypothetical backtracking counterfactual). An error signal can be constructed from intrinsic behavior during engram activity (ACG? firing rate? bursting activity?).
October 2, 2026 at 4:29 PM
Those two public datasets I had previously share have ephys of engram encoding (hypothetical factual) and recognition/recall (hypothetical backtracking counterfactual). An error signal can be constructed from intrinsic behavior during engram activity (ACG? firing rate? bursting activity?).
More theory preamble. I wanted to further motivate my intuition about the backtracking counterfactuals (ideas of David Lewis, Bernhard Schölkopf) and learning (ideas of Timothy O'Leary) to the evolution of engram ephys (ideas of Denise Cai, various labs) and intrinsic activity (ideas of Denise Cai).
October 2, 2026 at 4:18 PM
More theory preamble. I wanted to further motivate my intuition about the backtracking counterfactuals (ideas of David Lewis, Bernhard Schölkopf) and learning (ideas of Timothy O'Leary) to the evolution of engram ephys (ideas of Denise Cai, various labs) and intrinsic activity (ideas of Denise Cai).