Spray-dried microparticles with a stabilizing polymer excipient enable ultra-high protein concentration therapeutics for subcutaneous injection, and could expand home use of these critical pharmaceuticals.
Learn more in #ScienceTranslationalMedicine: https://scim.ag/4fVabSg
Learn more in #ScienceTranslationalMedicine: https://scim.ag/4fVabSg
Ultrahigh-concentration biologic therapeutics enabled by spray drying with a glassy surfactant excipient
A copolymer excipient enables stable, ultrahigh-concentration protein formulations for subcutaneous injection.
scim.ag
August 25, 2025 at 6:00 PM
Spray-dried microparticles with a stabilizing polymer excipient enable ultra-high protein concentration therapeutics for subcutaneous injection, and could expand home use of these critical pharmaceuticals.
Learn more in #ScienceTranslationalMedicine: https://scim.ag/4fVabSg
Learn more in #ScienceTranslationalMedicine: https://scim.ag/4fVabSg
No, your body can't reject hormones. At worst you can have an allergy to an excipient. For instance some injectables come in grape seed oil and some people are allergic to it. In that case the solution is to change method. If your doctor said that, ask for a 2nd opinion with a trained professional.
January 18, 2026 at 3:44 PM
No, your body can't reject hormones. At worst you can have an allergy to an excipient. For instance some injectables come in grape seed oil and some people are allergic to it. In that case the solution is to change method. If your doctor said that, ask for a 2nd opinion with a trained professional.
Analytical chemists assuming engineers won't change the excipient ratio
September 26, 2026 at 12:55 PM
Analytical chemists assuming engineers won't change the excipient ratio
*gives Levi an ibuprofen*
Levi: “for da bactewia?”
Me: “so this doesn’t actually act on bacteria, it’s a non-selective cox1 and cox2 inhibitor —”
Levi: “no it don’t”
Me: “…yes it does —”
Levi: “no it don’t, it’s purple”
Me: “yes it is, the purple comes from an excipient though,”
Levi: “for da bactewia?”
Me: “so this doesn’t actually act on bacteria, it’s a non-selective cox1 and cox2 inhibitor —”
Levi: “no it don’t”
Me: “…yes it does —”
Levi: “no it don’t, it’s purple”
Me: “yes it is, the purple comes from an excipient though,”
August 2, 2025 at 12:26 AM
*gives Levi an ibuprofen*
Levi: “for da bactewia?”
Me: “so this doesn’t actually act on bacteria, it’s a non-selective cox1 and cox2 inhibitor —”
Levi: “no it don’t”
Me: “…yes it does —”
Levi: “no it don’t, it’s purple”
Me: “yes it is, the purple comes from an excipient though,”
Levi: “for da bactewia?”
Me: “so this doesn’t actually act on bacteria, it’s a non-selective cox1 and cox2 inhibitor —”
Levi: “no it don’t”
Me: “…yes it does —”
Levi: “no it don’t, it’s purple”
Me: “yes it is, the purple comes from an excipient though,”
Because claims RFK Jr. made on Mikhaila Peterson’s podcast are SO egregiously false on multiple levels, I dissected it.
Key points:
Peanut oil isn’t a vaccine excipient.
Aluminum is not allergenic.
How aluminum adjuvants work is VASTLY different than food allergy immunology.
1/
Key points:
Peanut oil isn’t a vaccine excipient.
Aluminum is not allergenic.
How aluminum adjuvants work is VASTLY different than food allergy immunology.
1/
Aluminum vaccine adjuvants are not causing food allergies
RFK Jr. is, yet again, spreading dangerous and false information on immunology concepts he doesn't understand
news.immunologic.org
December 5, 2024 at 2:28 PM
Because claims RFK Jr. made on Mikhaila Peterson’s podcast are SO egregiously false on multiple levels, I dissected it.
Key points:
Peanut oil isn’t a vaccine excipient.
Aluminum is not allergenic.
How aluminum adjuvants work is VASTLY different than food allergy immunology.
1/
Key points:
Peanut oil isn’t a vaccine excipient.
Aluminum is not allergenic.
How aluminum adjuvants work is VASTLY different than food allergy immunology.
1/
Delightful read of the day (with terrible implications)
The journey of clonazepam from API in Guangzhou to the tablet being consumed is 63,162 kms
www.cfp.ca/content/71/4...
From McMaster (school of engineering and family medicine)
h/t Chris Hannah of @theglobeandmail.com
The journey of clonazepam from API in Guangzhou to the tablet being consumed is 63,162 kms
www.cfp.ca/content/71/4...
From McMaster (school of engineering and family medicine)
h/t Chris Hannah of @theglobeandmail.com
May 28, 2025 at 11:01 PM
Delightful read of the day (with terrible implications)
The journey of clonazepam from API in Guangzhou to the tablet being consumed is 63,162 kms
www.cfp.ca/content/71/4...
From McMaster (school of engineering and family medicine)
h/t Chris Hannah of @theglobeandmail.com
The journey of clonazepam from API in Guangzhou to the tablet being consumed is 63,162 kms
www.cfp.ca/content/71/4...
From McMaster (school of engineering and family medicine)
h/t Chris Hannah of @theglobeandmail.com
Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry #NPJVaccines www.nature.com/articles/s41...
Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry - npj Vaccines
npj Vaccines - Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry
www.nature.com
January 31, 2025 at 8:22 AM
Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry #NPJVaccines www.nature.com/articles/s41...
Autre définition importante : qu’est ce qu’un excipient ?
Ce sont des substances sans activité thérapeutique qui entrent dans la composition d’un médicament ou qui sont utilisés pour sa fabrication.
Ce sont des substances sans activité thérapeutique qui entrent dans la composition d’un médicament ou qui sont utilisés pour sa fabrication.
May 3, 2025 at 1:18 PM
Autre définition importante : qu’est ce qu’un excipient ?
Ce sont des substances sans activité thérapeutique qui entrent dans la composition d’un médicament ou qui sont utilisés pour sa fabrication.
Ce sont des substances sans activité thérapeutique qui entrent dans la composition d’un médicament ou qui sont utilisés pour sa fabrication.
Trying to come up with a good probability for what Replika Oxidant tastes like.. like, can i use ethylene glycol (what makes antifreeze sweet) to make it a lil unique? its toxic (like replika oxidant) but it IS also used in some pharmaceuticals as an excipient (almost none, BUT-!!), so-
December 25, 2024 at 2:20 AM
Trying to come up with a good probability for what Replika Oxidant tastes like.. like, can i use ethylene glycol (what makes antifreeze sweet) to make it a lil unique? its toxic (like replika oxidant) but it IS also used in some pharmaceuticals as an excipient (almost none, BUT-!!), so-
An excipient, yes, to deter you.
March 26, 2025 at 7:57 PM
An excipient, yes, to deter you.
IMJ March 2025 #FreeAccess
Review: Excipient-induced allergies in oral medications
bit.ly/43CIVDE
@marrow.bsky.social @theracp.bsky.social
Review: Excipient-induced allergies in oral medications
bit.ly/43CIVDE
@marrow.bsky.social @theracp.bsky.social
March 16, 2025 at 1:00 AM
IMJ March 2025 #FreeAccess
Review: Excipient-induced allergies in oral medications
bit.ly/43CIVDE
@marrow.bsky.social @theracp.bsky.social
Review: Excipient-induced allergies in oral medications
bit.ly/43CIVDE
@marrow.bsky.social @theracp.bsky.social
A copolymer excipient enables stable, ultrahigh-concentration protein formulations for subcutaneous injection @alexprossnitz.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 20, 2025 at 8:47 PM
A copolymer excipient enables stable, ultrahigh-concentration protein formulations for subcutaneous injection @alexprossnitz.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Moi c'est la crème fraîche, les desserts "spécialité lactée", le lait en poudre ajouté, et le lactose pur excipient dans les médicaments qui me gênent le plus
August 14, 2026 at 6:10 PM
Moi c'est la crème fraîche, les desserts "spécialité lactée", le lait en poudre ajouté, et le lactose pur excipient dans les médicaments qui me gênent le plus
Ultrahigh-concentration biologic therapeutics enabled by spray drying with a glassy surfactant excipient
"The technology could open the door for home injection of many protein-based drugs that are only available in the clinic."
www.science.org/doi/10.1126/...
"The technology could open the door for home injection of many protein-based drugs that are only available in the clinic."
www.science.org/doi/10.1126/...
August 21, 2025 at 2:45 AM
Ultrahigh-concentration biologic therapeutics enabled by spray drying with a glassy surfactant excipient
"The technology could open the door for home injection of many protein-based drugs that are only available in the clinic."
www.science.org/doi/10.1126/...
"The technology could open the door for home injection of many protein-based drugs that are only available in the clinic."
www.science.org/doi/10.1126/...
Em pareix rarissim, pero tal volta per a consumir certs medicaments? A voltes hi porten lactosa com a excipient
July 23, 2026 at 1:58 PM
Em pareix rarissim, pero tal volta per a consumir certs medicaments? A voltes hi porten lactosa com a excipient
Could be a mast cell issue? Problem may not be the active ingredient but an excipient. EG. I’m fine on the original brand name Ivabradine but generic Ivabradine has excipients that set my mast cells off. Only reason I knew it was an excipient issue was because I started taking brand name first.
December 8, 2024 at 5:00 AM
Could be a mast cell issue? Problem may not be the active ingredient but an excipient. EG. I’m fine on the original brand name Ivabradine but generic Ivabradine has excipients that set my mast cells off. Only reason I knew it was an excipient issue was because I started taking brand name first.
Hello, here's a little aid against daily horror, "Eropillzine 40 mg" can help... 😆 kck.st/48XcnFc
EROPILLZINE 40 mg
Contains high-quality active ingredients: Passion, Sensuality; feat. the stunning model Giagei! Excipient: Paper, Ink, and Pixels -NSFW
kck.st
November 18, 2024 at 5:31 PM
Hello, here's a little aid against daily horror, "Eropillzine 40 mg" can help... 😆 kck.st/48XcnFc
Why the fuck is there lactose in vagina estradiol suppositories? Any type of sugar (lactose is a milk sugar) in the “hoo-hah” would directly feed yeast, therefore that excipient ingredient could cause yeast infections. Are people that manufacture this stuff ignorant?
July 5, 2026 at 11:06 PM
Why the fuck is there lactose in vagina estradiol suppositories? Any type of sugar (lactose is a milk sugar) in the “hoo-hah” would directly feed yeast, therefore that excipient ingredient could cause yeast infections. Are people that manufacture this stuff ignorant?
Pas de plus clair aveu qu’ils n’en ont rien à foutre de leur électorat prolo qui n’est qu’un excipient pour les porter au pouvoir.
September 25, 2024 at 5:57 PM
Pas de plus clair aveu qu’ils n’en ont rien à foutre de leur électorat prolo qui n’est qu’un excipient pour les porter au pouvoir.
It’s not quite all nonsense. There’s often a grain of truth. Allergy to the vehicle/excipient (such as albumen) in vaccines, for example. I myself came down with shingles within a couple of days of receiving my first Covid vaccine. The problem is perhaps failure of risk comprehension.
September 17, 2026 at 12:40 PM
It’s not quite all nonsense. There’s often a grain of truth. Allergy to the vehicle/excipient (such as albumen) in vaccines, for example. I myself came down with shingles within a couple of days of receiving my first Covid vaccine. The problem is perhaps failure of risk comprehension.
With any drug you have to validate everything. Every excipient, incipient, method of analysis, raw material suppliers, analytical & manufacturing equipment, and ensure everything meets USP standards.
February 7, 2025 at 11:46 PM
With any drug you have to validate everything. Every excipient, incipient, method of analysis, raw material suppliers, analytical & manufacturing equipment, and ensure everything meets USP standards.
As a practical matter, isn’t it like putting the proverbial toothpaste back in the tube? If I were a SNAP excipient whose card suddenly had the regular amt I’d be at the store asap. How are states supposed to deal with that? States need to sue. USDA sent a letter telling states to proceed & some did
November 9, 2025 at 7:23 PM
As a practical matter, isn’t it like putting the proverbial toothpaste back in the tube? If I were a SNAP excipient whose card suddenly had the regular amt I’d be at the store asap. How are states supposed to deal with that? States need to sue. USDA sent a letter telling states to proceed & some did
Una mica agosarat dir que no serveix per res. Boiron i la fortuna que han fet venent excipient, discrepen.
April 22, 2026 at 2:58 PM
Una mica agosarat dir que no serveix per res. Boiron i la fortuna que han fet venent excipient, discrepen.