die Atemwege beschränkt bleibt. Daher stellt die gezielte Hemmung der ORF3a-vermittelten Lungen-Leber-Achse mit spezifischen Inhibitoren oder Antikörpern eine vielversprechende therapeutische Strategie zur Milderung von COVID-19-bedingten Leberschäden dar.«
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19 - Cell Discovery
Cell Discovery - Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19
www.nature.com
May 25, 2026 at 4:14 PM
die Atemwege beschränkt bleibt. Daher stellt die gezielte Hemmung der ORF3a-vermittelten Lungen-Leber-Achse mit spezifischen Inhibitoren oder Antikörpern eine vielversprechende therapeutische Strategie zur Milderung von COVID-19-bedingten Leberschäden dar.«
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Type 2 Diabetes increases metastasis of triple-negative breast cancer via exosomal microRNAs. The findings could lead to personalized treatment plans for breast cancer patients with metabolic conditions. 🩷🧪
BU Researchers Discover Connection Between Metabolism and Aggressive Breast
In a groundbreaking study conducted by the researchers at Boston University’s Chobanian & Avedisian School of Medicine, important insights into the relationship between diabetes and t
bioengineer.org
March 10, 2025 at 3:10 AM
Type 2 Diabetes increases metastasis of triple-negative breast cancer via exosomal microRNAs. The findings could lead to personalized treatment plans for breast cancer patients with metabolic conditions. 🩷🧪
Exosomal RNA can be isolated from various body fluids such as plasma, urine, saliva, and cerebrospinal fluid.
🔬 New research highlights how exosomal RNA & miRNAs could reshape inflammation research.
📌 Let’s break it down. 🧵👇
#SignalBoost #AcademicSky
🔬 New research highlights how exosomal RNA & miRNAs could reshape inflammation research.
📌 Let’s break it down. 🧵👇
#SignalBoost #AcademicSky
March 25, 2025 at 3:41 PM
Exosomal RNA can be isolated from various body fluids such as plasma, urine, saliva, and cerebrospinal fluid.
🔬 New research highlights how exosomal RNA & miRNAs could reshape inflammation research.
📌 Let’s break it down. 🧵👇
#SignalBoost #AcademicSky
🔬 New research highlights how exosomal RNA & miRNAs could reshape inflammation research.
📌 Let’s break it down. 🧵👇
#SignalBoost #AcademicSky
Not that this isn't really cool and important work, but I feel like rendering senescent cells proliferative again should be very concerning from the lens of potential oncogenicity, particularly since the major mechanism identified here is repression of cell cycle arrest checkpoints
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
Bi et al. propose the Senoreverse anti-aging strategy, which aims to reverse the proliferative
arrest of senescent cells. Exosomal miR-302b is identified as a Senoreverse candidate
that targets the ce...
www.cell.com
January 18, 2025 at 6:01 PM
Not that this isn't really cool and important work, but I feel like rendering senescent cells proliferative again should be very concerning from the lens of potential oncogenicity, particularly since the major mechanism identified here is repression of cell cycle arrest checkpoints
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
Bi et al. propose the Senoreverse anti-aging strategy, which aims to reverse the proliferative
arrest of senescent cells. Exosomal miR-302b is identified as a Senoreverse candidate
that targets the ce...
www.cell.com
January 16, 2025 at 2:28 PM
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Ruijin Hospital, 196 patients. In mild COVID, 53% of infected patients had abnormal liver tests.
Mouse and lab grown liver models suggest a viral protein called ORF3a can travel from lung to liver and promote fat buildup and inflammation.
www.nature.com/articles/s41...
Mouse and lab grown liver models suggest a viral protein called ORF3a can travel from lung to liver and promote fat buildup and inflammation.
www.nature.com/articles/s41...
Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19 - Cell Discovery
Cell Discovery - Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19
www.nature.com
May 23, 2026 at 10:54 PM
Ruijin Hospital, 196 patients. In mild COVID, 53% of infected patients had abnormal liver tests.
Mouse and lab grown liver models suggest a viral protein called ORF3a can travel from lung to liver and promote fat buildup and inflammation.
www.nature.com/articles/s41...
Mouse and lab grown liver models suggest a viral protein called ORF3a can travel from lung to liver and promote fat buildup and inflammation.
www.nature.com/articles/s41...
CD11d+ NK cell-derived exosomal HSPB1 suppresses angiogenesis in adenomyosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CD11d+ NK cell-derived exosomal HSPB1 suppresses angiogenesis in adenomyosis - Genes & Immunity
Genes & Immunity - CD11d+ NK cell-derived exosomal HSPB1 suppresses angiogenesis in adenomyosis
www.nature.com
February 28, 2026 at 3:45 PM
CD11d+ NK cell-derived exosomal HSPB1 suppresses angiogenesis in adenomyosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CHECK IT 🦠UT:
Exosomal siRNA delivery to inhibit bacterial gene translation
Proof-of principle in MRSA, using siMecA to silence the mecA gene, resensitizing the pathogen to methicillin
This RNA interference approach worked in the mouse model
#GeneSilencing #AMR
www.cell.com/cell-reports...
Exosomal siRNA delivery to inhibit bacterial gene translation
Proof-of principle in MRSA, using siMecA to silence the mecA gene, resensitizing the pathogen to methicillin
This RNA interference approach worked in the mouse model
#GeneSilencing #AMR
www.cell.com/cell-reports...
March 8, 2025 at 12:45 PM
CHECK IT 🦠UT:
Exosomal siRNA delivery to inhibit bacterial gene translation
Proof-of principle in MRSA, using siMecA to silence the mecA gene, resensitizing the pathogen to methicillin
This RNA interference approach worked in the mouse model
#GeneSilencing #AMR
www.cell.com/cell-reports...
Exosomal siRNA delivery to inhibit bacterial gene translation
Proof-of principle in MRSA, using siMecA to silence the mecA gene, resensitizing the pathogen to methicillin
This RNA interference approach worked in the mouse model
#GeneSilencing #AMR
www.cell.com/cell-reports...
Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19
Interesting but mechanistically weak and not suited to support strong causal claims, especially not for LongCovid.
www.nature.com/artic...
1/5
Interesting but mechanistically weak and not suited to support strong causal claims, especially not for LongCovid.
www.nature.com/artic...
1/5
Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19
Cell Discovery - Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19
www.nature.com
May 27, 2026 at 3:21 PM
Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19
Interesting but mechanistically weak and not suited to support strong causal claims, especially not for LongCovid.
www.nature.com/artic...
1/5
Interesting but mechanistically weak and not suited to support strong causal claims, especially not for LongCovid.
www.nature.com/artic...
1/5
Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
July 15, 2025 at 3:49 PM
Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
The pancreas does more than you think. Pancreatic Cancer often grows silently. Learn how symptoms, risks, and exosomal biomarker based detection are reshaping the fight.
Read more 👉 norgenbiotek.com/blog/pancrea...
#PancreaticCancer #HealthResearch #EarlyDetection
1/6
Read more 👉 norgenbiotek.com/blog/pancrea...
#PancreaticCancer #HealthResearch #EarlyDetection
1/6
April 15, 2025 at 3:07 PM
The pancreas does more than you think. Pancreatic Cancer often grows silently. Learn how symptoms, risks, and exosomal biomarker based detection are reshaping the fight.
Read more 👉 norgenbiotek.com/blog/pancrea...
#PancreaticCancer #HealthResearch #EarlyDetection
1/6
Read more 👉 norgenbiotek.com/blog/pancrea...
#PancreaticCancer #HealthResearch #EarlyDetection
1/6
Chinese colleagues present a method to combat MRSA by using exosomes to deliver siRNA into bacteria, silencing the gene responsible for #AMR. This approach could make MRSA treatable with conventional antibiotics, offering hope against multidrug-resistant infections.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
siRNA-AGO2 complex inhibits bacterial gene translation: A promising therapeutic strategy for superbug infection
Wang et al. report that the exosomal siRNA-AGO2 complex silences the target bacterial
gene by translational repression without mRNA degradation and consequently develop
a therapeutic strategy to impro...
www.cell.com
March 12, 2025 at 10:31 AM
Chinese colleagues present a method to combat MRSA by using exosomes to deliver siRNA into bacteria, silencing the gene responsible for #AMR. This approach could make MRSA treatable with conventional antibiotics, offering hope against multidrug-resistant infections.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers
www.frontiersin.org/journals/mol...
Review. "Our analyses suggest that EV-LncRNAs are molecular connectors linking the major etiological domains of CFS”
#MEcfs #PwME
www.frontiersin.org/journals/mol...
Review. "Our analyses suggest that EV-LncRNAs are molecular connectors linking the major etiological domains of CFS”
#MEcfs #PwME
Frontiers | The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers
Chronic fatigue syndrome (CFS) is a complex disease involving multiple systems throughout the body with unknown pathogenesis and is characterized by chronic ...
www.frontiersin.org
August 31, 2025 at 2:45 PM
The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers
www.frontiersin.org/journals/mol...
Review. "Our analyses suggest that EV-LncRNAs are molecular connectors linking the major etiological domains of CFS”
#MEcfs #PwME
www.frontiersin.org/journals/mol...
Review. "Our analyses suggest that EV-LncRNAs are molecular connectors linking the major etiological domains of CFS”
#MEcfs #PwME
🍹Sharma, Jiao et al. report glycosylation of small RNAs within #exosomes and propose a glycosylation-dependent mechanism for #RNA targeting into exosomes, which may influence intercellular communication and RNA stability in the extracellular environment.
👉https://rdcu.be/eykKY
bit.ly/455vyuP
👉https://rdcu.be/eykKY
bit.ly/455vyuP
Extracellular exosomal RNAs are glyco-modified - Nature Cell Biology
Sharma, Jiao and colleagues report glycosylation of small RNAs within exosomes and propose a glycosylation-dependent mechanism for RNA targeting into exosomes, which may influence intercellular commun...
bit.ly
July 29, 2025 at 12:07 PM
🍹Sharma, Jiao et al. report glycosylation of small RNAs within #exosomes and propose a glycosylation-dependent mechanism for #RNA targeting into exosomes, which may influence intercellular communication and RNA stability in the extracellular environment.
👉https://rdcu.be/eykKY
bit.ly/455vyuP
👉https://rdcu.be/eykKY
bit.ly/455vyuP
🎯 Could targeting senescent cells slow aging?
🌌 A recent paper explores “Senoreverse,” using exosomal miR-302b to counteract the proliferative arrest in aging cells.
🐭 The approach shows promise for extending lifespan and improving healthspan in mice.
#RNAsky
🧵
1/4
🌌 A recent paper explores “Senoreverse,” using exosomal miR-302b to counteract the proliferative arrest in aging cells.
🐭 The approach shows promise for extending lifespan and improving healthspan in mice.
#RNAsky
🧵
1/4
January 27, 2025 at 6:10 AM
🎯 Could targeting senescent cells slow aging?
🌌 A recent paper explores “Senoreverse,” using exosomal miR-302b to counteract the proliferative arrest in aging cells.
🐭 The approach shows promise for extending lifespan and improving healthspan in mice.
#RNAsky
🧵
1/4
🌌 A recent paper explores “Senoreverse,” using exosomal miR-302b to counteract the proliferative arrest in aging cells.
🐭 The approach shows promise for extending lifespan and improving healthspan in mice.
#RNAsky
🧵
1/4
🔬 Journal Club
This week, @martijnrutten.bsky.social presented "Exosomal miR-302b rejuvenates aging mice" (Bi et al., Cell Metab, 2025).
🧬 miR-302b rescues proliferative arrest in senescent cells
🐭 Improves tissue function in aged mice
Great discussion on the possibility of reversing senescence!
This week, @martijnrutten.bsky.social presented "Exosomal miR-302b rejuvenates aging mice" (Bi et al., Cell Metab, 2025).
🧬 miR-302b rescues proliferative arrest in senescent cells
🐭 Improves tissue function in aged mice
Great discussion on the possibility of reversing senescence!
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
Bi et al. propose the Senoreverse anti-aging strategy, which aims to reverse the proliferative
arrest of senescent cells. Exosomal miR-302b is identified as a Senoreverse candidate
that targets the ce...
www.cell.com
February 14, 2025 at 12:46 PM
🔬 Journal Club
This week, @martijnrutten.bsky.social presented "Exosomal miR-302b rejuvenates aging mice" (Bi et al., Cell Metab, 2025).
🧬 miR-302b rescues proliferative arrest in senescent cells
🐭 Improves tissue function in aged mice
Great discussion on the possibility of reversing senescence!
This week, @martijnrutten.bsky.social presented "Exosomal miR-302b rejuvenates aging mice" (Bi et al., Cell Metab, 2025).
🧬 miR-302b rescues proliferative arrest in senescent cells
🐭 Improves tissue function in aged mice
Great discussion on the possibility of reversing senescence!
Congratulations to Stephanie Efthymiou on successfully being awarded a NBA small acorns fund - 'Validating exosomal RNA profiling methods in plasma and CSF of patients with multiple sclerosis', starting in January 2026
December 8, 2025 at 4:42 PM
Congratulations to Stephanie Efthymiou on successfully being awarded a NBA small acorns fund - 'Validating exosomal RNA profiling methods in plasma and CSF of patients with multiple sclerosis', starting in January 2026
#WeekendRead! #LiveForever! Ji &co show @cp-cellmetabolism.bsky.social that stem cell derived exomes contain a miRA capable of block cell cycle inhibitors, allowing the proliferation of senescent cells & rejuvenating mice extending life span & physical performances! www.cell.com/cell-metabol...
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
Bi et al. propose the Senoreverse anti-aging strategy, which aims to reverse the proliferative
arrest of senescent cells. Exosomal miR-302b is identified as a Senoreverse candidate
that targets the ce...
www.cell.com
January 18, 2025 at 5:17 PM
#WeekendRead! #LiveForever! Ji &co show @cp-cellmetabolism.bsky.social that stem cell derived exomes contain a miRA capable of block cell cycle inhibitors, allowing the proliferation of senescent cells & rejuvenating mice extending life span & physical performances! www.cell.com/cell-metabol...
Interesting evidence that FGF9 protects high glucose-induced EMT in vitro
FGF9⏬in human #DiabeticNephropathy
A possible Exosomal circRNA-miRNA-FGF9 regulatory axis (in silico only, needs experimental validation)
@plosone.org 2025
journals.plos.org/plosone/arti...
FGF9⏬in human #DiabeticNephropathy
A possible Exosomal circRNA-miRNA-FGF9 regulatory axis (in silico only, needs experimental validation)
@plosone.org 2025
journals.plos.org/plosone/arti...
November 28, 2025 at 8:00 PM
Interesting evidence that FGF9 protects high glucose-induced EMT in vitro
FGF9⏬in human #DiabeticNephropathy
A possible Exosomal circRNA-miRNA-FGF9 regulatory axis (in silico only, needs experimental validation)
@plosone.org 2025
journals.plos.org/plosone/arti...
FGF9⏬in human #DiabeticNephropathy
A possible Exosomal circRNA-miRNA-FGF9 regulatory axis (in silico only, needs experimental validation)
@plosone.org 2025
journals.plos.org/plosone/arti...
Cancer stem cells-derived exosomal TSPAN8 enhances non-stem cancer cells stemness and promotes malignant progression in PDAC 🧪 www.nature.com/articles/s41...
Cancer stem cells-derived exosomal TSPAN8 enhances non-stem cancer cells stemness and promotes malignant progression in PDAC - Oncogene
Oncogene - Cancer stem cells-derived exosomal TSPAN8 enhances non-stem cancer cells stemness and promotes malignant progression in PDAC
www.nature.com
April 19, 2025 at 5:03 PM
Cancer stem cells-derived exosomal TSPAN8 enhances non-stem cancer cells stemness and promotes malignant progression in PDAC 🧪 www.nature.com/articles/s41...
La noticia que comparto de Nature es un resumen divulgativo del artículo, aunque para suscriptores. El artículo original (en abierto) es este. www.sciencedirect.com/science/arti...
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
Cellular senescence, a hallmark of aging, involves a stable exit from the cell cycle. Senescent cells (SnCs) are closely associated with aging and agi…
www.sciencedirect.com
January 18, 2025 at 11:16 AM
La noticia que comparto de Nature es un resumen divulgativo del artículo, aunque para suscriptores. El artículo original (en abierto) es este. www.sciencedirect.com/science/arti...