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elife.bsky.social
Acute opioid responses are modulated by dynamic interactions of <i>Oprm1</i> and <i>Fgf12</i>
Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12
A time-dependent genetic interaction between the µ opioid receptor and genes drives early morphine responses in mice, highlighting pathways linked to human substance use disorder.
buff.ly
September 29, 2026 at 8:01 PM
elife.bsky.social
Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12
elifesciences.org/articles/108...
Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12
A time-dependent genetic interaction between the µ opioid receptor and genes drives early morphine responses in mice, highlighting pathways linked to human substance use disorder.
elifesciences.org
September 29, 2026 at 3:11 PM
elife.bsky.social
Experiments reveal that a time-dependent epistatic interaction influences how mice respond to opioids, and that intracellular fibroblast growth factors also influence opioid sensitivity.
buff.ly/1iXyw1p
The Oprm1–Fgf12 network in opioid use disorder.
January 20, 2026 at 9:02 PM
biorxivpreprint.bsky.social
FGF12 Modulates Cardiomyocyte Hypertrophy by Inhibiting GATA4-ERK1/2 Phosphorylation Through Altered Intracellular Localization https://www.biorxiv.org/content/10.1101/2023.12.20.572709v1
FGF12 Modulates Cardiomyocyte Hypertrophy by Inhibiting GATA4-ERK1/2 Phosphorylation Through Altered Intracellular Localization https://www.biorxiv.org/content/10.1101/2023.12.20.572709v1
Background: Hypertrophic cardiomyopathy (HCM) is a heritable pathological condition resulting from m
www.biorxiv.org
December 22, 2023 at 12:20 PM
epilepsiajournal.bsky.social
FGF12 duplications in DEE impair Nav channel function, leading to a loss-of-function effect and epilepsy-related regression.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #FGF12 #intellectualdisability
September 11, 2025 at 7:39 PM
epilepsiajournal.bsky.social
Broadening the phenotype associated with pathogenic variants in the FGF12 gene: From developmental and epileptic encephalopathy to drug-responsive epilepsy with favorable cognitive outcome
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #DEE #earlyonset #FGF12 #FHF1 #sodiumchannelblocker
June 30, 2025 at 2:30 PM
biorxiv-molbio.bsky.social
FGF12 Modulates Cardiomyocyte Hypertrophy by Inhibiting GATA4-ERK1/2 Phosphorylation Through Altered Intracellular Localization https://www.biorxiv.org/content/10.1101/2023.12.20.572709v1
FGF12 Modulates Cardiomyocyte Hypertrophy by Inhibiting GATA4-ERK1/2 Phosphorylation Through Altered Intracellular Localization https://www.biorxiv.org/content/10.1101/2023.12.20.572709v1
Background: Hypertrophic cardiomyopathy (HCM) is a heritable pathological condition resulting from m
www.biorxiv.org
December 22, 2023 at 12:20 PM