A good starting point to understanding the function of any protein is to look at its structure. In this paper, the groups of @bornberglab.bsky.social and @KlaraHlouchova have designed a #FRET-FACS based assay that estimates the folding propensity of de novo proteins.
🧵 6/9
🧵 6/9
High-throughput Selection of Human de novo-emerged sORFs with High Folding Potential
Abstract. De novo genes emerge from previously noncoding stretches of the genome. Their encoded de novo proteins are generally expected to be similar to ra
academic.oup.com
March 16, 2025 at 5:03 PM
A good starting point to understanding the function of any protein is to look at its structure. In this paper, the groups of @bornberglab.bsky.social and @KlaraHlouchova have designed a #FRET-FACS based assay that estimates the folding propensity of de novo proteins.
🧵 6/9
🧵 6/9