by Manoj Thapa, Anuradha Kumari, Chui-Yoke Chin, Jacob E. Choby, Elahe Akbari, Bikash Bogati, Fengzhi Jin, Elise Furr, Daniel M. Chopyk, Nitya Koduri, Andrew Pahnke, Theodore L. Burns, Elizabeth J. Elrod, Eileen M. Burd, David S. Weiss, Arash Grakoui Recent advances suggest a correlation between gut dysbiosis and neurological diseases, however, relatively little is known about how gut bacteria impact the brain. Here, we reveal that bacteria can translocate directly from the gut to the brain in small numbers when mice are fed an atherogenic, high-fat diet (Paigen diet) that causes alterations in gut microbiome composition and gut barrier permeability. The bacteria were not found in other systemic sites or the blood, but were detected in the vagus nerve. Right cervical vagotomy reduced bacterial burden in the brain, implicating the vagus nerve as a conduit for bacterial translocation from the gut to the brain. Antibiotic treatment perturbed the composition of the gut microbiome and correspondingly changed the bacteria that localized to the brain in the setting of Paigen diet feeding. To further establish the gut as the origin of bacterial translocation to the brain, we gavaged exogenous Enterobacter cloacae into Paigen diet-fed mice, subsequently detecting the E. cloacae in the gut and brain. In addition, we monocolonized germ-free mice with E. cloacae and only cultured the bacteria from the brains of mice fed Paigen diet, but not those fed standard diet. Localization of bacteria to the brain in Paigen diet-fed mice was reversible with return to normal diet. Bacteria were also detected in the brain of murine models of Alzheimer’s, Parkinson’s, and autism spectrum disorder fed standard diet. These data reveal a bacterial translocation axis from the gut to the brain, impacted by environmental (diet) and genetic factors, and warrant further investigation to determine if this phenomenon also occurs in humans and to elucidate whether it may play a role in diverse neurological conditions.

Localising cosmopolitanism in place talk: Semiotic landscape as stance object - Volume 54 Issue 2

ニューヨーク連邦地方裁判所は22日、中国の化学品メーカーの女幹部に対し、「フェンタニル」の原料をアメリカへ密輸した罪などで懲役15年の実刑判決を言い渡しました。 中国フェンタニル組織、女幹部に懲役15年　日本法人のサイト運営者https://t.co/5lkSjF3AcN — 日本経済新聞 電子版（日経電子版） (@nikkei) August 22, 2025 実刑判決を受けたのは、中国・武漢の...

ニューヨーク連邦地方裁判所は22日、中国の化学品メーカーの女幹部に対し、「フェンタニル」の原料をアメリカへ密輸した罪などで懲役15年の実刑判決を言い渡しました。 中国フェンタニル組織、女幹部に懲役15年　日本法人のサイト運営者https://t.co/5lkSjF3AcN — 日本経済新聞 電子版（日経電子版） (@nikkei) August 22, 2025 実刑判決を受けたのは、中国・武漢の...

Inherently chiral scaffolds are a unique type of structurally fascinating building blocks, which have found increasing applications in the field of material chemistry, medicinal chemistry, asymmetric synthesis, molecular recognition and assembly. Owing to the steady demand for these chiral entities, numerous effort

by Manoj Thapa, Anuradha Kumari, Chui-Yoke Chin, Jacob E. Choby, Elahe Akbari, Bikash Bogati, Fengzhi Jin, Elise Furr, Daniel M. Chopyk, Nitya Koduri, Andrew Pahnke, Theodore L. Burns, Elizabeth J. Elrod, Eileen M. Burd, David S. Weiss, Arash Grakoui Recent advances suggest a correlation between gut dysbiosis and neurological diseases, however, relatively little is known about how gut bacteria impact the brain. Here, we reveal that bacteria can translocate directly from the gut to the brain in small numbers when mice are fed an atherogenic, high-fat diet (Paigen diet) that causes alterations in gut microbiome composition and gut barrier permeability. The bacteria were not found in other systemic sites or the blood, but were detected in the vagus nerve. Right cervical vagotomy reduced bacterial burden in the brain, implicating the vagus nerve as a conduit for bacterial translocation from the gut to the brain. Antibiotic treatment perturbed the composition of the gut microbiome and correspondingly changed the bacteria that localized to the brain in the setting of Paigen diet feeding. To further establish the gut as the origin of bacterial translocation to the brain, we gavaged exogenous Enterobacter cloacae into Paigen diet-fed mice, subsequently detecting the E. cloacae in the gut and brain. In addition, we monocolonized germ-free mice with E. cloacae and only cultured the bacteria from the brains of mice fed Paigen diet, but not those fed standard diet. Localization of bacteria to the brain in Paigen diet-fed mice was reversible with return to normal diet. Bacteria were also detected in the brain of murine models of Alzheimer’s, Parkinson’s, and autism spectrum disorder fed standard diet. These data reveal a bacterial translocation axis from the gut to the brain, impacted by environmental (diet) and genetic factors, and warrant further investigation to determine if this phenomenon also occurs in humans and to elucidate whether it may play a role in diverse neurological conditions.

by Manoj Thapa, Anuradha Kumari, Chui-Yoke Chin, Jacob E. Choby, Elahe Akbari, Bikash Bogati, Fengzhi Jin, Elise Furr, Daniel M. Chopyk, Nitya Koduri, Andrew Pahnke, Theodore L. Burns, Elizabeth J. Elrod, Eileen M. Burd, David S. Weiss, Arash Grakoui Recent advances suggest a correlation between gut dysbiosis and neurological diseases, however, relatively little is known about how gut bacteria impact the brain. Here, we reveal that bacteria can translocate directly from the gut to the brain in small numbers when mice are fed an atherogenic, high-fat diet (Paigen diet) that causes alterations in gut microbiome composition and gut barrier permeability. The bacteria were not found in other systemic sites or the blood, but were detected in the vagus nerve. Right cervical vagotomy reduced bacterial burden in the brain, implicating the vagus nerve as a conduit for bacterial translocation from the gut to the brain. Antibiotic treatment perturbed the composition of the gut microbiome and correspondingly changed the bacteria that localized to the brain in the setting of Paigen diet feeding. To further establish the gut as the origin of bacterial translocation to the brain, we gavaged exogenous Enterobacter cloacae into Paigen diet-fed mice, subsequently detecting the E. cloacae in the gut and brain. In addition, we monocolonized germ-free mice with E. cloacae and only cultured the bacteria from the brains of mice fed Paigen diet, but not those fed standard diet. Localization of bacteria to the brain in Paigen diet-fed mice was reversible with return to normal diet. Bacteria were also detected in the brain of murine models of Alzheimer’s, Parkinson’s, and autism spectrum disorder fed standard diet. These data reveal a bacterial translocation axis from the gut to the brain, impacted by environmental (diet) and genetic factors, and warrant further investigation to determine if this phenomenon also occurs in humans and to elucidate whether it may play a role in diverse neurological conditions.

FL118 was discovered in the laboratory of Fengzhi Li, PhD, at Roswell Park Cancer-fighting agent is based on compound used in traditional Chinese medicine FDA Orphan Drug Designation supports development of rare disease therapies Newswise — BUFFALO, N.Y. — The U.S. Food and Drug Administration has granted Rare Pediatric Disease Designation and Orphan Drug Designation to Canget BioTekpharma LLC, a Roswell Park spinoff company, for FL118, a novel anticancer drug candidate discovered at Roswell Park Comprehensive Cancer Center, for the treatment of osteosarcoma. Together, the designations strengthen the development position of FL118 and may help support future clinical, translational and strategic collaboration efforts aimed at advancing new treatment options for patients with osteosarcoma and other rare cancers. FL118, also known by its chemical name 10,11-methylenedioxy-20(S)-camptothecin (10,11-MD-CPT), is a novel camptothecin-derived small molecule based on a compound found in Xishu tree bark, and used in traditional Chinese medicine. FL118 was previously granted FDA Orphan Drug Designation for the treatment of pancreatic cancer, and the new osteosarcoma-related designations further expand the regulatory and development foundation for FL118 in rare and difficult-to-treat cancers. Osteosarcoma is a rare, aggressive bone cancer that most commonly affects children, adolescents and young adults. Despite advances in surgery...