(Hijyen hipotezi ile ilişkili: mikrobiyal çeşitlilik eksikliği hastalığı ağırlaştırabilir.)
• Çok yüksek serum IgE düzeyleri
(Ağır fenotip ve dirençli hastalıkla koreledir.)
• Filaggrin geninde mutasyon
(Cilt bariyer defekti → daha erken başlangıç, enfeksiyon riski, ağır seyir.)⚕️💊🩻
• Çok yüksek serum IgE düzeyleri
(Ağır fenotip ve dirençli hastalıkla koreledir.)
• Filaggrin geninde mutasyon
(Cilt bariyer defekti → daha erken başlangıç, enfeksiyon riski, ağır seyir.)⚕️💊🩻
July 28, 2026 at 11:01 PM
(Hijyen hipotezi ile ilişkili: mikrobiyal çeşitlilik eksikliği hastalığı ağırlaştırabilir.)
• Çok yüksek serum IgE düzeyleri
(Ağır fenotip ve dirençli hastalıkla koreledir.)
• Filaggrin geninde mutasyon
(Cilt bariyer defekti → daha erken başlangıç, enfeksiyon riski, ağır seyir.)⚕️💊🩻
• Çok yüksek serum IgE düzeyleri
(Ağır fenotip ve dirençli hastalıkla koreledir.)
• Filaggrin geninde mutasyon
(Cilt bariyer defekti → daha erken başlangıç, enfeksiyon riski, ağır seyir.)⚕️💊🩻
Loss of kallikrein 5 expression exacerbates allergic skin inflammation including impairing filaggrin processing, promoting Th2 differentiation and inducing dysbiosis from @cincychildrens.bsky.social www.mucosalimmunology.org/article/S193...
September 25, 2026 at 12:18 PM
Loss of kallikrein 5 expression exacerbates allergic skin inflammation including impairing filaggrin processing, promoting Th2 differentiation and inducing dysbiosis from @cincychildrens.bsky.social www.mucosalimmunology.org/article/S193...
Loss of kallikrein 5 expression exacerbates allergic skin inflammation including impairing filaggrin processing, promoting Th2 differentiation and inducing dysbiosis
@cincyresearch.bsky.social @mucosalimmunol.bsky.social
www.sciencedirect.com/science/arti...
@cincyresearch.bsky.social @mucosalimmunol.bsky.social
www.sciencedirect.com/science/arti...
Loss of kallikrein 5 expression exacerbates allergic skin inflammation including impairing filaggrin processing, promoting Th2 differentiation and inducing dysbiosis
Atopic dermatitis (AD) is a chronic allergic skin disease with T helper 2 (Th2) cell predominance and epithelial barrier impairment. The serine protea…
www.sciencedirect.com
September 21, 2026 at 3:20 PM
Loss of kallikrein 5 expression exacerbates allergic skin inflammation including impairing filaggrin processing, promoting Th2 differentiation and inducing dysbiosis
@cincyresearch.bsky.social @mucosalimmunol.bsky.social
www.sciencedirect.com/science/arti...
@cincyresearch.bsky.social @mucosalimmunol.bsky.social
www.sciencedirect.com/science/arti...
I just received Cetaphil PRO RestoraDerm Nourishing Body Wash With Filaggrin and Shea Butter - Non Soap Cleanser For Dry Itchy and Sensitive Skin - Fragrance Free, Paraben Free - Dermatologist Recommended, 295ml - Nour from Anonymous via Throne. Thank you! https://throne.com/wysticlipse #throne
September 21, 2026 at 9:48 PM
I just received Cetaphil PRO RestoraDerm Nourishing Body Wash With Filaggrin and Shea Butter - Non Soap Cleanser For Dry Itchy and Sensitive Skin - Fragrance Free, Paraben Free - Dermatologist Recommended, 295ml - Nour from Anonymous via Throne. Thank you! https://throne.com/wysticlipse #throne
I need to listen to more metal so I can get a better sense of the cadences but here's the very metal song I'm writing about acid mantles:
HELL YEAH ME AND MY SKIN
PH SO LOW WE KILL PATHOGENS
SECRETING ACIDS FROM WITHIN
I DON'T KNOW WHAT'S FILAGGRIN
HELL YEAH ME AND MY SKIN
PH SO LOW WE KILL PATHOGENS
SECRETING ACIDS FROM WITHIN
I DON'T KNOW WHAT'S FILAGGRIN
November 16, 2025 at 2:15 AM
I need to listen to more metal so I can get a better sense of the cadences but here's the very metal song I'm writing about acid mantles:
HELL YEAH ME AND MY SKIN
PH SO LOW WE KILL PATHOGENS
SECRETING ACIDS FROM WITHIN
I DON'T KNOW WHAT'S FILAGGRIN
HELL YEAH ME AND MY SKIN
PH SO LOW WE KILL PATHOGENS
SECRETING ACIDS FROM WITHIN
I DON'T KNOW WHAT'S FILAGGRIN
Downstream products of ARG actions like putrescine could rescue function of cells lacking ARG activity. Putrescine treatment rescued expression of proteins of barrier integrity incl Filaggrin (Flg), Involucrin (Ivl) and Loricrin (Lor) supporting a role for Arg in skin barrier
March 27, 2025 at 5:25 PM
Downstream products of ARG actions like putrescine could rescue function of cells lacking ARG activity. Putrescine treatment rescued expression of proteins of barrier integrity incl Filaggrin (Flg), Involucrin (Ivl) and Loricrin (Lor) supporting a role for Arg in skin barrier
I just received Cetaphil PRO Restoraderm Eczema Soothing Moisturizer With Colloidal Oats, Ceramides and Filaggrin, Lotion For Dry Itchy & Sensitive Skin, Paraben Free, Steroid Free, Dermatologist Recommended, 295ml - M from Anonymous via Throne. Thank you! https://throne.com/wysticlipse #throne
April 10, 2026 at 12:15 PM
I just received Cetaphil PRO Restoraderm Eczema Soothing Moisturizer With Colloidal Oats, Ceramides and Filaggrin, Lotion For Dry Itchy & Sensitive Skin, Paraben Free, Steroid Free, Dermatologist Recommended, 295ml - M from Anonymous via Throne. Thank you! https://throne.com/wysticlipse #throne
I just received Cetaphil PRO RestoraDerm Nourishing Body Wash With Filaggrin and Shea Butter - Non Soap Cleanser For Dry Itchy and Sensitive Skin - Fragrance Free, Paraben Free - Dermatologist Recommended, 295ml - Nour from Anonymous via Throne. Thank you! https://throne.com/wysticlipse #throne
April 10, 2026 at 12:15 PM
I just received Cetaphil PRO RestoraDerm Nourishing Body Wash With Filaggrin and Shea Butter - Non Soap Cleanser For Dry Itchy and Sensitive Skin - Fragrance Free, Paraben Free - Dermatologist Recommended, 295ml - Nour from Anonymous via Throne. Thank you! https://throne.com/wysticlipse #throne
The in vivo model supported this axis as well: in EL4 lymphoma-bearing mice, antibiotic treatment preserved near-normal filaggrin in tumour-adjacent epidermis. Together, the data support microbial-immune crosstalk as a mechanistic contributor to CTCL skin barrier pathology.
7/8
7/8
April 17, 2026 at 9:37 AM
The in vivo model supported this axis as well: in EL4 lymphoma-bearing mice, antibiotic treatment preserved near-normal filaggrin in tumour-adjacent epidermis. Together, the data support microbial-immune crosstalk as a mechanistic contributor to CTCL skin barrier pathology.
7/8
7/8
chapstick and balm that boosts your histadine-rich fibers (filaggrin).
Filaggrin in the frontline: role in skin barrier function and
disease
Recently, loss-of-function mutations in FLG, the human gene
encoding profilaggrin and filaggrin, have been identified as the cause of the
common skin condition ichthyosis vulgaris (which is characte...
www.ncbi.nlm.nih.gov
May 13, 2024 at 1:46 PM
chapstick and balm that boosts your histadine-rich fibers (filaggrin).
🔬 From our May issue (rupress.org/jem/issue/22...): Image shows human keratinocytes treated with IL-4 and stained for keratin14 (red) and filaggrin (yellow) #Basophils drive the resolution and promote wound healing in adult and aged mice, from Bex, Pellefigues et al. doi.org/10.1084/jem....
May 18, 2026 at 8:01 PM
🔬 From our May issue (rupress.org/jem/issue/22...): Image shows human keratinocytes treated with IL-4 and stained for keratin14 (red) and filaggrin (yellow) #Basophils drive the resolution and promote wound healing in adult and aged mice, from Bex, Pellefigues et al. doi.org/10.1084/jem....
The clinical data pointed in the same direction: after antibiotic eradication of SE-producing S. aureus, 3/4 CTCL patients showed partial restoration of filaggrin and loricrin in lesional skin, together with reduced inflammatory signaling and clinical improvement.
6/8
6/8
April 17, 2026 at 9:37 AM
The clinical data pointed in the same direction: after antibiotic eradication of SE-producing S. aureus, 3/4 CTCL patients showed partial restoration of filaggrin and loricrin in lesional skin, together with reduced inflammatory signaling and clinical improvement.
6/8
6/8
A preprint using: Filaggrin Monoclonal (RRID:AB_10987573) from @thermofishersci.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #methodsmatter
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #methodsmatter
www.biorxiv.org
December 11, 2025 at 5:05 PM
A preprint using: Filaggrin Monoclonal (RRID:AB_10987573) from @thermofishersci.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #methodsmatter
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #methodsmatter
Azitra gives its poster presentation today @ ASGCT in Boston.
COO Travis Whitfill invites you to stop by the Menino Convention Center.
An Engineered Human Filaggrin Secreting Staphylococcus epidermidis Strain for the Topical Treatment of Ichthyosis Vulgaris
#$AZTR
ir.azitrainc.com/news-release...
COO Travis Whitfill invites you to stop by the Menino Convention Center.
An Engineered Human Filaggrin Secreting Staphylococcus epidermidis Strain for the Topical Treatment of Ichthyosis Vulgaris
#$AZTR
ir.azitrainc.com/news-release...
Azitra, Inc. Announces Poster Presentation at ASGCT 2026 Highlighting ATR-01 Program for Ichthyosis Vulgaris | Azitra, Inc.
Preclinical data demonstrate ATR-01 delivers functional filaggrin, restoring skin barrier integrity and supporting advancement toward first-in-human studies BRANFORD, Conn., April 28, 2026 /PRNewswire...
ir.azitrainc.com
May 12, 2026 at 1:36 PM
Azitra gives its poster presentation today @ ASGCT in Boston.
COO Travis Whitfill invites you to stop by the Menino Convention Center.
An Engineered Human Filaggrin Secreting Staphylococcus epidermidis Strain for the Topical Treatment of Ichthyosis Vulgaris
#$AZTR
ir.azitrainc.com/news-release...
COO Travis Whitfill invites you to stop by the Menino Convention Center.
An Engineered Human Filaggrin Secreting Staphylococcus epidermidis Strain for the Topical Treatment of Ichthyosis Vulgaris
#$AZTR
ir.azitrainc.com/news-release...
Hard to say esp with hands not totally flat, seems in between mine and my wife's.
Anyway it's associated with a lot of skin stuff like excema and the filaggrin thing
Anyway it's associated with a lot of skin stuff like excema and the filaggrin thing
February 23, 2024 at 9:41 AM
Hard to say esp with hands not totally flat, seems in between mine and my wife's.
Anyway it's associated with a lot of skin stuff like excema and the filaggrin thing
Anyway it's associated with a lot of skin stuff like excema and the filaggrin thing
Open Access: Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma. First authors: Maria Gluud; corresponding authors: Terkild B. Buus, Niels Ødum
👉 doi.org/10.1111/all.70292
#Allergy_journal
👉 doi.org/10.1111/all.70292
#Allergy_journal
April 4, 2026 at 5:23 PM
Open Access: Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma. First authors: Maria Gluud; corresponding authors: Terkild B. Buus, Niels Ødum
👉 doi.org/10.1111/all.70292
#Allergy_journal
👉 doi.org/10.1111/all.70292
#Allergy_journal
wife has that but she has some weird skin conditions (filaggrin deficiency, eds, sensitive to damn near every chemical, probably because of the first thing)
I only get it where there's skin on skin like pits, tits
I only get it where there's skin on skin like pits, tits
February 23, 2024 at 8:59 AM
wife has that but she has some weird skin conditions (filaggrin deficiency, eds, sensitive to damn near every chemical, probably because of the first thing)
I only get it where there's skin on skin like pits, tits
I only get it where there's skin on skin like pits, tits
We are approaching merely rough dry skin (albeit on the palms of both hands)
You do need to take the full 4g from the study for it to help (the pills are huge and taste foul, I couldn't bear to take the full dose at one point)
Study with full text available
pubmed.ncbi.nlm.nih.gov/29042806/
You do need to take the full 4g from the study for it to help (the pills are huge and taste foul, I couldn't bear to take the full dose at one point)
Study with full text available
pubmed.ncbi.nlm.nih.gov/29042806/
Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis - PubMed
Atopic dermatitis (AD), also known as eczema, is one of the most common chronic skin conditions worldwide, affecting up to 16% of children and 10% of adults. It is incurable and has significant psycho...
pubmed.ncbi.nlm.nih.gov
September 8, 2025 at 7:24 AM
We are approaching merely rough dry skin (albeit on the palms of both hands)
You do need to take the full 4g from the study for it to help (the pills are huge and taste foul, I couldn't bear to take the full dose at one point)
Study with full text available
pubmed.ncbi.nlm.nih.gov/29042806/
You do need to take the full 4g from the study for it to help (the pills are huge and taste foul, I couldn't bear to take the full dose at one point)
Study with full text available
pubmed.ncbi.nlm.nih.gov/29042806/
The authors included RRIDs in their in Journal of Biomedical Science paper! We value the author's support of reproducibility. #RRID #OpenScience #ReproducibleResearch
Dual suppression of stemness and redox adaptation in glioblastoma through filaggrin upregulation by an abiraterone-based HDAC inhibitor - Journal of Biomedical Science
Background Temozolomide (TMZ) resistance in glioblastoma (GBM) remains a critical barrier to treatment success, driven by O6-methylguanine-DNA methyltransferase (MGMT) overexpression, glioma stem cell (GSC) persistence, and redox adaptation. Methods We developed cp8, a first-in-class abiraterone-based histone deacetylase (HDAC) inhibitor, to simultaneously target these resistance mechanisms. The orthotopic mouse models were used to evaluate the efficacy of cp8 compared to SAHA (vorinostat). The mouse survival period was recorded, and the tumor growth was monitored using the IVIS imaging system. Results Cp8 demonstrated approximately tenfold greater potency than SAHA, with IC₅₀ values ≤ 3 µM against TMZ-resistant GBM cells (compared with ≥ 30 µM for SAHA). Transcriptomic analysis revealed a unique ability of cp8 to upregulate filaggrin (FLG), a structural protein whose expression correlated with improved patient survival in TCGA
doi.org
April 11, 2026 at 7:00 AM
The authors included RRIDs in their in Journal of Biomedical Science paper! We value the author's support of reproducibility. #RRID #OpenScience #ReproducibleResearch
#AZTR Azitra, Inc. CEO Issues Letter to Shareholders Detailing Strategic Reorientation Initiatives and Outlook for 2026 and Beyond
https://www.stocktitan.net/news/AZTR/azitra-inc-ceo-issues-letter-to-shareholders-detailing-strategic-tul2oqx557eh.html
https://www.stocktitan.net/news/AZTR/azitra-inc-ceo-issues-letter-to-shareholders-detailing-strategic-tul2oqx557eh.html
Azitra, Inc. CEO Issues Letter to Shareholders Detailing Strategic Reorientation Initiatives and Outlook for 2026 and Beyond
Azitra (NYSE American: AZTR) CEO outlined a strategic reorientation toward programs with nearer-term value milestones, backed by a March 2026 financing of $10.5 million plus up to $21 million from warrant exercises.Key moves include launching the ATR-COSF cosmetic filaggrin initiative, new recombinant protein programs, continued ATR-04 enrollment, and pausing ATR-12 enrollment to conserve capital, with multiple potential partnering or commercialization opportunities from 2026 onward.
www.stocktitan.net
June 17, 2026 at 12:00 PM
#AZTR Azitra, Inc. CEO Issues Letter to Shareholders Detailing Strategic Reorientation Initiatives and Outlook for 2026 and Beyond
https://www.stocktitan.net/news/AZTR/azitra-inc-ceo-issues-letter-to-shareholders-detailing-strategic-tul2oqx557eh.html
https://www.stocktitan.net/news/AZTR/azitra-inc-ceo-issues-letter-to-shareholders-detailing-strategic-tul2oqx557eh.html
Long Read Sequencing of Filaggrin identifies extensive copy number variation in exon 3 and detects rare loss of function variants
https://doi.org/10.1016/j.xjidi.2026.100522
Grentzinger et al
#dermatology #dermscience #derm #dermatologia #dermresearch #openaccess #medical research
https://doi.org/10.1016/j.xjidi.2026.100522
Grentzinger et al
#dermatology #dermscience #derm #dermatologia #dermresearch #openaccess #medical research
September 5, 2026 at 2:35 PM
Long Read Sequencing of Filaggrin identifies extensive copy number variation in exon 3 and detects rare loss of function variants
https://doi.org/10.1016/j.xjidi.2026.100522
Grentzinger et al
#dermatology #dermscience #derm #dermatologia #dermresearch #openaccess #medical research
https://doi.org/10.1016/j.xjidi.2026.100522
Grentzinger et al
#dermatology #dermscience #derm #dermatologia #dermresearch #openaccess #medical research
PER2 gene variants might be linked to severe atopic dermatitis.
📄 Full article: https://food-medicine-protocol.ghost.io/how-per2-gene-disruption-may-undermine-skin-barrier-function-through-filaggrin-regulation/
#chronobiology #ShrineLongevity
📄 Full article: https://food-medicine-protocol.ghost.io/how-per2-gene-disruption-may-undermine-skin-barrier-function-through-filaggrin-regulation/
#chronobiology #ShrineLongevity
August 14, 2026 at 4:33 PM
PER2 gene variants might be linked to severe atopic dermatitis.
📄 Full article: https://food-medicine-protocol.ghost.io/how-per2-gene-disruption-may-undermine-skin-barrier-function-through-filaggrin-regulation/
#chronobiology #ShrineLongevity
📄 Full article: https://food-medicine-protocol.ghost.io/how-per2-gene-disruption-may-undermine-skin-barrier-function-through-filaggrin-regulation/
#chronobiology #ShrineLongevity
Azitra Co-founder & Chief Operating Officer, Travis Whitfill, provides the details behind the recent $10 million capital raise.
#$AZTR #Cosmeceuticals #SkinBarrier #Filaggrin #Dermatology #SkincareScience #skinmicrobiome
youtube.com/shorts/jKiXo...
#$AZTR #Cosmeceuticals #SkinBarrier #Filaggrin #Dermatology #SkincareScience #skinmicrobiome
youtube.com/shorts/jKiXo...
Azitra's Capital Raise
YouTube video by Unboxing Biotech
youtube.com
August 10, 2026 at 4:13 PM
Azitra Co-founder & Chief Operating Officer, Travis Whitfill, provides the details behind the recent $10 million capital raise.
#$AZTR #Cosmeceuticals #SkinBarrier #Filaggrin #Dermatology #SkincareScience #skinmicrobiome
youtube.com/shorts/jKiXo...
#$AZTR #Cosmeceuticals #SkinBarrier #Filaggrin #Dermatology #SkincareScience #skinmicrobiome
youtube.com/shorts/jKiXo...
Azitra Co-founder & Chief Operating Officer, Travis Whitfill, enumerates the impressive group of brands involved in microbiome and #filaggrin products.
#$AZTR
youtube.com/shorts/58WFJ...
#Cosmeceuticals #SkinBarrier #Dermatology #SkincareScience #skinmicrobiome
#$AZTR
youtube.com/shorts/58WFJ...
#Cosmeceuticals #SkinBarrier #Dermatology #SkincareScience #skinmicrobiome
Filaggrin Market Opportunity
YouTube video by Unboxing Biotech
youtube.com
July 26, 2026 at 2:40 PM
Azitra Co-founder & Chief Operating Officer, Travis Whitfill, enumerates the impressive group of brands involved in microbiome and #filaggrin products.
#$AZTR
youtube.com/shorts/58WFJ...
#Cosmeceuticals #SkinBarrier #Dermatology #SkincareScience #skinmicrobiome
#$AZTR
youtube.com/shorts/58WFJ...
#Cosmeceuticals #SkinBarrier #Dermatology #SkincareScience #skinmicrobiome
