A BBC investigation found that Cambodian workers making official football shirts for the world’s biggest clubs earn basic wages equivalent to less than GBP1 (approx. USD1.32) an hour and endure unsafe and exploitative conditions at two Cambodian factories.
www.bbc.com/sport/footba...
www.bbc.com/sport/footba...
Premier League football shirts made by workers on £1 an hour
A BBC Sport investigation traces official football shirt production to factories in Cambodia where workers are paid less than £1 an hour.
www.bbc.com
October 15, 2026 at 4:24 PM
A BBC investigation found that Cambodian workers making official football shirts for the world’s biggest clubs earn basic wages equivalent to less than GBP1 (approx. USD1.32) an hour and endure unsafe and exploitative conditions at two Cambodian factories.
www.bbc.com/sport/footba...
www.bbc.com/sport/footba...
LLL一周年です
【LLL】ドゥーマー【UTAUカバー】
www.youtube.com/watch?v=GBP1...
www.nicovideo.jp/watch/sm4688...
歌：LLL
調声・絵・動画：MAREFFY
#どっかのラララボ
【LLL】ドゥーマー【UTAUカバー】
www.youtube.com/watch?v=GBP1...
www.nicovideo.jp/watch/sm4688...
歌：LLL
調声・絵・動画：MAREFFY
#どっかのラララボ
【UTAUカバー】ドゥーマー【LLL】
YouTube video by Mareffy
www.youtube.com
October 6, 2026 at 12:02 PM
LLL一周年です
【LLL】ドゥーマー【UTAUカバー】
www.youtube.com/watch?v=GBP1...
www.nicovideo.jp/watch/sm4688...
歌：LLL
調声・絵・動画：MAREFFY
#どっかのラララボ
【LLL】ドゥーマー【UTAUカバー】
www.youtube.com/watch?v=GBP1...
www.nicovideo.jp/watch/sm4688...
歌：LLL
調声・絵・動画：MAREFFY
#どっかのラララボ
📢 Been off social media, but never too late to say our story on #GBP1 was published in EMBO J. Check it out here.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
August 4, 2026 at 3:06 PM
📢 Been off social media, but never too late to say our story on #GBP1 was published in EMBO J. Check it out here.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
An unusual Christmas Carol for these unusual times….
www.youtube.com/watch?v=gbp1...
www.youtube.com/watch?v=gbp1...
Carol for Another Christmas (1964) - Rod Serling's retelling of A Christmas Carol
YouTube video by MegaDude
www.youtube.com
December 7, 2024 at 12:47 AM
An unusual Christmas Carol for these unusual times….
www.youtube.com/watch?v=gbp1...
www.youtube.com/watch?v=gbp1...
Swine GBP1 restricts PDCoV replication via disrupting the replication and transcription complex formation journals.asm.org/doi/10.1128/...
Swine GBP1 restricts PDCoV replication via disrupting the replication and transcription complex formation | Journal of Virology
PDCoV is an enteric coronavirus that has garnered significant global attention due
to its current prevalence in causing diarrhea and even mortality in pigs, as well
as its broad host range encompassin...
journals.asm.org
April 22, 2026 at 12:58 PM
Swine GBP1 restricts PDCoV replication via disrupting the replication and transcription complex formation journals.asm.org/doi/10.1128/...
Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity - Nature Communications
Bats harbor diverse viruses but it’s less clear how they tolerate infection. Here, by characterizing innate immune responses in bat cells the authors show that IFN-beta signaling resists antagonistic ...
www.nature.com
July 1, 2025 at 1:42 PM
Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GBP1 proteins render bacteria harmless by encapsulating them. With the help of the Cryo-EM on Campus Berlin-Buch, researchers led by @mdc-berlin.bsky.social's Oliver Daumke and Misha Kudryashev now described in "The EMBO Journal" exactly how the proteins do this. 👇🏻
www.mdc-berlin.de/news/press/h...
www.mdc-berlin.de/news/press/h...
How a protein fights off bacteria
The details of many immune defense mechanisms are still unknown, but a new study sheds light on one such mechanism. Writing in “The EMBO Journal”, researchers led by Oliver Daumke and Misha Kudrya...
www.mdc-berlin.de
January 25, 2024 at 8:46 AM
GBP1 proteins render bacteria harmless by encapsulating them. With the help of the Cryo-EM on Campus Berlin-Buch, researchers led by @mdc-berlin.bsky.social's Oliver Daumke and Misha Kudryashev now described in "The EMBO Journal" exactly how the proteins do this. 👇🏻
www.mdc-berlin.de/news/press/h...
www.mdc-berlin.de/news/press/h...
Caspase-4 is also recruited to these structures in a GBP1-dependent manner, independently of LPS!
September 28, 2025 at 10:36 AM
Caspase-4 is also recruited to these structures in a GBP1-dependent manner, independently of LPS!
GBP1 is recruited to sites of 'sterile' actin-rich structures produced by FcgR-Tir chimera independently of LPS!
September 28, 2025 at 10:36 AM
GBP1 is recruited to sites of 'sterile' actin-rich structures produced by FcgR-Tir chimera independently of LPS!
GBP1 directly binds LPS and recruits caspase-4 on cytosolic Gram-negative bacteria. We showed LPS is internalised during EPEC infection (pubmed.ncbi.nlm.nih.gov/33378358/). But, does GBP1 recruitment need LPS or actin polymerisation? To address this, we reconstituted Tir-actin signalling.
September 28, 2025 at 10:36 AM
GBP1 directly binds LPS and recruits caspase-4 on cytosolic Gram-negative bacteria. We showed LPS is internalised during EPEC infection (pubmed.ncbi.nlm.nih.gov/33378358/). But, does GBP1 recruitment need LPS or actin polymerisation? To address this, we reconstituted Tir-actin signalling.
How does GBP1 sense these extracellular bacteria? Using a range of EPEC and EHEC mutants, we show that pathogen-induce actin polymerisation is essential for GBP1 recruitment, pyroptosis and IL-18 release (a substrate of human caspase-4).
September 28, 2025 at 10:36 AM
How does GBP1 sense these extracellular bacteria? Using a range of EPEC and EHEC mutants, we show that pathogen-induce actin polymerisation is essential for GBP1 recruitment, pyroptosis and IL-18 release (a substrate of human caspase-4).
Guess what, GBP1 recruits caspase-4 to EPEC/EHEC pedestals for pyroptosis. This clarifies the role of caspase-4 that we previously showed in pyroptosis caused by these pathogens. (pubmed.ncbi.nlm.nih.gov/31018119/; pubmed.ncbi.nlm.nih.gov/33378358/).
September 28, 2025 at 10:36 AM
Guess what, GBP1 recruits caspase-4 to EPEC/EHEC pedestals for pyroptosis. This clarifies the role of caspase-4 that we previously showed in pyroptosis caused by these pathogens. (pubmed.ncbi.nlm.nih.gov/31018119/; pubmed.ncbi.nlm.nih.gov/33378358/).
GBP1 is also recruited to actin pedestals of EHEC in epithelial cells and C. rodentium-infected colonocytes in vivo in mice.
September 28, 2025 at 10:36 AM
GBP1 is also recruited to actin pedestals of EHEC in epithelial cells and C. rodentium-infected colonocytes in vivo in mice.
We show that GBP1 is recruited to actin-rich pedestals of EPEC. The T3SS mutant strain (escF) cannot manipulate actin, recruit GBP1 or trigger pyroptosis. Importantly, GBP1 is recruited to pedestals of various EPEC strains independently of the type of their LPS O-antigens.
September 28, 2025 at 10:36 AM
We show that GBP1 is recruited to actin-rich pedestals of EPEC. The T3SS mutant strain (escF) cannot manipulate actin, recruit GBP1 or trigger pyroptosis. Importantly, GBP1 is recruited to pedestals of various EPEC strains independently of the type of their LPS O-antigens.
We've worked on extracellular Gram-negative pathogenic E. coli (EPEC & EHEC) for several years. EPEC is a major cause of childhood diarrhoeas and EHEC can be fatal even in adults. Here we show that GBP1 is required for EPEC/EHEC-induced pyroptosis in non-phagocytic cells.
September 28, 2025 at 10:36 AM
We've worked on extracellular Gram-negative pathogenic E. coli (EPEC & EHEC) for several years. EPEC is a major cause of childhood diarrhoeas and EHEC can be fatal even in adults. Here we show that GBP1 is required for EPEC/EHEC-induced pyroptosis in non-phagocytic cells.
📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...
biorxiv.org/content/10.1...
September 28, 2025 at 10:36 AM
📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...
biorxiv.org/content/10.1...
Gut Microbiota Dysbiosis Drives Myocardial Hypertrophy Through GBP2b/GBP1-Mediated Immune Reprogramming and Exosomal Signaling in Chronic Colitis https://www.biorxiv.org/content/10.64898/2026.05.27.728214v1
June 1, 2026 at 4:00 AM
Gut Microbiota Dysbiosis Drives Myocardial Hypertrophy Through GBP2b/GBP1-Mediated Immune Reprogramming and Exosomal Signaling in Chronic Colitis https://www.biorxiv.org/content/10.64898/2026.05.27.728214v1
#MysterySolved! Fantastic @cp-immunity.bsky.social by @brozlab.bsky.social, Began &co showing that GBP1 is essential for non-canonical #inflammasome activation during infections & acts as a mechanoenzime that fragments LPS micelles allowing Caspase-4 activity! www.sciencedirect.com/science/arti...
Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation
The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…
www.sciencedirect.com
February 16, 2026 at 6:29 PM
#MysterySolved! Fantastic @cp-immunity.bsky.social by @brozlab.bsky.social, Began &co showing that GBP1 is essential for non-canonical #inflammasome activation during infections & acts as a mechanoenzime that fragments LPS micelles allowing Caspase-4 activity! www.sciencedirect.com/science/arti...
