#GI1
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princessluna.bsky.social
The kitton laydee has an importnat nouncement. youtu.be/gI1-rItMrQA?...
BEWARE: This Product Could Kill Your Kitten
YouTube video by Kitten Lady
youtu.be
July 19, 2025 at 4:00 AM
humanite.fr
Sarkozy, Le Pen, Retailleau : qu'ils soient impliqués ou non dans des affaires judiciaires, ces derniers n'ont eu de cesse d'incriminer la justice. Elle serait aux mains de "juges rouges"...

Les juges cherchent-ils à FAIRE TOMBER des politiques ?
➡️ https://l.humanite.fr/gI1
May 25, 2026 at 11:01 AM
biophysicsguy.bsky.social
Excited to share our work is out in
@Nature
! We used TR cryo-EM to visualize the activation of Gi1 and G11 from NTSR1. With MD sims & work from the Blanchard and Lambert Labs, this revealed key differences driving signaling efficiency between G-proteins.
www.nature.com/articles/s41...
March 11, 2026 at 5:32 PM
plosbiology.org
The human #LactateReceptor HCAR1 is an emerging therapeutic target, but how does it work? This study reports the #cryoEM structure of HCAR1 in complex with heterotrimeric Gi1 protein to provide a structural framework for ligand recognition & receptor activation @plosbiology.org 🧪 plos.io/4ilzVqd
Top: Cryo-EM map and structural model of HCAR1-Gi1-scFv16 complex in the presence of CHBA (left) and apo form (second left). Cryo-EM maps and structural models of HCAR2-Gi1-scFv16 complex in the presence of MK-1903 (second right) and SCH900271 (right). The density of the agonist (shown as sticks) is depicted as gray meshes. The maps and structural models are colored by subunits. Bottom: Mechanism diagram of ligand recognition and selectivity of HCAR1. This study mainly showcases the HCAR1-Gi1 complexes in both the agonist-bound and apo forms, and the HCAR2-Gi1 complexes in the agonist-bound form. Four residues of HCAR1, namely R993.36, Y2687.43, E16645.51, and R712.60, are deemed crucial for ligand recognition. Notably, R993.36 undergoes a significant conformational change upon agonist binding. Furthermore, three residues in HCAR1/HCAR2, namely R71/L832.60, R79/W91ECL1, and Y75/Y872.64, play a decisive role in agonist selectivity between HCAR1 and HCAR2.
April 22, 2025 at 3:41 PM
nadinescholtes.bsky.social
www.youtube.com/watch?v=gI1-...

Do not buy those!!!

#cats #kitten #kittenlady
www.youtube.com
July 18, 2025 at 1:46 PM
plosbiology.org
#Sphingosine -1-phosphate receptors #S1PRs play complex roles in several pathological processes. #CryoEM structures of four agonist-bound S1PR1-Gi1 complexes reveal the structural determinants underlying agonist selectivity among different subtypes @plosbiology.org 🧪 plos.io/4co0A4W
Structural cartoon models of human S1PR1 in complex with Gi1, scFv16, and each of the four agonists: CYM5442, HY-X-1011, Ponesimod, or SAR247799. S1PR1 is colored marine, Gαi1 pale green, Gβ1 light blue, Gγ2 wheat, scFv16 gray, and agonists yellow.
April 13, 2026 at 9:01 AM
plosbiology.org
#Sphingosine -1-phosphate receptors #S1PRs play complex roles in several pathological processes. #CryoEM structures of four agonist-bound S1PR1-Gi1 complexes reveal the structural determinants underlying agonist selectivity among different subtypes @plosbiology.org 🧪 plos.io/4co0A4W
Structural cartoon models of human S1PR1 in complex with Gi1, scFv16, and each of the four agonists: CYM5442, HY-X-1011, Ponesimod, or SAR247799. S1PR1 is colored marine, Gαi1 pale green, Gβ1 light blue, Gγ2 wheat, scFv16 gray, and agonists yellow.
April 13, 2026 at 1:05 PM
nickcattles.bsky.social
Going live at 7pm (ET) to discuss the Patriots going to the Super Bowl. Absolutely unbelievable. Let's go!!!
www.youtube.com/watch?v=gi1-...
SHOCKING: New England Patriots OUTLAST Broncos, Super Bowl Bound!!
YouTube video by Locked On Patriots
www.youtube.com
January 25, 2026 at 11:50 PM
roseknapp.bsky.social
Gi1tch by Monotonne

music.apple.com/us/album/gi1...

#experimentalmusic #glitchmusic
Gi1tch - EP by Monotonne on Apple Music
Album · 2025 · 5 Songs
music.apple.com
June 24, 2025 at 3:44 AM
assimdisseojoao.bsky.social
Meus amores
Venha rir enquanto o tio chora e grita diante de O ABISMO
Live de react agora as 15:45
youtube.com/live/gi1...
MERGULHANDO na FOSSA SÉPTICA da INTERNET - Reacts que até DEUS DUVIDA
Venha se divertir com o meu sofrimento enquanto eu gargalho maniacamente na face do ABISMO► O Tio e a Expressão Popular fecharam uma parceria e o ganhador é ...
youtube.com
August 28, 2025 at 6:38 PM
lexpress.fr
Royaume-Uni : un réseau de blanchiment aidait la Russie à contourner les sanctions contre elle
➡️ https://l.lexpress.fr/gI1
November 21, 2025 at 12:11 PM
plosbiology.org
The human #LactateReceptor HCAR1 is an emerging therapeutic target, but how does it work? This study reports the #cryoEM structure of HCAR1 in complex with heterotrimeric Gi1 protein to provide a structural framework for ligand recognition & receptor activation @plosbiology.org 🧪 plos.io/4ilzVqd
Top: Cryo-EM map and structural model of HCAR1-Gi1-scFv16 complex in the presence of CHBA (left) and apo form (second left). Cryo-EM maps and structural models of HCAR2-Gi1-scFv16 complex in the presence of MK-1903 (second right) and SCH900271 (right). The density of the agonist (shown as sticks) is depicted as gray meshes. The maps and structural models are colored by subunits. Bottom: Mechanism diagram of ligand recognition and selectivity of HCAR1. This study mainly showcases the HCAR1-Gi1 complexes in both the agonist-bound and apo forms, and the HCAR2-Gi1 complexes in the agonist-bound form. Four residues of HCAR1, namely R993.36, Y2687.43, E16645.51, and R712.60, are deemed crucial for ligand recognition. Notably, R993.36 undergoes a significant conformational change upon agonist binding. Furthermore, three residues in HCAR1/HCAR2, namely R71/L832.60, R79/W91ECL1, and Y75/Y872.64, play a decisive role in agonist selectivity between HCAR1 and HCAR2.
April 23, 2025 at 1:25 PM
plosbiology.org
The human #LactateReceptor HCAR1 is an emerging therapeutic target, but how does it work? This study reports the #cryoEM structure of HCAR1 in complex with heterotrimeric Gi1 protein to provide a structural framework for ligand recognition & receptor activation @plosbiology.org 🧪 plos.io/4ilzVqd
Top: Cryo-EM map and structural model of HCAR1-Gi1-scFv16 complex in the presence of CHBA (left) and apo form (second left). Cryo-EM maps and structural models of HCAR2-Gi1-scFv16 complex in the presence of MK-1903 (second right) and SCH900271 (right). The density of the agonist (shown as sticks) is depicted as gray meshes. The maps and structural models are colored by subunits. Bottom: Mechanism diagram of ligand recognition and selectivity of HCAR1. This study mainly showcases the HCAR1-Gi1 complexes in both the agonist-bound and apo forms, and the HCAR2-Gi1 complexes in the agonist-bound form. Four residues of HCAR1, namely R993.36, Y2687.43, E16645.51, and R712.60, are deemed crucial for ligand recognition. Notably, R993.36 undergoes a significant conformational change upon agonist binding. Furthermore, three residues in HCAR1/HCAR2, namely R71/L832.60, R79/W91ECL1, and Y75/Y872.64, play a decisive role in agonist selectivity between HCAR1 and HCAR2.
April 23, 2025 at 8:23 AM
nickcattles.bsky.social
Latest “Locked On Patriots:” The Pats are Super Bowl Bound!!!

All Platforms: link.chtbl.com/LOPatriots?s...
YouTube: www.youtube.com/watch?v=gi1-...
January 26, 2026 at 12:53 AM
keepitbluedems.bsky.social
substack.com/@katiephang/...
Katie Phang (@katiephang)
Convicted Felon Donald Trump hijacks bipartisan affordable housing bill to try to extort a vote in support of the horrendous SAVE Act: https://youtube.com/shorts/dsc2WOvoyXE?si=gI1-ROXCwSot1dBO
substack.com
June 24, 2026 at 4:43 PM
hoernchencecile.bsky.social
Der Fall vor bei der Protest-Kletteraktion am gesperrten Aufzug Gl 1 am Bhf #Lüneburg im September gewarnt wurde, ist heute bei mir eingetreten.
#Aufzug Rückseite (ostseite) war außer Betrieb. Mensch mit #Rollstuhl blieb in der Bahnunterführung eigesperrt.
#Barrierebahn #Barrierefreihei #Ableismus
Bild vom kaputten Aufzug und Text darauf: Überraschung... Aufzug Hinterausgang Bhf LG war heute mittag kaputt! Ich musste Tragehilfe organisieren. Mobilitatseingeschränkte Menschen bleiben nämlich unten in der Unterführung eingesperrt oder erreichen Gleise 2 bis 5 nicht...weil GI1 derzeit auch keinen Aufzug hat Und Info nicht in DB App da Aufzug der Stadt gehört
March 14, 2024 at 1:54 PM
darksakura.bsky.social
VERY important if you're taking care of neonatal kittens. Do NOT buy an incubator that's less than $500.

www.youtube.com/watch?v=gI1-...
BEWARE: This Product Could Kill Your Kitten
YouTube video by Kitten Lady
www.youtube.com
June 21, 2026 at 6:11 AM
plosbiology.org
#Hydroxycarboxylic acid receptors HCAR2 & HCAR3 are key targets for treating #MetabolicDisorders. This study reports #cryoEM structures of #HCAR3 with several agonists, informing its ligand recognition & activation mechanism (& HCAR3/HCAR2 differences) @plosbiology.org 🧪 plos.io/48D365m
Cryo-EM structures of agonist-bound HCAR3-Gi1 and HCAR2-Gi1 complexes. (A) Schematic illustration of agonist selectivity to HCARs. (B-F) Cryo-EM maps and models in cartoon performance of HCAR3-Gi1 complexes in the presence of 6O (B), PLA (C), IBC293 (D), acifran (E), and HCAR2-Gi1 complex in the presence of acifran (F). Agonists are shown in stick representation, and corresponding electron densities are depicted as gray meshes. The maps and structural models are colored by subunits: Pale violet red, 6O-HCAR3; slate blue, PLA-HCAR3; medium sea green, IBC293-HCAR3; dodger blue, acifran-HCAR3; light salmon, acifran-HCAR2; light gray, Gαi; light blue, Gβ; light pink, Gγ; burly wood, scFv16; light green, 6O; cyan, PLA; khaki, IBC293; plum, acifran (HCAR3); medium aquamarine, acifran (HCAR2).
December 9, 2025 at 5:40 PM
whiskersandthings.bsky.social
If you foster kittens (or any kind of baby animals), DO NOT get this incubator! It may be affordable, but it's dangerous!! youtu.be/gI1-rItMrQA
BEWARE: This Product Could Kill Your Kitten
YouTube video by Kitten Lady
youtu.be
July 19, 2025 at 5:38 PM
nickcattles.bsky.social
Latest “Locked On Patriots:” Live Pats-Broncos postgame!

- Vrabel Outcoached Payton
- Defense Shows Out…Again.
- Two Ways Maye Helped the Pats Win

All Platforms: link.chtbl.com/LOPatriots?s...
YouTube: www.youtube.com/watch?v=gi1-...
January 26, 2026 at 1:09 PM
yumetuki16.bsky.social
函館スプリントステークス
◎アサカラキング
つえー馬がスプリントで前にいくならつえーでしょ

三宮ステークス
◎オメガギネス
2走前にGⅠ1番人気だった馬がただのOP戦で馬券外に飛ばないでしょ

エプソムカップ
◎アルナシーム
上位人気に不安点が多いので、オッズ調味も考えた消極的本命
1人気レーベンスティールは飛ぶと思う
June 9, 2024 at 4:03 AM
chaff37.bsky.social
嘘言うのよくないしなんか貼っとこ
radiology-history.online/history-gi1....
放射線医学の歴史
放射線医学史,放射線医学の歴史,History of Radiology
radiology-history.online
September 25, 2024 at 12:25 AM
nakagon.bsky.social
急に頭めっちゃ使ったからか、すっごい疲れた……。

馬名→レース→馬名山手線ゲームはGⅠ縛りすると難易度が上がることが分かりました。
GⅠ1勝馬を出せなくなるのが地味に痛い。
September 2, 2026 at 6:06 AM
rtbrasil.bsky.social
Conflito ucraniano é um confronto entre 'a Rússia e o Ocidente coletivo', afirma Dugin à RT

O filósofo e cientista político russo apontou que Moscou "foi provocada" pelos países ocidentais a "entrar nesse conflito".

📹 Confira o episódio completo: s.rtbrasil.com/gi1
October 29, 2025 at 7:59 PM
nomadotto.bsky.social
I was evaluating him in my GI1 / Krennic Twin Suns list. 6 power on R4 (without any additional cardplay) is a big benchmark.
September 29, 2025 at 3:51 PM