Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling - Nature Immunology
Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributi...
www.nature.com
November 20, 2024 at 7:28 PM
Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🚨 We have a new preprint out! 🧪
In this paper we look at GLUT4 trafficking. This is a short explainer thread, but please read the paper!
1/n 🧵
www.biorxiv.org/content/10.6...
In this paper we look at GLUT4 trafficking. This is a short explainer thread, but please read the paper!
1/n 🧵
www.biorxiv.org/content/10.6...
February 19, 2026 at 9:54 AM
🚨 We have a new preprint out! 🧪
In this paper we look at GLUT4 trafficking. This is a short explainer thread, but please read the paper!
1/n 🧵
www.biorxiv.org/content/10.6...
In this paper we look at GLUT4 trafficking. This is a short explainer thread, but please read the paper!
1/n 🧵
www.biorxiv.org/content/10.6...
Nice preprint! We still don’t know how insulin-responsive GLUT4 storage vesicles (GSVs) are made. @steveroyle.bsky.social shows a subset of intracellular nanovesicles sort and retain GLUT4, supplying components that build these unique vesicles.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 18, 2026 at 10:25 AM
Nice preprint! We still don’t know how insulin-responsive GLUT4 storage vesicles (GSVs) are made. @steveroyle.bsky.social shows a subset of intracellular nanovesicles sort and retain GLUT4, supplying components that build these unique vesicles.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Stiffness-induced impairment of GLUT4 trafficking in adult cardiomyocytes
Stiffness-induced impairment of GLUT4 trafficking in adult cardiomyocytes
Pathological stiffness disrupts glucose uptake in cardiomyocytes by altering microtubule-dependent GLUT4 trafficking. This study links mechanical stress to metabolic dysfunction and contractile impairment, identifying cytoskeletal remodeling and AMPK signaling as potential therapeutic targets in heart failure.
dlvr.it
July 17, 2026 at 11:23 PM
Stiffness-induced impairment of GLUT4 trafficking in adult cardiomyocytes
#LocationLocationLocation! @andrewgharrison6.bsky.social, Yang, Wang &co show @ Nature Immunology that in homeostasis GLUT4 is trapped in the Golgi, but upon virus encounter it relocates to the plasma membrane where it segregates & prevents signaling of RIG-I-like receptors! doi.org/10.1038/s415...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling - Nature Immunology
Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributi...
doi.org
November 20, 2024 at 4:04 PM
#LocationLocationLocation! @andrewgharrison6.bsky.social, Yang, Wang &co show @ Nature Immunology that in homeostasis GLUT4 is trapped in the Golgi, but upon virus encounter it relocates to the plasma membrane where it segregates & prevents signaling of RIG-I-like receptors! doi.org/10.1038/s415...
NOT ONLY THAT.
Part of the reason their blood glucose is so high is they are insensitive to insulin, They don't have GLUT4, the glucose transporter that we have that responds to insulin by heading to the membrane to suck up sugar.
Instead, their blood sugar is high, AND...
Part of the reason their blood glucose is so high is they are insensitive to insulin, They don't have GLUT4, the glucose transporter that we have that responds to insulin by heading to the membrane to suck up sugar.
Instead, their blood sugar is high, AND...
February 26, 2026 at 7:39 PM
NOT ONLY THAT.
Part of the reason their blood glucose is so high is they are insensitive to insulin, They don't have GLUT4, the glucose transporter that we have that responds to insulin by heading to the membrane to suck up sugar.
Instead, their blood sugar is high, AND...
Part of the reason their blood glucose is so high is they are insensitive to insulin, They don't have GLUT4, the glucose transporter that we have that responds to insulin by heading to the membrane to suck up sugar.
Instead, their blood sugar is high, AND...
In their Opinion article, Makoto Kanzaki and Gwyn Gould re-exam the model of GLUT4 trafficking fat and muscle cells based on new studies suggesting that heterotypic fusion with endosomes might play a more important role than previously realised.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
January 6, 2026 at 4:37 PM
In their Opinion article, Makoto Kanzaki and Gwyn Gould re-exam the model of GLUT4 trafficking fat and muscle cells based on new studies suggesting that heterotypic fusion with endosomes might play a more important role than previously realised.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Exciting findings from our neighbors Andrew Harrison, Duomeng Yang, and Penghua Wang @uconnhealth.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling - Nature Immunology
Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributi...
www.nature.com
November 20, 2024 at 6:11 PM
Exciting findings from our neighbors Andrew Harrison, Duomeng Yang, and Penghua Wang @uconnhealth.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Now that Bluesky is taking off, I should introduce myself!
I'm a post-doc at Warwick University in @steveroyle.bsky.social's lab, working on intracellular nanovesicles and GLUT4 trafficking. I'm generally interested in all things membrane trafficking and spend a lot of my time on the microscope.
I'm a post-doc at Warwick University in @steveroyle.bsky.social's lab, working on intracellular nanovesicles and GLUT4 trafficking. I'm generally interested in all things membrane trafficking and spend a lot of my time on the microscope.
November 12, 2024 at 9:42 AM
Now that Bluesky is taking off, I should introduce myself!
I'm a post-doc at Warwick University in @steveroyle.bsky.social's lab, working on intracellular nanovesicles and GLUT4 trafficking. I'm generally interested in all things membrane trafficking and spend a lot of my time on the microscope.
I'm a post-doc at Warwick University in @steveroyle.bsky.social's lab, working on intracellular nanovesicles and GLUT4 trafficking. I'm generally interested in all things membrane trafficking and spend a lot of my time on the microscope.
Clathrin differentially adapts its trimerisation domain during mammalian evolution to traffic the insulin-responsive GLUT4 glucose transporter www.biorxiv.org/content/10.6...
Clathrin differentially adapts its trimerisation domain during mammalian evolution to traffic the insulin-responsive GLUT4 glucose transporter
In humans, the CHC22 isoform of clathrin regulates glucose metabolism by trafficking the GLUT4 glucose transporter for intracellular storage in skeletal muscle and release following insulin signalling...
www.biorxiv.org
September 7, 2026 at 12:12 PM
Clathrin differentially adapts its trimerisation domain during mammalian evolution to traffic the insulin-responsive GLUT4 glucose transporter www.biorxiv.org/content/10.6...
Excited to have this preprint out, in which we characterise a sub-type of intracellular nanovesicles (INVs) which play a key role in the intracellular sequestration of GLUT4
🚨 We have a new preprint out! 🧪
In this paper we look at GLUT4 trafficking. This is a short explainer thread, but please read the paper!
1/n 🧵
www.biorxiv.org/content/10.6...
In this paper we look at GLUT4 trafficking. This is a short explainer thread, but please read the paper!
1/n 🧵
www.biorxiv.org/content/10.6...
February 19, 2026 at 3:12 PM
Excited to have this preprint out, in which we characterise a sub-type of intracellular nanovesicles (INVs) which play a key role in the intracellular sequestration of GLUT4
Our latest work showing that GLUT4 exofacial antibodies can measure translocation in humans and rodent skeletal muscle fibers and is impaired in TBC1D4 KO rats despite rescued GLUT4 expression. Congrats Kaspar and co-authors. DM me for open access version:
diabetesjournals.org/diabetes/art...
diabetesjournals.org/diabetes/art...
Exofacial Epitope–Specific Antibodies Detect GLUT4 Translocation in Adult Human, Rat, and Mouse Skeletal Muscle
Skeletal muscle glucose transporter 4 (GLUT4) translocation to the plasma membrane determines glucose uptake in response to insulin and exercise and is dis
diabetesjournals.org
February 17, 2026 at 4:08 PM
Our latest work showing that GLUT4 exofacial antibodies can measure translocation in humans and rodent skeletal muscle fibers and is impaired in TBC1D4 KO rats despite rescued GLUT4 expression. Congrats Kaspar and co-authors. DM me for open access version:
diabetesjournals.org/diabetes/art...
diabetesjournals.org/diabetes/art...
New #SkeletalMuscle paper: Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4). tinyurl.com/yddwvhww
Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4) - Skeletal Muscle
Background Insulin resistance and type 2 diabetes impair cellular regeneration in multiple tissues including skeletal muscle. The molecular basis for this impairment is largely unknown. Glucose uptake...
tinyurl.com
December 19, 2024 at 1:18 PM
New #SkeletalMuscle paper: Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4). tinyurl.com/yddwvhww
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 20, 2024 at 11:34 PM
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GLUT4 translocation with insulin: revisiting the case for dose-dependent quantal release https://www.biorxiv.org/content/10.1101/2025.04.11.648479v1
April 13, 2025 at 5:45 AM
GLUT4 translocation with insulin: revisiting the case for dose-dependent quantal release https://www.biorxiv.org/content/10.1101/2025.04.11.648479v1
Green Tea improves insulin sensitivity and glucose tolerance [via Agência FAPESP] 🧪⚗️💚🍵⚕️🩺
"Treatment with green tea increased the #expression of Insr, Irs1, Glut4, Hk1, and Pi3k – #genes [] important for glucose uptake and use in muscles."
agencia.fapesp.br/green-tea-im...
#green #tea #benefits
"Treatment with green tea increased the #expression of Insr, Irs1, Glut4, Hk1, and Pi3k – #genes [] important for glucose uptake and use in muscles."
agencia.fapesp.br/green-tea-im...
#green #tea #benefits
Green tea improves insulin sensitivity and glucose tolerance in obese mice
A study in an animal model analyzed the muscle metabolism of guinea pigs on a high-calorie diet. Ultimately, consumption of the plant extract increased the expression of genes associated with glucose ...
agencia.fapesp.br
October 8, 2025 at 9:59 PM
Green Tea improves insulin sensitivity and glucose tolerance [via Agência FAPESP] 🧪⚗️💚🍵⚕️🩺
"Treatment with green tea increased the #expression of Insr, Irs1, Glut4, Hk1, and Pi3k – #genes [] important for glucose uptake and use in muscles."
agencia.fapesp.br/green-tea-im...
#green #tea #benefits
"Treatment with green tea increased the #expression of Insr, Irs1, Glut4, Hk1, and Pi3k – #genes [] important for glucose uptake and use in muscles."
agencia.fapesp.br/green-tea-im...
#green #tea #benefits
We can't wait to hear from Shannan Foylan!
Shannan will discuss the nanoscale organisation and membrane dynamics of GLUT4 in adipocytes and cardiomyocytes, using super-resolution and expansion microscopy to investigate how insulin regulates GLUT4 distribution and mobility in metabolic tissues.
Shannan will discuss the nanoscale organisation and membrane dynamics of GLUT4 in adipocytes and cardiomyocytes, using super-resolution and expansion microscopy to investigate how insulin regulates GLUT4 distribution and mobility in metabolic tissues.
May 19, 2026 at 10:21 AM
We can't wait to hear from Shannan Foylan!
Shannan will discuss the nanoscale organisation and membrane dynamics of GLUT4 in adipocytes and cardiomyocytes, using super-resolution and expansion microscopy to investigate how insulin regulates GLUT4 distribution and mobility in metabolic tissues.
Shannan will discuss the nanoscale organisation and membrane dynamics of GLUT4 in adipocytes and cardiomyocytes, using super-resolution and expansion microscopy to investigate how insulin regulates GLUT4 distribution and mobility in metabolic tissues.
🚨 Poster alert! I’ll be presenting MON-573 at #ENDO2025 today from 12–1:30 PM.
🧬 Come learn about novel GLUT4 (SLC2A4) variants in atypical young-onset diabetes
📊 Proud to be part of the #RADIANT -study and this incredible research community.
@endocrinesociety.bsky.social
🧬 Come learn about novel GLUT4 (SLC2A4) variants in atypical young-onset diabetes
📊 Proud to be part of the #RADIANT -study and this incredible research community.
@endocrinesociety.bsky.social
July 14, 2025 at 3:52 PM
🚨 Poster alert! I’ll be presenting MON-573 at #ENDO2025 today from 12–1:30 PM.
🧬 Come learn about novel GLUT4 (SLC2A4) variants in atypical young-onset diabetes
📊 Proud to be part of the #RADIANT -study and this incredible research community.
@endocrinesociety.bsky.social
🧬 Come learn about novel GLUT4 (SLC2A4) variants in atypical young-onset diabetes
📊 Proud to be part of the #RADIANT -study and this incredible research community.
@endocrinesociety.bsky.social
High-fat diet ablates an insulin-responsive pool of GLUT4 glucose transporters in skeletal muscle https://www.biorxiv.org/content/10.1101/2025.06.29.662135v1
July 3, 2025 at 10:02 AM
High-fat diet ablates an insulin-responsive pool of GLUT4 glucose transporters in skeletal muscle https://www.biorxiv.org/content/10.1101/2025.06.29.662135v1
Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue
Background The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tis...
onlinelibrary.wiley.com
July 8, 2026 at 5:44 PM
Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Grabbing hold of GSVs nuked the insulin-induced mobilisation, but capture of INVs only partially reduced it. So the INVs and GSVs are not synonymous. Instead it seems that INVs sequester GLUT4 and related cargos into GSVs to form the insulin-responsive pool. This is an endosomal sorting step.
6/n
6/n
February 19, 2026 at 9:54 AM
Grabbing hold of GSVs nuked the insulin-induced mobilisation, but capture of INVs only partially reduced it. So the INVs and GSVs are not synonymous. Instead it seems that INVs sequester GLUT4 and related cargos into GSVs to form the insulin-responsive pool. This is an endosomal sorting step.
6/n
6/n
Breakthroughs in diabetes treatment! Explore how receptors like KATP, GLUT4, and PPAR-γ are targeted by new drugs and natural compounds from 2020–2024. A new era in glucose control!
www.scienceopen.com/hosted-docum...
#biguanides #DM #DPP4 #GLUT4 #PPARγ #SGLT2 #sulfonylureas
www.scienceopen.com/hosted-docum...
#biguanides #DM #DPP4 #GLUT4 #PPARγ #SGLT2 #sulfonylureas
Recent Developments in Diabetes Management: Exploring Receptors, Pathways, and Compounds
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d24020e141">Diabetes mellitus (DM) is a widespread metabolic disorder with profound effects on
vital o...
www.scienceopen.com
May 9, 2025 at 10:14 AM
Breakthroughs in diabetes treatment! Explore how receptors like KATP, GLUT4, and PPAR-γ are targeted by new drugs and natural compounds from 2020–2024. A new era in glucose control!
www.scienceopen.com/hosted-docum...
#biguanides #DM #DPP4 #GLUT4 #PPARγ #SGLT2 #sulfonylureas
www.scienceopen.com/hosted-docum...
#biguanides #DM #DPP4 #GLUT4 #PPARγ #SGLT2 #sulfonylureas
Check out this awesome article by Andrew during his time in
Penghua Wang's lab on GLUT4's role in innate immunity - it was a privilege to get to watch this work go from idea to reality during our PhDs in our many "window chats" and contribute to the project!
Penghua Wang's lab on GLUT4's role in innate immunity - it was a privilege to get to watch this work go from idea to reality during our PhDs in our many "window chats" and contribute to the project!
November 20, 2024 at 10:16 PM
Check out this awesome article by Andrew during his time in
Penghua Wang's lab on GLUT4's role in innate immunity - it was a privilege to get to watch this work go from idea to reality during our PhDs in our many "window chats" and contribute to the project!
Penghua Wang's lab on GLUT4's role in innate immunity - it was a privilege to get to watch this work go from idea to reality during our PhDs in our many "window chats" and contribute to the project!