Decades of research on the infamous antinutritional steroidal glycoalkaloids (SGAs) in Solanaceae plants have provided deep insights into their metabolism and roles. However, engineering SGAs in heterologous hosts has remained a challenge. We discovered...

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Decades of research on the infamous antinutritional steroidal glycoalkaloids (SGAs) in Solanaceae plants have provided deep insights into their metabolism and roles. However, engineering SGAs in heter...

Decades of research on the infamous antinutritional steroidal glycoalkaloids (SGAs) in Solanaceae plants have provided deep insights into their metabolism and roles. However, engineering SGAs in heter...

A recent study by Boccia et al. identified GAME15, a cellulose synthase-like protein that is essential for steroidal saponin and glycoalkaloid biosynthesis in Solanum species. GAME15 functions as a scaffold, interacting with key enzymes involved in the early steps of biosynthesis, enabling metabolic flux from cholesterol to steroidal defense compounds.

Decades of research on the infamous antinutritional steroidal glycoalkaloids (SGAs) in Solanaceae plants have provided deep insights into their metabolism and roles. However, engineering SGAs in heter...

This is part 7 of my (Josh Bycer’s) favorite demos from Steam Next Fest, June 2025 edition. 00:00 Intro00:19 Neon Inferno1:44 Vampire’s Best Friend4:05 Possessor(s)6:10 Sping7:25 Primland: The Magnus9:15 Glaciered11:13 Heroes Against Time12:42 Rogue Eclipse13:41 Jetrunner14:50 Funi Raccoon Game15:43 Hirogami17:10 Gurei18:51 Away From Home

This is part 7 of my (Josh Bycer’s) favorite demos from Steam Next Fest, June 2025 edition. 00:00 Intro00:19 Neon Inferno1:44 Vampire’s Best Friend4:05 Possessor(s)6:10 Sping7:25 Primland: The Magnus9:15 Glaciered11:13 Heroes Against Time12:42 Rogue Eclipse13:41 Jetrunner14:50 Funi Raccoon Game15:43 Hirogami17:10 Gurei18:51 Away From Home

This is part 7 of my (Josh Bycer’s) favorite demos from Steam Next Fest, June 2025 edition. 00:00 Intro00:19 Neon Inferno1:44 Vampire’s Best Friend4:05 Possessor(s)6:10 Sping7:25 Primland: The Magnus9:15 Glaciered11:13 Heroes Against Time12:42 Rogue Eclipse13:41 Jetrunner14:50 Funi Raccoon Game15:43 Hirogami17:10 Gurei18:51 Away From Home

A protein—dubbed GAME15—is the missing link in the pathway that Solanum plants like potatoes use to make molecules for pest defense. The findings in Science…

Check out my socials! | https://livelaughlewi.carrd.co/I stream on Twitch! | https://www.twitch.tv/livelaughlewi0:00 Game13:00 CW: Spiders13:08 Game15:00 CW:...

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A team of international scientists led by the University of California, Riverside, has developed a method to eliminate toxic compounds from potatoes, enhancing their safety and storage. The research focuses on managing steroidal glycoalkaloids (SGAs) through the protein GAME15, allowing the plant to produce these compounds solely in leaves. This could reduce food waste and be beneficial for space farming and vertical agriculture.