Unconventional T cells, including invariant natural killer T (iNKT) cells, gamma delta (γδ) T cells, and mucosal-associated invariant T (MAIT) cells, play important roles in both innate and adaptive immunity. These cells respond to tumors rapidly and influence the tumor microenvironment (TME). Recent advances in understanding their biology, as well as the development of novel therapeutic approaches, have underscored their potential in cancer immunotherapy. This commentary will assess these advances and translational possibilities in the field.

Renal involvement is a key determinant of prognosis in IgA vasculitis (IgAV), yet its underlying immunologic mechanisms remain incompletely elucidated. The role of γδ T cells and their subsets require...

Our findings suggest that γδT cells may enhance B-cell differentiation into antibody-producing plasma cells in BD patients with mucocutaneous and ocular clinical phenotypes.